Lu Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Dynamics of postsynaptic glutamate receptor targeting
    Lu Chen
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Curr Opin Neurobiol 17:53-8. 2007
  2. pmc Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity
    Bita Maghsoodi
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:16015-20. 2008
  3. pmc Identification of coevolving residues and coevolution potentials emphasizing structure, bond formation and catalytic coordination in protein evolution
    Daniel Y Little
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 4:e4762. 2009
  4. pmc Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity
    Jason Aoto
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Neuron 60:308-20. 2008
  5. pmc Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid
    Marta E Soden
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3200, USA
    J Neurosci 30:16910-21. 2010
  6. pmc Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation
    Tara E Tracy
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    EMBO J 30:1577-92. 2011
  7. pmc Accelerated experience-dependent pruning of cortical synapses in ephrin-A2 knockout mice
    Xinzhu Yu
    Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Neuron 80:64-71. 2013
  8. pmc Retinoic acid-gated sequence-specific translational control by RARalpha
    Michael M Poon
    Department of Molecular, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:20303-8. 2008
  9. ncbi request reprint Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation
    Jason Aoto
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Neurosci 27:7508-19. 2007
  10. ncbi request reprint Laminar distribution of NMDA receptor subunit (NR1, NR2A, NR2B) expression during the critical period in cat visual cortex
    George D Mower
    Department of Anatomical Sciences and Neurobiology, Health Sciences Center, University of Louisville School of Medicine, 500 South Preston St, A Bldg, Rm 902, Louisville, KY 40202, USA
    Brain Res Mol Brain Res 119:19-27. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Dynamics of postsynaptic glutamate receptor targeting
    Lu Chen
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Curr Opin Neurobiol 17:53-8. 2007
    ..In addition, recent studies show that postsynaptic scaffold molecules can be highly mobile. The dynamic nature of the synapse suggests that many mechanisms might be involved in regulating synapse formation and synaptic plasticity...
  2. pmc Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity
    Bita Maghsoodi
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:16015-20. 2008
    ..Taken together, our results provide a direct link between dendritically localized RARalpha and local GluR1 synthesis in RNA granules during RA-mediated synaptic signaling in homeostatic synaptic plasticity...
  3. pmc Identification of coevolving residues and coevolution potentials emphasizing structure, bond formation and catalytic coordination in protein evolution
    Daniel Y Little
    Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 4:e4762. 2009
    ....
  4. pmc Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity
    Jason Aoto
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Neuron 60:308-20. 2008
    ..Together, our data suggest that RA functions in homeostatic plasticity as a signaling molecule that increases synaptic strength by a protein synthesis-dependent mechanism...
  5. pmc Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid
    Marta E Soden
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3200, USA
    J Neurosci 30:16910-21. 2010
    ..Our results raise the possibility that at least some of the symptoms of fragile X syndrome reflect impaired homeostatic plasticity and impaired RA signaling...
  6. pmc Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation
    Tara E Tracy
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    EMBO J 30:1577-92. 2011
    ....
  7. pmc Accelerated experience-dependent pruning of cortical synapses in ephrin-A2 knockout mice
    Xinzhu Yu
    Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Neuron 80:64-71. 2013
    ..Together, our results suggest that ephrin-A2 regulates experience-dependent, NMDA receptor-mediated synaptic pruning through glial glutamate transport during maturation of the mouse cortex. ..
  8. pmc Retinoic acid-gated sequence-specific translational control by RARalpha
    Michael M Poon
    Department of Molecular, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:20303-8. 2008
    ..Taken together, our results demonstrate a ligand-gated translational regulation mechanism mediated by a non-genomic function of RA/RARalpha signaling...
  9. ncbi request reprint Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation
    Jason Aoto
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Neurosci 27:7508-19. 2007
    ..GRIP1 knockdown prevents the increase in shaft synapse density induced by ephrinB3 overexpression. Together, our results reveal a novel mechanism for independent modulation of shaft synapses through ephrinB3 reverse signaling...
  10. ncbi request reprint Laminar distribution of NMDA receptor subunit (NR1, NR2A, NR2B) expression during the critical period in cat visual cortex
    George D Mower
    Department of Anatomical Sciences and Neurobiology, Health Sciences Center, University of Louisville School of Medicine, 500 South Preston St, A Bldg, Rm 902, Louisville, KY 40202, USA
    Brain Res Mol Brain Res 119:19-27. 2003
    ..For all three NMDA receptor subunits, the laminar distribution was similar in normal and dark reared visual cortex at 20 weeks, indicating that the developmental changes in laminar pattern of expression are independent of visual input...
  11. ncbi request reprint Corticospinal tract transection permanently abolishes H-reflex down-conditioning in rats
    Xiang Yang Chen
    Laboratory of Nervous System Disorder, Wadsworth Center, New York State Department of Health and State University of New York, Albany, New York 12201 0509, USA
    J Neurotrauma 23:1705-12. 2006
    ..The results also suggest that the role of sensorimotor cortex in down-conditioning extends beyond generation of the essential CST activity...
  12. doi request reprint Signal-mediated dynamic retention of glycosyltransferases in the Golgi
    Linna Tu
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Special Administrative Region SAR of the People s Republic of China
    Science 321:404-7. 2008
    ..We propose that Vps74p maintains the steady-state localization of Golgi glycosyltransferases dynamically, by promoting their incorporation into COPI-coated vesicles...
  13. ncbi request reprint Operant conditioning of reciprocal inhibition in rat soleus muscle
    Xiang Yang Chen
    Wadsworth Center, Laboratory of Nervous System Disorders, New York State Department of Health and State University of New York, Albany, New York 12201 0509, USA
    J Neurophysiol 96:2144-50. 2006
    ..Final SOL RI and TA H-reflex sizes were significantly correlated. Thus like the SSR and the H-reflex, RI can be operantly conditioned; and conditioning one reflex can affect another reflex as well...
  14. ncbi request reprint Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors
    Lu Chen
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA
    Mol Pharmacol 64:703-6. 2003
    ..These results suggest that stargazin action is highly selective for AMPA receptors...
  15. pmc Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
    Eric Schnell
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 99:13902-7. 2002
    ..Finally, we make compensatory mutations to both PSD-95 and stargazin to demonstrate the central role of direct interactions between them in determining the number of synaptic AMPARs...
  16. ncbi request reprint Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors
    Dane M Chetkovich
    Department of Neurology, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 22:5791-6. 2002
    ..These data suggest that phosphorylation of the stargazin PDZ ligand can disrupt stargazin interaction with PSD-95 and thereby regulate synaptic AMPAR function...
  17. ncbi request reprint Corticospinal tract transection prevents operantly conditioned H-reflex increase in rats
    Xiang Yang Chen
    Laboratory of Nervous System Disorders, Wadsworth Center, New York State Department of Health and State University of New York, PO Box 509, Albany, New York 12201 0509, USA
    Exp Brain Res 144:88-94. 2002
    ....
  18. pmc Cerebellar cortical inhibition and classical eyeblink conditioning
    Shaowen Bao
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    Proc Natl Acad Sci U S A 99:1592-7. 2002
    ..Together, these results suggest that different aspects of the memories for eyeblink CRs are encoded in the cerebellar cortex and the cerebellar deep nuclei...

Research Grants5

  1. Mechanism of Stargazin-Regulated AMPAR Trafficking
    Lu Chen; Fiscal Year: 2005
    ..The proposed studies will advance our understanding on molecular mechanisms of synaptogenesis and plasticity, thereby providing insights in these brain diseases, and their remediation. ..
  2. Mechanism of Stargazin-Regulated AMPAR Trafficking
    Lu Chen; Fiscal Year: 2006
    ..The proposed studies will advance our understanding on molecular mechanisms of synaptogenesis and plasticity, thereby providing insights in these brain diseases, and their remediation. ..
  3. Mechanism of Stargazin-Regulated AMPAR Trafficking
    Lu Chen; Fiscal Year: 2007
    ..The proposed studies will advance our understanding on molecular mechanisms of synaptogenesis and plasticity, thereby providing insights in these brain diseases, and their remediation. ..
  4. Mechanism of Stargazin-Regulated AMPAR Trafficking
    Lu Chen; Fiscal Year: 2009
    ..The proposed studies will advance our understanding on molecular mechanisms of synaptogenesis and plasticity, thereby providing insights in these brain diseases, and their remediation. ..