Tsung Yu Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Different fast-gate regulation by external Cl(-) and H(+) of the muscle-type ClC chloride channels
    M F Chen
    Center for Neuroscience, University of California, Davis, CA 95616, USA
    J Gen Physiol 118:23-32. 2001
  2. ncbi Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
    J Gen Physiol 128:365-71. 2006
  3. ncbi Structure and function of clc channels
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, California 95616, USA
    Annu Rev Physiol 67:809-39. 2005
  4. ncbi Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels
    Tsung Yu Chen
    Center for Neuroscience University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
    J Gen Physiol 122:641-51. 2003
  5. ncbi Coupling gating with ion permeation in ClC channels
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
    Sci STKE 2003:pe23. 2003
  6. ncbi CLC-0 and CFTR: chloride channels evolved from transporters
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, California 95618, USA
    Physiol Rev 88:351-87. 2008
  7. ncbi Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California, Davis, 95616, USA
    J Gen Physiol 127:435-47. 2006
  8. ncbi Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents
    Chia Wei Lin
    Center for Neuroscience, University of California Davis, CA 95616, USA
    J Gen Physiol 122:147-59. 2003
  9. ncbi Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California Davis, CA, USA
    Biophys J 98:377-85. 2010
  10. ncbi Binding of ATP to the CBS domains in the C-terminal region of CLC-1
    Pang Yen Tseng
    Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA
    J Gen Physiol 137:357-68. 2011

Research Grants

  1. Gating-Permeation Coupling of CLC-0 Chloride Channel
    Tsung Yu Chen; Fiscal Year: 2007
  2. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2010
  3. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi Different fast-gate regulation by external Cl(-) and H(+) of the muscle-type ClC chloride channels
    M F Chen
    Center for Neuroscience, University of California, Davis, CA 95616, USA
    J Gen Physiol 118:23-32. 2001
    ..This [Cl(-)](o)-independent mechanism attracted little attention, but it appears to be the opening process that is modulated by external H(+)...
  2. ncbi Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
    J Gen Physiol 128:365-71. 2006
    ..Thus, the present work also suggests that CNG channels switch on and off the olfactory signaling pathway, and that the on and off signals may both be amplified by the subsequent olfactory signaling steps...
  3. ncbi Structure and function of clc channels
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, California 95616, USA
    Annu Rev Physiol 67:809-39. 2005
    ..The molecular basis to explain the difference between vertebrate and bacterial CLCs, especially the distinction between an ion channel and a transporter, remains a challenge in the structure/function studies for the CLC family...
  4. ncbi Electrostatic control and chloride regulation of the fast gating of ClC-0 chloride channels
    Tsung Yu Chen
    Center for Neuroscience University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
    J Gen Physiol 122:641-51. 2003
    ....
  5. ncbi Coupling gating with ion permeation in ClC channels
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
    Sci STKE 2003:pe23. 2003
    ....
  6. ncbi CLC-0 and CFTR: chloride channels evolved from transporters
    Tsung Yu Chen
    Center for Neuroscience and Department of Neurology, University of California, Davis, California 95618, USA
    Physiol Rev 88:351-87. 2008
    ..A promising byproduct of this exercise is a deeper mechanistic insight into how different transport proteins work at a fundamental level...
  7. ncbi Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California, Davis, 95616, USA
    J Gen Physiol 127:435-47. 2006
    ..The control of the accessibility to charged MTS reagents and the regulation of the anion permeation support the idea that K149 exerts an electrostatic effect on the channel function, confirming the prediction from computational studies...
  8. ncbi Probing the pore of ClC-0 by substituted cysteine accessibility method using methane thiosulfonate reagents
    Chia Wei Lin
    Center for Neuroscience, University of California Davis, CA 95616, USA
    J Gen Physiol 122:147-59. 2003
    ..Thus, the proposal that the glutamate side chain is the fast gate of the channel is applicable to ClC-0, revealing a structural and functional conservation of ClC channels between bacterial and vertebrate species...
  9. ncbi Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California Davis, CA, USA
    Biophys J 98:377-85. 2010
    ..These experiments also reveal that MTS modification of C229 can inhibit the current of CLC-0 depending on the amino acid placed at position 166...
  10. ncbi Binding of ATP to the CBS domains in the C-terminal region of CLC-1
    Pang Yen Tseng
    Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA
    J Gen Physiol 137:357-68. 2011
    ..This study also demonstrates that CLC-1 is a convenient experimental model for studying the interaction of nucleotides/nucleosides with the CBS domain...
  11. ncbi Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH
    Pang Yen Tseng
    Center foor Neuroscience and Department of Neurology, University of California, Davis, CA 95616, USA
    J Gen Physiol 130:217-21. 2007
    ..Here we show that in the presence of physiological concentrations of ATP, reduction of the intracellular pH indeed inhibits the expressed CLC-1, mostly by decreasing the open probability of the common gate of the channel...
  12. ncbi Amphiphilic blockers punch through a mutant CLC-0 pore
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95618, USA
    J Gen Physiol 133:59-68. 2009
    ..Furthermore, a minimal CPA-dissociation rate at a voltage 80 mV more negative than the Cl(-) reversal potential suggests that the outward blocker movement through the CLC-0 pore is more difficult than the inward movement...
  13. ncbi ATP inhibition of CLC-1 is controlled by oxidation and reduction
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California, Davis, Davis, CA 95618, USA
    J Gen Physiol 132:421-8. 2008
    ..These results suggest a novel view in muscle physiology that the mechanisms controlling muscle fatigability may include the oxidation of CLC-1...
  14. ncbi Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels
    Mei-Fang Chen
    Center for Neuroscience, University of California, Davis, CA 95616, USA
    J Gen Physiol 122:133-45. 2003
    ..On the other hand, the Cl--binding site at the selectivity filter controls the exit rate of Cl- and therefore determines the maximal channel conductance...
  15. ncbi Chloride channels and transporters in human corneal epithelium
    Lin Cao
    Department of Dermatology, University of California, Davis, CA 95618, USA
    Exp Eye Res 90:771-9. 2010
    ..Those molecules and their distribution may play important roles in maintaining resting Cl(-) fluxes and in regulating Cl(-) flux at corneal wounds, which may be a major contributor to wound electrical signaling...
  16. ncbi Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels
    Yong Li
    Center for Neuroscience and Department of Neurology, University of California, Davis, 95616, USA
    Biophys J 88:3936-45. 2005
    ..The finding also provides a convenient method to "cure" those atypical recording traces of ClC-0 expressed in Xenopus oocytes...
  17. ncbi Dominantly Inherited Myotonia Congenita Resulting from a Mutation That Increases Open Probability of the Muscle Chloride Channel CLC-1
    David P Richman
    Department of Neurology and Center for Neuroscience, University of California, Davis, CA, 95616, USA
    Neuromolecular Med 14:328-37. 2012
    ..Since expression levels of the mutant and wild-type subunits in artificial model cell systems were unable to explain the disease symptoms, the mechanism leading to dominant inheritance in this family remains to be determined...
  18. ncbi Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas
    William Harley
    Department of Neurology, University of California, Davis, USA
    Brain Res 1363:159-69. 2010
    ..Individually, Cariporide and SEA0400 are not cytotoxic, but in combination induced glioma cell death. Like amiloride, the combination of Cariporide and SEA0400 produced glioma cell death in the absence of demonstrable caspase activation...
  19. ncbi Large movement in the C terminus of CLC-0 chloride channel during slow gating
    Ekaterina A Bykova
    Department of Physiology and Membrane Biology, University of California, Davis, California 95616, USA
    Nat Struct Mol Biol 13:1115-9. 2006
    ..When combined with recent structural information on the CLC C terminus, our findings provide a structural model for understanding the conformational changes linked to slow gating in CLC transport proteins...
  20. ncbi Blocking pore-open mutants of CLC-0 by amphiphilic blockers
    Xiao Dong Zhang
    Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95618, USA
    J Gen Physiol 133:43-58. 2009
    ....

Research Grants9

  1. Gating-Permeation Coupling of CLC-0 Chloride Channel
    Tsung Yu Chen; Fiscal Year: 2007
    ..The results from this study will not only lead to a further understanding on the coupling of ion permeation to the fast gating in ClC-0 but will provide insight for understanding the gating of other CIC channels. ..
  2. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2010
    ....
  3. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2010
    ....