Ronald C Chen

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Receipt of guideline-concordant treatment in elderly prostate cancer patients
    Ronald C Chen
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Electronic address
    Int J Radiat Oncol Biol Phys 88:332-8. 2014
  2. doi request reprint Impact of age and comorbidity on treatment and outcomes in elderly cancer patients
    Ronald C Chen
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Semin Radiat Oncol 22:265-71. 2012
  3. doi request reprint Patient-reported quality of life during radiation treatment for localized prostate cancer: results from a prospective phase II trial
    Ronald C Chen
    Department of Radiation Oncology and Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599 7512, USA
    BJU Int 110:1690-5. 2012
  4. doi request reprint Is primary prostate cancer treatment influenced by likelihood of extraprostatic disease? A surveillance, epidemiology and end results patterns of care study
    Jordan A Holmes
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Radiat Oncol Biol Phys 84:88-94. 2012
  5. doi request reprint Racial differences in time from prostate cancer diagnosis to treatment initiation: a population-based study
    William A Stokes
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Cancer 119:2486-93. 2013
  6. pmc Receipt of National Comprehensive Cancer Network guideline-concordant prostate cancer care among African American and Caucasian American men in North Carolina
    Shellie D Ellis
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7411, USA
    Cancer 119:2282-90. 2013
  7. pmc Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery
    Shrirang Karve
    Laboratory of Nano and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:8230-5. 2012
  8. pmc Intensity-modulated radiation therapy, proton therapy, or conformal radiation therapy and morbidity and disease control in localized prostate cancer
    Nathan C Sheets
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC, USA
    JAMA 307:1611-20. 2012
  9. doi request reprint Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:201-5. 2012
  10. doi request reprint Phase I study of concurrent weekly docetaxel, high-dose intensity-modulated radiation therapy (IMRT) and androgen-deprivation therapy (ADT) for high-risk prostate cancer
    Ronald C Chen
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    BJU Int 110:E721-6. 2012

Detail Information

Publications39

  1. doi request reprint Receipt of guideline-concordant treatment in elderly prostate cancer patients
    Ronald C Chen
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Electronic address
    Int J Radiat Oncol Biol Phys 88:332-8. 2014
    ..To examine the proportion of elderly prostate cancer patients receiving guideline-concordant treatment, using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database...
  2. doi request reprint Impact of age and comorbidity on treatment and outcomes in elderly cancer patients
    Ronald C Chen
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Semin Radiat Oncol 22:265-71. 2012
    ..A systematic use of sophisticated assessments, such as the geriatric assessment, may allow physicians to select appropriate patients and reduce underutilization of aggressive treatments in elderly cancer patients...
  3. doi request reprint Patient-reported quality of life during radiation treatment for localized prostate cancer: results from a prospective phase II trial
    Ronald C Chen
    Department of Radiation Oncology and Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599 7512, USA
    BJU Int 110:1690-5. 2012
    ....
  4. doi request reprint Is primary prostate cancer treatment influenced by likelihood of extraprostatic disease? A surveillance, epidemiology and end results patterns of care study
    Jordan A Holmes
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Radiat Oncol Biol Phys 84:88-94. 2012
    ..To examine the patterns of primary treatment in a recent population-based cohort of prostate cancer patients, stratified by the likelihood of extraprostatic cancer as predicted by disease characteristics available at diagnosis...
  5. doi request reprint Racial differences in time from prostate cancer diagnosis to treatment initiation: a population-based study
    William A Stokes
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA
    Cancer 119:2486-93. 2013
    ..Using the Surveillance, Epidemiologic and End Results (SEER)-Medicare linked database, we compared time from diagnosis to treatment in AA and Caucasian prostate cancer patients...
  6. pmc Receipt of National Comprehensive Cancer Network guideline-concordant prostate cancer care among African American and Caucasian American men in North Carolina
    Shellie D Ellis
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7411, USA
    Cancer 119:2282-90. 2013
    ..Racial differences in care are well documented; however, few studies have characterized patients based on their prostate cancer risk category, which is required to differentiate appropriate from inappropriate guideline application...
  7. pmc Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery
    Shrirang Karve
    Laboratory of Nano and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:8230-5. 2012
    ..Our results demonstrate that NP drug-delivery systems can promote the readoption of abandoned drugs such as Wtmn by overcoming drug-delivery challenges...
  8. pmc Intensity-modulated radiation therapy, proton therapy, or conformal radiation therapy and morbidity and disease control in localized prostate cancer
    Nathan C Sheets
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC, USA
    JAMA 307:1611-20. 2012
    ..There has been rapid adoption of newer radiation treatments such as intensity-modulated radiation therapy (IMRT) and proton therapy despite greater cost and limited demonstrated benefit compared with previous technologies...
  9. doi request reprint Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:201-5. 2012
    ....
  10. doi request reprint Phase I study of concurrent weekly docetaxel, high-dose intensity-modulated radiation therapy (IMRT) and androgen-deprivation therapy (ADT) for high-risk prostate cancer
    Ronald C Chen
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    BJU Int 110:E721-6. 2012
    ..At a median follow-up of 2.2 years, biochemical progression-free survival was 94%. This triple-therapy regimen is safe and promising for further evaluation in prospective trials...
  11. doi request reprint Comparative effectiveness of intensity-modulated radiotherapy and conventional conformal radiotherapy in the treatment of prostate cancer after radical prostatectomy
    Gregg H Goldin
    Department of Radiation Oncology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA
    JAMA Intern Med 173:1136-43. 2013
    ..Radiotherapy is indicated after prostatectomy in select patients who have adverse pathologic features and in those with recurrent disease...
  12. doi request reprint Trends in the use of postprostatectomy therapies for patients with prostate cancer: a surveillance, epidemiology, and end results Medicare analysis
    Nathan C Sheets
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer 119:3295-301. 2013
    ..The goal of the current study was to examine patterns of care in patients with a pathologic indication for postprostatectomy radiotherapy (RT) using the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database...
  13. doi request reprint Who makes the decision regarding the treatment of clinically localized prostate cancer--the patient or physician?: results from a population-based study
    Lixin Song
    Adult and Geriatric Health Division, School of Nursing, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7460, USA
    Cancer 119:421-8. 2013
    ..The current study examined how patients' sociodemographic, cancer-related, and subjective affective factors impacted their role in treatment decision-making...
  14. pmc Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy
    Michael E Werner
    Laboratory of Nano and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    ACS Nano 5:8990-8. 2011
    ..To the best of our knowledge, our report is the first to demonstrate the potential of molecularly targeted NPs as a promising new class of radiosensitizers...
  15. doi request reprint The impact of local and regional disease extent on overall survival in patients with advanced stage IIIB/IV non-small cell lung carcinoma
    Daniel S Higginson
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    Int J Radiat Oncol Biol Phys 84:e385-92. 2012
    ..The results have implications regarding the selection of patients for whom palliative thoracic radiation therapy may be of most benefit...
  16. pmc Associations between patient-provider communication and socio-cultural factors in prostate cancer patients: a cross-sectional evaluation of racial differences
    Lixin Song
    School of Nursing, University of North Carolina, Chapel Hill, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA Electronic address
    Patient Educ Couns 97:339-46. 2014
    ..To examine the association between socio-cultural factors and patient-provider communication and related racial differences...
  17. doi request reprint Design of the North Carolina Prostate Cancer Comparative Effectiveness and Survivorship Study (NC ProCESS)
    Ronald C Chen
    Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, NC, USA
    J Comp Eff Res 4:3-9. 2015
    ..This study highlights several important considerations regarding stakeholder involvement, study design and generalizability regarding comparative effectiveness research in prostate cancer. ..
  18. pmc Urinary incontinence and health-related quality of life among older Americans with and without cancer: a cross-sectional study
    Alexandra J White
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Cancer 13:377. 2013
    ..UI and cancer diagnoses have been associated with decreases in HRQOL. This study evaluates the prevalence of UI and the impact on HRQOL among older cancer survivors...
  19. doi request reprint Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life after conventional and high-dose radiation for prostate cancer: a subgroup analysis of a randomized trial
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 78:1081-5. 2010
    ..2 GyE) or high-dose (79.2 GyE) radiation for prostate cancer...
  20. doi request reprint Use of bone scan during initial prostate cancer workup, downstream procedures, and associated Medicare costs
    Aaron D Falchook
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Int J Radiat Oncol Biol Phys 89:243-8. 2014
    ..We quantified the use of bone scans and downstream procedures, along with associated costs, in patients with high-risk prostate cancer, and their use in low- and intermediate-risk patients for whom these tests are not recommended...
  21. doi request reprint Muscle-invasive bladder cancer: evaluating treatment and survival in the National Cancer Data Base
    Angela B Smith
    Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Lineberger Comprehensive Cancer Center, Multidisciplinary Genitourinary Oncology, Chapel Hill, NC, USA
    BJU Int 114:719-26. 2014
    ..To evaluate the association between patterns of care and patient survival for the treatment of muscle-invasive bladder cancer (MIBC) using a large, national database...
  22. doi request reprint An overview of methods for comparative effectiveness research
    Anne Marie Meyer
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC Electronic address
    Semin Radiat Oncol 24:5-13. 2014
    ..To both inform and serve as a reference for readers of this issue of Seminars in Radiation Oncology as well as the broader oncology community, we describe CER and several of the more commonly used approaches and analytical methods. ..
  23. pmc Impact of diagnosis and treatment of clinically localized prostate cancer on health-related quality of life for older Americans: a population-based study
    Bryce B Reeve
    Lineberger Comprehensive Cancer Center Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer 118:5679-87. 2012
    ..In the current study, the authors addressed these gaps by providing unique estimates of the effects of a cancer diagnosis on HRQOL accounting for the confounding effects of ageing and comorbidity...
  24. doi request reprint Cancer screening rates in individuals with different life expectancies
    Trevor J Royce
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill2School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill
    JAMA Intern Med 174:1558-65. 2014
    ..Routine cancer screening has unproven net benefit for patients with limited life expectancy...
  25. pmc Coexistence of urinary incontinence and major depressive disorder with health-related quality of life in older Americans with and without cancer
    Alexandra J White
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27599 7435, USA
    J Cancer Surviv 8:497-507. 2014
    ..This study evaluates the prevalence and factors associated with major depressive disorder (MDD) in a population of cancer survivors and the impact of co-occurring MDD and urinary incontinence (UI) on health-related quality of life (HRQOL)...
  26. doi request reprint Comparing dosimetric, morbidity, quality of life, and cancer control outcomes after 3D conformal, intensity-modulated, and proton radiation therapy for prostate cancer
    Kevin A Pearlstein
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Semin Radiat Oncol 23:182-90. 2013
    ....
  27. doi request reprint Dose--volume effects on patient-reported acute gastrointestinal symptoms during chemoradiation therapy for rectal cancer
    Ronald C Chen
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 83:e513-7. 2012
    ..We examined whether dose-volume parameters of the small bowel and large bowel were associated with patient-reported gastrointestinal (GI) symptoms during 5-fluorouracil (5-FU)-based chemoradiation treatment for rectal cancer...
  28. doi request reprint The effects of cancer and racial disparities in health-related quality of life among older Americans: A case-control, population-based study
    Laura C Pinheiro
    Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Cancer 121:1312-20. 2015
    ..The authors prospectively assessed changes in HRQOL before and after a first cancer diagnosis among non-Hispanic whites (NHWs), African Americans (AAs), Hispanics, and Asians in a cohort of Medicare beneficiaries with and without cancer...
  29. doi request reprint Impact of comorbidity on health-related quality of life after prostate cancer treatment: combined analysis of two prospective cohort studies
    Bryce B Reeve
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BJU Int 114:E74-81. 2014
    ....
  30. doi request reprint National study to determine the comfort levels of radiation therapists and medical dosimetrists to report errors
    Jessica A Church
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Pract Radiat Oncol 3:e165-70. 2013
    ..We conducted a survey of radiation therapists and dosimetrists to examine the error reporting cultures in radiation oncology facilities across the United States and staff comfort in reporting errors...
  31. doi request reprint Impact of distance to a urologist on early diagnosis of prostate cancer among black and white patients
    Jordan A Holmes
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Urol 187:883-8. 2012
    ..We examined whether an increased distance to a urologist is associated with a delayed diagnosis of prostate cancer among black and white patients, as manifested by higher risk disease at diagnosis...
  32. pmc Practice-based evidence to evidence-based practice: building the National Radiation Oncology Registry
    Jason A Efstathiou
    Massachusetts General Hospital, Department of Radiation Oncology, Boston, MA 02114 2606, USA
    J Oncol Pract 9:e90-5. 2013
    ..The NROR pilot study will provide the framework for expansion to a nationwide electronic registry for radiation oncology. ..
  33. doi request reprint Recommendations for post-prostatectomy radiation therapy in the United States before and after the presentation of randomized trials
    Karen E Hoffman
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 185:116-20. 2011
    ....
  34. ncbi request reprint Trimodality bladder preservation therapy for muscle-invasive bladder cancer
    Ronald C Chen
    From the aDepartment of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, and bDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    J Natl Compr Canc Netw 11:952-60. 2013
    ..In the future, biomarkers may allow improved selection of patients for whom trimodality bladder preservation therapy is most likely to succeed. ..
  35. doi request reprint Guideline-discordant use of imaging during work-up of newly diagnosed prostate cancer
    Aaron D Falchook
    Cecil G Sheps Center for Health Services Research and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
    J Oncol Pract 11:e239-46. 2015
    ..We quantify the proportion of patients who received work-up discordant with NCCN guidelines...
  36. pmc Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database--UNC GOLD
    Sarah A Gallagher
    Department of Medicine, Division of Hematology and Medical Oncology, University of North Carolina, Chapel Hill, NC
    Urol Oncol 32:32.e1-9. 2014
    ..Despite the potential utility, there are many important considerations that must be addressed when developing and implementing a discipline-specific database...
  37. doi request reprint How does health literacy affect quality of life among men with newly diagnosed clinically localized prostate cancer? Findings from the North Carolina-Louisiana Prostate Cancer Project (PCaP)
    Lixin Song
    School of Nursing, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer 118:3842-51. 2012
    ..Yet little is known about how health literacy affects cancer populations. The authors examined the relation between health-related quality of life (HRQOL) and health literacy among men with prostate cancer...
  38. doi request reprint Predicting the need for palliative thoracic radiation after first-line chemotherapy for advanced nonsmall cell lung carcinoma
    Daniel S Higginson
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA
    Cancer 118:2744-51. 2012
    ....
  39. doi request reprint Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis
    Michael E Werner
    Laboratory of Nano and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Biomaterials 32:8548-54. 2011
    ..Our results suggest that folate-targeted nanoparticles containing chemoradiotherapy have the potential as a treatment for ovarian peritoneal metastasis...