Xinbin Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation
    Yong Sam Jung
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    Mol Cell Biol 30:1041-8. 2010
  2. pmc RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability
    Seong Jun Cho
    Center for Comparative Oncology, The University of California, Davis, CA 95616, USA
    Nucleic Acids Res 38:2256-67. 2010
  3. pmc Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
    W Yan
    Comparative Oncology Laboratory, University of California at Davis, Davis, CA, USA
    Oncogene 32:599-609. 2013
  4. pmc The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability
    Ariane Scoumanne
    The Center for Comparative Oncology, University of California at Davis, Davis, CA 95616, USA
    Nucleic Acids Res 39:213-24. 2011
  5. pmc SNF5, a core component of the SWI/SNF complex, is necessary for p53 expression and cell survival, in part through eIF4E
    Y Xu
    Center for Comparative Oncology, University of California, Davis, CA 95616, USA
    Oncogene 29:4090-100. 2010
  6. pmc DEC1 and MIC-1: New players of p53-dependent cell fate decision
    Yingjuan Qian
    Comparative Cancer Center University of California, Davis Davis, CA USA
    Cell Cycle 11:3525-6. 2012
  7. pmc PRMT5 is required for cell-cycle progression and p53 tumor suppressor function
    A Scoumanne
    Center for Comparative Oncology, University of California at Davis, CA 95616, USA
    Nucleic Acids Res 37:4965-76. 2009
  8. pmc HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63
    Wensheng Yan
    Comparative Oncology Laboratory, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e45336. 2012
  9. pmc Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, Davis, California 95616, USA
    J Invest Dermatol 133:1178-87. 2013
  10. pmc Poly (C)-binding protein 1 regulates p63 expression through mRNA stability
    Seong Jun Cho
    Comparative Oncology Laboratory, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e71724. 2013

Research Grants

  1. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2007
  2. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2009
  3. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2002
  4. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2006
  5. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2009
  6. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2005
  7. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2006
  8. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2006
  9. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2007
  10. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2007

Collaborators

Detail Information

Publications60

  1. pmc Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation
    Yong Sam Jung
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    Mol Cell Biol 30:1041-8. 2010
    ..We postulate that UV irradiation promotes cancer formation in part by destabilizing PolH via Pirh2-mediated 20S proteasomal degradation...
  2. pmc RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability
    Seong Jun Cho
    Center for Comparative Oncology, The University of California, Davis, CA 95616, USA
    Nucleic Acids Res 38:2256-67. 2010
    ..Together, we hypothesize that RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability...
  3. pmc Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
    W Yan
    Comparative Oncology Laboratory, University of California at Davis, Davis, CA, USA
    Oncogene 32:599-609. 2013
    ..Together, our data uncover a regulatory mechanism of mutant p53 transcription via HDAC8 and suggest that HDAC inhibitors and especially HDAC8-targeting agents might be explored as an adjuvant for tumors carrying a mutant p53...
  4. pmc The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability
    Ariane Scoumanne
    The Center for Comparative Oncology, University of California at Davis, Davis, CA 95616, USA
    Nucleic Acids Res 39:213-24. 2011
    ..Taken together, we revealed that PCBP4 regulates both basal and stress-induced p21 expression through binding p21 3'-UTR and modulating p21 mRNA stability...
  5. pmc SNF5, a core component of the SWI/SNF complex, is necessary for p53 expression and cell survival, in part through eIF4E
    Y Xu
    Center for Comparative Oncology, University of California, Davis, CA 95616, USA
    Oncogene 29:4090-100. 2010
    ..Together, our study results suggest that the p53 pathway is regulated by, and mediates the activity of, SNF5 in tumor suppression and prosurvival...
  6. pmc DEC1 and MIC-1: New players of p53-dependent cell fate decision
    Yingjuan Qian
    Comparative Cancer Center University of California, Davis Davis, CA USA
    Cell Cycle 11:3525-6. 2012
    ..Comment on: Qian Y, et al. Proc Natl Acad Sci USA 2012; 109:11300-5...
  7. pmc PRMT5 is required for cell-cycle progression and p53 tumor suppressor function
    A Scoumanne
    Center for Comparative Oncology, University of California at Davis, CA 95616, USA
    Nucleic Acids Res 37:4965-76. 2009
    ..Taken together, we uncovered that arginine methyltransferase PRMT5 is a major pro-survival factor regulating eIF4E expression and p53 translation...
  8. pmc HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63
    Wensheng Yan
    Comparative Oncology Laboratory, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e45336. 2012
    ..Together, our data suggest that HuR maintains cell proliferation and polarity of mammary epithelial cells at least in part via ΔNp63...
  9. pmc Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, Davis, California 95616, USA
    J Invest Dermatol 133:1178-87. 2013
    ..Collectively, our data suggest that Pirh2 has a physiologically relevant role in keratinocyte differentiation through the posttranslational modification of p63 protein...
  10. pmc Poly (C)-binding protein 1 regulates p63 expression through mRNA stability
    Seong Jun Cho
    Comparative Oncology Laboratory, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e71724. 2013
    ..Additionally, we found that a CU-rich element (CUE) in p63 3'UTR is bound by and responsive to PCBP1. Together, we conclude that PCBP1 regulates p63 expression via mRNA stability. ..
  11. pmc The p53-estrogen receptor loop in cancer
    C Berger
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    Curr Mol Med 13:1229-40. 2013
    ..Clinical correlations between estrogen receptors and p53 status have also been reported. Thus, this review will discuss the relationship between p53 and ERs at both the molecular and clinical levels. ..
  12. pmc p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability
    Wensheng Yan
    Comparative Oncology Laboratory, University of California at Davis, Davis, California, USA
    Mol Cell Biol 32:2336-48. 2012
    ..Due to the fact that RNPC1 is a target of p73, the mutual regulation between p73 and RNPC1 constitutes a novel feed-forward loop, which might be explored as a target for tumors without a functional p53...
  13. pmc Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality
    Seong Jun Cho
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:9362-7. 2013
    ..Thus, we postulate that as a membrane adhesion molecule, Ninj1 is an ideal target to regulate p53 activity via the p53-Ninj1 loop...
  14. pmc Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression
    Wensheng Yan
    Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 286:17478-86. 2011
    ..Taken together, we found that mutant p53 is a target of arsenic compounds, which provides an insight into exploring arsenic compound-based therapy for tumors harboring a mutant p53...
  15. pmc Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition
    Yanhong Zhang
    Comparative Oncology Laboratory, School of Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 287:17746-53. 2012
    ..Together, our data suggest that TAp73 is necessary for maintaining normal cell polarity by suppressing EMT...
  16. pmc DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation
    Yingjuan Qian
    From the Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 286:12033-41. 2011
    ..Together, we conclude that ΔNp63 is a novel target of DEC1 and HDAC2 and modulates the efficacy of HDAC inhibitors in growth suppression and keratinocyte differentiation...
  17. pmc MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth
    Nagalakshmi Nadiminty
    Department of Urology, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 7:e32832. 2012
    ..Prostate cancer (PCa) is characterized by deregulated expression of several tumor suppressor or oncogenic miRNAs. The objective of this study was the identification and characterization of miR-let-7c as a potential tumor suppressor in PCa...
  18. pmc Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas
    Jin Zhang
    Comparative Cancer Center, Schools of Medicine and Veterinary Medicine, University of California at Davis, USA
    Genes Dev 25:1528-43. 2011
    ..Together, we identified a novel p53-RNPC1 autoregulatory loop, and our findings suggest that RNPC1 plays a role in tumorigenesis by repressing p53 translation...
  19. pmc Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein
    Wensheng Yan
    Comparative Oncology Laboratory, University of California at Davis, Davis, California 95616, USA
    J Biol Chem 288:2907-13. 2013
    ..Together, these data suggest that arsenic degrades ΔNp63 protein at least in part via Pirh2-dependent proteolysis and that inhibition of ΔNp63 expression facilitates tumor cells to arsenic-induced death...
  20. pmc Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1
    Yingjuan Qian
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:11300-5. 2012
    ..Together, we hypothesize that DEC1 controls the response of p53-dependent cell survival vs. cell death to a stress signal through MIC-1...
  21. pmc DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
    Yingjuan Qian
    University of California Davis, Center for Comparative Oncology, Davis, CA 95616, USA
    J Biol Chem 283:2896-905. 2008
    ..Finally, we showed that DEC1-induced senescence is p21-independent. Taken together, our data provided strong evidence that DEC1 is one of the effectors downstream of p53 to promote premature senescence...
  22. pmc Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations
    Wensheng Yan
    Center for Comparative Oncology, University of California at Davis, Davis, California 95616, USA
    Cancer Res 68:6789-96. 2008
    ..Together, these findings suggest that one mechanism by which mutant p53 acquires its gain-of-function is through the inhibition of Id2 expression...
  23. pmc The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress
    Yanhong Zhang
    Center for Comparative Oncology, Schools of Medicine and Veterinary Medicine, University of California, Davis, California 95616, USA
    Cancer Res 69:6049-56. 2009
    ..Thus, due to its expression on the cell surface and its role in cell survival, GPR87 may be explored as a novel therapeutic target for cancer treatment and prevention...
  24. pmc Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop
    Ping Yang
    UC Davis Cancer Center Basic Sciences, University of California at Davis, Sacramento, California, USA
    Mol Cell Biol 32:3121-31. 2012
    ....
  25. pmc Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation
    Xiangling Chen
    Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 287:34410-8. 2012
    ..Taken together, these data reveal that serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation...
  26. pmc Functional p53 determines docetaxel sensitivity in prostate cancer cells
    Chengfei Liu
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    Prostate 73:418-27. 2013
    ..However, docetaxel resistance rapidly develops. Identifying the critical mechanisms giving rise to docetaxel resistance is the major challenge in advanced prostate cancer...
  27. pmc The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation
    Seong Jun Cho
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    J Biol Chem 287:14535-44. 2012
    ..Together, we have uncovered a novel mechanism by which HuR is regulated by RNPC1 via mRNA stability and HuR is a mediator of RNPC1-induced growth suppression...
  28. pmc Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival
    Yanhong Zhang
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    J Biol Chem 283:30689-98. 2008
    ..Consistent with this observation, STX6 knockdown inhibits cell adhesion. Together, we postulate that STX6 is an effector and a modulator of the p53 family in the regulation of cell adhesion and survival...
  29. pmc RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability
    Jin Zhang
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 107:9614-9. 2010
    ..Together, we uncovered a previously undetected mechanism by which p63 expression is regulated via mRNA stability and a novel regulatory feedback loop between RNPC1 and p63...
  30. pmc DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    DNA Repair (Amst) 11:177-84. 2012
    ..Taken together, we uncovered that Mdm2 serves as an E3 ligase for PolH polyubiquitination and proteasomal degradation in cells under the basal condition and in response to UV irradiation...
  31. pmc The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 286:35388-95. 2011
    ..Taken together, our findings indicate that Pirh2 promotes the proteasomal turnover of TAp73, and thus targeting Pirh2 to restore TAp73-mediated growth suppression in p53-deficient tumors may be developed as a novel anti-cancer strategy...
  32. pmc Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    Mol Cell Biol 31:3997-4006. 2011
    ....
  33. pmc Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1
    Min Zhang
    Comparative Oncology Laboratory, University of California at Davis, Davis, California 95616, USA
    Genes Dev 27:2246-58. 2013
    ..Together, we postulate that the p53-RNPC1 loop can be explored to increase or decrease p53 activity for cancer therapy. ..
  34. pmc RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability
    Tiffany Yin
    Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 288:23680-6. 2013
    ..Altogether, we uncover a novel mechanism by which MIC-1 can be regulated through RNPC1 via mRNA stability. ..
  35. pmc Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines
    Kyoung Won Seo
    Department of Surgical and Radiological Sciences, University of California Davis School of Veterinary Medicine, Davis, California, United States of America
    PLoS ONE 7:e42960. 2012
    ..These results support further studies examining the potential impact of quinolones on survival and proliferation of osteosarcoma...
  36. pmc TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function
    Jin Zhang
    Comparative Oncology Laboratory, University of California at Davis, Davis, California 95616, USA
    J Biol Chem 288:7727-37. 2013
    ..Together, we uncover a novel regulation of TAp73 protein stability by HDAC1-heat shock protein 90 chaperone complex, and our data suggest that TAp73 is a critical downstream mediator of HDAC1-regulated cell migration...
  37. pmc Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions
    Yanhong Zhang
    Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 286:16218-28. 2011
    ..Together, we postulate that EMT represents a mutant p53 gain of function and mutant p53 alters cell polarity via EMT...
  38. pmc Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability
    Yuqian Jiang
    From the Comparative Oncology Laboratory, University of California, Davis, California 95616
    J Biol Chem 289:3164-75. 2014
    ..Altogether, we uncovered that Rbm24 is a novel player in the p53 pathway, which may be explored to restore proper cell cycle control in p53-deficient tumors via p21. ..
  39. ncbi request reprint The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes
    Yang Xu
    Center for Comparative Oncology, University of California, Davis, CA 95616, USA
    J Biol Chem 282:37429-35. 2007
    ..Thus, we hypothesize that the potential tumor suppressor function for Brg1 is mediated in part through the p53 pathway...
  40. pmc Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent manners
    Seong Jun Cho
    Department of Surgical and Radiological Sciences, Comparative Cancer Center, University of California, Davis, California 95616, USA
    J Biol Chem 285:27159-66. 2010
    ....
  41. pmc Senescence regulation by the p53 protein family
    Yingjuan Qian
    Comparative Oncology Laboratory, University of California, Davis, CA, USA
    Methods Mol Biol 965:37-61. 2013
    ..In this chapter, we provide an overview on how p53, p63, p73, and their isoforms regulate cellular senescence and aging...
  42. pmc p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells
    Crystal E Berger
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    J Biol Chem 287:30117-27. 2012
    ..Altogether, this study provides an insight into a feedback loop between ERα and p53 and a biological role of p53 in the DNA damage response in ER-positive breast cancers...
  43. pmc Posttranscriptional regulation of p53 and its targets by RNA-binding proteins
    Jin Zhang
    Center for Comparative Oncology, University of California, Davis, CA 95616, USA
    Curr Mol Med 8:845-9. 2008
    ....
  44. pmc Characterization of functional domains necessary for mutant p53 gain of function
    Wensheng Yan
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    J Biol Chem 285:14229-38. 2010
    ..Thus, the inhibitory basic domain and the common property for p53 mutants can be explored for targeting tumors with mutant p53...
  45. pmc DeltaNp73 modulates nerve growth factor-mediated neuronal differentiation through repression of TrkA
    Jin Zhang
    Center for Comparative Oncology, 2128 Tupper Hall, University of California at Davis, Davis, CA 95616, USA
    Mol Cell Biol 27:3868-80. 2007
    ..Taken together, we conclude that DeltaNp73 negatively regulates NGF-mediated neuronal differentiation by transrepressing TrkA...
  46. pmc Identification of GRO1 as a critical determinant for mutant p53 gain of function
    Wensheng Yan
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    J Biol Chem 284:12178-87. 2009
    ..Thus, targeting GRO1 for cancer therapy would be applicable to a large portion of human tumors with mutant p53, but the exploration of GRO1 as a potential target should take the mutation status of p53 into consideration...
  47. pmc RNA-binding protein RBM24 regulates p63 expression via mRNA stability
    Enshun Xu
    Comparative Oncology Laboratory, University of California at Davis, Davis, CA 95616
    Mol Cancer Res 12:359-69. 2014
    ..Implications: Our study suggests that p63 is regulated by RBM24 via mRNA stability, which gives an insight into understanding how posttranscriptional regulatory mechanisms contribute to p63 expression...
  48. ncbi request reprint Targeted repression of bone morphogenetic protein 7, a novel target of the p53 family, triggers proliferative defect in p53-deficient breast cancer cells
    Wensheng Yan
    Center for Comparative Oncology, University of California at Davis, Davis, California 95616, USA
    Cancer Res 67:9117-24. 2007
    ..Together, we hypothesize that breast cancer patients with mutant p53 might benefit from targeted repression of BMP7 expression and/or targeted inhibition of the BMP7 pathway...
  49. ncbi request reprint The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners
    Ariane Scoumanne
    Center for Comparative Oncology, University of California at Davis, Davis, California 95616, USA
    J Biol Chem 282:15471-5. 2007
    ..Taken together, we uncovered that LSD1 has a pro-oncogenic function by modulating pro-survival gene expression and p53 transcriptional activity...
  50. pmc ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway
    Yingjuan Qian
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    J Biol Chem 283:22410-6. 2008
    ..Taken together, our study suggests that p53 trans-repressional activity can be mediated by its own target DEC1 and ID1 is an effector of the p53-dependent DNA damage response pathway...
  51. pmc Tumor suppression by p53: making cells senescent
    Yingjuan Qian
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    Histol Histopathol 25:515-26. 2010
    ..However, the role of p63 and p73 in cellular senescence is elusive. In this review, we will discuss how p53 regulates senescence and future studies about p53 family members in senescence...
  52. pmc Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    FEBS Lett 586:1397-402. 2012
    ..This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target...
  53. pmc Examination of the expanding pathways for the regulation of p21 expression and activity
    Yong Sam Jung
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    Cell Signal 22:1003-12. 2010
    ..This review will briefly discuss the activity of p21 and focus on current knowledge of the determinants that control p21 transcription, mRNA stability and translation, and protein stability and activity...
  54. pmc Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor
    Jin Zhang
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    Mol Cancer Res 7:67-78. 2009
    ..These similarities make the dog an excellent outbred spontaneous tumor model, and the dog can serve as a translation model from benchtop to cage side and then to bedside...
  55. pmc DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression
    Yingjuan Qian
    Comparative Oncology Laboratory, University of California Davis, Davis, California, United States of America
    PLoS ONE 9:e84015. 2014
    ....
  56. doi request reprint Development and characterization of 5 canine B-cell lymphoma cell lines
    Allison L Zwingenberger
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    Leuk Res 36:601-6. 2012
    ..All cell lines were tumorigenic in Nu/nu mice and were wild type for p53. Canine lymphoma cell lines serve as an important resource for translational lymphoma research...
  57. pmc MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells
    Nagalakshmi Nadiminty
    Department of Urology, University of California at Davis, Sacramento, California 95817, USA
    J Biol Chem 287:1527-37. 2012
    ..These results suggest that reconstitution of miR-let-7c may aid in targeting enhanced and hypersensitive AR in advanced prostate cancer...
  58. pmc Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells
    Yanhong Zhang
    Comparative Oncology Laboratory, Schools of Medicine and Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e85624. 2013
    ..Together, our data suggest that upon inactivating mutation of the p53 gene, mutant p53 acquires its gain of function by altering morphogenesis and promoting cell migration and invasion in part by upregulating EMT and c-Met. ..
  59. pmc Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions
    Jin Zhang
    University of California, Davis Davis, CA USA
    Cell Cycle 10:3237-6. 2011
    ..Comment on: Park HK, et al. Cell Cycle 2011; 10:2574-82...

Research Grants37

  1. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2007
    ..abstract_text> ..
  2. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2009
    ..abstract_text> ..
  3. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2002
    ..We will also determine the role of MCG1O in p53 tumor suppression, the mechanism by which MCG1O regulates gene expression, and whether MCG10 mediates activation or repression of some p53 target genes. ..
  4. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2006
    ..We will also determine the role of MCG1O in p53 tumor suppression, the mechanism by which MCG1O regulates gene expression, and whether MCG10 mediates activation or repression of some p53 target genes. ..
  5. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2009
    ..Thus, the regulation of ?Np63 expression by RNPC1 and Dec1 can be explored as a potential therapeutic strategy to manage tumors with amplified and/or over- expressed ?Np63. ..
  6. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2005
    ..We will also determine the role of MCG1O in p53 tumor suppression, the mechanism by which MCG1O regulates gene expression, and whether MCG10 mediates activation or repression of some p53 target genes. ..
  7. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2006
    ..abstract_text> ..
  8. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2006
    ..We will also determine the role of MCG1O in p53 tumor suppression, the mechanism by which MCG1O regulates gene expression, and whether MCG10 mediates activation or repression of some p53 target genes. ..
  9. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2007
    ..abstract_text> ..
  10. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2007
    ....
  11. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2006
    ..abstract_text> ..
  12. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2005
    ..abstract_text> ..
  13. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2010
    ..Thus, the proposed study to analyze how p21 expression is regulated by RNPC1 will further our understanding whether a cell cycle control mechanism can be restored in tumor cells. ..
  14. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2009
    ..Thus, the proposed study to analyze how p21 expression is regulated by RNPC1 will further our understanding whether a cell cycle control mechanism can be restored in tumor cells. ..
  15. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2004
    ..abstract_text> ..
  16. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2003
    ..abstract_text> ..
  17. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2010
    ....
  18. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2010
    ..abstract_text> ..
  19. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2010
    ..Thus, the regulation of ?Np63 expression by RNPC1 and Dec1 can be explored as a potential therapeutic strategy to manage tumors with amplified and/or over- expressed ?Np63. ..
  20. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2009
    ....
  21. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2007
    ....
  22. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2003
    ..We will also determine the role of MCG1O in p53 tumor suppression, the mechanism by which MCG1O regulates gene expression, and whether MCG10 mediates activation or repression of some p53 target genes. ..
  23. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2004
    ..abstract_text> ..
  24. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2004
    ..We will also determine the role of MCG1O in p53 tumor suppression, the mechanism by which MCG1O regulates gene expression, and whether MCG10 mediates activation or repression of some p53 target genes. ..
  25. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2005
    ..abstract_text> ..
  26. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2006
    ..abstract_text> ..
  27. The role of DNA polymerase eta in DNA damage response and p53 activation
    Xinbin Chen; Fiscal Year: 2010
    ....