M Chen

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Alzheimer's alpha-secretase may be a calcium-dependent protease
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa 33612, USA
    FEBS Lett 417:163-7. 1997
  2. ncbi request reprint Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
    Front Biosci 6:E1-E11. 2001
  3. ncbi request reprint Ca2+ signaling down-regulation in ageing and Alzheimer's disease: why is Ca2+ so difficult to measure?
    M Chen
    Neuroscience Research Laboratory, Bay Pines VA Medical Center, Florida 33744, USA
    Cell Calcium 26:149-54. 1999
  4. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part V: why is Ca2+ signal lower in the disease?
    M Chen
    Neuroscience Research Laboratory, Medical Research Service 151, Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA
    Front Biosci 4:A9-15. 1999
  5. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part IV: can calpain act as alpha-secretase?
    M Chen
    Neuroscience Research Laboratory, Medical Research Service 151, Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA
    Front Biosci 3:A66-75. 1998
  6. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part III: animal model
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 33612, USA Florida
    Front Biosci 3:A47-51. 1998
  7. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part II: therapeutic rationale
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 33612, USA Florida
    Front Biosci 3:A32-7. 1998
  8. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin; part I; a calcium deficit hypothesis
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida, USA
    Front Biosci 3:a27-31. 1998
  9. ncbi request reprint Alzheimer movement re-examined 25 years later: is it a "disease" or a senile condition in medical nature?
    M Chen
    Neuroscience Research Laboratory, Medical Research Service 151, Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA
    Front Biosci 6:E30-40. 2001
  10. ncbi request reprint Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles
    H L Fernandez
    Research and Development Service 151, Department of Veterans Affairs Medical Center, PO Box 4125, Bay Pines, FL 33744, USA
    Neuroscience 119:335-45. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Alzheimer's alpha-secretase may be a calcium-dependent protease
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa 33612, USA
    FEBS Lett 417:163-7. 1997
    ..Based on this, we proposed a model for the membrane orientations of the secretases for further discussions...
  2. ncbi request reprint Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
    Front Biosci 6:E1-E11. 2001
    ..Whatever precise mechanisms underlying their depositions, plaques and tangles are the natural products of aging, thus fundamentally different from pathological events such as cancer growth in concept...
  3. ncbi request reprint Ca2+ signaling down-regulation in ageing and Alzheimer's disease: why is Ca2+ so difficult to measure?
    M Chen
    Neuroscience Research Laboratory, Bay Pines VA Medical Center, Florida 33744, USA
    Cell Calcium 26:149-54. 1999
    ....
  4. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part V: why is Ca2+ signal lower in the disease?
    M Chen
    Neuroscience Research Laboratory, Medical Research Service 151, Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA
    Front Biosci 4:A9-15. 1999
    ..And we predict that this contention, though in contrast to many competing models, will be confirmed by the proposed experimentation in the future...
  5. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part IV: can calpain act as alpha-secretase?
    M Chen
    Neuroscience Research Laboratory, Medical Research Service 151, Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA
    Front Biosci 3:A66-75. 1998
    ..It is of interest to note that some of our previous theoretical predictions have been experimentally observed...
  6. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part III: animal model
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 33612, USA Florida
    Front Biosci 3:A47-51. 1998
    ..This suggests that a fully successful animal model for AD might be developed by improving the current paradigms. Furthermore, we discuss a potential relationship between AD and schizophrenia in terms of intracellular calcium imbalance...
  7. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin. Part II: therapeutic rationale
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 33612, USA Florida
    Front Biosci 3:A32-7. 1998
    ..Based on the analyses, we discuss some controversies in therapeutic strategies...
  8. ncbi request reprint The Alzheimer's plaques, tangles and memory deficits may have a common origin; part I; a calcium deficit hypothesis
    M Chen
    Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida, USA
    Front Biosci 3:a27-31. 1998
    ..The hypothesis predicts that presenilins most likely act as calcium channels in vivo and that their gene mutations may cause the disease by diminishing the Ca2+ channeling function...
  9. ncbi request reprint Alzheimer movement re-examined 25 years later: is it a "disease" or a senile condition in medical nature?
    M Chen
    Neuroscience Research Laboratory, Medical Research Service 151, Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA
    Front Biosci 6:E30-40. 2001
    ..This may be why after extensive studies for 25 years, the origin of senile dementia has remained an enigma...
  10. ncbi request reprint Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles
    H L Fernandez
    Research and Development Service 151, Department of Veterans Affairs Medical Center, PO Box 4125, Bay Pines, FL 33744, USA
    Neuroscience 119:335-45. 2003
    ....