Jun Chen

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity
    Rehana K Leak
    Department of Neurology, S507 Biomedical Science Tower, University of Pittsburgh, Pittsburgh PA 15213, USA
    CNS Neurol Disord Drug Targets 12:325-37. 2013
  2. doi request reprint Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    Xiaoming Hu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Stroke 43:3063-70. 2012
  3. pmc Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models
    Eveline H Shue
    Department of Neurosurgery, University of Rochester, Rochester, NY 14642, USA
    BMC Neurosci 9:29. 2008
  4. pmc Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions
    Wenting Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 41:2341-7. 2010
  5. pmc Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury
    R Anne Stetler
    Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, USA
    J Neurosci 32:2667-82. 2012
  6. pmc Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Shanghai, China
    J Neurochem 123:125-37. 2012
  7. pmc Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade
    Xiaoming Hu
    Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 31:247-61. 2011
  8. ncbi request reprint Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Yumin Luo
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Neurochem 97:435-48. 2006
  9. ncbi request reprint Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling
    Zhongfang Weng
    Department of Neurology, and Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 282:34479-91. 2007
  10. ncbi request reprint Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:9278-93. 2007

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity
    Rehana K Leak
    Department of Neurology, S507 Biomedical Science Tower, University of Pittsburgh, Pittsburgh PA 15213, USA
    CNS Neurol Disord Drug Targets 12:325-37. 2013
    ..Exogenous enhancement of HSP27 by rational drug design may lead to future therapies against a host of injuries, including but not limited to a harmful breach in brain vasculature...
  2. doi request reprint Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    Xiaoming Hu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Stroke 43:3063-70. 2012
    ..A comprehensive characterization of microglia/macrophage polarization after ischemia may advance our knowledge of poststroke damage/recovery...
  3. pmc Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models
    Eveline H Shue
    Department of Neurosurgery, University of Rochester, Rochester, NY 14642, USA
    BMC Neurosci 9:29. 2008
    ..In this study, we characterize the murine CNS expression pattern of PV-1 to determine whether localized PV-1 induction is conserved across species and disease state...
  4. pmc Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions
    Wenting Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 41:2341-7. 2010
    ..Here, we investigated the effect of omega-3 polyunsaturated fatty acids on brain damage and long-term neurological function after H/I in neonates...
  5. pmc Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury
    R Anne Stetler
    Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, USA
    J Neurosci 32:2667-82. 2012
    ..Together, these data demonstrate that HSP27 requires PKD-mediated phosphorylation for its suppression of ASK1 cell death signaling and neuroprotection against ischemic injury...
  6. pmc Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Shanghai, China
    J Neurochem 123:125-37. 2012
    ..This is the first demonstration that LPS pre-conditioning initiates multiple signaling pathways leading to mitochondrial biogenesis in neurons and that these dynamic changes contribute to ischemic tolerance...
  7. pmc Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade
    Xiaoming Hu
    Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 31:247-61. 2011
    ..Our results also suggest that PRX2 and ASK1 may be potential targets for neuroprotective intervention in PD...
  8. ncbi request reprint Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Yumin Luo
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Neurochem 97:435-48. 2006
    ..These results suggest that the PPAR-gamma agonist rosiglitazone has neuroprotective properties that are at least partially mediated via anti-inflammatory actions, and is thus a potential novel therapeutic agent for stroke...
  9. ncbi request reprint Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling
    Zhongfang Weng
    Department of Neurology, and Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 282:34479-91. 2007
    ..Collectively, these data provide evidence that leptin prevents the degeneration of dopaminergic neurons by 6-OHDA and may prove useful in the treatment of Parkinson disease...
  10. ncbi request reprint Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:9278-93. 2007
    ..Together, these results define calpain I-dependent AIF release as a novel signaling pathway that mediates neuronal cell death after cerebral ischemia...
  11. pmc Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling
    R Anne Stetler
    Department of Neurology and Center of Cerebrovascular Diseases Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 28:13038-55. 2008
    ..Based on these findings, we conclude that overexpression of Hsp27 confers long-lasting neuroprotection against ischemic brain injury via a previously unexplored association and inhibition of ASK1 kinase signaling...
  12. pmc Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways
    Peter S Vosler
    Department of Neurology and Center of Cerebrovascular Diseases Research, University of Pittsburgh School of Medicine, PA 15213, USA
    Exp Neurol 218:213-20. 2009
    ..Collectively, these findings link the two seemingly independent mechanisms triggering AIF-induced neuronal death...
  13. pmc Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair
    Suping Wang
    Department of Neurology, S 507 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 39:2587-95. 2008
    ..The objective of this study was to determine the neuroprotective effects of NAD(+) repletion against ischemic injury and the underlying mechanism...
  14. ncbi request reprint Erythropoietin protects CA1 neurons against global cerebral ischemia in rat: potential signaling mechanisms
    Feng Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci Res 83:1241-51. 2006
    ..These studies demonstrate that a single injection of EPO ICV up to 20 min after global ischemia is an effective neuroprotective agent and suggest that EPO is a viable candidate for treating global ischemic brain injury...
  15. ncbi request reprint Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection
    Yumin Luo
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Front Biosci 12:1852-62. 2007
    ..Further investigations elucidating the precise mechanism underlying the post-translational regulation of BER enzymes may lead to novel therapeutic strategies for cerebral ischemia...
  16. pmc Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury
    Feng Zhang
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Stroke 43:1390-7. 2012
    ..We hypothesize that chemically induced HO-1 upregulation with the novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imidazoline), a robust inducer of Phase 2 genes, protects neurons against ischemic injury...
  17. pmc Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia
    R Anne Stetler
    Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 107:3204-9. 2010
    ..Furthermore, the DNA repair function of APE1 was required for PACAP-mediated neuroprotection. Thus, induction of DNA repair enzymes may be a unique strategy for neuroprotection against hippocampal injury...
  18. ncbi request reprint Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia
    Feng Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 38:2329-36. 2007
    ..Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin was neuroprotective against ischemic brain injury...
  19. pmc Leptin protects hippocampal CA1 neurons against ischemic injury
    Feng Zhang
    Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 107:578-87. 2008
    ..Taken together, the results suggest that leptin protects against delayed ischemic neuronal death in the hippocampal CA1 by maintaining the pro-survival states of Akt and ERK1/2 MAPK signaling pathways...
  20. pmc Enhanced oligodendrogenesis and recovery of neurological function by erythropoietin after neonatal hypoxic/ischemic brain injury
    Masanori Iwai
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Stroke 41:1032-7. 2010
    ..Thus, we sought to determine the effects of delayed administration of EPO on white matter injury and recovery of neurological function after neonatal H/I...
  21. pmc Signal transducers and activators of transcription 5 contributes to erythropoietin-mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia
    Feng Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurobiol Dis 25:45-53. 2007
    ..These findings suggest an association between the activation of STAT5 and CA1 neuronal survival after cerebral ischemia...
  22. ncbi request reprint TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF
    Wei Yin
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neurobiol Dis 21:358-71. 2006
    ..Taken together, these results substantiate the feasibility of peripheral delivery of an anti-apoptotic factor into the brain of neonatal animals to reduce H-I-induced brain injury...
  23. ncbi request reprint Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 24:6189-201. 2004
    ....
  24. ncbi request reprint Preconditioning suppresses inflammation in neonatal hypoxic ischemia via Akt activation
    Wei Yin
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 38:1017-24. 2007
    ..Suppression of inflammation is a newly identified direct consequence of PI3-K/Akt signaling. We therefore investigated whether PI3-K/Akt suppresses inflammation and contributes to PC-induced neuroprotection...
  25. pmc When hypothermia meets hypotension and hyperglycemia: the diverse effects of adenosine 5'-monophosphate on cerebral ischemia in rats
    Feng Zhang
    Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, USA
    J Cereb Blood Flow Metab 29:1022-34. 2009
    ....
  26. pmc Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury
    Wei Yin
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 39:3057-63. 2008
    ..In this study, we report for the first time rapidly increased mitochondrial biogenesis in a rat model of neonatal hypoxic/ischemic brain injury (H-I)...
  27. ncbi request reprint Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture
    Wenjin Li
    Geriatric Research Educational and Clinical Center 00 GR H, VA Pittsburgh Healthcare System, Highland Drive, Pittsburgh, PA 15205, USA
    Neurochem Res 33:490-9. 2008
    ..Overexpression of COX-2 did not increase expression of cyclin D1 or phosphoretinoblastoma protein (pRb), or cleavage of caspase 3 suggesting that this cell cycle mechanism does not mediate COX-2 toxicity in this model...
  28. ncbi request reprint Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats
    Masanori Iwai
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Stroke 38:2795-803. 2007
    ..The current study investigates the effects of exogenous administration of EPO on revascularization and neurogenesis, 2 major events thought to contribute to neuronal replacement, in the neonatal brain after hypoxia/ischemia (H/I)...
  29. pmc Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials
    Armando P Signore
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 106:1977-90. 2008
    ..Coupled with evidence that leptin dysregulation in human disease also results in enhanced neuronal susceptibility to damage, development of leptin as a therapeutic methodology is an attractive and viable possibility...
  30. pmc The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury
    Wenjin Li
    Geriatric Research Educational and Clinical Center, VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, Pennsylvania 15205, USA
    J Neurochem 113:965-77. 2010
    ..Taken together, these results indicate that the cyclooxygenase activity of COX-2 is necessary to exacerbate neuronal hypoxia/ischemia injury rather than the peroxidase activity of the enzyme...
  31. ncbi request reprint 6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression
    Qinghua Liang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci Res 77:747-61. 2004
    ....
  32. pmc Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone
    Elizabeth R Sharlow
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 283:33516-26. 2008
    ..In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential...
  33. ncbi request reprint Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2
    Ganwei Lu
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Signal 19:867-79. 2007
    ....
  34. pmc Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death
    Peter S Vosler
    Geriatric Research, Educational, and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 108:18102-7. 2011
    ..Collectively, these data demonstrate that calpain-mediated degradation of a translation initiation factor, eIF4G1, is a cause of both persistent PSI and neuronal death...
  35. ncbi request reprint Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 23:1137-50. 2003
    ....
  36. pmc A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activities
    Jun Chen
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Carcinogenesis 32:1198-206. 2011
    ....
  37. pmc Adoptive regulatory T-cell therapy protects against cerebral ischemia
    Peiying Li
    Anesthesiology Department of Huashan Hospital, State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Ann Neurol 74:458-71. 2013
    ..We therefore evaluated the effect of Treg transfer in rodent models of ischemic stroke and further investigated the mechanism underlying Treg-afforded neuroprotection...
  38. ncbi request reprint Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death
    Armando P Signore
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 96:428-43. 2006
    ..These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease...
  39. pmc Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells
    Charleen T Chu
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 94:1685-95. 2005
    ..Studies of primary mouse midbrain cultures further supported a role for AIF in caspase-independent cell death in MPP+-treated dopaminergic neurons...
  40. doi request reprint Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2
    Jun Chen
    Departments of Pharmacology, and Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Res 68:3844-53. 2008
    ..In summary, our data indicate that PKD3 contributes to growth and survival of prostate cancer cells and may represent a novel therapeutic target for prostate cancer...
  41. ncbi request reprint Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway
    Wenjin Li
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 26:181-98. 2006
    ..These results suggest that the activation of the BER pathway may contribute to IP-induced neuroprotection by enhancing the repair of endogenous oxidative DNA damage after ischemic injury...
  42. ncbi request reprint Delivery of neurotherapeutics across the blood brain barrier in stroke
    Xiaoming Hu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Curr Pharm Des 18:3704-20. 2012
    ..Continuing modifications and improvements of CPPs are expected to enhance both their feasibility in clinical stroke management and their specificity towards particular cell types...
  43. ncbi request reprint Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family
    Jun Chen
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem J 411:333-42. 2008
    ..In summary, individual C1 domains of PKD isoforms differ in ligand-binding activity and selectivity, implying isoform-selective regulation of PKD by phorbol esters and DAG...
  44. pmc Bid-cardiolipin interaction at mitochondrial contact site contributes to mitochondrial cristae reorganization and cytochrome C release
    Tae Hyoung Kim
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Biol Cell 15:3061-72. 2004
    ..These findings thus suggest that interactions of Bid with mitochondrial cardiolipin at the contact site can contribute significantly to its functions...
  45. pmc Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility
    Courtney R LaValle
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    BMC Chem Biol 10:5. 2010
    ..In an effort to further enhance its selectivity and potency for potential in vivo application, small molecule analogs of CID755673 were generated by modifying both the core structure and side-chains...
  46. pmc Microglia/macrophage polarization dynamics in white matter after traumatic brain injury
    Guohua Wang
    1 State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China 2 Department of Neurology, Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 3 Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, China
    J Cereb Blood Flow Metab 33:1864-74. 2013
    ..The M1 phenotypic shift may propel WMI progression and represents a rational target for TBI treatment. ..
  47. ncbi request reprint Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection
    Xunming Ji
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Front Biosci 12:1737-47. 2007
    ..These results suggest that the attenuation of oxidative DNA damage and DNA damage-triggered pro-death signaling events may be an important mechanism underlying the neuroprotective effect of mild hypothermia against ischemic brain injury...
  48. ncbi request reprint Drug-induced hypothermia in stroke models: does it always protect?
    Meijuan Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15213, USA
    CNS Neurol Disord Drug Targets 12:371-80. 2013
    ..This article provides guidance for future clinical trials and animal studies on pharmacological cooling in the setting of acute stroke...
  49. ncbi request reprint BimEL up-regulation potentiates AIF translocation and cell death in response to MPTP
    Anthony K F Liou
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    FASEB J 19:1350-2. 2005
    ....
  50. ncbi request reprint Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia
    Xiao Ming Yin
    Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    J Biol Chem 277:42074-81. 2002
    ..Thus, the role of Bid in the induction of ischemic neuronal death may render this molecule an attractive target for future therapeutic intervention...
  51. ncbi request reprint Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion
    Jing Lan
    Department of Neurology and Pittsburgh Institute of Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 23:1324-39. 2003
    ..These results strongly suggest that inducible DNA BER constitutes an important endogenous mechanism that protects brain against ischemia-induced oxidative neuronal injury...
  52. ncbi request reprint PCR expression mutagenesis: a high-throughput mutation assay applied to the glucocorticoid receptor ligand-binding domain
    Jun Chen
    Steroid Hormones Section, NIDDK LMCB, National Institutes of Health, Bethesda, MD, USA
    Biochem Biophys Res Commun 321:893-9. 2004
    ..In combination with automation, PEM provides a more rapid and efficient tool for probing the role of each amino acid in the biological functions of a given protein...
  53. doi request reprint Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia
    Peiying Li
    From the Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA P L, L M, J C, X H Anesthesiology Department of Huashan Hospital, State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China P L, L M, J C, X H Department of Neurology and Key Laboratory of Cerebral Microcirculation, University of Shandong, Taian, Shandong, China G Z, B L S Affiliated Hospital of Taishan Medical College, Taian, Shandong, China G Z, B L S Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA R K L and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA J C, X H
    Stroke 44:3509-15. 2013
    ..However, the effect of Tregs on systemic inflammatory responses and immune status has not been fully characterized...
  54. pmc Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    Meijuan Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China
    Prog Neurobiol 100:30-47. 2013
    ..Following this background, we expand our discussion to the neuroprotective effects of phase II enzymes and the potential application of Nrf2 inducers to the treatment of neurological diseases...
  55. ncbi request reprint Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells
    Wei Pei
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    FASEB J 17:520-2. 2003
    ..Taken together, these results suggest that there are two routes by which cortical neurons degenerate during ischemic injury or in neurodegenerative diseases...
  56. pmc Mitochondrial targets for stroke: focusing basic science research toward development of clinically translatable therapeutics
    Peter S Vosler
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 40:3149-55. 2009
    ..Despite many promising prospects, attempts at translating neuroprotective agents that show success in animal models of stroke have resulted in very limited clinical success...
  57. pmc Protective effects and mechanisms of sirtuins in the nervous system
    Feng Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China
    Prog Neurobiol 95:373-95. 2011
    ....
  58. ncbi request reprint Enhancement of metabolic oxidative stress-induced cytotoxicity by the thioredoxin inhibitor 1-methylpropyl 2-imidazolyl disulfide is mediated through the ASK1-SEK1-JNK1 pathway
    Yong J Lee
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Mol Pharmacol 62:1409-17. 2002
    ..Therefore, IV-2 enhances glucose deprivation-induced cytotoxicity by promoting glucose deprivation-induced activation of the ASK1-SEK1-JNK1 pathway...
  59. pmc Heat shock proteins: cellular and molecular mechanisms in the central nervous system
    R Anne Stetler
    Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, United States
    Prog Neurobiol 92:184-211. 2010
    ....
  60. pmc The dynamics of the mitochondrial organelle as a potential therapeutic target
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University Shanghai Medical College, Shanghai, China
    J Cereb Blood Flow Metab 33:22-32. 2013
    ..An overview of the system as it is currently understood is presented, and current assessment strategies and their limitations are discussed...
  61. ncbi request reprint To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways
    Anthony K F Liou
    Department of Neurology, University of Pittsburgh School of Medicine, S526 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Prog Neurobiol 69:103-42. 2003
    ..Hopefully, this added research effort will provide a more detailed knowledge from which better therapeutic strategies can be developed to treat these acute brain injuries...
  62. pmc Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury
    Ling Zhang
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Tissue Eng Part A 19:1909-18. 2013
    ..The present study demonstrated that UBM is not only biocompatible within the brain tissue, but also can exert protective effects upon injured brain. ..
  63. ncbi request reprint Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus
    Kenji Kawaguchi
    Department of Neurology, University of Pittsburgh, PA 15260, USA
    Brain Res 1050:130-7. 2005
    ..These results suggest that COX-2 activity can contribute to epileptic neuronal injury and that selective COX-2 inhibitors are neuroprotective...
  64. ncbi request reprint Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes
    Jun Chen
    Department of Pharmacology, University of Pittsburgh, E1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Mol Pharmacol 67:152-62. 2005
    ..Taken together, our results indicate that PKD, specifically PKD3, directly contributes to insulin-independent basal glucose uptake in L6 skeletal muscle cells...
  65. ncbi request reprint Differential expression of splice variants of chemokine CCL27 mRNA in lens, cornea, and retina of the normal mouse eye
    Dolena R Ledee
    National Eye Institute, NIH, Bethesda, MD, USA
    Mol Vis 10:663-7. 2004
    ..Constitutive expression of RNA sequences complementary to the chemokine CCL27 mRNA has been found in the normal mouse eye. This study examines the nature and location of these endogenous RNAs in ocular tissues...
  66. ncbi request reprint Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex
    Jun Chen
    Steroid Hormones Section, NIDDK LMCB, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
    Biochemistry 43:245-55. 2004
    ..Finally, as the domain organization of GMEB-2 and -1 is extremely similar, we conclude that the quantitative differences in activities derive from variations in amino acid sequence rather than more global features of protein structure...
  67. ncbi request reprint Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway
    Yanqin Gao
    Department of Neurology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Cereb Blood Flow Metab 25:694-712. 2005
    ....
  68. ncbi request reprint Individual C1 domains of PKD3 in phorbol ester-induced plasma membrane translocation of PKD3 in intact cells
    Gülsüm Anderson
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cell Signal 17:1397-411. 2005
    ..PKC, by directly activating PKD3, regulates its plasma membrane localization in intact cells...
  69. ncbi request reprint In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis
    Guodong Cao
    Department of Neurology and Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:5423-31. 2002
    ....
  70. ncbi request reprint Correlations between edema and the immediate and prolonged painful consequences of inflammation: therapeutic implications?
    William R Lariviere
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Sheng Li Xue Bao 57:278-88. 2005
    ..This analysis represents a method for determining which inflammatory processes are the most promising therapeutic targets against the multiple painful consequences of inflammation...
  71. pmc Monocyte chemotactic protein 1 promotes lung cancer-induced bone resorptive lesions in vivo
    Zhong Cai
    Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Neoplasia 11:228-36. 2009
    ..The MCP-1 knockdown significantly diminished A549 cell growth. We conclude that MCP-1 promotes lung cancer-induced osteoclast activity and thus bone resorptive lesions in vivo...
  72. ncbi request reprint Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
    Shuchen Li
    Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Biol Chem 277:26912-20. 2002
    ..Together, these events ensure a successful progression of the death program initiated by the death receptor activation in the hepatocyte...
  73. ncbi request reprint Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite
    Xiaopeng Zhang
    Department of Anesthesiology and Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    J Neurochem 82:181-91. 2002
    ....
  74. ncbi request reprint Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria
    Dexi Chen
    Department of Neurology, Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 81:1273-84. 2002
    ..These results strongly suggest that the decline in BER activity may be an important mechanism contributing to the age-dependent accumulation of oxidative DNA lesions in brain mitochondria...
  75. ncbi request reprint Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia
    Guodong Cao
    Department of Neurology and Pittsburgh Institute of Neurological Disorders, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA 15213, U S A
    J Cereb Blood Flow Metab 22:534-46. 2002
    ..These results suggest that the caspase-9-dependent intrinsic pathway may be the primary mechanism responsible for the activation of caspase-3 in ischemic hippocampal neurons...
  76. ncbi request reprint The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195
    Jun Chen
    Huntsman Cancer Institute, Section of Oncology, Department of Medicine, University of Utah, 2000 Circle of Hope, Suite 5244, Salt Lake City, UT 84112, USA
    Mol Cancer Ther 1:961-7. 2002
    ..The combination of PK11195 and HA14-1 could therefore serve as a potentially useful approach to enhance apoptosis in cancer...
  77. ncbi request reprint Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737
    Stephen K Tahir
    Global Pharmaceutical Product Research Division, Abbott Laboratories, Abbott Park Road, Abbott Park, IL 60064, USA
    Cancer Res 67:1176-83. 2007
    ..Overall, these observations provide further insight as to the mechanistic bases for ABT-737 efficacy in SCLC and will be helpful for profiling patients and aiding in the rational design of combination therapies...
  78. ncbi request reprint Role of central NMDA versus non-NMDA receptor in spinal withdrawal reflex in spinal anesthetized rats under normal and hyperexcitable conditions
    Hao Jun You
    Center for Sensory Motor Interaction SMI, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7, Building D 3, DK 9220 Aalborg, Denmark
    Brain Res 981:12-22. 2003
    ..In BV-induced inflammation, however, central non-NMDA receptors, but not NMDA receptors, play a pivotal role in the generation of persistent hyperexcitability to mechanical and electrical stimuli at different frequencies (3 Hz, 20 Hz)...
  79. ncbi request reprint Effects of intravenous Injections Paederiae and Stauntonia on spontaneous pain, hyperalgesia and inflammation induced by cutaneous chemical tissue injury in the rat
    Xiao Li Peng
    Pain Research Center, Institute of Neuroscience, The Fourth Military Medical University, Xi an 710032
    Sheng Li Xue Bao 55:516-24. 2003
    ..The BV test might be a useful model of pain to evaluate and screen anti-nociceptive and anti-inflammatory effects of certain compounds of the Chinese medicinal herbs on the pathological origins of pain...
  80. ncbi request reprint ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis
    Hannah M Lui
    Department of Pediatrics, Division of Hematology Oncology, Stanford University School of Medicine, Stanford, CA 94305 5149, USA
    Mol Cancer Res 1:508-18. 2003
    ..These data suggest that ARMER is a novel ER integral membrane protein which protects cells by inhibiting caspase-9 activity and reveal a possible role for ARMER in cell survival...
  81. ncbi request reprint Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric-oxide synthase activation and cytotoxicity
    Jun Chen
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 278:28089-100. 2003
    ..These data demonstrate a novel pathway of dopamine-mediated postsynaptic oxidative stress and cell death through direct activation of NOS enzymes by D1 dopamine receptors and its associated signaling pathways...
  82. ncbi request reprint Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: a comparative study between formalin test and bee venom test in the rat
    Hui Sheng Chen
    Pain Research Center, Institute of Neuroscience, The Fourth Military Medical University, Xi an, China
    Anesthesiology 98:1231-6. 2003
    ..The roles of descending facilitatory pathway from the rostral medial medulla (RMM) in development of persistent spontaneous nociception and hyperalgesia were evaluated in the bee venom (BV) test and the formalin test...
  83. ncbi request reprint Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex
    Ming Gang Liu
    Institute for Biomedical Sciences of Pain, Capital Medical University, Beijing 100069, PR China
    Neurosci Lett 427:39-43. 2007
    ..Also, the two JNK isoforms are supposed to function differently according to their locations within the rat central nervous system...
  84. ncbi request reprint Evidence for peripherally antinociceptive action of propofol in rats: behavioral and spinal neuronal responses to subcutaneous bee venom
    Yan Yan Sun
    Pain Research Center, Institute of Neuroscience, Fourth Military Medical University, 17 West Chang le Road, Xi an 710032, PR China
    Brain Res 1043:231-5. 2005
    ..This result indicates that besides central actions, propofol has peripherally antinociceptive action as well...
  85. ncbi request reprint Age-related changes in deterministic behaviors of nociceptive firing of rat dorsal horn neurons
    Ji Hong Zheng
    Pain Research Center, Institute of Neuroscience, K K Leung Brain Research Centre, The Fourth Military Medical University, Xi an 710032, China
    Sheng Li Xue Bao 56:178-82. 2004
    ....
  86. pmc Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in naïve and pain-experiencing rats
    She Wei Guo
    Institute for Biomedical Sciences of Pain, Capital Medical University, Beijing 100069, PR China
    BMC Neurosci 8:53. 2007
    ....
  87. ncbi request reprint Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors
    Fa Le Cao
    Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, PR China
    Neurosci Lett 427:50-4. 2007
    ....
  88. ncbi request reprint Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity
    Bo Duan
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 27:11139-48. 2007
    ..Specific blockade of Ca2+-permeable ASIC1a channels thus may have antinociceptive effect by reducing or preventing the development of central sensitization induced by inflammation...
  89. ncbi request reprint Complexity of tissue injury-induced nociceptive discharge of dorsal horn wide dynamic range neurons in the rat, correlation with the effect of systemic morphine
    Ji Hong Zheng
    Pain Research Center PRC, Institute of Neuroscience, The Fourth Military Medical University, Xi an 710032, PR China
    Brain Res 1001:143-9. 2004
    ..Moreover, the response of the nociceptive discharge to analgesics may be related to the nonlinear dynamics feature of nociceptive neurons, which can be quantitatively characterized by the degree of complexity...
  90. ncbi request reprint D1 dopamine receptor mediates dopamine-induced cytotoxicity via the ERK signal cascade
    Jun Chen
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    J Biol Chem 279:39317-30. 2004
    ..These data provide novel mechanistic insights into the role of ERK in the cytotoxicity mediated upon activation of the D1 dopamine receptor...
  91. ncbi request reprint Differential roles of spinal protein kinases C and a in development of primary heat and mechanical hypersensitivity induced by subcutaneous bee venom chemical injury in the rat
    Kai Cheng Li
    Pain Research Center PRC, Institute of Neuroscience, Fourth Military Medical University, Xi an, China
    Neurosignals 12:292-301. 2003
    ..Taken together with our previous report however, spinal PKC and PKA are likely to be simultaneously involved in the central processes of both PSN and MIH hypersensitivity...
  92. pmc Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia
    Xiu Yu Cui
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Mol Pain 4:17. 2008
    ..In the present study, we investigated the role of mitogen-activated protein kinase (MAPK) in the generation of BV-induced pain hypersensitivity...
  93. ncbi request reprint Differential actions of intrathecal nociceptin on persistent spontaneous nociception, hyperalgesia and inflammation produced by subcutaneous bee venom injection in conscious rats
    Yan Yan Sun
    Pain Research Center, Institute of Neuroscience, The Fourth Military Medical University, Xi an 710032, China
    Sheng Li Xue Bao 56:321-7. 2004
    ....
  94. ncbi request reprint Distinct BAG-1 isoforms have different anti-apoptotic functions in BAG-1-transfected C33A human cervical carcinoma cell line
    Jun Chen
    Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, NF, Canada A1B 3V6
    Oncogene 21:7050-9. 2002
    ..These in vitro results suggest that distinct isoforms of BAG-1 have different anti-apoptotic functions and their functions may be correlated to increased Bcl-2 expression...
  95. ncbi request reprint [Establishment of human hepatocellular carcinoma cell line with spontaneous pulmonary metastasis through in vivo selection]
    Yan Li
    Liver Cancer Institute and Zhong Shan Hospital of Fudan University, Shanghai, 200032, China
    Zhonghua Yi Xue Za Zhi 82:601-5. 2002
    ..To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide suitable model for the study of lung-metastasis-related molecular mechanisms...
  96. ncbi request reprint Detection of deterministic behavior within the tissue injury-induced persistent firing of nociceptive neurons in the dorsal horn of the rat spinal cord
    Ji Hong Zheng
    Department of Anatomy and K K Leung Brain Research Centre, The Fourth Military Medical University, Xi an 710032, People s Republic of China
    J Comput Neurosci 13:23-34. 2002
    ..By using this method we suggest that BV-induced nociceptive discharge of spinal WDR neuron be a kind of deterministic activity and various UPOs may play some role in temporal coding of sensory information...
  97. ncbi request reprint Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation
    Tzyh Chyuan Hour
    Department of Urology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei 100, Taiwan, Republic of China
    Prostate 51:211-8. 2002
    ..The modulatory effects and molecular mechanisms of curcumin (CCM) on the cytotoxicity of chemotherapeutic agents to prostate cancer cells were explored...
  98. ncbi request reprint Estrogen regulates CCR gene expression and function in T lymphocytes
    RuRan Mo
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 174:6023-9. 2005
    ..Our results indicate an important role of estrogen in determining T cell chemokine response that may help explain the increased susceptibility and severity of autoimmune diseases in females...
  99. ncbi request reprint Application of large-scale transiently transfected cells to functional assays of ion channels: different targets and assay formats
    Bruce R Bianchi
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Assay Drug Dev Technol 5:417-24. 2007
    ..Hence, the utilization of LSTT cells could reduce the need for stable cell lines, and enable development of functional assays in a more timely and economic fashion for different ion channels and different assay formats...
  100. ncbi request reprint Arsenic trioxide as a novel anticancer agent against human transitional carcinoma--characterizing its apoptotic pathway
    Yeong Shiau Pu
    Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung Shan South Road, Taipei, Taiwan 100, ROC
    Anticancer Drugs 13:293-300. 2002
    ..The As(2)O(3)-mediated cytotoxicity appeared to go through the conventional apoptotic pathway. Our results have clinical implications and warrant further investigation...
  101. ncbi request reprint Differential effect of peripheral glutamate (NMDA, non-NMDA) receptor antagonists on bee venom-induced spontaneous nociception and sensitization
    Hao Jun You
    Center for Sensory Motor Interaction SMI, Laboratory for Experimental Pain Research, Aalborg University, Aalborg, Denmark
    Brain Res Bull 58:561-7. 2002
    ..The data suggest that the peripheral NMDA receptor, but not non-NMDA receptor, plays a pivotal role in the bee venom-induced persistent nociception and hyperexcitability...

Research Grants39

  1. INDUCIBLE DNA REPAIR IN CEREBRAL ISCHEMIA
    Jun Chen; Fiscal Year: 2005
    ..The in vitro models will complement the in vivo studies by allowing for precise mechanistic studies to be performed. ..
  2. Programmed Cell Death Induced by Cerebral Ischemia
    Jun Chen; Fiscal Year: 2006
    ..abstract_text> ..
  3. Neuroprotection in Models of Cerebral Ischemia
    Jun Chen; Fiscal Year: 2007
    ..abstract_text> ..
  4. Apoptosis Execution Pathways in Dopaminergic Cell Death
    Jun Chen; Fiscal Year: 2007
    ..3. Test the hypotheses that Bax is a direct mediator for AIF release, and Bax contributes to dopaminergic cell death by activating both AIF-dependent and caspase-dependent pathways. ..
  5. Neuroprotective effect of HSP27 in Cerebral Ischemia
    Jun Chen; Fiscal Year: 2007
    ..The in vitro models will complement the in vivo studies by allowing for precise mechanistic studies to be performed. ..
  6. INDUCIBLE DNA REPAIR IN CEREBRAL ISCHEMIA
    Jun Chen; Fiscal Year: 2010
    ..This information will be valuable for future development of new therapeutic strategies for the treatment of stroke. ..
  7. Neuroprotective effect of HSP27 in Cerebral Ischemia
    Jun Chen; Fiscal Year: 2010
    ..The in vitro models will complement the in vivo studies by allowing for precise mechanistic studies to be performed. ..
  8. INDUCIBLE DNA REPAIR IN CEREBRAL ISCHEMIA
    Jun Chen; Fiscal Year: 2000
    ..The expression and activity of DNA repair enzymes will be studied and the effect of pharmacologic inhibition of these enzymes upon DNA damage and neuronal survival investigated. ..
  9. Neuroprotection Against Parkinsonian Cell Death
    Jun Chen; Fiscal Year: 2010
    ..This information will be valuable for future development of new therapeutic strategies for the treatment of Parkinson's disease and, possibly, other neurological disorders. ..