Wilbur H Chen

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi request reprint Vaccines for enteric infections
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Gastroenterol 28:18-23. 2012
  2. doi request reprint Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 14:269-78. 2008
  3. pmc Vaccination in the elderly: an immunological perspective
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Trends Immunol 30:351-9. 2009
  4. doi request reprint Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 16:322-32. 2010
  5. pmc Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Immunol Lett 141:227-34. 2012
  6. pmc Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vaccine 29:2865-73. 2011
  7. pmc Adjuvanted intranasal Norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues
    Samer S El-Kamary
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 202:1649-58. 2010
  8. pmc The TLR4 antagonist Eritoran protects mice from lethal influenza infection
    Kari Ann Shirey
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
    Nature 497:498-502. 2013
  9. pmc Phase 2 assessment of the safety and immunogenicity of two inactivated pandemic monovalent H1N1 vaccines in adults as a component of the U.S. pandemic preparedness plan in 2009
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vaccine 30:4240-8. 2012
  10. ncbi request reprint A case for immunization against nosocomial infections
    Alan S Cross
    Department of Medicine, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    J Leukoc Biol 83:483-8. 2008

Detail Information

Publications13

  1. doi request reprint Vaccines for enteric infections
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Curr Opin Gastroenterol 28:18-23. 2012
    ..To provide a review of currently licensed enteric vaccines and their efficacy based on completed field trials...
  2. doi request reprint Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 14:269-78. 2008
    ..We conclude that further studies on the use of J5dLPS-OMP for the prevention of nosocomial pneumonia are warranted...
  3. pmc Vaccination in the elderly: an immunological perspective
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Trends Immunol 30:351-9. 2009
    ..However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned to improve the effectiveness of next generation vaccines...
  4. doi request reprint Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Innate Immun 16:322-32. 2010
    ..These observations provide further evidence for the inclusion of innate immune-based adjuvants during the development of next-generation vaccines...
  5. pmc Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Immunol Lett 141:227-34. 2012
    ..Alternatively activated macrophages (AAM) in the lungs may play a critical role in eliciting the hypersusceptibility to secondary bacterial pneumonia...
  6. pmc Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vaccine 29:2865-73. 2011
    ....
  7. pmc Adjuvanted intranasal Norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues
    Samer S El-Kamary
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 202:1649-58. 2010
    ..Noroviruses cause significant morbidity and mortality from acute gastroenteritis in all age groups worldwide...
  8. pmc The TLR4 antagonist Eritoran protects mice from lethal influenza infection
    Kari Ann Shirey
    Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
    Nature 497:498-502. 2013
    ..Thus, Eritoran blockade of TLR signalling represents a novel therapeutic approach for inflammation associated with influenza, and possibly other infections...
  9. pmc Phase 2 assessment of the safety and immunogenicity of two inactivated pandemic monovalent H1N1 vaccines in adults as a component of the U.S. pandemic preparedness plan in 2009
    Wilbur H Chen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vaccine 30:4240-8. 2012
    ....
  10. ncbi request reprint A case for immunization against nosocomial infections
    Alan S Cross
    Department of Medicine, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    J Leukoc Biol 83:483-8. 2008
    ..Such a strategy could reduce or ameliorate nosocomial infections and perhaps limit dissemination of nosocomial pathogens. Thus, a more aggressive effort to develop vaccines for nosocomial infections is warranted...
  11. pmc Role of Bacillus anthracis spore structures in macrophage cytokine responses
    Subhendu Basu
    Center for Vaccine Development, Department of Medicine, University of Maryland, 685 W Baltimore Street, HSF I 480, Baltimore, MD 21201, USA
    Infect Immun 75:2351-8. 2007
    ..anthracis involves multiple pattern recognition receptors and signaling pathways, and (iv) compared to other cytokines, IL-1beta is expressed at a lower spore concentration...
  12. pmc Association between methicillin-resistant Staphylococcus aureus colonization and infection may not differ by age group
    Adebola O Ajao
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Control Hosp Epidemiol 34:93-5. 2013
    ..Among 7,405 patients (9,511 admissions), MRSA colonization was significantly associated with infection (adjusted odds ratio, 13.7 [95% confidence interval, 7.3-25.7]) but did not differ significantly by age group...
  13. pmc Bench-to-bedside review: vaccine protection strategies during pandemic flu outbreaks
    Joel V Chua
    Infectious Disease, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Crit Care 14:218. 2010
    ..These include the use of cell-culture-based growth systems, concomitant use of adjuvants, whole virus vaccines, recombinant protein vaccines, plasmid DNA vaccines, virus-like particle vaccines, and universal flu vaccines...