Songcang Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects
    J Raber
    Gladstone Molecular Neurobiology Program and the Department of Neurology, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 272:15057-60. 1997
  2. doi request reprint Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart
    Songcang Chen
    Diabetes Center, University of California at San Francisco, San Francisco, CA 94143 0540, United States
    J Steroid Biochem Mol Biol 136:150-5. 2013
  3. doi request reprint A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation
    Songcang Chen
    Diabetes Center, University of California at San Francisco, CA 94143 0540, United States
    J Steroid Biochem Mol Biol 122:326-32. 2010
  4. doi request reprint Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy
    Songcang Chen
    Diabetes Center UCSF, San Francisco, CA 94143 0540, USA
    Circulation 124:1838-47. 2011
  5. ncbi request reprint Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells
    S Chen
    Diabetes Center, University of California at San Francisco, San Francisco, California 94143 0540, USA
    Kidney Int 72:300-6. 2007
  6. ncbi request reprint Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells
    Songcang Chen
    Diabetes Center, 1119 HSW, University of California at San Francisco, San Francisco, CA 94143 0540, USA
    Hypertension 43:866-71. 2004
  7. pmc Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity
    Songcang Chen
    Diabetes Center, University of California at San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0540, USA
    J Steroid Biochem Mol Biol 118:135-41. 2010
  8. pmc Expression of the vitamin d receptor is increased in the hypertrophic heart
    Songcang Chen
    Diabetes Center, University of California at San Francisco, CA 94143 0540, USA
    Hypertension 52:1106-12. 2008
  9. pmc Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents
    Songcang Chen
    Diabetes Center, UCSF, San Francisco, California 94143 0540, USA
    J Clin Invest 119:1647-58. 2009
  10. ncbi request reprint A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation
    Songcang Chen
    Diabetes Center, University of California, San Francisco, CA 94143 0540, USA
    Hypertension 47:252-8. 2006

Detail Information

Publications22

  1. ncbi request reprint Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects
    J Raber
    Gladstone Molecular Neurobiology Program and the Department of Neurology, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 272:15057-60. 1997
    ..An imbalance between the effects of OB on corticotropin-releasing factor release from the hypothalamus and on adrenocorticotrophic hormone release from the pituitary could contribute to obesity...
  2. doi request reprint Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart
    Songcang Chen
    Diabetes Center, University of California at San Francisco, San Francisco, CA 94143 0540, United States
    J Steroid Biochem Mol Biol 136:150-5. 2013
    ..The anti-hypertrophic activity appears to be at least partially intrinsic to the cardiac myocyte and may involve suppression of the MCIP 1 protein. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  3. doi request reprint A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation
    Songcang Chen
    Diabetes Center, University of California at San Francisco, CA 94143 0540, United States
    J Steroid Biochem Mol Biol 122:326-32. 2010
    ....
  4. doi request reprint Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy
    Songcang Chen
    Diabetes Center UCSF, San Francisco, CA 94143 0540, USA
    Circulation 124:1838-47. 2011
    ..Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function...
  5. ncbi request reprint Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells
    S Chen
    Diabetes Center, University of California at San Francisco, San Francisco, California 94143 0540, USA
    Kidney Int 72:300-6. 2007
    ..The increase in this receptor expression may account for some of the reported beneficial effect of 1,25(OH)(2)D3 on the cardiovascular system and kidney...
  6. ncbi request reprint Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells
    Songcang Chen
    Diabetes Center, 1119 HSW, University of California at San Francisco, San Francisco, CA 94143 0540, USA
    Hypertension 43:866-71. 2004
    ..Collectively, these data imply that Sgk1 operates over an eNOS-independent, p38 MAPK-dependent pathway in mediating osmotic induction of the NPR-A gene promoter...
  7. pmc Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity
    Songcang Chen
    Diabetes Center, University of California at San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0540, USA
    J Steroid Biochem Mol Biol 118:135-41. 2010
    ....
  8. pmc Expression of the vitamin d receptor is increased in the hypertrophic heart
    Songcang Chen
    Diabetes Center, University of California at San Francisco, CA 94143 0540, USA
    Hypertension 52:1106-12. 2008
    ....
  9. pmc Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents
    Songcang Chen
    Diabetes Center, UCSF, San Francisco, California 94143 0540, USA
    J Clin Invest 119:1647-58. 2009
    ....
  10. ncbi request reprint A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation
    Songcang Chen
    Diabetes Center, University of California, San Francisco, CA 94143 0540, USA
    Hypertension 47:252-8. 2006
    ..Collectively, these findings demonstrate that ET uses 2 complementary signal transduction cascades (ERK and p38 MAPK) to control proliferative activity of vascular smooth muscle cells...
  11. ncbi request reprint 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells
    Songcang Chen
    Diabetes Center, University of California at San Francisco, 3rd and Parnassus Avenue, San Francisco, CA 94143 0540, USA
    J Am Soc Nephrol 16:329-39. 2005
    ..Amplification of NPR-A activity represents a plausible mechanism to account for at least some of the beneficial effects that VD exerts on cardiovascular function...
  12. ncbi request reprint Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1
    Dolkun Rahmutula
    Diabetes Center and Department of Medicine, University of California at San Francisco, USA
    Hypertension 44:283-8. 2004
    ....
  13. ncbi request reprint 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity
    Songcang Chen
    Diabetes Center and Department of Medicine, University of California at San Francisco, 94143 0540, USA
    Regul Pept 128:197-202. 2005
    ..We conclude that the inhibition may arise from protein-protein interactions between the liganded VDR and stimulatory transcription factors that bind in this region...
  14. ncbi request reprint Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK
    Songcang Chen
    Diabetes Center Metabolic Research Unit, University of California at San Francisco, San Francisco, California 94143, USA
    J Biol Chem 277:6037-43. 2002
    ....
  15. ncbi request reprint Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells
    Qiong Ye
    Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, CA 94143 0540, USA
    Hypertension 41:675-81. 2003
    ..Collectively, these data demonstrate the presence of a number of independent but highly interactive local regulatory networks governing fluid and electrolyte handling in this distal nephron segment...
  16. ncbi request reprint Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells
    Songcang Chen
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0540, USA
    J Biol Chem 279:13755-63. 2004
    ..This results from the phosphorylation and subsequent inactivation of two inhibitory kinases (WEE1 and MYT1) that tonically suppress CDK2 and CDC2 activity and activation of a phosphatase (CDC25A) that increases CDK2 activity...
  17. pmc Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2
    DENIS J GLENN
    Department of Medicine and Diabetes Center, University of California at San Francisco, USA
    Hypertension 53:549-55. 2009
    ..These data suggest a model in which YY1 activates hBNP transcription through interaction with histone deacetylase 2...
  18. pmc Vitamin D and the heart
    David G Gardner
    Diabetes Center, University of California at San Francisco, San Francisco, California and
    Am J Physiol Regul Integr Comp Physiol 305:R969-77. 2013
    ....
  19. ncbi request reprint Molecular biology of the natriuretic peptide system: implications for physiology and hypertension
    David G Gardner
    Diabetes Center, University of California at San Francisco, San Francisco, CA 94143 0540, USA
    Hypertension 49:419-26. 2007
  20. ncbi request reprint Retinoids and cell growth in the cardiovascular system
    D G Gardner
    Department of Medicine, University of California at San Francisco 94143 0540, USA
    Life Sci 65:1607-13. 1999
    ..These activities together with favorable effects on the clotting mechanism suggest that retinoids may prove useful in the management of hypertrophic/hyperproliferative disorders of the heart and vascular wall...
  21. ncbi request reprint Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor
    Songcang Chen
    Diabetes Center Metabolic Research Unit and Department of Medicine, University of California, San Francisco 94143 0540, California, USA
    J Biol Chem 277:32498-504. 2002
    ....
  22. ncbi request reprint Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
    Wei Xiang
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 288:E125-32. 2005
    ....