Xi Chen

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. pmc Expanding the rule set of DNA circuitry with associative toehold activation
    Xi Chen
    Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin Texas 78712, USA
    J Am Chem Soc 134:263-71. 2012
  2. doi request reprint Coupling two different nucleic acid circuits in an enzyme-free amplifier
    Yu Jiang
    Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Molecules 17:13211-20. 2012
  3. pmc Adapting enzyme-free DNA circuits to the detection of loop-mediated isothermal amplification reactions
    Bingling Li
    Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    Anal Chem 84:8371-7. 2012
  4. pmc Spatial control of DNA reaction networks by DNA sequence
    Peter B Allen
    Institute of Cell and Molecular Biology, University of Texas at Austin, 1 University Station A4800, Austin, TX 78712 0159, USA
    Molecules 17:13390-402. 2012
  5. pmc DNA circuits as amplifiers for the detection of nucleic acids on a paperfluidic platform
    Peter B Allen
    University of Texas at Austin, Chemistry and Biochemistry Dept, 1 University Station, A4800, USA
    Lab Chip 12:2951-8. 2012
  6. pmc Probing spatial organization of DNA strands using enzyme-free hairpin assembly circuits
    Bingling Li
    Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    J Am Chem Soc 134:13918-21. 2012
  7. pmc Stacking nonenzymatic circuits for high signal gain
    Xi Chen
    Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX 78712
    Proc Natl Acad Sci U S A 110:5386-91. 2013
  8. pmc Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code
    Mengmeng Zhang
    Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station A5300, Austin, TX 78712, USA
    ACS Chem Biol 7:1462-70. 2012
  9. pmc Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods
    Bingling Li
    Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
    Nucleic Acids Res 39:e110. 2011

Collaborators

  • Andrew D Ellington
  • Yan Zhang
  • Bingling Li
  • Peter B Allen
  • Yu Jiang
  • Mengmeng Zhang
  • Seyed A Arshad
  • Yonghua Luo
  • Felicia A Etzkorn
  • Joseph P Noel
  • Xiaodong J Wang
  • Marianne E Bowman

Detail Information

Publications9

  1. pmc Expanding the rule set of DNA circuitry with associative toehold activation
    Xi Chen
    Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin Texas 78712, USA
    J Am Chem Soc 134:263-71. 2012
    ....
  2. doi request reprint Coupling two different nucleic acid circuits in an enzyme-free amplifier
    Yu Jiang
    Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Molecules 17:13211-20. 2012
    ..The modular circuit connections also allowed the output reporter to be readily modified to a G-quadruplex-DNAzyme that yielded a fluorescent signal...
  3. pmc Adapting enzyme-free DNA circuits to the detection of loop-mediated isothermal amplification reactions
    Bingling Li
    Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    Anal Chem 84:8371-7. 2012
    ..The AND-GATE detector will act as a simultaneous, specific readout of the LAMP product, rather than of competing and parasitic amplicons...
  4. pmc Spatial control of DNA reaction networks by DNA sequence
    Peter B Allen
    Institute of Cell and Molecular Biology, University of Texas at Austin, 1 University Station A4800, Austin, TX 78712 0159, USA
    Molecules 17:13390-402. 2012
    ..The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns...
  5. pmc DNA circuits as amplifiers for the detection of nucleic acids on a paperfluidic platform
    Peter B Allen
    University of Texas at Austin, Chemistry and Biochemistry Dept, 1 University Station, A4800, USA
    Lab Chip 12:2951-8. 2012
    ..By bridging the gap between the low concentrations of LAMP amplicons and the limits of fluorescence detection, the non-enzymatic amplifier allowed us to detect as few as 1200 input templates in a paperfluidic format...
  6. pmc Probing spatial organization of DNA strands using enzyme-free hairpin assembly circuits
    Bingling Li
    Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    J Am Chem Soc 134:13918-21. 2012
    ..These findings highlight the potential impacts of DNA circuitry on DNA nanotechnology and provide new tools for further development of these fields...
  7. pmc Stacking nonenzymatic circuits for high signal gain
    Xi Chen
    Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX 78712
    Proc Natl Acad Sci U S A 110:5386-91. 2013
    ..Implementation of these unique methods and design principles should greatly empower molecular programming in general and DNA-based molecular diagnostics in particular...
  8. pmc Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code
    Mengmeng Zhang
    Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station A5300, Austin, TX 78712, USA
    ACS Chem Biol 7:1462-70. 2012
    ..These data exemplify for the first time how modulation of proline isomerization can kinetically impact signal transduction in transcription regulation...
  9. pmc Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods
    Bingling Li
    Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
    Nucleic Acids Res 39:e110. 2011
    ..Overall, these data demonstrate that catalyzed hairpin assembly is suitable for analyte detection and signal amplification in a 'plug-and-play' fashion...