Xuemei Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Transgenically expressed viral RNA silencing suppressors interfere with microRNA methylation in Arabidopsis
    Bin Yu
    Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    FEBS Lett 580:3117-20. 2006
  2. pmc Approaches for studying microRNA and small interfering RNA methylation in vitro and in vivo
    Zhiyong Yang
    Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California Riverside, Riverside, California, USA
    Methods Enzymol 427:139-54. 2007
  3. pmc MicroRNA metabolism in plants
    Xuemei Chen
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Curr Top Microbiol Immunol 320:117-36. 2008
  4. pmc The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis
    Bin Yu
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 105:10073-8. 2008
  5. pmc HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide
    Zhiyong Yang
    Department of Botany and Plant Sciences, University of California Riverside, Riverside, CA 92521, USA
    Nucleic Acids Res 34:667-75. 2006
  6. pmc Generation of a luciferase-based reporter for CHH and CG DNA methylation in Arabidopsis thaliana
    Thanh Theresa Dinh
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA, 92521, USA
    Silence 4:1. 2013
  7. pmc Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana
    So Youn Won
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA, 92521, USA
    Silence 3:6. 2012
  8. pmc Small RNAs in development - insights from plants
    Xuemei Chen
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, United States
    Curr Opin Genet Dev 22:361-7. 2012
  9. pmc Genome-wide analysis reveals rapid and dynamic changes in miRNA and siRNA sequence and expression during ovule and fiber development in allotetraploid cotton (Gossypium hirsutum L.)
    Mingxiong Pang
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, One University Station, A 4800, Austin, TX 78712, USA
    Genome Biol 10:R122. 2009
  10. pmc Computational prediction of novel non-coding RNAs in Arabidopsis thaliana
    Dandan Song
    Department of Computer Science and Technology, Tsinghua University, Beijing 100084, PR China
    BMC Bioinformatics 10:S36. 2009

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Transgenically expressed viral RNA silencing suppressors interfere with microRNA methylation in Arabidopsis
    Bin Yu
    Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    FEBS Lett 580:3117-20. 2006
    ..These findings suggest miRNA/miRNA* as the in vivo substrates for the HEN1 miRNA methyltransferase and raise intriguing possibilities regarding the cellular location of miRNA methylation...
  2. pmc Approaches for studying microRNA and small interfering RNA methylation in vitro and in vivo
    Zhiyong Yang
    Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California Riverside, Riverside, California, USA
    Methods Enzymol 427:139-54. 2007
    ..Here we describe methods to characterize the biochemical activities of the HEN1 protein both in vitro and in vivo, and methods to analyze the methylation status of small RNAs in vivo...
  3. pmc MicroRNA metabolism in plants
    Xuemei Chen
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Curr Top Microbiol Immunol 320:117-36. 2008
    ..This chapter summarizes the current knowledge as well as gaps in our understanding of plant miRNA biogenesis and function...
  4. pmc The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis
    Bin Yu
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 105:10073-8. 2008
    ..Therefore, we uncovered an evolutionarily conserved factor in miRNA biogenesis. We propose that DDL participates in miRNA biogenesis by facilitating DCL1 to access or recognize pri-miRNAs...
  5. pmc HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide
    Zhiyong Yang
    Department of Botany and Plant Sciences, University of California Riverside, Riverside, CA 92521, USA
    Nucleic Acids Res 34:667-75. 2006
    ..These findings indicate that HEN1 specifically methylates miRNAs and siRNAs and implicate the importance of the 2'-O-methyl group in the biology of RNA silencing...
  6. pmc Generation of a luciferase-based reporter for CHH and CG DNA methylation in Arabidopsis thaliana
    Thanh Theresa Dinh
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA, 92521, USA
    Silence 4:1. 2013
    ..To aid the comprehensive identification of players in DNA methylation, we generated a transgenic reporter system that permits genetic and chemical genetic screens in Arabidopsis...
  7. pmc Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana
    So Youn Won
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA, 92521, USA
    Silence 3:6. 2012
    ..abstract:..
  8. pmc Small RNAs in development - insights from plants
    Xuemei Chen
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, United States
    Curr Opin Genet Dev 22:361-7. 2012
    ..I do not recount the numerous developmental processes regulated by small RNAs; instead, I focus on major principles that have been derived from recent studies and draw parallels, when applicable, between plants and animals...
  9. pmc Genome-wide analysis reveals rapid and dynamic changes in miRNA and siRNA sequence and expression during ovule and fiber development in allotetraploid cotton (Gossypium hirsutum L.)
    Mingxiong Pang
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, One University Station, A 4800, Austin, TX 78712, USA
    Genome Biol 10:R122. 2009
    ..Many of these factors are targets of microRNAs (miRNAs) that mediate target gene regulation by mRNA degradation or translational repression...
  10. pmc Computational prediction of novel non-coding RNAs in Arabidopsis thaliana
    Dandan Song
    Department of Computer Science and Technology, Tsinghua University, Beijing 100084, PR China
    BMC Bioinformatics 10:S36. 2009
    ..Among the available computational methods, the comparative genomic approach seems to be the most powerful to detect ncRNAs. The recent completion of the sequencing of several major plant genomes has made the approach possible for plants...
  11. ncbi request reprint Small RNAs and their roles in plant development
    Xuemei Chen
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, California 92521, USA
    Annu Rev Cell Dev Biol 25:21-44. 2009
    ....
  12. pmc A silencing safeguard: links between RNA silencing and mRNA processing in Arabidopsis
    Xuemei Chen
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Dev Cell 14:811-2. 2008
    ....
  13. pmc Small RNAs - secrets and surprises of the genome
    Xuemei Chen
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Plant J 61:941-58. 2010
    ..Here, I attempt to recount the developments of the small RNA field in the pre- and post-genomic era, in celebration of the 10th anniversary of the completion of the first plant genome...
  14. ncbi request reprint MicroRNA biogenesis and function in plants
    Xuemei Chen
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    FEBS Lett 579:5923-31. 2005
    ..A large category of miRNA targets consists of genes encoding transcription factors that play important roles in patterning the plant form...
  15. pmc siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis
    Bin Yu
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Nucleic Acids Res 38:5844-50. 2010
    ..In addition, our findings imply the existence of a negative modifier of HEN1 activity in the Columbia genetic background...
  16. pmc The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation
    Yuanyuan Zhao
    Department of Botany and Plant Sciences, Center for Plant Biology, Institute of Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA
    Curr Biol 22:689-94. 2012
    ..We show that uridylation leads to miRNA degradation, and the degradation is most likely through an enzyme that is distinct from that causing the 3' truncation in hen1 mutants...
  17. pmc AGAMOUS terminates floral stem cell maintenance in Arabidopsis by directly repressing WUSCHEL through recruitment of Polycomb Group proteins
    Xigang Liu
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, California 92521, USA
    Plant Cell 23:3654-70. 2011
    ..Our studies identify core components of the network governing the temporal program of floral stem cells...
  18. pmc ARGONAUTE10 and ARGONAUTE1 regulate the termination of floral stem cells through two microRNAs in Arabidopsis
    Lijuan Ji
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California Riverside, Riverside, California, United States of America
    PLoS Genet 7:e1001358. 2011
    ....
  19. pmc Biochemical activities of Arabidopsis RNA-dependent RNA polymerase 6
    Julien Curaba
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    J Biol Chem 283:3059-66. 2008
    ..Our findings have important implications on the processes involving RDR6 in vivo and provide new biochemical insights into the mechanisms of RNA silencing in Arabidopsis...
  20. pmc Degradation of microRNAs by a family of exoribonucleases in Arabidopsis
    Vanitharani Ramachandran
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USA
    Science 321:1490-2. 2008
    ..Therefore, we have uncovered the enzymes that degrade miRNAs and demonstrated that miRNA turnover is crucial for plant development...
  21. pmc POWERDRESS and diversified expression of the MIR172 gene family bolster the floral stem cell network
    Rae Eden Yumul
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California Riverside, Riverside, California, USA
    PLoS Genet 9:e1003218. 2013
    ....
  22. pmc miR172 regulates stem cell fate and defines the inner boundary of APETALA3 and PISTILLATA expression domain in Arabidopsis floral meristems
    Li Zhao
    Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute of Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USA
    Plant J 51:840-9. 2007
    ..Given the antiquity of miR172 in land plants, our findings have implications for the recruitment of a microRNA in the building of a flower in evolution...
  23. pmc MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis
    Shengben Li
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA
    Cell 153:562-74. 2013
    ..This study demonstrates that translation inhibition is an important activity of plant miRNAs, reveals the subcellular location of this activity, and uncovers a previously unknown function of the ER...
  24. pmc The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element
    Thanh Theresa Dinh
    Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Development 139:1978-86. 2012
    ..It also sets the foundation for understanding the basis of the broad biological functions of AP2 in Arabidopsis, as well as the divergent biological functions of AP2 orthologs in dicotyledonous plants...
  25. ncbi request reprint Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis
    Junjie Li
    Department of Botany and Plant Sciences, Institute of Integrative Genome Research, University of California, Riverside, Riverside, California 92508, USA
    Curr Biol 15:1501-7. 2005
    ..We conclude that 3'-end methylation is a common step in miRNA and siRNA metabolism and likely protects the 3' ends of the small RNAs from the uridylation activity...
  26. pmc RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana
    Xian Bing Wang
    Center for Plant Cell Biology, Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 107:484-9. 2010
    ..Our work thus identifies a distinct mechanism for the amplification of immunity effectors, which together with the requirement for the biogenesis of endogenous siRNAs, may play a role in the emergence and expansion of eukaryotic RDRs...
  27. pmc The role of Mediator in small and long noncoding RNA production in Arabidopsis thaliana
    Yun Ju Kim
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA, USA
    EMBO J 30:814-22. 2011
    ..This study expands the function of Mediator to include Pol II-mediated intergenic transcription and implicates a role of Mediator in genome stability...
  28. pmc Intergenic transcription by RNA polymerase II coordinates Pol IV and Pol V in siRNA-directed transcriptional gene silencing in Arabidopsis
    Binglian Zheng
    Department of Botany and Plant Sciences and Institute of Integrative Genome Biology, University of California at Riverside, Riverside, California 92521, USA
    Genes Dev 23:2850-60. 2009
    ..This study establishes that intergenic transcription by Pol II is required for siRNA-mediated TGS, and reveals an intricate collaboration and division of labor among the three polymerases in gene silencing...
  29. ncbi request reprint DNA topoisomerase I affects polycomb group protein-mediated epigenetic regulation and plant development by altering nucleosome distribution in Arabidopsis
    Xigang Liu
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, California 92521 Key Laboratory of Agricultural Water Resource, Hebei Laboratory of Agricultural Water Saving, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050021, China
    Plant Cell 26:2803-17. 2014
    ..This study uncovers a connection between TOP1α and PcG, which explains the specific developmental functions of TOP1α...
  30. pmc DNA topoisomerase 1α promotes transcriptional silencing of transposable elements through DNA methylation and histone lysine 9 dimethylation in Arabidopsis
    Thanh Theresa Dinh
    Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute of Integrative Genome Biology, University of California Riverside, Riverside, California, United States of America ChemGen IGERT program, Center for Plant Cell Biology, Institute of Integrative Genome Biology, University of California Riverside, Riverside, California, United States of America
    PLoS Genet 10:e1004446. 2014
    ..This study assigned a new role in epigenetic silencing to an enzyme that affects DNA topology. ..
  31. ncbi request reprint Roles of small RNAs in soybean defense against Phytophthora sojae infection
    James Wong
    Department of Plant Pathology and Microbiology, University of California, Riverside, CA, 92521, USA Center for Plant Cell Biology, University of California, Riverside, CA, 92521, USA
    Plant J 79:928-40. 2014
    ..This work identifies specific miRNAs and phasiRNAs that regulate defense-associated genes in soybean during Phytophthora infection. ..
  32. ncbi request reprint AUXIN RESPONSE FACTOR 3 integrates the functions of AGAMOUS and APETALA2 in floral meristem determinacy
    Xigang Liu
    Key Laboratory of Agricultural Water Resources, Hebei Laboratory of Agricultural Water Saving, Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 286 Huaizhong RD, Shijiazhuang, 050021, China Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA, 92521, USA
    Plant J 80:629-41. 2014
    ..This study uncovered a role for ARF3 in FM determinacy and revealed relationships among genes in the genetic network governing FM determinacy...
  33. pmc Floral patterning defects induced by Arabidopsis APETALA2 and microRNA172 expression in Nicotiana benthamiana
    Sizolwenkosi Mlotshwa
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Mol Biol 61:781-93. 2006
    ..benthamiana normal floral homeotic gene function in perianth organs. Our studies uncover the potential utility of the Arabidopsis AP2/miR172 system as a tool for manipulation of floral architecture and flowering time in non-model plants...
  34. pmc Traffic into silence: endomembranes and post-transcriptional RNA silencing
    Yun Ju Kim
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology University of California, Riverside, CA, USA
    EMBO J 33:968-80. 2014
    ....
  35. pmc Regulation of small RNA stability: methylation and beyond
    Lijuan Ji
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Cell Res 22:624-36. 2012
    ..Investigations are ongoing to further understand how small RNA stability impacts their accumulation in vivo in order to improve the utilization of RNA silencing in biotechnology and therapeutic applications...
  36. pmc Small RNA metabolism in Arabidopsis
    Vanitharani Ramachandran
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Trends Plant Sci 13:368-74. 2008
    ..Here, we review the biogenesis of small RNAs, and we discuss the major outstanding questions in small RNA metabolism and function...
  37. ncbi request reprint Analysis of miRNA Modifications
    Bin Yu
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, Riverside, CA, USA
    Methods Mol Biol 592:137-48. 2010
    ....
  38. pmc Dynamics of histone H3 lysine 27 trimethylation in plant development
    Binglian Zheng
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Curr Opin Plant Biol 14:123-9. 2011
    ....
  39. pmc Biogenesis, turnover, and mode of action of plant microRNAs
    Kestrel Rogers
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Plant Cell 25:2383-99. 2013
    ..Here, we review the mechanisms underlying the biogenesis, turnover, and activities of plant miRNAs. ..
  40. ncbi request reprint Genetic screens for floral mutants in Arabidopsis thaliana: enhancers and suppressors
    Thanh Theresa Dinh
    Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA, USA
    Methods Mol Biol 1110:127-56. 2014
    ....
  41. pmc Oomycete pathogens encode RNA silencing suppressors
    Yongli Qiao
    Department of Plant Pathology and Microbiology, University of California, Riverside, Riverside, California, USA
    Nat Genet 45:330-3. 2013
    ..These findings identify RNA silencing suppression as a common strategy used by pathogens across kingdoms to cause disease and are consistent with RNA silencing having key roles in host defense...
  42. ncbi request reprint Methylation as a crucial step in plant microRNA biogenesis
    Bin Yu
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 307:932-5. 2005
    ..Our studies uncover a new and crucial step in plant miRNA biogenesis and have profound implications in the function of miRNAs...
  43. pmc PAUSED, a putative exportin-t, acts pleiotropically in Arabidopsis development but is dispensable for viability
    Junjie Li
    Waksman Institute, Rutgers University, Piscataway, New Jersey 08854, USA
    Plant Physiol 132:1913-24. 2003
    ..In addition, a paused null allele, paused-6, is still viable, suggesting the presence of redundant tRNA export pathway(s) in Arabidopsis...
  44. ncbi request reprint HUA ENHANCER2, a putative DExH-box RNA helicase, maintains homeotic B and C gene expression in Arabidopsis
    Tamara L Western
    Waksman Institute, Rutgers University, 190 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Development 129:1569-81. 2002
    ....
  45. ncbi request reprint The regulation of genes and genomes by small RNAs
    Victor Ambros
    Dartmouth Medical School, Hanover, NH 03755, USA
    Development 134:1635-41. 2007
    ....
  46. ncbi request reprint CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana
    Wonkeun Park
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Curr Biol 12:1484-95. 2002
    ....
  47. ncbi request reprint Two RNA binding proteins, HEN4 and HUA1, act in the processing of AGAMOUS pre-mRNA in Arabidopsis thaliana
    Yulan Cheng
    Waksman Institute, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Dev Cell 4:53-66. 2003
    ..Our studies underscore the importance of RNA processing in modulating plant development...
  48. ncbi request reprint HEN1 functions pleiotropically in Arabidopsis development and acts in C function in the flower
    Xuemei Chen
    Waksman Institute, Rutgers, The State University of New Jersey, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Development 129:1085-94. 2002
    ..Therefore, HEN1, like the A function gene AP2, plays multiple roles in plant development as well as acting in organ identity specification in the flower. HEN1 codes for a novel protein and is expressed throughout the plant...
  49. pmc Small RNA-directed epigenetic natural variation in Arabidopsis thaliana
    Jixian Zhai
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 4:e1000056. 2008
    ..Methylation analysis revealed that 88% of the examined loci (37 out of 42) were specifically methylated in Ler but not Col, suggesting that small RNA can direct epigenetic differences between two closely related Arabidopsis ecotypes...
  50. ncbi request reprint Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance
    Stéphanie Boutet
    Laboratoire de Biologie Cellulaire, INRA, 78026 Versailles Cedex, France
    Curr Biol 13:843-8. 2003
    ....
  51. ncbi request reprint A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development
    Xuemei Chen
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Science 303:2022-5. 2004
    ..Therefore, miRNA172 likely acts in cell-fate specification as a translational repressor of APETALA2 in Arabidopsis flower development...
  52. ncbi request reprint Posttranscriptional control of plant development
    Yulan Cheng
    Developmental Genetics Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York, New York 10016, USA
    Curr Opin Plant Biol 7:20-5. 2004
    ..Despite the limited knowledge of the underlying molecular mechanisms, posttranscriptional regulation is known to play a key role in the control of plant development...
  53. ncbi request reprint HUA ENHANCER3 reveals a role for a cyclin-dependent protein kinase in the specification of floral organ identity in Arabidopsis
    Wenming Wang
    Waksman Institute, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Development 131:3147-56. 2004
    ..Therefore, CDK8 plays a role in cell differentiation in a multicellular organism...
  54. pmc DICER-LIKE2 plays a primary role in transitive silencing of transgenes in Arabidopsis
    Sizolwenkosi Mlotshwa
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, United States of America
    PLoS ONE 3:e1755. 2008
    ..We conclude that DCL2 plays an essential, as opposed to redundant, role in transitive silencing of transgenes and may play a more important role in silencing of viruses than currently thought...
  55. pmc A marked end
    Xuemei Chen
    Nat Struct Mol Biol 14:259-60. 2007
  56. pmc Topomimetics of amphipathic beta-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins
    Xuemei Chen
    Department of Chemistry and Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Med Chem 49:7754-65. 2006
    ..This research contributes to the development of pharmaceutical agents against endotoxemia and septic shock...
  57. pmc siRNAs targeting an intronic transposon in the regulation of natural flowering behavior in Arabidopsis
    Jun Liu
    Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA
    Genes Dev 18:2873-8. 2004
    ..Our studies have general implications for the role of transposable elements in eukaryotic gene expression and evolution...
  58. pmc A uniform system for microRNA annotation
    Victor Ambros
    Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
    RNA 9:277-9. 2003
    ..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families...