Wei Min Chen

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Power and robustness of linkage tests for quantitative traits in general pedigrees
    Wei Min Chen
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA
    Genet Epidemiol 28:11-23. 2005
  2. ncbi request reprint Estimating the power of variance component linkage analysis in large pedigrees
    Wei Min Chen
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Genet Epidemiol 30:471-84. 2006
  3. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
  4. ncbi request reprint Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression
    Wei Min Chen
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genet Epidemiol 26:265-72. 2004
  5. pmc Family-based association tests for genomewide association scans
    Wei Min Chen
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Am J Hum Genet 81:913-26. 2007
  6. pmc The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
    Siguang Li
    Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS Genet 3:e194. 2007
  7. pmc Variance components linkage analysis with repeated measurements
    Liming Liang
    Department of Biostatistics, University of Michigan, Ann Arbor, Mich, USA
    Hum Hered 67:237-47. 2009
  8. ncbi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
  9. ncbi request reprint Transmission disequilibrium test with discordant sib pairs when parents are available
    Hong Wen Deng
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Hum Genet 110:451-61. 2002
  10. pmc In silico method for inferring genotypes in pedigrees
    Joshua T Burdick
    Department of Pediatrics, University of Pennsylvania, 3516 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:1002-4. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Power and robustness of linkage tests for quantitative traits in general pedigrees
    Wei Min Chen
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA
    Genet Epidemiol 28:11-23. 2005
    ..While we have not yet examined the performance of our procedures in the context of selective sampling via computer simulations, the proposed tests satisfy all of the other qualities of an ideal quantitative trait linkage analysis method...
  2. ncbi request reprint Estimating the power of variance component linkage analysis in large pedigrees
    Wei Min Chen
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Genet Epidemiol 30:471-84. 2006
    ..Our algorithms for power analysis together with polygenic analysis are implemented in a freely available computer program, POLY...
  3. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
    ..44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development...
  4. ncbi request reprint Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression
    Wei Min Chen
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genet Epidemiol 26:265-72. 2004
    ..Third, our general framework suggests important extensions to the Haseman-Elston approach which make more complete use of the data in extended pedigrees and allow a natural incorporation of environmental and other covariates...
  5. pmc Family-based association tests for genomewide association scans
    Wei Min Chen
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Am J Hum Genet 81:913-26. 2007
    ..Our genotype-inference algorithm and the proposed association tests are implemented in software that is available for free...
  6. pmc The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
    Siguang Li
    Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS Genet 3:e194. 2007
    ..Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values...
  7. pmc Variance components linkage analysis with repeated measurements
    Liming Liang
    Department of Biostatistics, University of Michigan, Ann Arbor, Mich, USA
    Hum Hered 67:237-47. 2009
    ..A number of methods have been proposed to model repeated measures in linkage analysis. Here, we focus on assessing the impact of repeated measures on the power and cost of a linkage study...
  8. ncbi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  9. ncbi request reprint Transmission disequilibrium test with discordant sib pairs when parents are available
    Hong Wen Deng
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Hum Genet 110:451-61. 2002
    ..Importantly, the TDT(DS) not only may be more powerful, it also has the advantage of being able to test for segregation distortion that may yield false linkage/association in the TDT(D)...
  10. pmc In silico method for inferring genotypes in pedigrees
    Joshua T Burdick
    Department of Pediatrics, University of Pennsylvania, 3516 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:1002-4. 2006
    ..The method can be used to obtain high-density genotypes in different family structures, including nuclear families commonly used in complex disease gene mapping studies...
  11. pmc Heritability of cardiovascular and personality traits in 6,148 Sardinians
    Giuseppe Pilia
    Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Ospedale Microcitemico, Cagliari, Italy
    PLoS Genet 2:e132. 2006
    ..Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits...
  12. pmc Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
    ..These changes could have a significant impact on the risk of obesity-related morbidity in the general population...