Wei Min Chen

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM)
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    BMC Med Genet 12:124. 2011
  2. pmc Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, West Complex, 6th Floor, Suite 6111, PO Box 800717, University of Virginia, Charlottesville, VA 22908, USA
    BMC Proc 5:S68. 2011
  3. pmc A generalized family-based association test for dichotomous traits
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    Am J Hum Genet 85:364-76. 2009
  4. pmc Family-based association tests for genomewide association scans
    Wei Min Chen
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Am J Hum Genet 81:913-26. 2007
  5. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
  6. ncbi request reprint Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression
    Wei Min Chen
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genet Epidemiol 26:265-72. 2004
  7. pmc Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM)
    Michele M Sale
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e22297. 2011
  8. pmc A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 57:2858-61. 2008
  9. ncbi request reprint Estimating the power of variance component linkage analysis in large pedigrees
    Wei Min Chen
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Genet Epidemiol 30:471-84. 2006
  10. pmc A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2
    E Kaitlynn Allen
    Center for Public Health Genomics, University of Virginia, P O Box 800717, Charlottesville, VA, USA
    J Assoc Res Otolaryngol 14:791-800. 2013

Detail Information

Publications26

  1. pmc Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM)
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    BMC Med Genet 12:124. 2011
    ..We carried out a nonparametric linkage analysis, modeling marker-to-marker linkage disequilibrium...
  2. pmc Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, West Complex, 6th Floor, Suite 6111, PO Box 800717, University of Virginia, Charlottesville, VA 22908, USA
    BMC Proc 5:S68. 2011
    ..7 to 1.0. These results suggest that the use of classical linkage and association methods in large families can provide a useful approach to identifying variants that are responsible for diseases and complex traits in families...
  3. pmc A generalized family-based association test for dichotomous traits
    Wei Min Chen
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    Am J Hum Genet 85:364-76. 2009
    ..For the T1D association at gene UBASH3A, the GDT resulted in a genome-wide significance (p = 4.3 x 10(-6)), much stronger than the published significance (p = 10(-4))...
  4. pmc Family-based association tests for genomewide association scans
    Wei Min Chen
    Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Am J Hum Genet 81:913-26. 2007
    ..Our genotype-inference algorithm and the proposed association tests are implemented in software that is available for free...
  5. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
    ..44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development...
  6. ncbi request reprint Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression
    Wei Min Chen
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genet Epidemiol 26:265-72. 2004
    ..Third, our general framework suggests important extensions to the Haseman-Elston approach which make more complete use of the data in extended pedigrees and allow a natural incorporation of environmental and other covariates...
  7. pmc Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM)
    Michele M Sale
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e22297. 2011
    ..The candidate gene variants examined do not appear to make a major contribution to COME/ROM susceptibility, despite a priori evidence from functional or animal model studies for a role in COME/ROM pathology...
  8. pmc A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 57:2858-61. 2008
    ..In the current study, we tested for evidence of loci associated with type 1 diabetes utilizing genome-wide linkage scan data and family-based association methods...
  9. ncbi request reprint Estimating the power of variance component linkage analysis in large pedigrees
    Wei Min Chen
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Genet Epidemiol 30:471-84. 2006
    ..Our algorithms for power analysis together with polygenic analysis are implemented in a freely available computer program, POLY...
  10. pmc A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2
    E Kaitlynn Allen
    Center for Public Health Genomics, University of Virginia, P O Box 800717, Charlottesville, VA, USA
    J Assoc Res Otolaryngol 14:791-800. 2013
    ..This SNP is within a 537 kb intergenic region, bordered by CDCA7 and SP3. The genomic and functional significance of this newly identified locus in COME/ROM pathogenesis requires additional investigation. ..
  11. pmc Analysis of family- and population-based samples in cohort genome-wide association studies
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
    Hum Genet 131:275-87. 2012
    ..g., variance-component model for quantitative traits or generalized estimating equations for dichotomous traits) perform best in the context of combined family- and population-based cohort GWAS...
  12. doi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  13. pmc Population structure of Hispanics in the United States: the multi-ethnic study of atherosclerosis
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Genet 8:e1002640. 2012
    ....
  14. pmc Robust relationship inference in genome-wide association studies
    Ani Manichaikul
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Bioinformatics 26:2867-73. 2010
    ..Existing algorithms for relationship inference have a major weakness of estimating allele frequencies at each SNP from the entire sample, under a strong assumption of homogeneous population structure. This assumption is often untenable...
  15. doi request reprint Planning and executing a genome wide association study (GWAS)
    Michele M Sale
    Department of Medicine, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Methods Mol Biol 590:403-18. 2009
    ....
  16. pmc Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes 58:1018-22. 2009
    ..However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk...
  17. ncbi request reprint Power and robustness of linkage tests for quantitative traits in general pedigrees
    Wei Min Chen
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA
    Genet Epidemiol 28:11-23. 2005
    ..While we have not yet examined the performance of our procedures in the context of selective sampling via computer simulations, the proposed tests satisfy all of the other qualities of an ideal quantitative trait linkage analysis method...
  18. pmc Variance components linkage analysis with repeated measurements
    Liming Liang
    Department of Biostatistics, University of Michigan, Ann Arbor, Mich, USA
    Hum Hered 67:237-47. 2009
    ..A number of methods have been proposed to model repeated measures in linkage analysis. Here, we focus on assessing the impact of repeated measures on the power and cost of a linkage study...
  19. pmc Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei Min Chen
    Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 118:2620-8. 2008
    ....
  20. pmc Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC)
    Joan E Hilner
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Clin Trials 7:S5-S32. 2010
    ..The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide...
  21. doi request reprint Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke
    Stephen R Williams
    Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Genet 10:e1004214. 2014
    ..These data emphasize the importance of a concerted effort to understand regulators of one carbon metabolism as potential therapeutic targets...
  22. pmc The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts
    Siguang Li
    Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS Genet 3:e194. 2007
    ..Our results suggest that polymorphisms in GLUT9 could affect glucose metabolism and uric acid synthesis and/or renal reabsorption, influencing serum uric acid levels over a wide range of values...
  23. pmc Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
    ..These changes could have a significant impact on the risk of obesity-related morbidity in the general population...
  24. pmc In silico method for inferring genotypes in pedigrees
    Joshua T Burdick
    Department of Pediatrics, University of Pennsylvania, 3516 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:1002-4. 2006
    ..The method can be used to obtain high-density genotypes in different family structures, including nuclear families commonly used in complex disease gene mapping studies...
  25. pmc Heritability of cardiovascular and personality traits in 6,148 Sardinians
    Giuseppe Pilia
    Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Ospedale Microcitemico, Cagliari, Italy
    PLoS Genet 2:e132. 2006
    ..Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits...
  26. ncbi request reprint Transmission disequilibrium test with discordant sib pairs when parents are available
    Hong Wen Deng
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Hum Genet 110:451-61. 2002
    ..Importantly, the TDT(DS) not only may be more powerful, it also has the advantage of being able to test for segregation distortion that may yield false linkage/association in the TDT(D)...