Xuemei Chen


Affiliation: University of California
Country: USA


  1. Wang S, Quan L, Li S, You C, Zhang Y, Gao L, et al. The Protein Phosphatase 4 Complex Promotes Transcription and Processing of Primary microRNAs in Arabidopsis. Plant Cell. 2019;: pubmed publisher
    ..Moreover, we showed that hundreds of introns exhibit splicing defects in pp4r3a mutants. Together, this study revealed a role of Arabidopsis PP4 in transcription and nuclear RNA metabolism. ..
  2. Cai Q, Liang C, Wang S, Hou Y, Gao L, Liu L, et al. The disease resistance protein SNC1 represses the biogenesis of microRNAs and phased siRNAs. Nat Commun. 2018;9:5080 pubmed publisher
    ..Taken together, this study suggests an R gene-miRNA-phasiRNA regulatory module that amplifies plant immune responses. ..
  3. Liu L, Chen X. Intercellular and systemic trafficking of RNAs in plants. Nat Plants. 2018;4:869-878 pubmed publisher
    ..This review summarizes the current knowledge of local and systemic RNA movement, and discusses the potential regulatory mechanisms and biological significance of RNA trafficking in plants. ..
  4. Peng T, Qiao M, Liu H, Teotia S, Zhang Z, Zhao Y, et al. A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants. Mol Plant. 2018;11:1400-1417 pubmed publisher
    ..ffr.mtu.edu/designindex2.php) to display the transcriptomic and miRNAomic changes in STTM-induced miRNA knockdown plants. ..
  5. Chen J, Liu L, You C, Gu J, Ruan W, Zhang L, et al. Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun. 2018;9:3585 pubmed publisher
    ..These extensive structural and biochemical studies may shed light on a common 3' end trimming mechanism for 3'→5' exonucleases in the metabolism of small non-coding RNAs. ..
  6. Chen X. Small RNAs in development - insights from plants. Curr Opin Genet Dev. 2012;22:361-7 pubmed publisher
    ..I do not recount the numerous developmental processes regulated by small RNAs; instead, I focus on major principles that have been derived from recent studies and draw parallels, when applicable, between plants and animals. ..
  7. Sanei M, Chen X. Mechanisms of microRNA turnover. Curr Opin Plant Biol. 2015;27:199-206 pubmed publisher
    ..Here we discuss the mechanisms that control miRNA turnover in plants and, where applicable, make references to similarities and differences in these mechanisms between plants and animals. ..
  8. Song J, Song J, Mo B, Chen X. Uridylation and adenylation of RNAs. Sci China Life Sci. 2015;58:1057-66 pubmed publisher
    ..RNA tailing and its outcomes have been associated with human diseases such as cancer. Here, we review recent developments in RNA uridylation and adenylation and discuss the future prospects in this research area. ..
  9. Chen X. Small RNAs and their roles in plant development. Annu Rev Cell Dev Biol. 2009;25:21-44 pubmed publisher

More Information


  1. Liu L, Chen X. RNA Quality Control as a Key to Suppressing RNA Silencing of Endogenous Genes in Plants. Mol Plant. 2016;9:826-36 pubmed publisher
    ..Here we review recent advances on RNA quality control and its role in the suppression of RNA silencing at endogenous genes and discuss the mechanisms underlying the crosstalk among these pathways. ..
  2. Cui J, You C, Chen X. The evolution of microRNAs in plants. Curr Opin Plant Biol. 2017;35:61-67 pubmed publisher
    ..Both inter-species and intra-species divergence of miRNAs exhibits functional adaptation and adaptation to changing environments in evolution. Here we summarize recent progress in studies on the evolution of MIR and related genes. ..
  3. Chen X. MicroRNA biogenesis and function in plants. FEBS Lett. 2005;579:5923-31 pubmed
    ..A large category of miRNA targets consists of genes encoding transcription factors that play important roles in patterning the plant form. ..
  4. Chen X. Small RNAs - secrets and surprises of the genome. Plant J. 2010;61:941-58 pubmed publisher
    ..Here, I attempt to recount the developments of the small RNA field in the pre- and post-genomic era, in celebration of the 10th anniversary of the completion of the first plant genome. ..
  5. Su Z, Zhao L, Zhao Y, Li S, Won S, Cai H, et al. The THO Complex Non-Cell-Autonomously Represses Female Germline Specification through the TAS3-ARF3 Module. Curr Biol. 2017;27:1597-1609.e2 pubmed publisher
    ..Our findings reveal the role of a small-RNA pathway in the regulation of female germline specification in Arabidopsis. ..
  6. You C, Cui J, Wang H, Qi X, Kuo L, Ma H, et al. Conservation and divergence of small RNA pathways and microRNAs in land plants. Genome Biol. 2017;18:158 pubmed publisher
    ..Our phylogenetic analyses of miRNAs in bryophytes, lycophytes, ferns, and angiosperms refine the time-of-origin for conserved miRNA families as well as small RNA machinery in land plants. ..
  7. Jia T, Zhang B, You C, Zhang Y, Zeng L, Li S, et al. The Arabidopsis MOS4-Associated Complex Promotes MicroRNA Biogenesis and Precursor Messenger RNA Splicing. Plant Cell. 2017;29:2626-2643 pubmed publisher
    ..We also discovered global intron retention defects in mutants in three subunits of MAC, thus linking MAC function to splicing in Arabidopsis. ..
  8. Li S, Liu L, Li S, Gao L, Zhao Y, Kim Y, et al. SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. Nucleic Acids Res. 2016;44:608-20 pubmed publisher
    ..This work has uncovered a novel, anti-silencing function for a member of the Su(var)3-9 family that has previously been associated with silencing through H3K9 methylation. ..
  9. Li S, Vandivier L, Tu B, Gao L, Won S, Li S, et al. Detection of Pol IV/RDR2-dependent transcripts at the genomic scale in Arabidopsis reveals features and regulation of siRNA biogenesis. Genome Res. 2015;25:235-45 pubmed publisher
    ..These findings begin to reveal features of Pol IV/RDR2-mediated transcription at the heart of genome stability in plants. ..
  10. Liu X, Gao L, Dinh T, Shi T, Li D, Wang R, et al. DNA topoisomerase I affects polycomb group protein-mediated epigenetic regulation and plant development by altering nucleosome distribution in Arabidopsis. Plant Cell. 2014;26:2803-17 pubmed publisher
    ..This study uncovers a connection between TOP1? and PcG, which explains the specific developmental functions of TOP1?. ..
  11. Chen X. A silencing safeguard: links between RNA silencing and mRNA processing in Arabidopsis. Dev Cell. 2008;14:811-2 pubmed publisher