Kuan Ming Chen

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G
    Kuan Ming Chen
    University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics, Minneapolis, MN 55455, United States
    FEBS Lett 581:4761-6. 2007
  2. doi request reprint Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G
    Kuan Ming Chen
    Department of Biochemistry, Molecular Biology and Biophysics, of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 452:116-9. 2008
  3. pmc Solution NMR structure of the N-terminal domain of the human DEK protein
    Matthew Devany
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Protein Sci 17:205-15. 2008
  4. pmc Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G
    Stefan Harjes
    Department of Biochemistry, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA
    J Virol 87:7008-14. 2013
  5. pmc An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model
    Elena Harjes
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, 55455, USA
    J Mol Biol 389:819-32. 2009

Collaborators

Detail Information

Publications5

  1. pmc Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G
    Kuan Ming Chen
    University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics, Minneapolis, MN 55455, United States
    FEBS Lett 581:4761-6. 2007
    ..These data corroborated an APOBEC2-based structural model for the catalytic domain of APOBEC3G indicating that most non-essential residues are solvent accessible and most essential residues cluster within the protein core...
  2. doi request reprint Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G
    Kuan Ming Chen
    Department of Biochemistry, Molecular Biology and Biophysics, of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 452:116-9. 2008
    ..The structure of the APOBEC3G catalytic domain will help us to understand functions of other family members and interactions that occur with pathogenic proteins such as HIV-1 Vif...
  3. pmc Solution NMR structure of the N-terminal domain of the human DEK protein
    Matthew Devany
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Protein Sci 17:205-15. 2008
    ..Our study illustrates a new structural variant and reveals novel dsDNA-binding properties for proteins containing the SAP/SAF motif...
  4. pmc Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G
    Stefan Harjes
    Department of Biochemistry, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA
    J Virol 87:7008-14. 2013
    ..Protonation of H216 appeared important for HIV-1 restriction activity as well, since substitutions of H216 resulted in lower restriction in vivo...
  5. pmc An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model
    Elena Harjes
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, 55455, USA
    J Mol Biol 389:819-32. 2009
    ....