Kai Chen

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols
    Elad Anter
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 96:1072-8. 2005
  2. pmc Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1
    Tomonaga Ichikawa
    Cardiovascular Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Endocrinology 149:4086-94. 2008
  3. pmc Regulation of ROS signal transduction by NADPH oxidase 4 localization
    Kai Chen
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 181:1129-39. 2008
  4. doi request reprint Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease
    Kai Chen
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue N, S3 851, Worcester, MA 01655, USA
    Curr Atheroscler Rep 14:476-83. 2012
  5. pmc Downstream targets and intracellular compartmentalization in Nox signaling
    Kai Chen
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School Worcester, Massachusetts 01605, USA
    Antioxid Redox Signal 11:2467-80. 2009
  6. pmc NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation
    Siobhan M Craige
    University of Massachusetts Medical School, Department of Medicine Division of Cardiovascular Medicine, Worcester, MA 01605, USA
    Circulation 124:731-40. 2011
  7. pmc Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction
    Natalie C Ward
    Cardiovascular Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Clin Exp Pharmacol Physiol 38:328-33. 2011
  8. pmc Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction
    Eberhard Schulz
    Department of Cardiology, 2nd Medical Clinic of the University Hospital Mainz, Johannes Gutenberg University, Mainz, Germany
    Circulation 118:1347-57. 2008
  9. ncbi request reprint Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:850-8. 2007
  10. ncbi request reprint YFP photoconversion revisited: confirmation of the CFP-like species
    Michael T Kirber
    Nat Methods 4:767-8. 2007

Collaborators

  • Shane R Thomas
  • J F Keaney
  • Natalie C Ward
  • Hui Xiao
  • Rei Shibata
  • Siobhan M Craige
  • Kathy Griendling
  • M P Murphy
  • A Daiber
  • Hui Wang
  • Shu Chien
  • Eberhard Schulz
  • T Munzel
  • Patrick A Adegboyega
  • Weibo Cai
  • Xiaoyuan Chen
  • Tomonaga Ichikawa
  • Gang Niu
  • Jurgen K Willmann
  • Michael T Kirber
  • Xiaoli Ma
  • Yuhui Jiang
  • Annong Huang
  • Nopparat Nuntharatanapong
  • Elad Anter
  • Maria C Wendt
  • Feng Yin
  • Ian Y Chen
  • Taixing Cui
  • Martin Rodriguez-Porcel
  • Yuqing E Chen
  • Francisco J Schopfer
  • Sanjiv S Gambhir
  • Ramasamy Paulmurugan
  • Yusen Liu
  • Jifeng Zhang
  • David S Wang
  • Mark Rollins
  • Paul R S Baker
  • Bruce A Freeman
  • Olivier Gheysens
  • Albert Koong
  • Lina He
  • Qizhen Cao
  • Zongyao Wen
  • Shuhong Huang
  • Dagong Sun
  • Jing He
  • Josh Sultz
  • Zhu Zeng
  • Xiaoli Zhang
  • Jingwu Xie
  • Weibo Ka
  • Yuanxin Zhang
  • Dongqi He
  • Hongwei Zhang
  • Weijuan Yao
  • Zhiyu Tang
  • Tao Sheng
  • Kazuyuki Hatakeyama
  • Palarp Sinhaseni
  • Andrei L Kleschyov
  • Ying Yi Zhang
  • Alexander Mülsch
  • Oz M Shapira
  • Richard H Karas
  • Ulrich Walter
  • BERNARD LASSEGUE
  • Karsten Sydow
  • Chide Han
  • You yi Zhang
  • Li Chen
  • Qi Xu
  • Yong Yu Wang
  • Ming Zheng
  • Ping Li

Detail Information

Publications24

  1. pmc p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols
    Elad Anter
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 96:1072-8. 2005
    ..These findings suggest p38 MAP kinase-mediated eNOS activation requires ERalpha and these data uncover a new mechanism of ERalpha activation that has broad implications for NO bioactivity and endothelial cell phenotype...
  2. pmc Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1
    Tomonaga Ichikawa
    Cardiovascular Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Endocrinology 149:4086-94. 2008
    ..Taken together, our data demonstrate that nitroalkenes inhibit proinflammatory STAT signaling through inducting MKP-1 in macrophages...
  3. pmc Regulation of ROS signal transduction by NADPH oxidase 4 localization
    Kai Chen
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 181:1129-39. 2008
    ..These data indicate that the specificity of intracellular ROS-mediated signal transduction may be modulated by the localization of Nox isoforms within specific subcellular compartments...
  4. doi request reprint Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease
    Kai Chen
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue N, S3 851, Worcester, MA 01655, USA
    Curr Atheroscler Rep 14:476-83. 2012
    ....
  5. pmc Downstream targets and intracellular compartmentalization in Nox signaling
    Kai Chen
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School Worcester, Massachusetts 01605, USA
    Antioxid Redox Signal 11:2467-80. 2009
    ..Herein we review recent data that link cellular NADPH oxidase enzymes to ROS signaling, with a particular focus on the mechanism(s) involved in achieving signaling specificity...
  6. pmc NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation
    Siobhan M Craige
    University of Massachusetts Medical School, Department of Medicine Division of Cardiovascular Medicine, Worcester, MA 01605, USA
    Circulation 124:731-40. 2011
    ..NADPH oxidase 4 (Nox4) is a reactive oxygen species-producing enzyme that is highly expressed in the endothelium, yet its specific role is unknown. We sought to determine the role of Nox4 in the endothelial response to hypoxia...
  7. pmc Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction
    Natalie C Ward
    Cardiovascular Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Clin Exp Pharmacol Physiol 38:328-33. 2011
    ..This provides a mechanism for reduced nitric oxide bioactivity and endothelial dysfunction in diseases with elevated 20-HETE levels, such as hypertension...
  8. pmc Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction
    Eberhard Schulz
    Department of Cardiology, 2nd Medical Clinic of the University Hospital Mainz, Johannes Gutenberg University, Mainz, Germany
    Circulation 118:1347-57. 2008
    ..Oxidative injury and dysfunction of the vascular endothelium are early and causal features of many vascular diseases. Single antioxidant strategies to prevent vascular injury have met with mixed results...
  9. ncbi request reprint Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
    Weibo Cai
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd P095, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 34:850-8. 2007
    ..Here we report for the first time the quantitative positron emission tomography (PET) imaging of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab...
  10. ncbi request reprint YFP photoconversion revisited: confirmation of the CFP-like species
    Michael T Kirber
    Nat Methods 4:767-8. 2007
  11. ncbi request reprint Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor
    Gang Niu
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305 5484, USA
    Mol Imaging Biol 10:99-106. 2008
    ..The aim of this study is to non-invasively monitor the epidermal growth factor receptor (EGFR) response to a Hsp90 inhibitor-17-AAG treatment in a PC-3 prostate cancer model...
  12. doi request reprint Monitoring of the biological response to murine hindlimb ischemia with 64Cu-labeled vascular endothelial growth factor-121 positron emission tomography
    Jurgen K Willmann
    Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, Calif, USA
    Circulation 117:915-22. 2008
    ....
  13. ncbi request reprint TRAIL gene reorganizes the cytoskeleton and decreases the motility of human leukemic Jurkat cells
    Yuhui Jiang
    Department of Biophysics, Health Science Center, Peking University, Beijing, People s Republic of China
    Cell Motil Cytoskeleton 63:471-82. 2006
    ..These findings contribute to the knowledge on the role of TRAIL in tumor metastasis and provide mechanistic basis for the clinical application of TRAIL and tumor therapy...
  14. ncbi request reprint Hedgehog signaling is activated in subsets of esophageal cancers
    Xiaoli Ma
    Institute of Developmental Biology, School of Life Sciences, Shandong University, Jinan, China
    Int J Cancer 118:139-48. 2006
    ..Our data also indicate that downregulation of Gli1 expression may be an important mechanism by which KAAD-cyclopamine inhibits growth and induces apoptosis in esophageal cancer cells...
  15. ncbi request reprint Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart
    Feng Yin
    Institute of Vascular Medicine, Peking University Third Hospital and The Reference Laboratory of Education Ministry on Molecular Cardiology, Beijing 100083, People s Republic of China
    J Biol Chem 278:21070-5. 2003
    ....
  16. ncbi request reprint Oxidative stress and endothelial nitric oxide bioactivity
    Shane R Thomas
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Room W507, Boston, MA 02118, U S A
    Antioxid Redox Signal 5:181-94. 2003
    ..This review outlines how different forms of oxidative stress can impact on NO bioactivity and discusses strategies to prevent oxidative stress-induced endothelial dysfunction...
  17. ncbi request reprint Beyond LDL oxidation: ROS in vascular signal transduction
    Kai Chen
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Free Radic Biol Med 35:117-32. 2003
    ..In this review, the data linking ROS to cell signaling is discussed and the notion that ROS mediate a vascular "injury" response is proposed...
  18. ncbi request reprint Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation
    Kai Chen
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:39527-33. 2003
    ..Thus, these data link PDGF beta receptor transactivation to H2O2-induced p53 phosphorylation and suggest a functional role for growth factor receptors in modulation of p53 function...
  19. ncbi request reprint Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling
    Kai Chen
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, 715 Albany Street, MA 02118, USA
    J Biol Chem 279:35079-86. 2004
    ..These data establish a novel role for the mitochondrion as a proximal target specific to H(2)O(2)-induced signaling and growth factor transactivation...
  20. ncbi request reprint Reactive oxygen species-mediated signal transduction in the endothelium
    Kai Chen
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Endothelium 11:109-21. 2004
    ..In this review, the data linking ROS to kinase activation and cell signaling in the endothelium is discussed, with a particular emphasis on the roles of protein thiol modification...
  21. ncbi request reprint Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3
    Annong Huang
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circ Res 96:164-71. 2005
    ..Thus, IFN-gamma and TNF-alpha exert distinct but cooperative roles for BH4 biosynthesis in endothelium that may have important implications for vascular function during vascular inflammation...
  22. ncbi request reprint EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis
    Nopparat Nuntharatanapong
    Evans Memorial Department of Medicine, Boston Univ School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118, USA
    Am J Physiol Heart Circ Physiol 289:H99-H107. 2005
    ..Insofar as endothelial dysfunction promotes vascular disease, these data provide a mechanism for the increased incidence of cardiovascular disease due to arsenite exposure...
  23. ncbi request reprint Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
    Maria C Wendt
    The University Clinics Eppendorf, Division of Cardiology, Hamburg, Germany
    Free Radic Biol Med 39:381-91. 2005
    ..We conclude that in addition to phagocytic NADPH oxidase, also nonphagocytic, vascular NADPH oxidase subunit nox1, uncoupled NOSIII, and plasma xanthine oxidase contribute to endothelial dysfunction in the setting of diabetes mellitus...
  24. ncbi request reprint Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway
    Shane R Thomas
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118 USA
    J Biol Chem 277:6017-24. 2002
    ..This response may represent an attempt by endothelial cells to maintain NO bioactivity under conditions of enhanced oxidative stress...