Chen Izu Y, McCulle S, Ward C, Soeller C, Allen B, Rabang C, et al. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J. 2006;91:1-13 pubmed
..The importance of cluster size and three-dimensional spacing for current E-C coupling models is discussed. ..
Chen Izu Y, Ward C, Stark W, Banyasz T, Sumandea M, Balke C, et al. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007;293:H2409-17 pubmed
..Furthermore, the spacing between RyR(2) clusters was shortened in failing hearts, as predicted by quantitative model simulation to increase spontaneous Ca(2+) wave generation and arrhythmias. ..
