Lee May Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Gynecologic cancer prevention in Lynch syndrome/hereditary nonpolyposis colorectal cancer families
    Lee May Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA
    Obstet Gynecol 110:18-25. 2007
  2. ncbi request reprint Single-agent pulse dactinomycin has only modest activity for methotrexate-resistant gestational trophoblastic neoplasia
    Lee May Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco Medical Center, San Francisco, CA 94115 USA
    Gynecol Oncol 94:204-7. 2004
  3. ncbi request reprint Discordance between beliefs and recommendations of gynecologic oncologists in ovarian cancer management
    L Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco Comprehensive Cancer Center, San Francisco, CA 94143 1702, USA
    Int J Gynecol Cancer 14:1055-62. 2004
  4. ncbi request reprint Perioperative outcomes comparing patient controlled epidural versus intravenous analgesia in gynecologic oncology surgery
    Lee May Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA
    Gynecol Oncol 115:357-61. 2009
  5. doi request reprint Influence of gynecologic oncologists on the survival of patients with endometrial cancer
    John K Chan
    University of California, San Francisco UCSF School of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143 1702, USA
    J Clin Oncol 29:832-8. 2011
  6. ncbi request reprint Risk-reducing salpingo-oophorectomy in BRCA mutation carriers: role of serial sectioning in the detection of occult malignancy
    C Bethan Powell
    Gynecologic Oncology Program and Cancer Risk Program, University of California San Francisco Comprehensive Cancer Center, 2340 Sutter Street, Room N424, San Francisco, CA 94143, USA
    J Clin Oncol 23:127-32. 2005
  7. doi request reprint Risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers: experience with a consecutive series of 111 patients using a standardized surgical-pathological protocol
    C Bethan Powell
    Cancer Risk Program, Department of Pathology, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Int J Gynecol Cancer 21:846-51. 2011
  8. doi request reprint COMT polymorphisms affecting protein expression are risk factors for endometrial cancer
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 47:768-74. 2008
  9. ncbi request reprint Early detection of high-grade tubal serous carcinoma in women at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery
    Joseph T Rabban
    Departments of Pathology Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco Cancer Risk Program, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
    Am J Surg Pathol 38:729-42. 2014
  10. pmc Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancer
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Carcinogenesis 31:1620-6. 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Gynecologic cancer prevention in Lynch syndrome/hereditary nonpolyposis colorectal cancer families
    Lee May Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA
    Obstet Gynecol 110:18-25. 2007
    ..This study models a comparison of management strategies for women who carry a Lynch/HNPCC mutation...
  2. ncbi request reprint Single-agent pulse dactinomycin has only modest activity for methotrexate-resistant gestational trophoblastic neoplasia
    Lee May Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco Medical Center, San Francisco, CA 94115 USA
    Gynecol Oncol 94:204-7. 2004
    ..To determine the effectiveness of single-agent pulse dactinomycin for methotrexate-resistant low-risk gestational trophoblastic neoplasia (GTN)...
  3. ncbi request reprint Discordance between beliefs and recommendations of gynecologic oncologists in ovarian cancer management
    L Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco Comprehensive Cancer Center, San Francisco, CA 94143 1702, USA
    Int J Gynecol Cancer 14:1055-62. 2004
    ..The purpose of this study was to determine how physician experts make decisions for clinical scenarios in ovarian cancer and describe a profile of factors reported to influence treatment decisions...
  4. ncbi request reprint Perioperative outcomes comparing patient controlled epidural versus intravenous analgesia in gynecologic oncology surgery
    Lee May Chen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA
    Gynecol Oncol 115:357-61. 2009
    ..Our aim was to compare perioperative patient controlled epidural analgesia (PCEA) versus patient controlled intravenous analgesia (PCA) after gynecologic oncology laparotomy...
  5. doi request reprint Influence of gynecologic oncologists on the survival of patients with endometrial cancer
    John K Chan
    University of California, San Francisco UCSF School of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143 1702, USA
    J Clin Oncol 29:832-8. 2011
    ..Therefore, we propose to determine the influence of gynecologic oncologists on the treatment and survival of patients with endometrial cancer...
  6. ncbi request reprint Risk-reducing salpingo-oophorectomy in BRCA mutation carriers: role of serial sectioning in the detection of occult malignancy
    C Bethan Powell
    Gynecologic Oncology Program and Cancer Risk Program, University of California San Francisco Comprehensive Cancer Center, 2340 Sutter Street, Room N424, San Francisco, CA 94143, USA
    J Clin Oncol 23:127-32. 2005
    ..Two recent studies of BRCA mutation carriers reported occult malignancy in 2.5% of women undergoing RRSO. This study aimed to increase this detection rate using a protocol...
  7. doi request reprint Risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers: experience with a consecutive series of 111 patients using a standardized surgical-pathological protocol
    C Bethan Powell
    Cancer Risk Program, Department of Pathology, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Int J Gynecol Cancer 21:846-51. 2011
    ..We report outcomes in 111 consecutive BRCA-positive women who had RRSO using a rigorous surgical-pathological protocol from 1996 to 2008...
  8. doi request reprint COMT polymorphisms affecting protein expression are risk factors for endometrial cancer
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 47:768-74. 2008
    ..This is the first study demonstrating that polymorphisms in COMT codon 62 and codon 158 altered protein expression levels in EC, suggesting that they may be risk factors for EC in Caucasians...
  9. ncbi request reprint Early detection of high-grade tubal serous carcinoma in women at low risk for hereditary breast and ovarian cancer syndrome by systematic examination of fallopian tubes incidentally removed during benign surgery
    Joseph T Rabban
    Departments of Pathology Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco Cancer Risk Program, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
    Am J Surg Pathol 38:729-42. 2014
    ..We propose that the tubal fimbriae should be completely examined in all patients undergoing benign surgery even if there are no clinical features to suggest risk for hereditary breast and ovarian cancer syndrome. ..
  10. pmc Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancer
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Carcinogenesis 31:1620-6. 2010
    ..This is the first report to show that UGT2B17 and Mcl-1 expression are upregulated in EC tissues and that UGT2B17 depletion induces inhibition of cell growth and apoptosis in EC cells through Mcl-1 downregulation...
  11. doi request reprint Factors associated with publication of plenary presentations at the Society of Gynecologic Oncologists annual meeting
    Joshua G Cohen
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1600 Divisadero Street, San Francisco, CA 94143 1702, USA
    Gynecol Oncol 128:128-31. 2013
    ..To determine the rate and factors associated with publication of plenary abstract presentations from the Society of Gynecologic Oncologists annual meeting...
  12. doi request reprint Characteristics of success in mentoring and research productivity - a case-control study of academic centers
    Joshua G Cohen
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143 1702, USA
    Gynecol Oncol 125:8-13. 2012
    ..Thus, we performed a case-control study to identify characteristics of successful mentoring programs...
  13. doi request reprint Rules of tumor cell development and their application to biomarkers for ovarian cancer
    Monica R McLemore
    Department of Physiological Nursing, University of California, San Francisco, USA
    Oncol Nurs Forum 35:403-9. 2008
    ..To apply the Hanahan and Weinberg conceptual framework for tumor development to the specific biomarkers observed or expressed in ovarian cancer...
  14. doi request reprint Correlation of macroscopic and microscopic pathology in risk reducing salpingo-oophorectomy: implications for intraoperative specimen evaluation
    Joseph T Rabban
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94313, USA
    Gynecol Oncol 121:466-71. 2011
    ..The aim of this study was to correlate the macroscopic and microscopic pathologic findings in RRSO...
  15. doi request reprint Surveillance of survivors: follow-up after risk-reducing salpingo-oophorectomy in BRCA 1/2 mutation carriers
    Jocelyn S Chapman
    UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143, USA
    Gynecol Oncol 122:339-43. 2011
    ..To characterize the post-operative care of BRCA1 and BRCA2 mutation carriers who undergo risk-reducing salpingo-oophorectomy (RRSO)...
  16. doi request reprint Multistep level sections to detect occult fallopian tube carcinoma in risk-reducing salpingo-oophorectomies from women with BRCA mutations: implications for defining an optimal specimen dissection protocol
    Joseph T Rabban
    Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Am J Surg Pathol 33:1878-85. 2009
    ..Guidelines for evaluation of RRSO specimens should emphasize the use of an optimal dissection protocol and the importance of thin tissue slice intervals...
  17. ncbi request reprint Association of tumor morphology with mismatch-repair protein status in older endometrial cancer patients: implications for universal versus selective screening strategies for Lynch syndrome
    Joseph T Rabban
    Departments of Pathology Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco Cancer Risk Program, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
    Am J Surg Pathol 38:793-800. 2014
    ..Further work to identify phenotypic features of endometrial cancers with methylated MLH1 that would allow them to be excluded from LS screening would also contribute to cost-effectiveness. ..
  18. ncbi request reprint CT and MRI of adnexal masses in patients with primary nonovarian malignancy
    Wei Chao Chang
    Department of Radiology, University of California San Francisco, Box 0628, M 372 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 186:1039-45. 2006
    ..The purpose of this pictorial essay is to review the differential considerations when an adnexal mass is detected on CT or MRI in a patient with a primary nonovarian malignancy...
  19. doi request reprint A cost-effectiveness analysis of prophylactic surgery versus gynecologic surveillance for women from hereditary non-polyposis colorectal cancer (HNPCC) Families
    Kathleen Y Yang
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, 1600 Divisadero St 4th Floor, San Francisco, CA 94115 1702, USA
    Fam Cancer 10:535-43. 2011
    ..Further, because risk-reducing surgery leads to both the lowest costs and the highest number of QALYs, it is a dominant strategy. Risk-reducing surgery is the most cost-effective option from a societal healthcare cost perspective...
  20. ncbi request reprint High-dose rate brachytherapy using inverse planning simulated annealing for locoregionally advanced cervical cancer: a clinical report with 2-year follow-up
    Daniel H Kim
    Department of Radiation Oncology, University of California, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 75:1329-34. 2009
    ..We present clinical outcomes of image-guided brachytherapy using inverse planning simulated annealing (IPSA) planned high-dose rate (HDR) brachytherapy boost for locoregionally advanced cervical cancer...
  21. ncbi request reprint Synchronous ovarian granulosa cell tumor and uterine serous carcinoma: a rare association of a high-risk endometrial cancer with anestrogenic ovarian tumor
    Joseph T Rabban
    Department of Pathology, University of California, San Francisco, CA 94143, USA
    Gynecol Oncol 103:1164-8. 2006
    ..The endometrial carcinoma is thought to occur under the influence of the estrogen receptor pathway and is typically a low-grade, low-stage endometrioid adenocarcinoma...
  22. ncbi request reprint Superficial endometrial spread of squamous cell cervical carcinoma: a diagnostic challenge at magnetic resonance imaging
    Felix Adler
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    J Comput Assist Tomogr 31:247-50. 2007
    ....
  23. doi request reprint Predictors of intensive care unit utilization in gynecologic oncology surgery
    Rachel Ruskin
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Helen Diller Family Cancer Center, University of California, CA, USA
    Int J Gynecol Cancer 21:1336-42. 2011
    ..The objectives of the study were to examine factors predicting intensive care unit (ICU) admission after surgery for gynecologic cancer and to determine the impact of ICU admission on survival...
  24. doi request reprint Predictors of high symptom burden in gynecologic oncology outpatients: who should be referred to outpatient palliative care?
    Carolyn Lefkowits
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94117, USA Electronic address
    Gynecol Oncol 132:698-702. 2014
    ..To characterize symptom prevalence in gynecologic oncology outpatients and identify predictors of high symptom burden...
  25. ncbi request reprint Ovarian pathology in risk-reducing salpingo-oophorectomies from women with BRCA mutations, emphasizing the differential diagnosis of occult primary and metastatic carcinoma
    Joseph T Rabban
    Department of Pathology, University of California, M 551 San Francisco, California 94143, USA
    Am J Surg Pathol 33:1125-36. 2009
    ....
  26. ncbi request reprint Decidualized endometrioma during pregnancy: recognizing an imaging mimic of ovarian malignancy
    Liina Poder
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    J Comput Assist Tomogr 32:555-8. 2008
    ....
  27. doi request reprint A comparison of the cyclic variation in serum levels of CA125 across the menstrual cycle using two commercial assays
    Monica R McLemore
    School of Nursing, Department of Physiological Nursing, University of California, San Francisco, CA 94117, USA
    Biol Res Nurs 14:250-6. 2012
    ..The purpose of this study was to determine if serum concentrations of CA125 differed across the three phases of the menstrual cycle in healthy, premenopausal women using two commercially available assays...
  28. doi request reprint An economic analysis of robotic versus laparoscopic surgery for endometrial cancer: costs, charges and reimbursements to hospitals and professionals
    Pavithra Venkat
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    Gynecol Oncol 125:237-40. 2012
    ..To determine the actual costs, charges, and reimbursements associated with robotic vs. laparoscopic surgery for endometrial cancer...
  29. doi request reprint Squamous metaplasia of the ovarian surface epithelium and subsurface fibrosis: distinctive pathologic findings in the ovaries and fallopian tubes of patients on peritoneal dialysis
    Elizabeth M Hosfield
    Department of Pathology, University of California, San Francisco, California 94143, USA
    Int J Gynecol Pathol 27:465-74. 2008
    ..Dialysis-associated changes involving the ovary and fallopian tube form a mechanical barrier that could contribute to the low rate of fertility in peritoneal dialysis patients...
  30. ncbi request reprint Awareness of gynecologic surveillance in women from hereditary non-polyposis colorectal cancer families
    Kathleen Yang
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF Comprehensive Cancer Center, 1600 Divisadero St, 4th Floor, San Francisco, CA 94115, USA
    Fam Cancer 5:405-9. 2006
    ..To determine knowledge of gynecologic cancer risk and screening in women with HNPCC...
  31. doi request reprint Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients
    Joshua G Cohen
    Division of Gynecologic Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
    Am J Obstet Gynecol 203:347.e1-6. 2010
    ..To determine the clinicopathologic factors associated with survival in neuroendocrine small cell cervical cancer patients...
  32. ncbi request reprint A randomized study of the effectiveness of a brief psychosocial intervention for women attending a gynecologic cancer clinic
    C Bethan Powell
    Department of Obstetrics, Division of Gynecologic Oncology, Gynecology and Reproductive Sciences, UCSF, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143, USA
    Gynecol Oncol 111:137-43. 2008
    ..While there are many psychosocial interventions for cancer patients, few are brief in nature. The aim of this study was to investigate the usefulness of a single-visit psychosocial intervention for gynecologic cancer patients...
  33. ncbi request reprint CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility
    Hiroshi Hirata
    Department of Urology, University of California at San Francisco, San Francisco, CA 94121, USA
    Cancer 112:1964-73. 2008
    ..The authors hypothesized that single nucleotide polymorphisms (single nucleotide polymorphisms) of CYP1A1, CYP1A2, CYP1B1, CYP17, SULT1A1, SULT1E1, and SHBG genes may be risk factors for endometrial cancer...
  34. ncbi request reprint Cost-effectiveness analyses in gynecologic oncology: methodological quality and trends
    Michael R Manuel
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco UCSF, San Francisco, CA 94143, USA
    Gynecol Oncol 93:1-8. 2004
    ..To evaluate methodological quality and trends of cost-effectiveness analyses (CEA) published in gynecologic oncology...
  35. pmc Epidemiological and genetic factors associated with ovarian cancer
    Monica R McLemore
    Department of Physiologic Nursing, School of Nursing, University of California, San Francisco, 520 Frederick St, 31, San Francisco, CA 94117, USA
    Cancer Nurs 32:281-8; quiz 289-90. 2009
    ..The article concludes with a discussion of how oncology nurses can apply this information to improve patient care...
  36. ncbi request reprint Disease and treatment characteristics do not predict symptom occurrence profiles in oncology outpatients receiving chemotherapy
    Christine Miaskowski
    Department of Physiological Nursing, School of Nursing, University of California at San Francisco, San Francisco, California
    Cancer 120:2371-8. 2014
    ..In addition, differences in quality of life outcomes were evaluated...
  37. doi request reprint Symptom management in gynecologic malignancies
    Carolyn Casey
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA
    Expert Rev Anticancer Ther 11:1077-89. 2011
    ..Literature regarding epidemiology, assessment and management of pain, fatigue, nausea/vomiting, lymphedema, ascites, depression, anxiety and sexual dysfunction in gynecologic oncology patients will be reviewed in this article...
  38. ncbi request reprint Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome
    Kathleen M Schmeler
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    N Engl J Med 354:261-9. 2006
    ..We designed this study to determine the reduction in the risk of gynecologic cancers associated with prophylactic hysterectomy and bilateral salpingo-oophorectomy in women with the Lynch syndrome...
  39. ncbi request reprint Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions
    Johnathan M Lancaster
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Gynecol Oncol 107:159-62. 2007
    ..This commentary provides guidance on identification of patients who may benefit from hereditary cancer risk assessment for Hereditary Breast/Ovarian Cancer and the Lynch/Hereditary Non-Polyposis Colorectal Cancer syndrome...
  40. ncbi request reprint Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma
    Russell R Broaddus
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:87-94. 2006
    ..It was the purpose of this study to pathologically characterize a series of HNPCC associated endometrial carcinomas...
  41. ncbi request reprint Gynecologic cancer as a "sentinel cancer" for women with hereditary nonpolyposis colorectal cancer syndrome
    Karen H Lu
    Department of Gynecologic Oncology, Division of Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Obstet Gynecol 105:569-74. 2005
    ..The purpose of this study was to estimate whether women with hereditary nonpolyposis colorectal cancer syndrome who develop 2 primary cancers present with gynecologic or colon cancer as their "sentinel cancer."..
  42. ncbi request reprint Magnetic resonance imaging of ovarian cancer arising in endometriomas
    Troy T Wu
    Keck School of Medicine, University of Southern California, Los Angeles, CA 94143 0628, USA
    J Comput Assist Tomogr 28:836-8. 2004
    ....
  43. ncbi request reprint Ovarian cancer. Clinical practice guidelines in oncology
    Robert J Morgan
    City of Hope Cancer Center, USA
    J Natl Compr Canc Netw 4:912-39. 2006