Zhang M, Ergin V, Lin L, Stork C, Chen L, Zheng S. Axonogenesis Is Coordinated by Neuron-Specific Alternative Splicing Programming and Splicing Regulator PTBP2. Neuron. 2019;101:690-706.e10 pubmed publisher
..We conclude that PTBP2-orchestrated alternative splicing programming is required for robust generation of a single axon in mammals. ..
Lee H, Chen L. Inference of kinship using spatial distributions of SNPs for genome-wide association studies. BMC Genomics. 2016;17:372 pubmed publisher
..Our method KIND usually produces more accurate and more robust kinship coefficient estimates than existing methods especially for populations with extreme stratification. It can serve as an important and very efficient tool for GWASs. ..
Chen L. A global comparison between nuclear and cytosolic transcriptomes reveals differential compartmentalization of alternative transcript isoforms. Nucleic Acids Res. 2010;38:1086-97 pubmed publisher
..In contrast, nonsense-mediated decay is significantly more associated with the isoforms enriched in the nucleus than those enriched in the cytosol. ..
Chen L. Characterization and comparison of human nuclear and cytosolic editomes. Proc Natl Acad Sci U S A. 2013;110:E2741-7 pubmed publisher
..This suggests that editing can mediate RNA memory on evolutionary time-scales to maintain ancestral genetic information. ..