Wei Chen

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells
    E Ashley Moseman
    University of Minnesota Cancer Center and Department of Pediatrics, and Division of Hematology, Oncology, and Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    J Immunol 173:4433-42. 2004
  2. ncbi request reprint FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides to enhance T-cell and natural killer cell function
    Wei Chen
    University of Minnesota Cancer Center, Minneapolis, Minnesota 5455, USA
    Biol Blood Marrow Transplant 11:23-34. 2005
  3. pmc The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
    Wei Chen
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics and The Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 181:5396-404. 2008
  4. pmc Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors
    Wei Chen
    Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, niversity of Minnesota, Minneapolis, MN 55455, USA
    Blood 103:2547-53. 2004
  5. ncbi request reprint In vivo vaccination with tumor cell lysate plus CpG oligodeoxynucleotides eradicates murine glioblastoma
    Anhua Wu
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunother 30:789-97. 2007
  6. pmc In vivo measurement of CBF using ¹⁷O NMR signal of metabolically produced H₂¹⁷O as a perfusion tracer
    Xiao Hong Zhu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Magn Reson Med 70:309-14. 2013
  7. pmc Oxygen is a master regulator of the immunogenicity of primary human glioma cells
    Michael R Olin
    Department of Pediatrics, Graduate Program in Neuroscience, Biostatistics and Bioinformatics, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota, USA
    Cancer Res 71:6583-9. 2011
  8. pmc In vitro and in vivo studies of 17O NMR sensitivity at 9.4 and 16.4 T
    Ming Lu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 69:1523-7. 2013
  9. ncbi request reprint Expression of MHC I and NK ligands on human CD133+ glioma cells: possible targets of immunotherapy
    Anhua Wu
    Department of Neurosurgery, University of Minnesota Medical School, 3500B LRB MTRF, Minneapolis, MN, 55455, USA
    J Neurooncol 83:121-31. 2007
  10. doi request reprint Effective CpG immunotherapy of breast carcinoma prevents but fails to eradicate established brain metastasis
    Zhengming Xiong
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 14:5484-93. 2008

Research Grants

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells
    E Ashley Moseman
    University of Minnesota Cancer Center and Department of Pediatrics, and Division of Hematology, Oncology, and Bone Marrow Transplantation, Minneapolis, MN 55455, USA
    J Immunol 173:4433-42. 2004
    ..This study demonstrates that TLR9 stimulation can promote PDC-mediated generation of CD4(+)CD25(+) Treg cells and suggests PDCs may play an important role in the maintenance of immunological tolerance...
  2. ncbi request reprint FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides to enhance T-cell and natural killer cell function
    Wei Chen
    University of Minnesota Cancer Center, Minneapolis, Minnesota 5455, USA
    Biol Blood Marrow Transplant 11:23-34. 2005
    ..These findings suggest that FLT3-L mobilization of DC precursors followed by a specific DC stimulus such as CpG ODN may provide a novel strategy to manipulate antitumor immunity in patients after HCT...
  3. pmc The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
    Wei Chen
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics and The Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 181:5396-404. 2008
    ..Our results demonstrate that the IDO pathway is essential for PDC-driven Treg generation from CD4(+)CD25(-) T cells and implicate the generation of kynurenine pathway metabolites as the critical mediator of this process...
  4. pmc Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors
    Wei Chen
    Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, niversity of Minnesota, Minneapolis, MN 55455, USA
    Blood 103:2547-53. 2004
    ..This culture system, combined with the use of adult peripheral blood CD34+ HPCs purified from G-CSF-mobilized donors, permits the generation of more than 10(9) IPCs from a single blood donor...
  5. ncbi request reprint In vivo vaccination with tumor cell lysate plus CpG oligodeoxynucleotides eradicates murine glioblastoma
    Anhua Wu
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunother 30:789-97. 2007
    ..05). These results suggest direct vaccination with CpG/lysate provides an alternative and effective approach to induce host antitumor immunity and warrants clinical investigation in the immunotherapy of cancer...
  6. pmc In vivo measurement of CBF using ¹⁷O NMR signal of metabolically produced H₂¹⁷O as a perfusion tracer
    Xiao Hong Zhu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Magn Reson Med 70:309-14. 2013
    ....
  7. pmc Oxygen is a master regulator of the immunogenicity of primary human glioma cells
    Michael R Olin
    Department of Pediatrics, Graduate Program in Neuroscience, Biostatistics and Bioinformatics, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota, USA
    Cancer Res 71:6583-9. 2011
    ....
  8. pmc In vitro and in vivo studies of 17O NMR sensitivity at 9.4 and 16.4 T
    Ming Lu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 69:1523-7. 2013
    ....
  9. ncbi request reprint Expression of MHC I and NK ligands on human CD133+ glioma cells: possible targets of immunotherapy
    Anhua Wu
    Department of Neurosurgery, University of Minnesota Medical School, 3500B LRB MTRF, Minneapolis, MN, 55455, USA
    J Neurooncol 83:121-31. 2007
    ..We conclude that CD133-posistive and CD133-negative glioma cells may be similarly resistant to immune surveillance, but that INF-gamma may partially restore their immunogenicity and potentiate their lysis by NK cells...
  10. doi request reprint Effective CpG immunotherapy of breast carcinoma prevents but fails to eradicate established brain metastasis
    Zhengming Xiong
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 14:5484-93. 2008
    ..Breast cancer patients with brain metastasis have a dismal prognosis. We determined the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) to treat or prevent brain metastasis in a mouse model...
  11. ncbi request reprint Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis, MN 55455, USA
    Exp Hematol 34:1403-12. 2006
    ....
  12. pmc The change of functional connectivity specificity in rats under various anesthesia levels and its neural origin
    Xiao Liu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, 2021 6th St SE, Minneapoli, MN 55455, USA
    Brain Topogr 26:363-77. 2013
    ..The specific-to-less-specific transition of resting-state networks may reflect a functional reorganization of the brain at different anesthesia levels or brain states...
  13. pmc Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells
    Xueqing Liang
    Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 115:5041-52. 2010
    ..These findings provide new understanding of CpG ODN-mediated antitumor effects and support for the development of TLR9-targeted therapy for human CLL...
  14. ncbi request reprint Gene therapy of murine solid tumors with T cells transduced with a retroviral vascular endothelial growth factor--immunotoxin target gene
    Ni Jin
    Section on Experimental Cancer Immunology, Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Hum Gene Ther 13:497-508. 2002
    ..Together, these data indicate that gene therapy of T cells with retrovirus containing a VEGF-immunotoxin target gene may be a valid means of inhibiting a broad range of solid tumors dependent on angiogenesis...
  15. pmc Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuroimage 64:437-47. 2013
    ....
  16. pmc Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies
    Brenda J Weigel
    Department of Pediatrics, Division of Hematology Oncology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Am J Hematol 87:953-6. 2012
    ..2 mg/m(2) twice weekly with evidence of sustained tolerability and clinical activity in hematologic malignancies. Systemic TLR agonists for the treatment of hematologic malignancies warrant further study...
  17. pmc Simultaneous measurement of glucose blood-brain transport constants and metabolic rate in rat brain using in-vivo 1H MRS
    Fei Du
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 32:1778-87. 2012
    ..The overall results indicate that the new approach is robust and reliable for in-vivo measurements of both brain glucose metabolic rate and transport constants, and has potential for human application...
  18. pmc Superior efficacy of tumor cell vaccines grown in physiologic oxygen
    Michael R Olin
    Departments of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
    Clin Cancer Res 16:4800-8. 2010
    ..Atmospheric oxygen (∼20% O(2)) has been the universal condition employed to culture tumor cells used as vaccine antigen. We tested the hypothesis that reducing oxygen tension would increase the efficacy of tumor cell lysate vaccines...
  19. pmc An fMRI study of neural interaction in large-scale cortico-thalamic visual network
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street S E, Minneapolis, MN 55455, USA
    Neuroimage 42:1110-7. 2008
    ....
  20. pmc Three-dimensional imaging of complex neural activation in humans from EEG
    Lei Ding
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 56:1980-8. 2009
    ....
  21. pmc Linear and nonlinear relationships between visual stimuli, EEG and BOLD fMRI signals
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA
    Neuroimage 50:1054-66. 2010
    ..The validated cross-modal relationship between fMRI and EEG may provide a theoretical basis for the integration of these two modalities...
  22. pmc High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School of Medicine, 2021 6 th Street S E, Minneapolis, MN 55455, USA
    Neuroimage 50:1456-63. 2010
    ....
  23. pmc A correlation-matrix-based hierarchical clustering method for functional connectivity analysis
    Xiao Liu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA
    J Neurosci Methods 211:94-102. 2012
    ..Moreover, its sensitivity of detecting patterns remains relatively high even for a single dataset. In conclusion, the CMBHC method could be a useful tool for investigating resting-state brain connectivity and function...
  24. pmc Large enhancement of perfusion contribution on fMRI signal
    Xiao Wang
    Department of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Cereb Blood Flow Metab 32:907-18. 2012
    ....
  25. ncbi request reprint Noninvasive study of neurovascular coupling during graded neuronal suppression
    Nanyin Zhang
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 28:280-90. 2008
    ..This study extends the range of the neurovascular coupling relationship from graded neuronal excitation conditions to graded neuronal suppression conditions...
  26. ncbi request reprint Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene
    Daniel A Vallera
    University of Minnesota Cancer Center, Department of Therapeutic Radiology, Section on Experimental Cancer Immunology, Minneapolis, MN 55455, USA
    Hum Gene Ther 14:1787-98. 2003
    ..Furthermore, the Bax construct may be particularly useful as a nonimmunogenic substitute for bacterial toxins in retIT...
  27. pmc New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 29:10-8. 2009
    ..They also suggest that in vivo (17)O MRS imaging should provide a sensitive neuroimaging modality for mapping CMRO(2) and its change induced by brain physiology and/or pathologic alteration...
  28. ncbi request reprint Ultrahigh field magnetic resonance imaging and spectroscopy
    Kamil Ugurbil
    Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Magn Reson Imaging 21:1263-81. 2003
  29. pmc Investigating the source of BOLD nonlinearity in human visual cortex in response to paired visual stimuli
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Neuroimage 43:204-12. 2008
    ..They also suggest a possible mechanism to improve the spatial specificity of gradient-echo BOLD signal for fMRI mapping based on the characteristics of vascular refractoriness...
  30. pmc Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortex
    Chang Hwan Im
    Department of Biomedical Engineering, University of Minnesota, 7 105 Hasselmo Hall, 312 Church St S E, Minneapolis, MN 55455, USA
    J Neurosci Methods 161:142-54. 2007
    ..The present results suggest that the spatial resolution of the EEG cortical source imaging can correctly discriminate cortical activation changes in V1 corresponding to less than 3 degrees visual field changes...
  31. ncbi request reprint Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study
    Xiao Hong Zhu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:1225-34. 2007
    ..This approach, thus, should provide a promising neuroimaging modality for studying oxidative metabolism and bioenergetics associated with brain functions and diseases...
  32. ncbi request reprint Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 57:103-14. 2007
    ..The MSS MT approach should provide an important modality for noninvasively studying the essential roles of ATP metabolism in brain bioenergetics, function, and diseases...
  33. ncbi request reprint Study of Brain Function and Bioenergetics using fMRI and In Vivo MRS at High Fields
    Wei Chen
    Center for Magnetic Resonance Research, Departments of Radiology and Biomedical Engineering, University of Minnesota, 2021 6th St SE Minneapolis, Minnesota, USA phone 612 625 8814 fax 612 626 2004 e mail
    Conf Proc IEEE Eng Med Biol Soc 4:4174-7. 2005
    ..This talk will discuss the developed MR technologies and their applications in brain study at high fields...
  34. pmc Tightly coupled brain activity and cerebral ATP metabolic rate
    Fei Du
    Department of Radiology, Center for Magnetic Resonance Research and Department of Biomedical Engineering, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 105:6409-14. 2008
    ....
  35. doi request reprint (1)H MRS in the rat brain under pentobarbital anesthesia: accurate quantification of in vivo spectra in the presence of propylene glycol
    Isabelle Iltis
    Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 59:631-5. 2008
    ..The chemical shifts and J-coupling values reported here can be used to simulate the spectrum of PG at any field strength, with various pulse sequences...
  36. ncbi request reprint Probing fast neuronal interaction using fMRI
    Nanyin Zhang
    Dept of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 1:13-6. 2006
    ..The results reveal that the gradient acoustic noise does interfere with the neural behavior in human visual cortex...
  37. pmc Three-dimensional source imaging from simultaneously recorded ERP and BOLD-fMRI
    Xiaoxiao Bai
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Neural Syst Rehabil Eng 17:101-6. 2009
    ..The present results demonstrate the merits of high-resolution spatiotemporal functional neuroimaging by integrating the simultaneously recorded fMRI and EEG data...
  38. doi request reprint Functional MRI study of brain function under resting and activated states
    Wei Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4061-3. 2009
    ..We have found a strong correlation between the spontaneous brain activity and BOLD fluctuation indicating a tight neurovascular relation...
  39. ncbi request reprint Insulin reduces the BOLD response but is without effect on the VEP during presentation of a visual task in humans
    Elizabeth R Seaquist
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    J Cereb Blood Flow Metab 27:154-60. 2007
    ..These findings highlight the complexity that must be considered when interpreting differences in fMRI responses between groups of subjects that differ in insulin concentration and/or insulin sensitivity...
  40. ncbi request reprint An inverted-microstrip resonator for human head proton MR imaging at 7 tesla
    Xiaoliang Zhang
    Center for Magnetic Resonance Research, Department of Radiology, The University of Minnesota, Minneapolis, MN 55455, USA
    IEEE Trans Biomed Eng 52:495-504. 2005
    ..The proposed iMTL volume coil provides an efficient and alternative solution to design high-frequency and large-size volume coils for human MR applications at very high fields...
  41. ncbi request reprint Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T
    Shalom Michaeli
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 47:629-33. 2002
    ..At high field, signal loss resulting from T2 decay can be substantially reduced using a Carr-Purcell-type SE sequence...
  42. ncbi request reprint Transmit and receive transmission line arrays for 7 Tesla parallel imaging
    Gregor Adriany
    Center for Magnetic Resonance Research, Department of Radiology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 53:434-45. 2005
    ..A one-dimensional reduction factor of 4 was robustly achieved with an average g value of 1.25 with the eight-channel transmit/receive coils...
  43. ncbi request reprint Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coil
    Xiaoliang Zhang
    Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S E, Department of Radiology, Minneapolis, Minnesota, USA
    MAGMA 16:77-85. 2003
    ..Compared to most contemporary MR approaches, the REDE implanted RF provides a simple, accurate, and promising solution for determination of AIF in small experimental animals...
  44. doi request reprint Quantitatively Interpreting fMRI signal
    Nanyin Zhang
    Center for Magnetic Resonance Research, The Department of Radiology, The University of Minnesota Twin Cities, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:4415-8. 2008
    ....
  45. doi request reprint Brain imaging developments based on in vivo MRS
    Wei Chen
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:50-2. 2009
    ..These new methods have been successfully applied for investigating the neuroenergetics changes associated with brain activation...
  46. ncbi request reprint A dynamic fMRI study of illusory double-flash effect on human visual cortex
    Nanyin Zhang
    Departments of Radiology and Biomedical Engineering, Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S E, Minneapolis, MN 55455, USA
    Exp Brain Res 172:57-66. 2006
    ..Finally, this work demonstrates a unique merit of fMRI for providing both temporal and spatial information regarding cross-modal neural interaction between different sensory systems...
  47. ncbi request reprint Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses
    Brenda J Weigel
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis 55455, USA
    Blood 100:4169-76. 2002
    ..These data have important clinical implications and are the first to show that Flt3L-generated DCs can provide antitumor protection and that nontoxic agents such as CpGs and Flt3L may be useful in the clinical development of DC vaccines...
  48. pmc ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method
    Qiang Xiong
    Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, USA
    Circ Res 108:653-63. 2011
    ..However, its lengthy data acquisition time greatly limits the wide biomedical applications in vivo, especially for studies requiring high spatial and temporal resolutions...
  49. ncbi request reprint Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains
    Ming Lu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Magn Reson Med 71:1959-72. 2014
    ..We report here a novel in vivo (31) P MRS method for noninvasive measurement of intracellular NAD concentrations and NAD(+) /NADH ratio in the brain...
  50. pmc Vaccination for invasive canine meningioma induces in situ production of antibodies capable of antibody-dependent cell-mediated cytotoxicity
    Brian M Andersen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Cancer Res 73:2987-97. 2013
    ..These data show the feasibility and immunologic efficacy of vaccine immunotherapy for a large animal model of human meningioma and warrant further development toward human trials...
  51. pmc Relayed magnetization transfer from nuclear Overhauser effect and chemical exchange observed by in vivo ³¹P MRS in rat brain
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Magn Reson Imaging 30:716-21. 2012
    ..The unique relayed magnetization transfer effects through spin diffusion were observed in the rat brain using in vivo (31)P magnetic resonance spectroscopy...
  52. pmc Quantitative imaging of energy expenditure in human brain
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuroimage 60:2107-17. 2012
    ....
  53. pmc Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy
    Hao Lei
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 Sixth Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:14409-14. 2003
    ..1 +/- 2.8 micromol ATP/g per min, which agreed well with the value that was calculated indirectly from the cerebral metabolic rate of glucose consumption reported previously...
  54. ncbi request reprint A microstrip transmission line volume coil for human head MR imaging at 4T
    Xiaoliang Zhang
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S E, Minneapolis, MN, USA
    J Magn Reson 161:242-51. 2003
    ..The results of this study demonstrate that the MTL volume coil design provides an efficient and simple solution to RF volume coil design for human MR studies at high fields...
  55. ncbi request reprint In vivo 17O NMR approaches for brain study at high field
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th St SE, Minneapolis, MN 55455, USA
    NMR Biomed 18:83-103. 2005
    ..This approach should be promising for studying the central role of oxidative metabolism in brain function and neurological diseases. Finally, the similar approach could potentially be applied to image CMRO2 noninvasively in human brain...
  56. ncbi request reprint Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla
    Joseph Lee
    Department of Medicine, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA
    J Magn Reson Imaging 24:1269-76. 2006
    ..To develop a rapid, robust, and accurate method for assessing myocardial energetics in mice and demonstrate its applicability to mouse models of acquired and genetic heart disease...
  57. pmc Distinction in coherent neural network between resting and working brain states
    Xiao Liu
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Brain Connect 1:377-88. 2011
    ..Finally, a similar fMRI experiment was also conducted under brief, short stimulation to examine how the stimulation paradigm can affect the observations...
  58. ncbi request reprint Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalation
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 24:840-8. 2004
    ..The results from this work show (1) the validity of the simplified methods for quantifying CMRO2, and (2) the feasibility for establishing a completely noninvasive 17O MR approach for imaging CMRO2 in vivo...
  59. pmc In vivo proton MRS to quantify anesthetic effects of pentobarbital on cerebral metabolism and brain activity in rat
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 62:1385-93. 2009
    ....
  60. pmc Novel strategy for measuring creatine kinase reaction rate in the in vivo heart
    Qiang Xiong
    Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Am J Physiol Heart Circ Physiol 297:H1010-9. 2009
    ..This method is validated using an in vivo pig model to evaluate the forward pseudo-first-order rate constant of myocardial CK reaction noninvasively...
  61. pmc Functional cortical source imaging from simultaneously recorded ERP and fMRI
    Chang Hwan Im
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci Methods 157:118-23. 2006
    ..The present results demonstrate that reliable cortical source images can be acquired during simultaneous fMRI scanning and they may be used for multimodal functional source imaging studies...
  62. ncbi request reprint Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T
    Hao Lei
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Magn Reson Med 49:979-84. 2003
    ..The changes in T(2) should be taken into account for the quantification of metabolite concentrations during ischemia...
  63. pmc Mapping the bilateral visual integration by EEG and fMRI
    Zhongming Liu
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 46:989-97. 2009
    ....
  64. pmc In vivo 31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 T
    Hongyan Qiao
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Magn Reson Imaging 24:1281-6. 2006
    ..Finally, the approach used in this study for calculating in vivo 31P MRS sensitivity provides a general tool in estimating the relative NMR detection sensitivity for any nuclear spin at a given field strength...
  65. ncbi request reprint In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: an initial experience
    Hao Lei
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 49:199-205. 2003
    ..24 +/- 0.03 s(-1). The results from this study suggest that ultra-high-field strength is advantageous for performing in vivo (31)P magnetic resonance spectroscopy (MRS) in the human brain...
  66. pmc Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 99:13194-9. 2002
    ....
  67. pmc Neural origin of spontaneous hemodynamic fluctuations in rats under burst-suppression anesthesia condition
    Xiao Liu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
    Cereb Cortex 21:374-84. 2011
    ..They provide insights into the neurophysiological basis for the use of BOLD- and CBF-based fMRI signals for noninvasively imaging spontaneous and synchronous brain activity under various brain states...
  68. ncbi request reprint Identification of EGFRvIII-derived CTL epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomas
    An hua Wu
    Department of Neurosurgery, University of Minnesota Medical School, 2001 Sixth Street, Minneapolis, SE, MN 55455, USA
    J Neurooncol 76:23-30. 2006
    ..These results suggest that vaccination with EGFRvIII peptide-pulsed DCs or adoptive transfer of in vitro elicited EGFRvIII-specific CTLs by EGFRvIII peptide-pulsed DCs are potential approaches to the treatment of glioma patients...
  69. ncbi request reprint Higher-order harmonic transmission-line RF coil design for MR applications
    Xiaoliang Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, 55455, USA
    Magn Reson Med 53:1234-9. 2005
    ..This work demonstrates that the use of higher-order harmonics in a transmission-line resonator provides an alternative, efficient approach to the design of large and high-frequency RF coils...
  70. ncbi request reprint In vivo 1H2O T2+ measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrast
    Robert Bartha
    The Center for Magnetic Resonance Research and Department of Radiology, The University of Minnesota, Minneapolis, Minnesota, USA
    Magn Reson Med 47:742-50. 2002
    ..These results are consistent with higher levels of compartmentalized ferritin and increased blood volume in gray matter compared to white matter in this region of the brain...
  71. ncbi request reprint Influence of gradient acoustic noise on fMRI response in the human visual cortex
    Nanyin Zhang
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 54:258-63. 2005
    ..This study provides evidence of the auditory-visual interaction during fMRI studies, and the results should have an impact on fMRI applications...
  72. doi request reprint Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by Mitochondria
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN, USA
    Methods Mol Biol 489:317-57. 2009
    ....
  73. ncbi request reprint Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression
    Taoyong Chen
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai 200433, P R China
    Blood 103:413-21. 2004
    ..Impairment of DC migration due to inhibition of PGE2 production and regulation of chemokine receptor expression may contribute, in part, to CsA-mediated immunosuppression...
  74. ncbi request reprint [Gene expression of extracellular-signal regulated protein kinase 5 and their MAPKK in fetal skin hypertrophic scars]
    Wei Chen
    Key Research Laboratory of Wound Repair, 304th Hopital of PLA, Beijing 100037, China
    Zhonghua Zheng Xing Wai Ke Za Zhi 20:222-4. 2004
    ..To explore the change of gene expression of extracellular-signal regulated protein kinase 5 (ERK5) and its upstream signaling molecule (MEK5) in fetal skin of differentially developmental stages and hypertrophic scars...
  75. pmc Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    Jing Tan
    Molecular Pharmacology, Genome Institute of Singapore, 138672, Singapore
    Genes Dev 21:1050-63. 2007
    ..Our results demonstrate the unique feature of DZNep as a novel chromatin remodeling compound and suggest that pharmacologic reversal of PRC2-mediated gene repression by DZNep may constitute a novel approach for cancer therapy...
  76. ncbi request reprint Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis
    Nan Li
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, P R China
    Cancer Res 67:11176-85. 2007
    ..The data suggest that phosphorylated p53 (Ser(15/18)) might translocate to lysosome via forming complexes with adaptor protein LAPF and subsequently result in LMP and apoptosis, which might be in a transcription-independent manner...
  77. pmc Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis
    Lang Bao
    Research Unit of Infection and Immunity, West China Medical Center, Sichuan University, No 17, 3rd Section, Ren Min Nan Road, Chengdu, Sichuan 610041, People s Republic of China
    Infect Immun 71:1656-61. 2003
    ..Both rBCG-1 and rBCG-2 conferred marked protection against M. tuberculosis infection, yet in terms of protective efficacy, they showed no significant improvements upon conventional BCG vaccine...
  78. ncbi request reprint Real-time detection of respiratory activity using an inertial measurement unit
    Henrik Gollee
    Centre for Rehabilitation Engineering, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK
    Conf Proc IEEE Eng Med Biol Soc 2007:2230-3. 2007
    ..This novel method could therefore be suitable for use in automatic abdominal stimulation systems to support respiratory activity in tetraplegia where the stimulation is applied depending on the respirator activity of the subject...
  79. pmc Multipotent adult progenitor cells sustain function of ischemic limbs in mice
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 118:505-14. 2008
    ..Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients...
  80. ncbi request reprint Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen-specific CD8+ T-cell response and inhibits the PSCA+ tumors growth in mice
    Xiaopeng Zhang
    State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongdajie, Fengtai, Beijing 100071, China
    J Gene Med 9:715-26. 2007
    ....
  81. ncbi request reprint [Therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on murine melanoma in vivo]
    Wei Chen
    Institute of Immunology, College of Medicine, Zhejiang University, Hangzhou 310031, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 34:73-6. 2005
    ..To investigate the therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on established murine melanoma in vivo...
  82. ncbi request reprint Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8
    Hai Feng Duan
    Beijing Institute of Radiation Medicine, Haidian District, Beijing, China
    J Natl Cancer Inst 99:1551-5. 2007
    ..TEM8-Fc is a novel therapeutic antibody-like agent in the management of solid tumors that may act by trapping M2-PK...
  83. pmc Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
    Mark G Manfredi
    Department of Oncology, Millennium Pharmaceuticals Inc, 40 Landsdowne Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:4106-11. 2007
    ..MLN8054 is a selective inhibitor of Aurora A kinase that robustly inhibits growth of human tumor xenografts and represents an attractive modality for therapeutic intervention of human cancers...
  84. pmc Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
    ..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...
  85. ncbi request reprint Proteasome-mediated destruction of the cyclin a/cyclin-dependent kinase 2 complex suppresses tumor cell growth in vitro and in vivo
    Wei Chen
    Neuro Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorder and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 64:3949-57. 2004
    ..These data demonstrate that cyclin A and/or the cyclin A/cdk2 complex is a promising anticancer target with a high therapeutic index...
  86. ncbi request reprint Small antisense RNA to cyclin D1 generated by pre-tRNA splicing inhibits growth of human hepatoma cells
    Dazhi Lai
    Beijing Institute of Microbiology and Epidemiology, 20 Dongdajie, Fengtai, Beijing 100071, China
    FEBS Lett 576:481-6. 2004
    ..Such tumor growth inhibition might be due to apoptosis caused by reduced cyclin D1 expression as revealed by immunohistochemical analysis of tumor samples...
  87. pmc RAGE ligation affects T cell activation and controls T cell differentiation
    Yali Chen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 181:4272-8. 2008
    ..We conclude that activation of RAGE on T cells is involved in early events that lead to differentiation of Th1(+) T cells...
  88. doi request reprint Association between arterial stiffness and peritoneal small solute transport rate
    Xing wei Zhe
    Division of Nephrology, Peking University Third Hospital, Beijing, China
    Artif Organs 32:416-9. 2008
    ....
  89. ncbi request reprint Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production
    Nathalie Bendriss-Vermare
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Leukoc Biol 78:954-66. 2005
    ....
  90. ncbi request reprint Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes
    Wei Chen
    Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
    Endocrinology 145:627-38. 2004
    ..Thus, IGF-I/IGFBP-3 affords more efficient protection from insulitis, beta-cell destruction, and T1D than IGF-I, and this complex may represent an efficacious therapeutic treatment for the prevention of T1D...
  91. ncbi request reprint Effects of progesterone on growth factor expression in human uterine leiomyoma
    Takeshi Maruo
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Steroids 68:817-24. 2003
    ..This may also explain why the size of uterine myomas during pregnancy does not increase despite the overwhelming increase in circulating concentrations of sex steroid hormones...
  92. ncbi request reprint The conformations of the amyloid-beta (21-30) fragment can be described by three families in solution
    Wei Chen
    Departement de Physique, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Chem Phys 125:084911. 2006
    ..Moreover, it provides further evidence of the capability of ART OPEP in providing a reliable conformational picture of peptides in solution...
  93. ncbi request reprint Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells
    Qin Xu
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Clin Endocrinol Metab 90:953-61. 2005
    ....
  94. ncbi request reprint Analysis of wave behavior in lossy dielectric samples at high field
    Qing X Yang
    Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Magn Reson Med 47:982-9. 2002
    ..The numerical calculation method is validated with experimental results. The general behavior of the RF field with respect to the average brain electrical properties in a frequency range of 42-350 MHz is also analyzed...
  95. ncbi request reprint [Effects of schisandrin B on reversing multidrug resistance in human breast cancer cells transfected with mdr1 gene]
    Ling Li
    Cancer Institute, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China
    Zhonghua Yi Xue Za Zhi 85:1633-7. 2005
    ..To investigate the multidrug resistance (MDR) reversal activity of schisandrin B (SchB) in transfected human breast cancer cell line MCF-7/MDR1...
  96. ncbi request reprint Impact of multiple cardiovascular risk factors on femoral artery intima-media thickness in asymptomatic young adults (the Bogalusa Heart Study)
    Timir K Paul
    Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Cardiol 95:469-73. 2005
    ..Further, ultrasonography of the femoral artery in conjunction with multiple risk factor profiling can be helpful in risk stratification...
  97. ncbi request reprint [Expression of matrix metalloproteinases and their inhibitors in fetal skin and their biological significance]
    Wen Juan Li
    Key Research Laboratory of Wound Repair, First Affiliated Hospital of General Hospital of PLA, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 18:303-6. 2006
    ..To investigate the expression characteristics of matrix metalloproteinases (MMP-2, MMP-3, MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1, TIMP-2) in developing fetal skin and their potential biological significance...

Research Grants4

  1. LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLS
    Wei Chen; Fiscal Year: 2002
    ..3. To develop methods develops for in vitro induction of MiHA-specific T cells for leukemia therapy. ..
  2. LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLS
    Wei Chen; Fiscal Year: 1999
    ..3. To develop methods develops for in vitro induction of MiHA-specific T cells for leukemia therapy. ..
  3. LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLS
    Wei Chen; Fiscal Year: 2000
    ..3. To develop methods develops for in vitro induction of MiHA-specific T cells for leukemia therapy. ..
  4. LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLS
    Wei Chen; Fiscal Year: 2001
    ..3. To develop methods develops for in vitro induction of MiHA-specific T cells for leukemia therapy. ..