Lin Feng Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Assessing acetylation of NF-kappaB
    Lin-feng Chen
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94158, USA
    Methods 36:368-75. 2005
  2. ncbi NF-kappaB RelA phosphorylation regulates RelA acetylation
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, 1650 Owens St, San Francisco, CA 94158, USA
    Mol Cell Biol 25:7966-75. 2005
  3. ncbi p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    Jan Bohuslav
    Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143 1234, USA
    J Biol Chem 279:26115-25. 2004
  4. ncbi NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    EMBO J 25:139-49. 2006
  5. ncbi Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    EMBO J 21:6539-48. 2002
  6. ncbi Sustained induction of NF-kappa B is required for efficient expression of latent human immunodeficiency virus type 1
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    J Virol 81:6043-56. 2007
  7. ncbi Regulation of NF-kappaB action by reversible acetylation
    Warner C Greene
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Novartis Found Symp 259:208-17; discussion 218-25. 2004
  8. ncbi SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    Jennifer Chen
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:40364-74. 2005
  9. ncbi Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65
    ALISON M O'MAHONY
    Gladstone Institute for Virology and Immunology, Department of Medicine, University of California, San Francisco, California 94141, USA
    J Biol Chem 279:18137-45. 2004
  10. ncbi Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
    Hye Sook Kwon
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 3:158-67. 2008

Collaborators

  • Li Gan
  • Michael W McBurney
  • Leonard Buckbinder
  • Lennart Mucke
  • H Nakano
  • R Marmorstein
  • Beinan Wang
  • ERIC M VERDIN
  • Warner C Greene
  • Samuel A Williams
  • Hakju Kwon
  • Hirofumi Jono
  • Hajime Ishinaga
  • Soo-Mi Kweon
  • Haidong Xu
  • Jae Hyang Lim
  • Jian-Dong Li
  • Hye Sook Kwon
  • Tomoaki Koga
  • Jian dong Li
  • Jennifer Chen
  • Jan Bohuslav
  • ALISON M O'MAHONY
  • Melanie Ott
  • Michael M Brent
  • Hye-Sook Kwon
  • Martina Schnolzer
  • Ruth Getachew
  • Prerana Jayakumar
  • Un Hwan Ha
  • Un-Hwan Ha
  • Xin Hua Feng
  • Haodong Xu
  • Xin-Hua Feng
  • Chen Yan
  • Soo Mi Kweon
  • Carmen M Ruiz-Jarabo
  • Davida Rixter
  • Saili Yi
  • Yungui Zhou
  • Sarah Mueller-Steiner
  • Yajun Mu
  • Eirini Trompouki
  • Katrien Van Beneden
  • George Mosialos
  • Dwayne Bisgrove
  • Zhixing K Pan
  • David Fenard
  • Mauricio Montano

Detail Information

Publications16

  1. ncbi Assessing acetylation of NF-kappaB
    Lin-feng Chen
    Gladstone Institute of Virology and Immunology, University of California, San Francisco 94158, USA
    Methods 36:368-75. 2005
    ..Anti-RelA antibodies that selectively react with site-specific acetylated forms of RelA are a singularly powerful tool for the study of NF-kappaB acetylation both in vivo and in vitro...
  2. ncbi NF-kappaB RelA phosphorylation regulates RelA acetylation
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, 1650 Owens St, San Francisco, CA 94158, USA
    Mol Cell Biol 25:7966-75. 2005
    ..These findings indicate that the acetylation of RelA at lysine 310 is importantly regulated by prior phosphorylation of serines 276 and 536. Such phosphorylated and acetylated forms of RelA display enhanced transcriptional activity...
  3. ncbi p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    Jan Bohuslav
    Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143 1234, USA
    J Biol Chem 279:26115-25. 2004
    ..These findings highlight a rather unusual pathway of NF-kappaB activation, which is utilized by the p53 tumor suppressor...
  4. ncbi NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    EMBO J 25:139-49. 2006
    ..The combination of HDAC inhibitors and Tat merits consideration as a new strategy for purging latent HIV proviruses from their cellular reservoirs...
  5. ncbi Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    EMBO J 21:6539-48. 2002
    ..Together, these findings highlight how site-specific acetylation of RelA differentially regulates distinct biological activities of the NF-kappaB transcription factor complex...
  6. ncbi Sustained induction of NF-kappa B is required for efficient expression of latent human immunodeficiency virus type 1
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    J Virol 81:6043-56. 2007
    ..Conversely, the action of this phosphatase is overcome in the presence of Tat, promoting very efficient RNA Pol II elongation...
  7. ncbi Regulation of NF-kappaB action by reversible acetylation
    Warner C Greene
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Novartis Found Symp 259:208-17; discussion 218-25. 2004
    ....
  8. ncbi SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    Jennifer Chen
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:40364-74. 2005
    ..They also implicate SIRT1 in this pathway and highlight the therapeutic potential of resveratrol and other sirtuin-activating compounds in Alzheimer disease...
  9. ncbi Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65
    ALISON M O'MAHONY
    Gladstone Institute for Virology and Immunology, Department of Medicine, University of California, San Francisco, California 94141, USA
    J Biol Chem 279:18137-45. 2004
    ..IKK2 plays a dominant role in signaling for IkappaBalpha degradation, whereas IKK1 appears to play an important role in enhancing the transcriptional activity of NF-kappaB by promoting RelA/p65 phosphorylation...
  10. ncbi Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
    Hye Sook Kwon
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94158, USA
    Cell Host Microbe 3:158-67. 2008
    ..These events likely contribute to the state of immune cell hyperactivation found in HIV-infected individuals...
  11. ncbi Shaping the nuclear action of NF-kappaB
    Lin-feng Chen
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    Nat Rev Mol Cell Biol 5:392-401. 2004
  12. ncbi Prostratin antagonizes HIV latency by activating NF-kappaB
    Samuel A Williams
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94141, USA
    J Biol Chem 279:42008-17. 2004
    ..These findings provide new insights into the molecular pathway through which prostratin antagonizes HIV latency highlighting a central role for the action of NF-kappaB...
  13. ncbi NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway
    Hirofumi Jono
    Gonda Department of Cell and Molecular Biology, House Ear Institute, and Department of Otolaryngology, University of Southern California, Los Angeles, CA 90057, USA
    J Biol Chem 279:36171-4. 2004
    ..In addition, TRAF2 and TRAF6 appear to be differentially involved in NF-kappaB-dependent induction of CYLD by TNF-alpha and NTHi. These findings provide novel insights into the autoregulation of NF-kappaB activation...
  14. ncbi Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK
    Soo-Mi Kweon
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 351:368-75. 2006
    ....
  15. ncbi TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation
    Hajime Ishinaga
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    EMBO J 26:1150-62. 2007
    ..These studies provide new insights into the novel regulation of NF-kappaB by TGF-beta signaling...
  16. ncbi Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation
    Lin-feng Chen
    Gladstone Institute of Virology and Immunology, University of California, P.O. Box 419100, San Francisco, CA 94141-9100, USA
    J Mol Med 81:549-57. 2003
    ..This readies the cell for the next NF-kappaB-inducing stimulus. Thus, reversible acetylation of RelA serves as an important intranuclear regulatory mechanism that further provides for dynamic control of NF-kappaB action...