Xinbin Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation
    Yong Sam Jung
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    Mol Cell Biol 30:1041-8. 2010
  2. pmc The p53-Estrogen Receptor Loop in Cancer
    C Berger
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    Curr Mol Med 13:1229-40. 2013
  3. pmc Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    Mol Cell Biol 31:3997-4006. 2011

Research Grants

  1. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2007
  2. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2009
  3. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2007
  4. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2007
  5. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2006
  6. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2009
  7. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2010
  8. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2010
  9. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2010
  10. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2010

Collaborators

  • Yong Sam Jung
  • C Berger
  • Y Qian
  • Anne Hakem
  • Razqallah Hakem
  • Gang Liu

Detail Information

Publications3

  1. pmc Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation
    Yong Sam Jung
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    Mol Cell Biol 30:1041-8. 2010
    ..We postulate that UV irradiation promotes cancer formation in part by destabilizing PolH via Pirh2-mediated 20S proteasomal degradation...
  2. pmc The p53-Estrogen Receptor Loop in Cancer
    C Berger
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    Curr Mol Med 13:1229-40. 2013
    ..Clinical correlations between estrogen receptors and p53 status have also been reported. Thus, this review will discuss the relationship between p53 and ERs at both the molecular and clinical levels. ..
  3. pmc Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    Mol Cell Biol 31:3997-4006. 2011
    ....

Research Grants37

  1. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2007
    ..abstract_text> ..
  2. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2009
    ..abstract_text> ..
  3. The transcriptional activity of p63, a p53 family member
    Xinbin Chen; Fiscal Year: 2007
    ..abstract_text> ..
  4. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2007
    ....
  5. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2006
    ..We will also determine the role of MCG1O in p53 tumor suppression, the mechanism by which MCG1O regulates gene expression, and whether MCG10 mediates activation or repression of some p53 target genes. ..
  6. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2009
    ....
  7. Molecular Oncogenic Properties of Mutant p53
    Xinbin Chen; Fiscal Year: 2010
    ....
  8. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2010
    ..Thus, the proposed study to analyze how p21 expression is regulated by RNPC1 will further our understanding whether a cell cycle control mechanism can be restored in tumor cells. ..
  9. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2010
    ..Thus, the regulation of ?Np63 expression by RNPC1 and Dec1 can be explored as a potential therapeutic strategy to manage tumors with amplified and/or over- expressed ?Np63. ..
  10. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2010
    ..abstract_text> ..
  11. The role of DNA polymerase eta in DNA damage response and p53 activation
    Xinbin Chen; Fiscal Year: 2010
    ....