Research Topics
| Wei ChenSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitorsWei Chen
Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, niversity of Minnesota, Minneapolis, MN 55455, USA
Blood 103:2547-53. 2004..This culture system, combined with the use of adult peripheral blood CD34+ HPCs purified from G-CSF-mobilized donors, permits the generation of more than 10(9) IPCs from a single blood donor...- The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generationWei Chen
Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics and The Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunol 181:5396-404. 2008..Our results demonstrate that the IDO pathway is essential for PDC-driven Treg generation from CD4(+)CD25(-) T cells and implicate the generation of kynurenine pathway metabolites as the critical mediator of this process... 
FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides to enhance T-cell and natural killer cell functionWei Chen
University of Minnesota Cancer Center, Minneapolis, Minnesota 5455, USA
Biol Blood Marrow Transplant 11:23-34. 2005..These findings suggest that FLT3-L mobilization of DC precursors followed by a specific DC stimulus such as CpG ODN may provide a novel strategy to manipulate antitumor immunity in patients after HCT...- In vivo vaccination with tumor cell lysate plus CpG oligodeoxynucleotides eradicates murine glioblastomaAnhua Wu
Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Immunother 30:789-97. 2007..05). These results suggest direct vaccination with CpG/lysate provides an alternative and effective approach to induce host antitumor immunity and warrants clinical investigation in the immunotherapy of cancer... - Oxygen is a master regulator of the immunogenicity of primary human glioma cellsMichael R Olin
Department of Pediatrics, Graduate Program in Neuroscience, Biostatistics and Bioinformatics, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota, USA
Cancer Res 71:6583-9. 2011.... - Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cellsE Ashley Moseman
University of Minnesota Cancer Center and Department of Pediatrics, and Division of Hematology, Oncology, and Bone Marrow Transplantation, Minneapolis, MN 55455, USA
J Immunol 173:4433-42. 2004..This study demonstrates that TLR9 stimulation can promote PDC-mediated generation of CD4(+)CD25(+) Treg cells and suggests PDCs may play an important role in the maintenance of immunological tolerance... - Expression of MHC I and NK ligands on human CD133+ glioma cells: possible targets of immunotherapyAnhua Wu
Department of Neurosurgery, University of Minnesota Medical School, 3500B LRB MTRF, Minneapolis, MN, 55455, USA
J Neurooncol 83:121-31. 2007..We conclude that CD133-posistive and CD133-negative glioma cells may be similarly resistant to immune surveillance, but that INF-gamma may partially restore their immunogenicity and potentiate their lysis by NK cells... 
Effective CpG immunotherapy of breast carcinoma prevents but fails to eradicate established brain metastasisZhengming Xiong
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Clin Cancer Res 14:5484-93. 2008..Breast cancer patients with brain metastasis have a dismal prognosis. We determined the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) to treat or prevent brain metastasis in a mouse model...- Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responsesBrenda J Weigel
University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis, MN 55455, USA
Exp Hematol 34:1403-12. 2006.... - Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cellsXueqing Liang
Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 115:5041-52. 2010..These findings provide new understanding of CpG ODN-mediated antitumor effects and support for the development of TLR9-targeted therapy for human CLL... - Gene therapy of murine solid tumors with T cells transduced with a retroviral vascular endothelial growth factor--immunotoxin target geneNi Jin
Section on Experimental Cancer Immunology, Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Hum Gene Ther 13:497-508. 2002..Together, these data indicate that gene therapy of T cells with retrovirus containing a VEGF-immunotoxin target gene may be a valid means of inhibiting a broad range of solid tumors dependent on angiogenesis... - Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignanciesBrenda J Weigel
Department of Pediatrics, Division of Hematology Oncology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
Am J Hematol 87:953-6. 2012..2 mg/m(2) twice weekly with evidence of sustained tolerability and clinical activity in hematologic malignancies. Systemic TLR agonists for the treatment of hematologic malignancies warrant further study... - Simultaneous measurement of glucose blood-brain transport constants and metabolic rate in rat brain using in-vivo 1H MRSFei Du
Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Cereb Blood Flow Metab 32:1778-87. 2012..The overall results indicate that the new approach is robust and reliable for in-vivo measurements of both brain glucose metabolic rate and transport constants, and has potential for human application... - Superior efficacy of tumor cell vaccines grown in physiologic oxygenMichael R Olin
Departments of Pediatrics, University of Minnesota, Minneapolis, 55455, USA
Clin Cancer Res 16:4800-8. 2010..Atmospheric oxygen (∼20% O(2)) has been the universal condition employed to culture tumor cells used as vaccine antigen. We tested the hypothesis that reducing oxygen tension would increase the efficacy of tumor cell lysate vaccines... - Linear and nonlinear relationships between visual stimuli, EEG and BOLD fMRI signalsZhongming Liu
Department of Biomedical Engineering, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA
Neuroimage 50:1054-66. 2010..The validated cross-modal relationship between fMRI and EEG may provide a theoretical basis for the integration of these two modalities... - Three-dimensional imaging of complex neural activation in humans from EEGLei Ding
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
IEEE Trans Biomed Eng 56:1980-8. 2009.... - An fMRI study of neural interaction in large-scale cortico-thalamic visual networkNanyin Zhang
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street S E, Minneapolis, MN 55455, USA
Neuroimage 42:1110-7. 2008.... - High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleusNanyin Zhang
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School of Medicine, 2021 6 th Street S E, Minneapolis, MN 55455, USA
Neuroimage 50:1456-63. 2010.... - Large enhancement of perfusion contribution on fMRI signalXiao Wang
Department of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
J Cereb Blood Flow Metab 32:907-18. 2012.... - Probing fast neuronal interaction using fMRINanyin Zhang
Dept. of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Conf Proc IEEE Eng Med Biol Soc 1:13-6. 2006..The results reveal that the gradient acoustic noise does interfere with the neural behavior in human visual cortex... - Functional MRI study of brain function under resting and activated statesWei Chen
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4061-3. 2009..We have found a strong correlation between the spontaneous brain activity and BOLD fluctuation indicating a tight neurovascular relation... - A dynamic fMRI study of illusory double-flash effect on human visual cortexNanyin Zhang
Departments of Radiology and Biomedical Engineering, Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S.E, Minneapolis, MN 55455, USA
Exp Brain Res 172:57-66. 2006..Finally, this work demonstrates a unique merit of fMRI for providing both temporal and spatial information regarding cross-modal neural interaction between different sensory systems... - Insulin reduces the BOLD response but is without effect on the VEP during presentation of a visual task in humansElizabeth R Seaquist
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
J Cereb Blood Flow Metab 27:154-60. 2007..These findings highlight the complexity that must be considered when interpreting differences in fMRI responses between groups of subjects that differ in insulin concentration and/or insulin sensitivity... - (1)H MRS in the rat brain under pentobarbital anesthesia: accurate quantification of in vivo spectra in the presence of propylene glycolIsabelle Iltis
Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Magn Reson Med 59:631-5. 2008..The chemical shifts and J-coupling values reported here can be used to simulate the spectrum of PG at any field strength, with various pulse sequences... - Three-dimensional source imaging from simultaneously recorded ERP and BOLD-fMRIXiaoxiao Bai
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
IEEE Trans Neural Syst Rehabil Eng 17:101-6. 2009..The present results demonstrate the merits of high-resolution spatiotemporal functional neuroimaging by integrating the simultaneously recorded fMRI and EEG data... - Study of Brain Function and Bioenergetics using fMRI and In Vivo MRS at High FieldsWei Chen
Center for Magnetic Resonance Research, Departments of Radiology and Biomedical Engineering, University of Minnesota, 2021 6th St SE Minneapolis, Minnesota, USA phone 612 625 8814 fax 612 626 2004 e mail
Conf Proc IEEE Eng Med Biol Soc 4:4174-7. 2005..This talk will discuss the developed MR technologies and their applications in brain study at high fields... - Tightly coupled brain activity and cerebral ATP metabolic rateFei Du
Department of Radiology, Center for Magnetic Resonance Research and Department of Biomedical Engineering, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 105:6409-14. 2008.... - Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison studyXiao Hong Zhu
Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Cereb Blood Flow Metab 27:1225-34. 2007..This approach, thus, should provide a promising neuroimaging modality for studying oxidative metabolism and bioenergetics associated with brain functions and diseases... - Noninvasive study of neurovascular coupling during graded neuronal suppressionNanyin Zhang
Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Cereb Blood Flow Metab 28:280-90. 2008..This study extends the range of the neurovascular coupling relationship from graded neuronal excitation conditions to graded neuronal suppression conditions... - Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortexChang Hwan Im
Department of Biomedical Engineering, University of Minnesota, 7 105 Hasselmo Hall, 312 Church St S E, Minneapolis, MN 55455, USA
J Neurosci Methods 161:142-54. 2007..The present results suggest that the spatial resolution of the EEG cortical source imaging can correctly discriminate cortical activation changes in V1 corresponding to less than 3 degrees visual field changes... - Investigating the source of BOLD nonlinearity in human visual cortex in response to paired visual stimuliNanyin Zhang
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
Neuroimage 43:204-12. 2008..They also suggest a possible mechanism to improve the spatial specificity of gradient-echo BOLD signal for fMRI mapping based on the characteristics of vascular refractoriness... - Quantitatively Interpreting fMRI signalNanyin Zhang
Center for Magnetic Resonance Research, The Department of Radiology, The University of Minnesota Twin Cities, USA
Conf Proc IEEE Eng Med Biol Soc 2008:4415-8. 2008.... - Brain imaging developments based on in vivo MRSWei Chen
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Conf Proc IEEE Eng Med Biol Soc 2009:50-2. 2009..These new methods have been successfully applied for investigating the neuroenergetics changes associated with brain activation... - New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brainXiao Hong Zhu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Cereb Blood Flow Metab 29:10-8. 2009..They also suggest that in vivo (17)O MRS imaging should provide a sensitive neuroimaging modality for mapping CMRO(2) and its change induced by brain physiology and/or pathologic alteration... - Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coilXiaoliang Zhang
Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S.E, Department of Radiology, Minneapolis, Minnesota, USA
MAGMA 16:77-85. 2003..Compared to most contemporary MR approaches, the REDE implanted RF provides a simple, accurate, and promising solution for determination of AIF in small experimental animals... - Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brainFei Du
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Magn Reson Med 57:103-14. 2007..The MSS MT approach should provide an important modality for noninvasively studying the essential roles of ATP metabolism in brain bioenergetics, function, and diseases... - Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein geneDaniel A Vallera
University of Minnesota Cancer Center, Department of Therapeutic Radiology, Section on Experimental Cancer Immunology, Minneapolis, MN 55455, USA
Hum Gene Ther 14:1787-98. 2003..Furthermore, the Bax construct may be particularly useful as a nonimmunogenic substitute for bacterial toxins in retIT... - Ultrahigh field magnetic resonance imaging and spectroscopyKamil Ugurbil
Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Magn Reson Imaging 21:1263-81. 2003 - Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responsesBrenda J Weigel
University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology Oncology and Blood and Marrow Transplant, Minneapolis 55455, USA
Blood 100:4169-76. 2002..These data have important clinical implications and are the first to show that Flt3L-generated DCs can provide antitumor protection and that nontoxic agents such as CpGs and Flt3L may be useful in the clinical development of DC vaccines... - Transmit and receive transmission line arrays for 7 Tesla parallel imagingGregor Adriany
Center for Magnetic Resonance Research, Department of Radiology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Magn Reson Med 53:434-45. 2005..A one-dimensional reduction factor of 4 was robustly achieved with an average g value of 1.25 with the eight-channel transmit/receive coils... - Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7TShalom Michaeli
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
Magn Reson Med 47:629-33. 2002..At high field, signal loss resulting from T2 decay can be substantially reduced using a Carr-Purcell-type SE sequence... - An inverted-microstrip resonator for human head proton MR imaging at 7 teslaXiaoliang Zhang
Center for Magnetic Resonance Research, Department of Radiology, The University of Minnesota, Minneapolis, MN 55455, USA
IEEE Trans Biomed Eng 52:495-504. 2005..The proposed iMTL volume coil provides an efficient and alternative solution to design high-frequency and large-size volume coils for human MR applications at very high fields... - ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer methodQiang Xiong
Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, USA
Circ Res 108:653-63. 2011..However, its lengthy data acquisition time greatly limits the wide biomedical applications in vivo, especially for studies requiring high spatial and temporal resolutions... - Relayed magnetization transfer from nuclear Overhauser effect and chemical exchange observed by in vivo ³¹P MRS in rat brainFei Du
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Magn Reson Imaging 30:716-21. 2012..The unique relayed magnetization transfer effects through spin diffusion were observed in the rat brain using in vivo (31)P magnetic resonance spectroscopy... - Quantitative imaging of energy expenditure in human brainXiao Hong Zhu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Neuroimage 60:2107-17. 2012.... - Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 TeslaJoseph Lee
Department of Medicine, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA
J Magn Reson Imaging 24:1269-76. 2006.... - A microstrip transmission line volume coil for human head MR imaging at 4TXiaoliang Zhang
Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S.E, Minneapolis, MN, USA
J Magn Reson 161:242-51. 2003..The results of this study demonstrate that the MTL volume coil design provides an efficient and simple solution to RF volume coil design for human MR studies at high fields... - Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopyHao Lei
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 Sixth Street SE, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 100:14409-14. 2003..1 +/- 2.8 micromol ATP/g per min, which agreed well with the value that was calculated indirectly from the cerebral metabolic rate of glucose consumption reported previously... - In vivo 17O NMR approaches for brain study at high fieldXiao-Hong Zhu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th St SE, Minneapolis, MN 55455, USA
NMR Biomed 18:83-103. 2005..This approach should be promising for studying the central role of oxidative metabolism in brain function and neurological diseases. Finally, the similar approach could potentially be applied to image CMRO2 noninvasively in human brain... - A correlation-matrix-based hierarchical clustering method for functional connectivity analysisXiao Liu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA School of Statistics, University of Minnesota, Minneapolis, MN, USA Electronic address
J Neurosci Methods 211:94-102. 2012..Moreover, its sensitivity of detecting patterns remains relatively high even for a single dataset. In conclusion, the CMBHC method could be a useful tool for investigating resting-state brain connectivity and function... - Distinction in coherent neural network between resting and working brain statesXiao Liu
Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
Brain Connect 1:377-88. 2011..Finally, a similar fMRI experiment was also conducted under brief, short stimulation to examine how the stimulation paradigm can affect the observations... - In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: an initial experienceHao Lei
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Magn Reson Med 49:199-205. 2003..24 +/- 0.03 s(-1). The results from this study suggest that ultra-high-field strength is advantageous for performing in vivo (31)P magnetic resonance spectroscopy (MRS) in the human brain... - Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high fieldXiao-Hong Zhu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 99:13194-9. 2002.... - Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 THao Lei
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA
Magn Reson Med 49:979-84. 2003..The changes in T(2) should be taken into account for the quantification of metabolite concentrations during ischemia... - Mapping the bilateral visual integration by EEG and fMRIZhongming Liu
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
Neuroimage 46:989-97. 2009.... - Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalationNanyin Zhang
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, Minnesota 55455, USA
J Cereb Blood Flow Metab 24:840-8. 2004..The results from this work show (1) the validity of the simplified methods for quantifying CMRO2, and (2) the feasibility for establishing a completely noninvasive 17O MR approach for imaging CMRO2 in vivo... - Novel strategy for measuring creatine kinase reaction rate in the in vivo heartQiang Xiong
Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Am J Physiol Heart Circ Physiol 297:H1010-9. 2009..This method is validated using an in vivo pig model to evaluate the forward pseudo-first-order rate constant of myocardial CK reaction noninvasively... - Functional cortical source imaging from simultaneously recorded ERP and fMRIChang-Hwan Im
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
J Neurosci Methods 157:118-23. 2006..The present results demonstrate that reliable cortical source images can be acquired during simultaneous fMRI scanning and they may be used for multimodal functional source imaging studies... - In vivo proton MRS to quantify anesthetic effects of pentobarbital on cerebral metabolism and brain activity in ratFei Du
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Magn Reson Med 62:1385-93. 2009.... - In vivo 31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 THongyan Qiao
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
Magn Reson Imaging 24:1281-6. 2006..Finally, the approach used in this study for calculating in vivo 31P MRS sensitivity provides a general tool in estimating the relative NMR detection sensitivity for any nuclear spin at a given field strength... - Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke miceXiao Hong Zhu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Neuroimage 64:437-47. 2013.... - Neural origin of spontaneous hemodynamic fluctuations in rats under burst-suppression anesthesia conditionXiao Liu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Cereb Cortex 21:374-84. 2011..They provide insights into the neurophysiological basis for the use of BOLD- and CBF-based fMRI signals for noninvasively imaging spontaneous and synchronous brain activity under various brain states... - Identification of EGFRvIII-derived CTL epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomasAn-hua Wu
Department of Neurosurgery, University of Minnesota Medical School, 2001 Sixth Street, Minneapolis, SE, MN 55455, USA
J Neurooncol 76:23-30. 2006..These results suggest that vaccination with EGFRvIII peptide-pulsed DCs or adoptive transfer of in vitro elicited EGFRvIII-specific CTLs by EGFRvIII peptide-pulsed DCs are potential approaches to the treatment of glioma patients... - Influence of gradient acoustic noise on fMRI response in the human visual cortexNanyin Zhang
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Magn Reson Med 54:258-63. 2005..This study provides evidence of the auditory-visual interaction during fMRI studies, and the results should have an impact on fMRI applications... - Higher-order harmonic transmission-line RF coil design for MR applicationsXiaoliang Zhang
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, 55455, USA
Magn Reson Med 53:1234-9. 2005..This work demonstrates that the use of higher-order harmonics in a transmission-line resonator provides an alternative, efficient approach to the design of large and high-frequency RF coils... - In vivo 1H2O T2+ measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrastRobert Bartha
The Center for Magnetic Resonance Research and Department of Radiology, The University of Minnesota, Minneapolis, Minnesota, USA
Magn Reson Med 47:742-50. 2002..These results are consistent with higher levels of compartmentalized ferritin and increased blood volume in gray matter compared to white matter in this region of the brain... - Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by MitochondriaXiao Hong Zhu
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, School of Medicine, Minneapolis, MN, USA
Methods Mol Biol 489:317-57. 2009.... - Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expressionTaoyong Chen
Institute of Immunology, Second Military Medical University, 800 Xiangyin Rd, Shanghai 200433, P R China
Blood 103:413-21. 2004..Impairment of DC migration due to inhibition of PGE2 production and regulation of chemokine receptor expression may contribute, in part, to CsA-mediated immunosuppression... - [Therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on murine melanoma in vivo]Wei Chen
Institute of Immunology, College of Medicine, Zhejiang University, Hangzhou 310031, China
Zhejiang Da Xue Xue Bao Yi Xue Ban 34:73-6. 2005..The activity of NK cells was also enhanced after interleukin-12 gene delivery in vivo. CONCLUSION: Cationic liposome-mediated interleukin-12 gene delivery has significantly therapeutic effects on mice melanoma in vivo... - Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cellsQin Xu
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
J Clin Endocrinol Metab 90:953-61. 2005.... - Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosisLang Bao
Research Unit of Infection and Immunity, West China Medical Center, Sichuan University, No 17, 3rd Section, Ren Min Nan Road, Chengdu, Sichuan 610041, People s Republic of China
Infect Immun 71:1656-61. 2003..Both rBCG-1 and rBCG-2 conferred marked protection against M. tuberculosis infection, yet in terms of protective efficacy, they showed no significant improvements upon conventional BCG vaccine... - Small antisense RNA to cyclin D1 generated by pre-tRNA splicing inhibits growth of human hepatoma cellsDazhi Lai
Beijing Institute of Microbiology and Epidemiology, 20 Dongdajie, Fengtai, Beijing 100071, China
FEBS Lett 576:481-6. 2004..Such tumor growth inhibition might be due to apoptosis caused by reduced cyclin D1 expression as revealed by immunohistochemical analysis of tumor samples... - [Gene expression of extracellular-signal regulated protein kinase 5 and their MAPKK in fetal skin hypertrophic scars]Wei Chen
Key Research Laboratory of Wound Repair, 304th Hopital of PLA, Beijing 100037, China
Zhonghua Zheng Xing Wai Ke Za Zhi 20:222-4. 2004..The activation of ERK5 gene expression in hypertrophic scars versus normal skin might be one of the mechanisms controlling the formation of hypertrophic scars, in which the role of MEK5 needed to be further studied... - Proteasome-mediated destruction of the cyclin a/cyclin-dependent kinase 2 complex suppresses tumor cell growth in vitro and in vivoWei Chen
Neuro Oncology Branch, National Cancer Institute, National Institutes of Neurological Disorder and Stroke, NIH, Bethesda, Maryland 20892, USA
Cancer Res 64:3949-57. 2004..These data demonstrate that cyclin A and/or the cyclin A/cdk2 complex is a promising anticancer target with a high therapeutic index... - Effects of progesterone on growth factor expression in human uterine leiomyomaTakeshi Maruo
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Steroids 68:817-24. 2003..This may also explain why the size of uterine myomas during pregnancy does not increase despite the overwhelming increase in circulating concentrations of sex steroid hormones... - Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetesWei Chen
Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
Endocrinology 145:627-38. 2004..Thus, IGF-I/IGFBP-3 affords more efficient protection from insulitis, beta-cell destruction, and T1D than IGF-I, and this complex may represent an efficacious therapeutic treatment for the prevention of T1D... - Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine productionNathalie Bendriss-Vermare
Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
J Leukoc Biol 78:954-66. 2005.... - Association between arterial stiffness and peritoneal small solute transport rateXing wei Zhe
Division of Nephrology, Peking University Third Hospital, Beijing, China
Artif Organs 32:416-9. 2008.... - Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosisTimothy A Chan
Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
PLoS Med 5:e114. 2008..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation... - Multipotent adult progenitor cells sustain function of ischemic limbs in miceXabier L Aranguren
Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
J Clin Invest 118:505-14. 2008..Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients... - Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosisNan Li
Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, P R China
Cancer Res 67:11176-85. 2007..The data suggest that phosphorylated p53 (Ser(15/18)) might translocate to lysosome via forming complexes with adaptor protein LAPF and subsequently result in LMP and apoptosis, which might be in a transcription-independent manner... - Real-time detection of respiratory activity using an inertial measurement unitHenrik Gollee
Centre for Rehabilitation Engineering, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK
Conf Proc IEEE Eng Med Biol Soc 2007:2230-3. 2007..This novel method could therefore be suitable for use in automatic abdominal stimulation systems to support respiratory activity in tetraplegia where the stimulation is applied depending on the respirator activity of the subject... - RAGE ligation affects T cell activation and controls T cell differentiationYali Chen
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 181:4272-8. 2008..We conclude that activation of RAGE on T cells is involved in early events that lead to differentiation of Th1(+) T cells... - Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8Hai Feng Duan
Beijing Institute of Radiation Medicine, Haidian District, Beijing, China
J Natl Cancer Inst 99:1551-5. 2007..TEM8-Fc is a novel therapeutic antibody-like agent in the management of solid tumors that may act by trapping M2-PK... - Vaccination with a DNA vaccine based on human PSCA and HSP70 adjuvant enhances the antigen-specific CD8+ T-cell response and inhibits the PSCA+ tumors growth in miceXiaopeng Zhang
State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongdajie, Fengtai, Beijing 100071, China
J Gene Med 9:715-26. 2007.... - Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cellsJing Tan
Molecular Pharmacology, Genome Institute of Singapore, 138672, Singapore
Genes Dev 21:1050-63. 2007..Our results demonstrate the unique feature of DZNep as a novel chromatin remodeling compound and suggest that pharmacologic reversal of PRC2-mediated gene repression by DZNep may constitute a novel approach for cancer therapy... - Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinaseMark G Manfredi
Department of Oncology, Millennium Pharmaceuticals Inc, 40 Landsdowne Street, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:4106-11. 2007..MLN8054 is a selective inhibitor of Aurora A kinase that robustly inhibits growth of human tumor xenografts and represents an attractive modality for therapeutic intervention of human cancers... - The conformations of the amyloid-beta (21-30) fragment can be described by three families in solutionWei Chen
Departement de Physique, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
J Chem Phys 125:084911. 2006..Moreover, it provides further evidence of the capability of ART OPEP in providing a reliable conformational picture of peptides in solution... - Impact of multiple cardiovascular risk factors on femoral artery intima-media thickness in asymptomatic young adults (the Bogalusa Heart Study)Timir K Paul
Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
Am J Cardiol 95:469-73. 2005..Further, ultrasonography of the femoral artery in conjunction with multiple risk factor profiling can be helpful in risk stratification... - Analysis of wave behavior in lossy dielectric samples at high fieldQing X Yang
Center for NMR Research, Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Magn Reson Med 47:982-9. 2002..The numerical calculation method is validated with experimental results. The general behavior of the RF field with respect to the average brain electrical properties in a frequency range of 42-350 MHz is also analyzed... - [Expression of matrix metalloproteinases and their inhibitors in fetal skin and their biological significance]Wen-Juan Li
Key Research Laboratory of Wound Repair, First Affiliated Hospital of General Hospital of PLA, Beijing 100037, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 18:303-6. 2006..Higher expression of MMP-2, MMP-3 and MMP-9 and lower protein levels of TIMP-1 and TIMP-2 may provide an antiscarring signal in healing of wound during early periods of gestation... - [Effects of schisandrin B on reversing multidrug resistance in human breast cancer cells transfected with mdr1 gene]Ling Li
Cancer Institute, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China
Zhonghua Yi Xue Za Zhi 85:1633-7. 2005..CONCLUSION: SchB is able to restore the drug sensitivity in the transfected MCF7/MDR1 cells, with a possible mechanism of increasing the drug influx via inhibiting the P-gp function...
Research Grants
- LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLSWei Chen; Fiscal Year: 2002..3. To develop methods develops for in vitro induction of MiHA-specific T cells for leukemia therapy. ..