Wei Chen

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study
    Xiao Hong Zhu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:1225-34. 2007
  2. pmc Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging
    W Chen
    Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, 2021 Sixth Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 96:2430-4. 1999
  3. ncbi request reprint Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 57:103-14. 2007
  4. ncbi request reprint Study of Brain Function and Bioenergetics using fMRI and In Vivo MRS at High Fields
    Wei Chen
    Center for Magnetic Resonance Research, Departments of Radiology and Biomedical Engineering, University of Minnesota, 2021 6th St SE Minneapolis, Minnesota, USA phone 612 625 8814 fax 612 626 2004 e mail
    Conf Proc IEEE Eng Med Biol Soc 4:4174-7. 2005
  5. ncbi request reprint Functional MRI study of brain function under resting and activated states
    Wei Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4061-3. 2009
  6. ncbi request reprint Brain imaging developments based on in vivo MRS
    Wei Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:50-2. 2009
  7. ncbi request reprint Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using (1)H-[(13)C] MRS and fMRI
    W Chen
    Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 45:349-55. 2001
  8. ncbi request reprint High spatial resolution functional magnetic resonance imaging at very-high-magnetic field
    W Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Top Magn Reson Imaging 10:63-78. 1999
  9. ncbi request reprint Correlation of activation sizes between lateral geniculate nucleus and primary visual cortex in humans
    W Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Magn Reson Med 45:202-5. 2001
  10. ncbi request reprint Mapping brain metabolites using a double echo-filter metabolite imaging (DEFMI) technique
    W Chen
    Radiology Department, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Magn Reson 140:363-70. 1999

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study
    Xiao Hong Zhu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:1225-34. 2007
    ..This approach, thus, should provide a promising neuroimaging modality for studying oxidative metabolism and bioenergetics associated with brain functions and diseases...
  2. pmc Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging
    W Chen
    Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, 2021 Sixth Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 96:2430-4. 1999
    ..This will have an impact for studying the thalamocortical networks in the human brain...
  3. ncbi request reprint Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 57:103-14. 2007
    ..The MSS MT approach should provide an important modality for noninvasively studying the essential roles of ATP metabolism in brain bioenergetics, function, and diseases...
  4. ncbi request reprint Study of Brain Function and Bioenergetics using fMRI and In Vivo MRS at High Fields
    Wei Chen
    Center for Magnetic Resonance Research, Departments of Radiology and Biomedical Engineering, University of Minnesota, 2021 6th St SE Minneapolis, Minnesota, USA phone 612 625 8814 fax 612 626 2004 e mail
    Conf Proc IEEE Eng Med Biol Soc 4:4174-7. 2005
    ..This talk will discuss the developed MR technologies and their applications in brain study at high fields...
  5. ncbi request reprint Functional MRI study of brain function under resting and activated states
    Wei Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4061-3. 2009
    ..We have found a strong correlation between the spontaneous brain activity and BOLD fluctuation indicating a tight neurovascular relation...
  6. ncbi request reprint Brain imaging developments based on in vivo MRS
    Wei Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:50-2. 2009
    ..These new methods have been successfully applied for investigating the neuroenergetics changes associated with brain activation...
  7. ncbi request reprint Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using (1)H-[(13)C] MRS and fMRI
    W Chen
    Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 45:349-55. 2001
    ..Magn Reson Med 45:349-355, 2001...
  8. ncbi request reprint High spatial resolution functional magnetic resonance imaging at very-high-magnetic field
    W Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Top Magn Reson Imaging 10:63-78. 1999
    ..0 and 4.0 Tesla). They reveal that high-resolution fMRI at very-high-magnetic field is promising for functional mapping of brain organization from large cortical networks, small nuclei, and even to cellular layer structures...
  9. ncbi request reprint Correlation of activation sizes between lateral geniculate nucleus and primary visual cortex in humans
    W Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Magn Reson Med 45:202-5. 2001
    ..96, and 2) the capability of fMRI for quantifying spatial correlation between cortical and subcortical activation. Magn Reson Med 45:202-205, 2001...
  10. ncbi request reprint Mapping brain metabolites using a double echo-filter metabolite imaging (DEFMI) technique
    W Chen
    Radiology Department, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Magn Reson 140:363-70. 1999
    ..The results reveal that the DEFMI technique is promising for applications in metabolism studies aimed at investigating physiological and pathological questions...
  11. ncbi request reprint In vitro and in vivo studies of 1H NMR visibility to detect deoxyhemoglobin and deoxymyoglobin signals in myocardium
    W Chen
    Department of Radiology, University of Minnesota School of Medicine, Minneapolis 55455, USA
    Magn Reson Med 42:1-5. 1999
    ..7 T when a 0.5-1.0 msec long Gaussian excitation pulse is used. Therefore, the resonance peak detected at approximately 72 ppm (relative to the water resonance) in the ischemic canine myocardium in vivo is dominated by deoxymyoglobin...
  12. doi request reprint Quantitatively Interpreting fMRI signal
    Nanyin Zhang
    Center for Magnetic Resonance Research, The Department of Radiology, The University of Minnesota Twin Cities, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:4415-8. 2008
    ....
  13. pmc Tightly coupled brain activity and cerebral ATP metabolic rate
    Fei Du
    Department of Radiology, Center for Magnetic Resonance Research and Department of Biomedical Engineering, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 105:6409-14. 2008
    ....
  14. pmc Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortex
    Chang Hwan Im
    Department of Biomedical Engineering, University of Minnesota, 7 105 Hasselmo Hall, 312 Church St S E, Minneapolis, MN 55455, USA
    J Neurosci Methods 161:142-54. 2007
    ..The present results suggest that the spatial resolution of the EEG cortical source imaging can correctly discriminate cortical activation changes in V1 corresponding to less than 3 degrees visual field changes...
  15. pmc In vivo measurement of CBF using ¹⁷O NMR signal of metabolically produced H₂¹⁷O as a perfusion tracer
    Xiao Hong Zhu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Magn Reson Med 70:309-14. 2013
    ....
  16. pmc Three-dimensional source imaging from simultaneously recorded ERP and BOLD-fMRI
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Neural Syst Rehabil Eng 17:101-6. 2009
    ..The present results demonstrate the merits of high-resolution spatiotemporal functional neuroimaging by integrating the simultaneously recorded fMRI and EEG data...
  17. pmc High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School of Medicine, 2021 6 th Street S E, Minneapolis, MN 55455, USA
    Neuroimage 50:1456-63. 2010
    ....
  18. pmc ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method
    Qiang Xiong
    Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, USA
    Circ Res 108:653-63. 2011
    ..However, its lengthy data acquisition time greatly limits the wide biomedical applications in vivo, especially for studies requiring high spatial and temporal resolutions...
  19. pmc Linear and nonlinear relationships between visual stimuli, EEG and BOLD fMRI signals
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA
    Neuroimage 50:1054-66. 2010
    ..The validated cross-modal relationship between fMRI and EEG may provide a theoretical basis for the integration of these two modalities...
  20. ncbi request reprint Polarization of the RF field in a human head at high field: a study with a quadrature surface coil at 7.0 T
    Jinghua Wang
    Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Magn Reson Med 48:362-9. 2002
    ..Theoretical and experimental results for a phantom and the human head at 7.0 T are presented. The results are theoretically important and practically useful for high-field quadrature coil design and application...
  21. ncbi request reprint In vivo vaccination with tumor cell lysate plus CpG oligodeoxynucleotides eradicates murine glioblastoma
    Anhua Wu
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunother 30:789-97. 2007
    ..05). These results suggest direct vaccination with CpG/lysate provides an alternative and effective approach to induce host antitumor immunity and warrants clinical investigation in the immunotherapy of cancer...
  22. pmc Radiolabeled phenethylguanidines: novel imaging agents for cardiac sympathetic neurons and adrenergic tumors
    David M Raffel
    Division of Nuclear Medicine, Department of Radiology, 3480 Kresge III Building, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Med Chem 50:2078-88. 2007
    ..These encouraging findings demonstrate that radiolabeled phenethylguanidines deserve further investigation as radiotracers of cardiac sympathetic innervation and adrenergic tumors...
  23. pmc An fMRI study of neural interaction in large-scale cortico-thalamic visual network
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street S E, Minneapolis, MN 55455, USA
    Neuroimage 42:1110-7. 2008
    ....
  24. pmc Simultaneous measurement of glucose blood-brain transport constants and metabolic rate in rat brain using in-vivo 1H MRS
    Fei Du
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 32:1778-87. 2012
    ..The overall results indicate that the new approach is robust and reliable for in-vivo measurements of both brain glucose metabolic rate and transport constants, and has potential for human application...
  25. pmc Quantitative imaging of energy expenditure in human brain
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuroimage 60:2107-17. 2012
    ....
  26. pmc Oxygen is a master regulator of the immunogenicity of primary human glioma cells
    Michael R Olin
    Department of Pediatrics, Graduate Program in Neuroscience, Biostatistics and Bioinformatics, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota, USA
    Cancer Res 71:6583-9. 2011
    ....
  27. pmc In vivo proton MRS to quantify anesthetic effects of pentobarbital on cerebral metabolism and brain activity in rat
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 62:1385-93. 2009
    ....
  28. ncbi request reprint In vivo 17O NMR approaches for brain study at high field
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th St SE, Minneapolis, MN 55455, USA
    NMR Biomed 18:83-103. 2005
    ..This approach should be promising for studying the central role of oxidative metabolism in brain function and neurological diseases. Finally, the similar approach could potentially be applied to image CMRO2 noninvasively in human brain...
  29. ncbi request reprint Manipulation of image intensity distribution at 7.0 T: passive RF shimming and focusing with dielectric materials
    Qing X Yang
    Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Magn Reson Imaging 24:197-202. 2006
    ..To investigate the effects of high dielectric material padding on RF field distribution in the human head at 7.0 T, and demonstrate the feasibility and effectiveness of RF passive shimming and focusing with such an approach...
  30. ncbi request reprint Noninvasive study of neurovascular coupling during graded neuronal suppression
    Nanyin Zhang
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 28:280-90. 2008
    ..This study extends the range of the neurovascular coupling relationship from graded neuronal excitation conditions to graded neuronal suppression conditions...
  31. pmc In vitro and in vivo studies of 17O NMR sensitivity at 9.4 and 16.4 T
    Ming Lu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 69:1523-7. 2013
    ....
  32. pmc The change of functional connectivity specificity in rats under various anesthesia levels and its neural origin
    Xiao Liu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, 2021 6th St SE, Minneapoli, MN 55455, USA
    Brain Topogr 26:363-77. 2013
    ..The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states...
  33. pmc Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuroimage 64:437-47. 2013
    ....
  34. pmc Relayed magnetization transfer from nuclear Overhauser effect and chemical exchange observed by in vivo ³¹P MRS in rat brain
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Magn Reson Imaging 30:716-21. 2012
    ..The unique relayed magnetization transfer effects through spin diffusion were observed in the rat brain using in vivo (31)P magnetic resonance spectroscopy...
  35. ncbi request reprint Probing fast neuronal interaction using fMRI
    Nanyin Zhang
    Dept of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 1:13-6. 2006
    ..The results reveal that the gradient acoustic noise does interfere with the neural behavior in human visual cortex...
  36. pmc Investigating the source of BOLD nonlinearity in human visual cortex in response to paired visual stimuli
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Neuroimage 43:204-12. 2008
    ..They also suggest a possible mechanism to improve the spatial specificity of gradient-echo BOLD signal for fMRI mapping based on the characteristics of vascular refractoriness...
  37. doi request reprint Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by Mitochondria
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN, USA
    Methods Mol Biol 489:317-57. 2009
    ....
  38. pmc Baseline BOLD correlation predicts individuals' stimulus-evoked BOLD responses
    Xiao Liu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 54:2278-86. 2011
    ..This study highlights the importance to integrate the information from both resting-state coherent networks and task-evoked neural responses for a better understanding of how the brain functions...
  39. pmc Three-dimensional imaging of complex neural activation in humans from EEG
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 56:1980-8. 2009
    ....
  40. ncbi request reprint An inverted-microstrip resonator for human head proton MR imaging at 7 tesla
    Xiaoliang Zhang
    Center for Magnetic Resonance Research, Department of Radiology, The University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 52:495-504. 2005
    ..The proposed iMTL volume coil provides an efficient and alternative solution to design high-frequency and large-size volume coils for human MR applications at very high fields...
  41. ncbi request reprint Phantom design method for high-field MRI human systems
    Qing X Yang
    Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Magn Reson Med 52:1016-20. 2004
    ....
  42. ncbi request reprint Transmit and receive transmission line arrays for 7 Tesla parallel imaging
    Gregor Adriany
    Center for Magnetic Resonance Research, Department of Radiology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 53:434-45. 2005
    ..A one-dimensional reduction factor of 4 was robustly achieved with an average g value of 1.25 with the eight-channel transmit/receive coils...
  43. pmc Neural origin of spontaneous hemodynamic fluctuations in rats under burst-suppression anesthesia condition
    Xiao Liu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Cereb Cortex 21:374-84. 2011
    ..They provide insights into the neurophysiological basis for the use of BOLD- and CBF-based fMRI signals for noninvasively imaging spontaneous and synchronous brain activity under various brain states...
  44. ncbi request reprint Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalation
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 24:840-8. 2004
    ..The results from this work show (1) the validity of the simplified methods for quantifying CMRO2, and (2) the feasibility for establishing a completely noninvasive 17O MR approach for imaging CMRO2 in vivo...
  45. pmc Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 99:13194-9. 2002
    ....
  46. ncbi request reprint In vivo 1H2O T2+ measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrast
    Robert Bartha
    The Center for Magnetic Resonance Research and Department of Radiology, The University of Minnesota, Minneapolis, Minnesota, USA
    Magn Reson Med 47:742-50. 2002
    ..These results are consistent with higher levels of compartmentalized ferritin and increased blood volume in gray matter compared to white matter in this region of the brain...
  47. pmc In vivo 31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 T
    Hongyan Qiao
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Magn Reson Imaging 24:1281-6. 2006
    ..Finally, the approach used in this study for calculating in vivo 31P MRS sensitivity provides a general tool in estimating the relative NMR detection sensitivity for any nuclear spin at a given field strength...
  48. pmc Radiotracers for cardiac sympathetic innervation: transport kinetics and binding affinities for the human norepinephrine transporter
    David M Raffel
    Division of Nuclear Medicine, Department of Radiology, 2276 Medical Sciences I Building, University of Michigan Medical School, 1301 Catherine Street, SPC 5610, Ann Arbor, MI 48109, USA
    Nucl Med Biol 40:331-7. 2013
    ..For comparison, the NET transport kinetics and binding affinities of some [(3)H]-labeled biogenic amines were also determined...
  49. pmc Novel strategy for measuring creatine kinase reaction rate in the in vivo heart
    Qiang Xiong
    Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Am J Physiol Heart Circ Physiol 297:H1010-9. 2009
    ..This method is validated using an in vivo pig model to evaluate the forward pseudo-first-order rate constant of myocardial CK reaction noninvasively...
  50. pmc Mapping the bilateral visual integration by EEG and fMRI
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 46:989-97. 2009
    ....
  51. ncbi request reprint Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coil
    Xiaoliang Zhang
    Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S E, Department of Radiology, Minneapolis, Minnesota, USA
    MAGMA 16:77-85. 2003
    ..Compared to most contemporary MR approaches, the REDE implanted RF provides a simple, accurate, and promising solution for determination of AIF in small experimental animals...
  52. ncbi request reprint Gene therapy of murine solid tumors with T cells transduced with a retroviral vascular endothelial growth factor--immunotoxin target gene
    Ni Jin
    Section on Experimental Cancer Immunology, Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Hum Gene Ther 13:497-508. 2002
    ..Together, these data indicate that gene therapy of T cells with retrovirus containing a VEGF-immunotoxin target gene may be a valid means of inhibiting a broad range of solid tumors dependent on angiogenesis...
  53. ncbi request reprint Ultrahigh field magnetic resonance imaging and spectroscopy
    Kamil Ugurbil
    Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Magn Reson Imaging 21:1263-81. 2003
  54. pmc A correlation-matrix-based hierarchical clustering method for functional connectivity analysis
    Xiao Liu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA
    J Neurosci Methods 211:94-102. 2012
    ..Moreover, its sensitivity of detecting patterns remains relatively high even for a single dataset. In conclusion, the CMBHC method could be a useful tool for investigating resting-state brain connectivity and function...
  55. pmc Large enhancement of perfusion contribution on fMRI signal
    Xiao Wang
    Department of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Cereb Blood Flow Metab 32:907-18. 2012
    ....
  56. ncbi request reprint Effective CpG immunotherapy of breast carcinoma prevents but fails to eradicate established brain metastasis
    Zhengming Xiong
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 14:5484-93. 2008
    ..Breast cancer patients with brain metastasis have a dismal prognosis. We determined the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) to treat or prevent brain metastasis in a mouse model...
  57. pmc Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy
    Hao Lei
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 Sixth Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:14409-14. 2003
    ..1 +/- 2.8 micromol ATP/g per min, which agreed well with the value that was calculated indirectly from the cerebral metabolic rate of glucose consumption reported previously...
  58. pmc New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 29:10-8. 2009
    ..They also suggest that in vivo (17)O MRS imaging should provide a sensitive neuroimaging modality for mapping CMRO(2) and its change induced by brain physiology and/or pathologic alteration...
  59. pmc Functional cortical source imaging from simultaneously recorded ERP and fMRI
    Chang Hwan Im
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci Methods 157:118-23. 2006
    ..The present results demonstrate that reliable cortical source images can be acquired during simultaneous fMRI scanning and they may be used for multimodal functional source imaging studies...
  60. ncbi request reprint Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla
    Joseph Lee
    Department of Medicine, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA
    J Magn Reson Imaging 24:1269-76. 2006
    ..To develop a rapid, robust, and accurate method for assessing myocardial energetics in mice and demonstrate its applicability to mouse models of acquired and genetic heart disease...
  61. ncbi request reprint In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: an initial experience
    Hao Lei
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 49:199-205. 2003
    ..24 +/- 0.03 s(-1). The results from this study suggest that ultra-high-field strength is advantageous for performing in vivo (31)P magnetic resonance spectroscopy (MRS) in the human brain...
  62. ncbi request reprint Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T
    Hao Lei
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Magn Reson Med 49:979-84. 2003
    ..The changes in T(2) should be taken into account for the quantification of metabolite concentrations during ischemia...
  63. ncbi request reprint A dynamic fMRI study of illusory double-flash effect on human visual cortex
    Nanyin Zhang
    Departments of Radiology and Biomedical Engineering, Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S E, Minneapolis, MN 55455, USA
    Exp Brain Res 172:57-66. 2006
    ..Finally, this work demonstrates a unique merit of fMRI for providing both temporal and spatial information regarding cross-modal neural interaction between different sensory systems...
  64. ncbi request reprint Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells
    E Ashley Moseman
    University of Minnesota Cancer Center and Department of Pediatrics, and Division of Hematology, Oncology, and Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    J Immunol 173:4433-42. 2004
    ..This study demonstrates that TLR9 stimulation can promote PDC-mediated generation of CD4(+)CD25(+) Treg cells and suggests PDCs may play an important role in the maintenance of immunological tolerance...
  65. ncbi request reprint (1)H MRS in the rat brain under pentobarbital anesthesia: accurate quantification of in vivo spectra in the presence of propylene glycol
    Isabelle Iltis
    Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 59:631-5. 2008
    ..The chemical shifts and J-coupling values reported here can be used to simulate the spectrum of PG at any field strength, with various pulse sequences...
  66. pmc Distinction in coherent neural network between resting and working brain states
    Xiao Liu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Brain Connect 1:377-88. 2011
    ..Finally, a similar fMRI experiment was also conducted under brief, short stimulation to examine how the stimulation paradigm can affect the observations...
  67. ncbi request reprint Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T
    Shalom Michaeli
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 47:629-33. 2002
    ..At high field, signal loss resulting from T2 decay can be substantially reduced using a Carr-Purcell-type SE sequence...
  68. pmc Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells
    Xueqing Liang
    Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 115:5041-52. 2010
    ..These findings provide new understanding of CpG ODN-mediated antitumor effects and support for the development of TLR9-targeted therapy for human CLL...
  69. ncbi request reprint A microstrip transmission line volume coil for human head MR imaging at 4T
    Xiaoliang Zhang
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S E, Minneapolis, MN, USA
    J Magn Reson 161:242-51. 2003
    ..The results of this study demonstrate that the MTL volume coil design provides an efficient and simple solution to RF volume coil design for human MR studies at high fields...
  70. ncbi request reprint Insulin reduces the BOLD response but is without effect on the VEP during presentation of a visual task in humans
    Elizabeth R Seaquist
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    J Cereb Blood Flow Metab 27:154-60. 2007
    ..These findings highlight the complexity that must be considered when interpreting differences in fMRI responses between groups of subjects that differ in insulin concentration and/or insulin sensitivity...
  71. pmc Superior efficacy of tumor cell vaccines grown in physiologic oxygen
    Michael R Olin
    Departments of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
    Clin Cancer Res 16:4800-8. 2010
    ..Atmospheric oxygen (∼20% O(2)) has been the universal condition employed to culture tumor cells used as vaccine antigen. We tested the hypothesis that reducing oxygen tension would increase the efficacy of tumor cell lysate vaccines...
  72. pmc Dependence of cardiac 11C-meta-hydroxyephedrine retention on norepinephrine transporter density
    David M Raffel
    Department of Radiology, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, 48109 0552, USA
    J Nucl Med 47:1490-6. 2006
    ..The goal of this study was to characterize the dependence of HED retention on nerve density in rats with graded levels of cardiac denervation induced chemically with the neurotoxin 6-hydroxydopamine (6-OHDA)...
  73. pmc The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
    Wei Chen
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics and The Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 181:5396-404. 2008
    ..Our results demonstrate that the IDO pathway is essential for PDC-driven Treg generation from CD4(+)CD25(-) T cells and implicate the generation of kynurenine pathway metabolites as the critical mediator of this process...
  74. ncbi request reprint Analysis of wave behavior in lossy dielectric samples at high field
    Qing X Yang
    Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Magn Reson Med 47:982-9. 2002
    ..The numerical calculation method is validated with experimental results. The general behavior of the RF field with respect to the average brain electrical properties in a frequency range of 42-350 MHz is also analyzed...
  75. ncbi request reprint Higher-order harmonic transmission-line RF coil design for MR applications
    Xiaoliang Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Magn Reson Med 53:1234-9. 2005
    ..This work demonstrates that the use of higher-order harmonics in a transmission-line resonator provides an alternative, efficient approach to the design of large and high-frequency RF coils...
  76. ncbi request reprint Influence of gradient acoustic noise on fMRI response in the human visual cortex
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 54:258-63. 2005
    ..This study provides evidence of the auditory-visual interaction during fMRI studies, and the results should have an impact on fMRI applications...
  77. ncbi request reprint Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis 55455, USA
    Blood 100:4169-76. 2002
    ..These data have important clinical implications and are the first to show that Flt3L-generated DCs can provide antitumor protection and that nontoxic agents such as CpGs and Flt3L may be useful in the clinical development of DC vaccines...
  78. pmc Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors
    Wei Chen
    Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, niversity of Minnesota, Minneapolis, MN 55455, USA
    Blood 103:2547-53. 2004
    ..This culture system, combined with the use of adult peripheral blood CD34+ HPCs purified from G-CSF-mobilized donors, permits the generation of more than 10(9) IPCs from a single blood donor...
  79. ncbi request reprint Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis, MN 55455, USA
    Exp Hematol 34:1403-12. 2006
    ....
  80. ncbi request reprint Expression of MHC I and NK ligands on human CD133+ glioma cells: possible targets of immunotherapy
    Anhua Wu
    Department of Neurosurgery, University of Minnesota Medical School, 3500B LRB MTRF, Minneapolis, MN, 55455, USA
    J Neurooncol 83:121-31. 2007
    ..We conclude that CD133-posistive and CD133-negative glioma cells may be similarly resistant to immune surveillance, but that INF-gamma may partially restore their immunogenicity and potentiate their lysis by NK cells...
  81. ncbi request reprint FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides to enhance T-cell and natural killer cell function
    Wei Chen
    University of Minnesota Cancer Center, Minneapolis, Minnesota 5455, USA
    Biol Blood Marrow Transplant 11:23-34. 2005
    ..These findings suggest that FLT3-L mobilization of DC precursors followed by a specific DC stimulus such as CpG ODN may provide a novel strategy to manipulate antitumor immunity in patients after HCT...
  82. ncbi request reprint Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene
    Daniel A Vallera
    University of Minnesota Cancer Center, Department of Therapeutic Radiology, Section on Experimental Cancer Immunology, Minneapolis, MN 55455, USA
    Hum Gene Ther 14:1787-98. 2003
    ..Furthermore, the Bax construct may be particularly useful as a nonimmunogenic substitute for bacterial toxins in retIT...
  83. pmc Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging
    Peter A Jarzyna
    Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1234, New York, NY 10029, USA
    Biomaterials 30:6947-54. 2009
    ..The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo...
  84. ncbi request reprint Binding of [3H]mazindol to cardiac norepinephrine transporters: kinetic and equilibrium studies
    David M Raffel
    Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, 3480 Kresge III Building, Ann Arbor 48109 0552, USA
    Naunyn Schmiedebergs Arch Pharmacol 370:9-16. 2004
    ..These studies demonstrate the high selectivity of [3H]mazindol binding for the norepinephrine transporter in membrane preparations from mammalian hearts...
  85. ncbi request reprint Identification of EGFRvIII-derived CTL epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomas
    An hua Wu
    Department of Neurosurgery, University of Minnesota Medical School, 2001 Sixth Street, Minneapolis, SE, MN 55455, USA
    J Neurooncol 76:23-30. 2006
    ..These results suggest that vaccination with EGFRvIII peptide-pulsed DCs or adoptive transfer of in vitro elicited EGFRvIII-specific CTLs by EGFRvIII peptide-pulsed DCs are potential approaches to the treatment of glioma patients...
  86. ncbi request reprint The conformations of the amyloid-beta (21-30) fragment can be described by three families in solution
    Wei Chen
    Departement de Physique, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Chem Phys 125:084911. 2006
    ..Moreover, it provides further evidence of the capability of ART OPEP in providing a reliable conformational picture of peptides in solution...
  87. pmc Multipotent adult progenitor cells sustain function of ischemic limbs in mice
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 118:505-14. 2008
    ..Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients...
  88. ncbi request reprint [Therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on murine melanoma in vivo]
    Wei Chen
    Institute of Immunology, College of Medicine, Zhejiang University, Hangzhou 310031, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 34:73-6. 2005
    ..To investigate the therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on established murine melanoma in vivo...
  89. pmc Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
    ..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...
  90. ncbi request reprint Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression
    Taoyong Chen
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai 200433, P R China
    Blood 103:413-21. 2004
    ..Impairment of DC migration due to inhibition of PGE2 production and regulation of chemokine receptor expression may contribute, in part, to CsA-mediated immunosuppression...
  91. ncbi request reprint Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells
    Qin Xu
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Clin Endocrinol Metab 90:953-61. 2005
    ....
  92. ncbi request reprint Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis
    Nan Li
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, P R China
    Cancer Res 67:11176-85. 2007
    ..The data suggest that phosphorylated p53 (Ser(15/18)) might translocate to lysosome via forming complexes with adaptor protein LAPF and subsequently result in LMP and apoptosis, which might be in a transcription-independent manner...
  93. ncbi request reprint Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production
    Nathalie Bendriss-Vermare
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Leukoc Biol 78:954-66. 2005
    ....
  94. doi request reprint Association between arterial stiffness and peritoneal small solute transport rate
    Xing wei Zhe
    Division of Nephrology, Peking University Third Hospital, Beijing, China
    Artif Organs 32:416-9. 2008
    ....
  95. ncbi request reprint Real-time detection of respiratory activity using an inertial measurement unit
    Henrik Gollee
    Centre for Rehabilitation Engineering, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK
    Conf Proc IEEE Eng Med Biol Soc 2007:2230-3. 2007
    ..This novel method could therefore be suitable for use in automatic abdominal stimulation systems to support respiratory activity in tetraplegia where the stimulation is applied depending on the respirator activity of the subject...
  96. ncbi request reprint Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8
    Hai Feng Duan
    Beijing Institute of Radiation Medicine, Haidian District, Beijing, China
    J Natl Cancer Inst 99:1551-5. 2007
    ..TEM8-Fc is a novel therapeutic antibody-like agent in the management of solid tumors that may act by trapping M2-PK...
  97. ncbi request reprint Small antisense RNA to cyclin D1 generated by pre-tRNA splicing inhibits growth of human hepatoma cells
    Dazhi Lai
    Beijing Institute of Microbiology and Epidemiology, 20 Dongdajie, Fengtai, Beijing 100071, China
    FEBS Lett 576:481-6. 2004
    ..Such tumor growth inhibition might be due to apoptosis caused by reduced cyclin D1 expression as revealed by immunohistochemical analysis of tumor samples...
  98. pmc RAGE ligation affects T cell activation and controls T cell differentiation
    Yali Chen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 181:4272-8. 2008
    ..We conclude that activation of RAGE on T cells is involved in early events that lead to differentiation of Th1(+) T cells...
  99. pmc Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis
    Lang Bao
    Research Unit of Infection and Immunity, West China Medical Center, Sichuan University, No 17, 3rd Section, Ren Min Nan Road, Chengdu, Sichuan 610041, People s Republic of China
    Infect Immun 71:1656-61. 2003
    ..Both rBCG-1 and rBCG-2 conferred marked protection against M. tuberculosis infection, yet in terms of protective efficacy, they showed no significant improvements upon conventional BCG vaccine...
  100. ncbi request reprint Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes
    Wei Chen
    Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
    Endocrinology 145:627-38. 2004
    ..Thus, IGF-I/IGFBP-3 affords more efficient protection from insulitis, beta-cell destruction, and T1D than IGF-I, and this complex may represent an efficacious therapeutic treatment for the prevention of T1D...
  101. ncbi request reprint Effects of progesterone on growth factor expression in human uterine leiomyoma
    Takeshi Maruo
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Steroids 68:817-24. 2003
    ..This may also explain why the size of uterine myomas during pregnancy does not increase despite the overwhelming increase in circulating concentrations of sex steroid hormones...

Research Grants31

  1. PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRI
    Wei Chen; Fiscal Year: 2005
    ....
  2. STUDY OF BRAIN OXIDATIVE METABOLISM BY 17-0 MRS IMAGING
    Wei Chen; Fiscal Year: 2006
    ..Extensive preliminary data are presented demonstrating a high signal-to-noise for the 170 MRS imaging measurement at high magnetic fields of 7 to 9.4 Tesla in rats and humans, and that the proposed goals can be achieved. ..
  3. Study of Brain Oxidative Metabolism by 17-0 imaging
    Wei Chen; Fiscal Year: 2010
    ..The success in developing the 17O-based CMRO2 imaging modality will further enhance the ability of MR technology in neuroscience discovery and potentially in diagnosis of brain diseases. ..
  4. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 1999
    ..abstract_text> ..
  5. Novel RF Coils for In Vivo MR Applications at High Field
    Wei Chen; Fiscal Year: 2004
    ..abstract_text> ..
  6. STUDY OF BRAIN OXIDATIVE METABOLISM BY 17-0 MRS IMAGING
    Wei Chen; Fiscal Year: 2005
    ..Extensive preliminary data are presented demonstrating a high signal-to-noise for the 170 MRS imaging measurement at high magnetic fields of 7 to 9.4 Tesla in rats and humans, and that the proposed goals can be achieved. ..
  7. Novel RF Coils for In Vivo MR Applications at High Field
    Wei Chen; Fiscal Year: 2005
    ..abstract_text> ..
  8. Novel RF Coils for In Vivo MR Applications at High Field
    Wei Chen; Fiscal Year: 2006
    ..abstract_text> ..
  9. Novel RF Coils for In Vivo MR Applications at High Field
    Wei Chen; Fiscal Year: 2007
    ..abstract_text> ..
  10. Study of Brain Oxidative Metabolism buy 17-0 imaging
    Wei Chen; Fiscal Year: 2007
    ..The success in developing the 17O-based CMRO2 imaging modality will further enhance the ability of MR technology in neuroscience discovery and potentially in diagnosis of brain diseases. ..
  11. Study of Brain Oxidative Metabolism by 17-0 imaging
    Wei Chen; Fiscal Year: 2009
    ..The success in developing the 17O-based CMRO2 imaging modality will further enhance the ability of MR technology in neuroscience discovery and potentially in diagnosis of brain diseases. ..
  12. Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain Function
    Wei Chen; Fiscal Year: 2009
    ....
  13. Study of Brain Oxidative Metabolism by 17-0 imaging
    Wei Chen; Fiscal Year: 2009
    ..The success in developing the 17O-based CMRO2 imaging modality will further enhance the ability of MR technology in neuroscience discovery and potentially in diagnosis of brain diseases. ..
  14. PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRI
    Wei Chen; Fiscal Year: 2004
    ....
  15. STUDY OF BRAIN OXIDATIVE METABOLISM BY 17-0 MRS IMAGING
    Wei Chen; Fiscal Year: 2004
    ..Extensive preliminary data are presented demonstrating a high signal-to-noise for the 170 MRS imaging measurement at high magnetic fields of 7 to 9.4 Tesla in rats and humans, and that the proposed goals can be achieved. ..
  16. Novel RF Coils for In Vivo MR Applications at High Field
    Wei Chen; Fiscal Year: 2003
    ..abstract_text> ..
  17. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 1999
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  18. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 2000
    ..abstract_text> ..
  19. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 2000
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  20. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 2001
    ..abstract_text> ..
  21. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 2001
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  22. STUDY OF BRAIN OXIDATIVE METABOLISM BY 17-0 MRS IMAGING
    Wei Chen; Fiscal Year: 2002
    ..Extensive preliminary data are presented demonstrating a high signal-to-noise for the 170 MRS imaging measurement at high magnetic fields of 7 to 9.4 Tesla in rats and humans, and that the proposed goals can be achieved. ..
  23. PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRI
    Wei Chen; Fiscal Year: 2002
    ....
  24. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 2002
    ..abstract_text> ..
  25. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 2002
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  26. STUDY OF BRAIN OXIDATIVE METABOLISM BY 17-0 MRS IMAGING
    Wei Chen; Fiscal Year: 2003
    ..Extensive preliminary data are presented demonstrating a high signal-to-noise for the 170 MRS imaging measurement at high magnetic fields of 7 to 9.4 Tesla in rats and humans, and that the proposed goals can be achieved. ..
  27. PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRI
    Wei Chen; Fiscal Year: 2003
    ....
  28. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 2003
    ..abstract_text> ..
  29. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 2003
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  30. Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain Function
    Wei Chen; Fiscal Year: 2010
    ....