Linan Chen

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. doi request reprint Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice
    Linan Chen
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 28:425-33. 2008
  2. ncbi request reprint Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice
    Linan Chen
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:21418-26. 2005
  3. ncbi request reprint Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
    Wonsuk Yang
    Department of Neurology, The University of Chicago, IL 60637, USA
    Hum Mol Genet 16:2900-10. 2007
  4. ncbi request reprint Transgenic mouse models of dopamine deficiency
    Linan Chen
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA
    Ann Neurol 54:S91-102. 2003
  5. pmc Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
    Deepti Malhotra
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7624, 615 North Wolfe St, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 178:592-604. 2008

Collaborators

Detail Information

Publications5

  1. doi request reprint Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice
    Linan Chen
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 28:425-33. 2008
    ..The present study has significant clinical implications, because dopamine replacement therapy is the mainstay of PD treatment. In addition, our model provides an efficient in vivo approach to test therapeutic agents for PD...
  2. ncbi request reprint Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice
    Linan Chen
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:21418-26. 2005
    ..These data represent the in vivo evidence that loss of DJ-1 function alters nigrostriatal dopaminergic function and produces motor deficits...
  3. ncbi request reprint Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
    Wonsuk Yang
    Department of Neurology, The University of Chicago, IL 60637, USA
    Hum Mol Genet 16:2900-10. 2007
    ..In conclusion, this study raises the possibility that environmental and genetic factors might cooperatively involve the mechanisms underlying proteasome impairment in PD brains...
  4. ncbi request reprint Transgenic mouse models of dopamine deficiency
    Linan Chen
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA
    Ann Neurol 54:S91-102. 2003
    ..We have reviewed a comprehensive list of those genes and compared genetic mutations/variations in humans and transgenic mouse models. The significance and limitations of these animal models as well as future directions are discussed...
  5. pmc Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
    Deepti Malhotra
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7624, 615 North Wolfe St, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 178:592-604. 2008
    ..NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression that inhibits oxidative stress...