Research Topics
Genomes and GenesSpecies | Wei Min ChenSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigreesWei Min Chen
Center for Public Health Genomics, University of Virginia, West Complex, 6th Floor, Suite 6111, PO Box 800717, University of Virginia, Charlottesville, VA 22908, USA
BMC Proc 5:S68. 2011..7 to 1.0. These results suggest that the use of classical linkage and association methods in large families can provide a useful approach to identifying variants that are responsible for diseases and complex traits in families...- Family-based association tests for genomewide association scansWei Min Chen
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Am J Hum Genet 81:913-26. 2007..Our genotype-inference algorithm and the proposed association tests are implemented in software that is available for free... - A generalized family-based association test for dichotomous traitsWei Min Chen
Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
Am J Hum Genet 85:364-76. 2009..For the T1D association at gene UBASH3A, the GDT resulted in a genome-wide significance (p = 4.3 x 10(-6)), much stronger than the published significance (p = 10(-4))... - Common variants in the GDF5-UQCC region are associated with variation in human heightSerena Sanna
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Genet 40:198-203. 2008..44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development... - A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3Patrick Concannon
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
Diabetes 57:2858-61. 2008..In the current study, we tested for evidence of loci associated with type 1 diabetes utilizing genome-wide linkage scan data and family-based association methods... 
Estimating the power of variance component linkage analysis in large pedigreesWei Min Chen
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Genet Epidemiol 30:471-84. 2006..Our algorithms for power analysis together with polygenic analysis are implemented in a freely available computer program, POLY...- Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM)Wei Min Chen
Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
BMC Med Genet 12:124. 2011..We carried out a nonparametric linkage analysis, modeling marker-to-marker linkage disequilibrium... - Analysis of family- and population-based samples in cohort genome-wide association studiesAni Manichaikul
Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
Hum Genet 131:275-87. 2012..g., variance-component model for quantitative traits or generalized estimating equations for dichotomous traits) perform best in the context of combined family- and population-based cohort GWAS... 
Newly identified loci that influence lipid concentrations and risk of coronary artery diseaseCristen J Willer
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
Nat Genet 40:161-9. 2008..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...- Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM)Michele M Sale
Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
PLoS ONE 6:e22297. 2011..The candidate gene variants examined do not appear to make a major contribution to COME/ROM susceptibility, despite a priori evidence from functional or animal model studies for a role in COME/ROM pathology... - Population structure of Hispanics in the United States: the multi-ethnic study of atherosclerosisAni Manichaikul
Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
PLoS Genet 8:e1002640. 2012.... - Robust relationship inference in genome-wide association studiesAni Manichaikul
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
Bioinformatics 26:2867-73. 2010..Existing algorithms for relationship inference have a major weakness of estimating allele frequencies at each SNP from the entire sample, under a strong assumption of homogeneous population structure. This assumption is often untenable... - Power and robustness of linkage tests for quantitative traits in general pedigreesWei Min Chen
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA
Genet Epidemiol 28:11-23. 2005..While we have not yet examined the performance of our procedures in the context of selective sampling via computer simulations, the proposed tests satisfy all of the other qualities of an ideal quantitative trait linkage analysis method... - Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levelsWei Min Chen
Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
J Clin Invest 118:2620-8. 2008.... - Variance components linkage analysis with repeated measurementsLiming Liang
Department of Biostatistics, University of Michigan, Ann Arbor, Mich, USA
Hum Hered 67:237-47. 2009..A number of methods have been proposed to model repeated measures in linkage analysis. Here, we focus on assessing the impact of repeated measures on the power and cost of a linkage study... - Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics ConsortiumPatrick Concannon
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
Diabetes 58:1018-22. 2009..However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk... - Planning and executing a genome wide association study (GWAS)Michele M Sale
Department of Medicine, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
Methods Mol Biol 590:403-18. 2009.... - Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC)Joan E Hilner
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
Clin Trials 7:S5-S32. 2010..The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide... - Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regressionWei-Min Chen
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
Genet Epidemiol 26:265-72. 2004..Third, our general framework suggests important extensions to the Haseman-Elston approach which make more complete use of the data in extended pedigrees and allow a natural incorporation of environmental and other covariates... - Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traitsAngelo Scuteri
Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
PLoS Genet 3:e115. 2007..These changes could have a significant impact on the risk of obesity-related morbidity in the general population... - In silico method for inferring genotypes in pedigreesJoshua T Burdick
Department of Pediatrics, University of Pennsylvania, 3516 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA
Nat Genet 38:1002-4. 2006..The method can be used to obtain high-density genotypes in different family structures, including nuclear families commonly used in complex disease gene mapping studies... - The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohortsSiguang Li
Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America
PLoS Genet 3:e194. 2007..Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values... - Heritability of cardiovascular and personality traits in 6,148 SardiniansGiuseppe Pilia
Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Ospedale Microcitemico, Cagliari, Italy
PLoS Genet 2:e132. 2006..Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits... - Transmission disequilibrium test with discordant sib pairs when parents are availableHong Wen Deng
Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
Hum Genet 110:451-61. 2002..Importantly, the TDT(DS) not only may be more powerful, it also has the advantage of being able to test for segregation distortion that may yield false linkage/association in the TDT(D)...