Jun Chen

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling
    Wenting Zhang
    From the State Key Laboratory of Medical Neurobiology, Institute of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China W Z, J L, X H, P L, Y G, J C Center of Cerebrovascular Disease Research, Department of Neurology, University of Pittsburgh School of Medicine, PA X H, J C Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA R K L Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA X H, J C
    Stroke 46:2943-50. 2015
  2. pmc HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity
    Rehana K Leak
    Department of Neurology, S507 Biomedical Science Tower, University of Pittsburgh, Pittsburgh PA 15213, USA
    CNS Neurol Disord Drug Targets 12:325-37. 2013
  3. pmc Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models
    Eveline H Shue
    Department of Neurosurgery, University of Rochester, Rochester, NY 14642, USA
    BMC Neurosci 9:29. 2008
  4. pmc Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions
    Wenting Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 41:2341-7. 2010
  5. pmc Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury
    R Anne Stetler
    Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, USA
    J Neurosci 32:2667-82. 2012
  6. pmc Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Shanghai, China
    J Neurochem 123:125-37. 2012
  7. ncbi request reprint Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Yumin Luo
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Neurochem 97:435-48. 2006
  8. ncbi request reprint Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:9278-93. 2007
  9. pmc Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption
    Ni Zeng
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai
    Int J Nanomedicine 7:3703-18. 2012
  10. pmc Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1
    Meijuan Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China, Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China, Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania 15282, Department of Neurology and Key Laboratory of Cerebral Microcirculation, University of Shandong, Affiliated Hospital of Taishan Medical College, Taian, Shandong 271000, China, and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania 15240
    J Neurosci 34:1903-15. 2014

Collaborators

Detail Information

Publications142 found, 100 shown here

  1. doi request reprint n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling
    Wenting Zhang
    From the State Key Laboratory of Medical Neurobiology, Institute of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China W Z, J L, X H, P L, Y G, J C Center of Cerebrovascular Disease Research, Department of Neurology, University of Pittsburgh School of Medicine, PA X H, J C Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA R K L Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA X H, J C
    Stroke 46:2943-50. 2015
    ..This study tested the hypothesis that n-3 PUFAs enhance Akt-dependent prosurvival signaling by promoting the biosynthesis of phosphatidylserine in neuronal cell membranes...
  2. pmc HSP27 protects the blood-brain barrier against ischemia-induced loss of integrity
    Rehana K Leak
    Department of Neurology, S507 Biomedical Science Tower, University of Pittsburgh, Pittsburgh PA 15213, USA
    CNS Neurol Disord Drug Targets 12:325-37. 2013
    ..Exogenous enhancement of HSP27 by rational drug design may lead to future therapies against a host of injuries, including but not limited to a harmful breach in brain vasculature...
  3. pmc Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models
    Eveline H Shue
    Department of Neurosurgery, University of Rochester, Rochester, NY 14642, USA
    BMC Neurosci 9:29. 2008
    ..In this study, we characterize the murine CNS expression pattern of PV-1 to determine whether localized PV-1 induction is conserved across species and disease state...
  4. pmc Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions
    Wenting Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 41:2341-7. 2010
    ..Here, we investigated the effect of omega-3 polyunsaturated fatty acids on brain damage and long-term neurological function after H/I in neonates...
  5. pmc Phosphorylation of HSP27 by protein kinase D is essential for mediating neuroprotection against ischemic neuronal injury
    R Anne Stetler
    Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, USA
    J Neurosci 32:2667-82. 2012
    ..Together, these data demonstrate that HSP27 requires PKD-mediated phosphorylation for its suppression of ASK1 cell death signaling and neuroprotection against ischemic injury...
  6. pmc Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Shanghai, China
    J Neurochem 123:125-37. 2012
    ..This is the first demonstration that LPS pre-conditioning initiates multiple signaling pathways leading to mitochondrial biogenesis in neurons and that these dynamic changes contribute to ischemic tolerance...
  7. ncbi request reprint Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
    Yumin Luo
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Neurochem 97:435-48. 2006
    ..These results suggest that the PPAR-gamma agonist rosiglitazone has neuroprotective properties that are at least partially mediated via anti-inflammatory actions, and is thus a potential novel therapeutic agent for stroke...
  8. ncbi request reprint Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:9278-93. 2007
    ..Together, these results define calpain I-dependent AIF release as a novel signaling pathway that mediates neuronal cell death after cerebral ischemia...
  9. pmc Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption
    Ni Zeng
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai
    Int J Nanomedicine 7:3703-18. 2012
    ..However, their cellular interaction and in vivo behavior have not been fully developed and characterized...
  10. pmc Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1
    Meijuan Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China, Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China, Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania 15282, Department of Neurology and Key Laboratory of Cerebral Microcirculation, University of Shandong, Affiliated Hospital of Taishan Medical College, Taian, Shandong 271000, China, and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania 15240
    J Neurosci 34:1903-15. 2014
    ..Further investigation of n-3 PUFA neuroprotective mechanisms may accelerate the development of stroke therapies. ..
  11. pmc Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling
    R Anne Stetler
    Department of Neurology and Center of Cerebrovascular Diseases Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 28:13038-55. 2008
    ..Based on these findings, we conclude that overexpression of Hsp27 confers long-lasting neuroprotection against ischemic brain injury via a previously unexplored association and inhibition of ASK1 kinase signaling...
  12. pmc Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways
    Peter S Vosler
    Department of Neurology and Center of Cerebrovascular Diseases Research, University of Pittsburgh School of Medicine, PA 15213, USA
    Exp Neurol 218:213-20. 2009
    ..Collectively, these findings link the two seemingly independent mechanisms triggering AIF-induced neuronal death...
  13. pmc Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade
    Xiaoming Hu
    Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 31:247-61. 2011
    ..Our results also suggest that PRX2 and ASK1 may be potential targets for neuroprotective intervention in PD...
  14. ncbi request reprint Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling
    Zhongfang Weng
    Department of Neurology, and Pittsburgh Institute of Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 282:34479-91. 2007
    ..Collectively, these data provide evidence that leptin prevents the degeneration of dopaminergic neurons by 6-OHDA and may prove useful in the treatment of Parkinson disease...
  15. ncbi request reprint Erythropoietin protects CA1 neurons against global cerebral ischemia in rat: potential signaling mechanisms
    Feng Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci Res 83:1241-51. 2006
    ..These studies demonstrate that a single injection of EPO ICV up to 20 min after global ischemia is an effective neuroprotective agent and suggest that EPO is a viable candidate for treating global ischemic brain injury...
  16. pmc Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair
    Suping Wang
    Department of Neurology, S 507 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 39:2587-95. 2008
    ..The objective of this study was to determine the neuroprotective effects of NAD(+) repletion against ischemic injury and the underlying mechanism...
  17. doi request reprint Enhanced intracellular delivery and chemotherapy for glioma rats by transferrin-conjugated biodegradable polymersomes loaded with doxorubicin
    Zhiqing Pang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People s Republic of China, 201203
    Bioconjug Chem 22:1171-80. 2011
    ..These results indicated that Tf-PO-DOX could significantly enhance the intracellular delivery of DOX in glioma and the chemotherapeutic effect of DOX for glioma rats...
  18. ncbi request reprint Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection
    Yumin Luo
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Front Biosci 12:1852-62. 2007
    ..Further investigations elucidating the precise mechanism underlying the post-translational regulation of BER enzymes may lead to novel therapeutic strategies for cerebral ischemia...
  19. pmc Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury
    Feng Zhang
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Stroke 43:1390-7. 2012
    ..We hypothesize that chemically induced HO-1 upregulation with the novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imidazoline), a robust inducer of Phase 2 genes, protects neurons against ischemic injury...
  20. pmc Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia
    R Anne Stetler
    Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 107:3204-9. 2010
    ..Furthermore, the DNA repair function of APE1 was required for PACAP-mediated neuroprotection. Thus, induction of DNA repair enzymes may be a unique strategy for neuroprotection against hippocampal injury...
  21. pmc miR-15b suppression of Bcl-2 contributes to cerebral ischemic injury and is reversed by sevoflurane preconditioning
    Hong Shi
    State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    CNS Neurol Disord Drug Targets 12:381-91. 2013
    ....
  22. ncbi request reprint Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture
    Wenjin Li
    Geriatric Research Educational and Clinical Center 00 GR H, VA Pittsburgh Healthcare System, Highland Drive, Pittsburgh, PA 15205, USA
    Neurochem Res 33:490-9. 2008
    ..Overexpression of COX-2 did not increase expression of cyclin D1 or phosphoretinoblastoma protein (pRb), or cleavage of caspase 3 suggesting that this cell cycle mechanism does not mediate COX-2 toxicity in this model...
  23. ncbi request reprint TAT-mediated delivery of Bcl-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF
    Wei Yin
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neurobiol Dis 21:358-71. 2006
    ..Taken together, these results substantiate the feasibility of peripheral delivery of an anti-apoptotic factor into the brain of neonatal animals to reduce H-I-induced brain injury...
  24. ncbi request reprint Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia
    Feng Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 38:2329-36. 2007
    ..Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin was neuroprotective against ischemic brain injury...
  25. pmc Leptin protects hippocampal CA1 neurons against ischemic injury
    Feng Zhang
    Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 107:578-87. 2008
    ..Taken together, the results suggest that leptin protects against delayed ischemic neuronal death in the hippocampal CA1 by maintaining the pro-survival states of Akt and ERK1/2 MAPK signaling pathways...
  26. pmc Enhanced oligodendrogenesis and recovery of neurological function by erythropoietin after neonatal hypoxic/ischemic brain injury
    Masanori Iwai
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Stroke 41:1032-7. 2010
    ..Thus, we sought to determine the effects of delayed administration of EPO on white matter injury and recovery of neurological function after neonatal H/I...
  27. pmc Neuroprotection against hypoxic-ischemic brain injury by inhibiting the apoptotic protease activating factor-1 pathway
    Yanqin Gao
    State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Stroke 41:166-72. 2010
    ..This study was performed to determine whether targeted inhibition of the apoptotic protease activating factor-1 (Apaf-1) signaling pathway downstream of mitochondrial damage confers neuroprotection in rodent models of neonatal H-I...
  28. pmc Microglia/macrophage polarization dynamics in white matter after traumatic brain injury
    Guohua Wang
    1 State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China 2 Department of Neurology, Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 3 Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, Nantong, China
    J Cereb Blood Flow Metab 33:1864-74. 2013
    ..The M1 phenotypic shift may propel WMI progression and represents a rational target for TBI treatment. ..
  29. pmc Signal transducers and activators of transcription 5 contributes to erythropoietin-mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia
    Feng Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurobiol Dis 25:45-53. 2007
    ..These findings suggest an association between the activation of STAT5 and CA1 neuronal survival after cerebral ischemia...
  30. ncbi request reprint Preconditioning suppresses inflammation in neonatal hypoxic ischemia via Akt activation
    Wei Yin
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 38:1017-24. 2007
    ..Suppression of inflammation is a newly identified direct consequence of PI3-K/Akt signaling. We therefore investigated whether PI3-K/Akt suppresses inflammation and contributes to PC-induced neuroprotection...
  31. pmc When hypothermia meets hypotension and hyperglycemia: the diverse effects of adenosine 5'-monophosphate on cerebral ischemia in rats
    Feng Zhang
    Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, USA
    J Cereb Blood Flow Metab 29:1022-34. 2009
    ....
  32. doi request reprint Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    Xiaoming Hu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Stroke 43:3063-70. 2012
    ..A comprehensive characterization of microglia/macrophage polarization after ischemia may advance our knowledge of poststroke damage/recovery...
  33. pmc Omega-3 polyunsaturated fatty acid supplementation improves neurologic recovery and attenuates white matter injury after experimental traumatic brain injury
    Hongjian Pu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China
    J Cereb Blood Flow Metab 33:1474-84. 2013
    ..The protective impact of ω-3 PUFAs supports the clinical use of this dietary supplement as a prophylaxis against traumatic brain injury and other nervous system disorders. ..
  34. pmc Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke
    Peiying Li
    From the State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China P L, L M, X L, Y Gao, J C, X H Center of Cerebrovascular Disease Research P L, L M, Y Gan, J Z, J C, X H and Departments of Surgery and Immunology, Starzl Transplantation Institute A W T, University of Pittsburgh School of Medicine, PA Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, PA P L, X H and Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, People s Republic of China X L
    Stroke 45:857-64. 2014
    ..The mechanisms underlying Treg interactions with neutrophils remain elusive. This study evaluates the contribution of program death 1-ligand 1 (PD-L1) to Treg-mediated neutrophil inhibition and neuroprotection after cerebral ischemia...
  35. pmc Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury
    Wei Yin
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 39:3057-63. 2008
    ..In this study, we report for the first time rapidly increased mitochondrial biogenesis in a rat model of neonatal hypoxic/ischemic brain injury (H-I)...
  36. ncbi request reprint Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats
    Masanori Iwai
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Stroke 38:2795-803. 2007
    ..The current study investigates the effects of exogenous administration of EPO on revascularization and neurogenesis, 2 major events thought to contribute to neuronal replacement, in the neonatal brain after hypoxia/ischemia (H/I)...
  37. doi request reprint Activatable cell penetrating peptide-conjugated nanoparticles with enhanced permeability for site-specific targeting delivery of anticancer drug
    Huimin Xia
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, PR China
    Bioconjug Chem 24:419-30. 2013
    ..The findings suggested that ALMWP-NP could be used as a safe and effective tumor-targeting drug delivery system and opened a new gateway to the application of cell-penetrating peptides for targeted antitumor therapy...
  38. ncbi request reprint Sevoflurane preconditioning protects blood-brain-barrier against brain ischemia
    Qiong Yu
    Department of Anesthesiology of Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Front Biosci (Elite Ed) 3:978-88. 2011
    ..In conclusion, repeated sevoflurane preconditioning confered potent protection against brain ischemia, partly by improving BBB integrity...
  39. pmc Intracellular delivery mechanism and brain delivery kinetics of biodegradable cationic bovine serum albumin-conjugated polymersomes
    Zhiqing Pang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai
    Int J Nanomedicine 7:3421-32. 2012
    ..A novel brain drug delivery system using cationic bovine serum albumin (CBSA)-conjugated biodegradable polymersomes (CBSA-PO) was prepared, and its intracellular delivery mechanism and brain delivery kinetics were evaluated...
  40. pmc Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death
    Peter S Vosler
    Geriatric Research, Educational, and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 108:18102-7. 2011
    ..Collectively, these data demonstrate that calpain-mediated degradation of a translation initiation factor, eIF4G1, is a cause of both persistent PSI and neuronal death...
  41. ncbi request reprint Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2
    Ganwei Lu
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Signal 19:867-79. 2007
    ....
  42. pmc Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials
    Armando P Signore
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 106:1977-90. 2008
    ..Coupled with evidence that leptin dysregulation in human disease also results in enhanced neuronal susceptibility to damage, development of leptin as a therapeutic methodology is an attractive and viable possibility...
  43. pmc The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury
    Wenjin Li
    Geriatric Research Educational and Clinical Center, VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, Pennsylvania 15205, USA
    J Neurochem 113:965-77. 2010
    ..Taken together, these results indicate that the cyclooxygenase activity of COX-2 is necessary to exacerbate neuronal hypoxia/ischemia injury rather than the peroxidase activity of the enzyme...
  44. pmc Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone
    Elizabeth R Sharlow
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 283:33516-26. 2008
    ..In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential...
  45. doi request reprint Co-administration of dual-targeting nanoparticles with penetration enhancement peptide for antiglioblastoma therapy
    Deyu Miao
    Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P R China
    Mol Pharm 11:90-101. 2014
    ..The findings here suggested that the strategy by coadministrating BBB/BBTB and glioma cells dual-targeting nanocarriers with a tumor penetration enhancement peptide represent a promising platform for antiglioma drug delivery. ..
  46. pmc White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke
    Jun Suenaga
    Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 272:109-19. 2015
    ..Furthermore, aged mice exhibit deterioration of functional outcomes after stroke and this deterioration is linked to white matter damage and reductions in M2 microglia/macrophage polarization. ..
  47. pmc Apurinic/apyrimidinic endonuclease 1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury
    Rehana K Leak
    1 State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Antioxid Redox Signal 22:135-48. 2015
    ..We tested the hypothesis that APE1 upregulation protects neuronal structure and function against transient global cerebral ischemia (tGCI)...
  48. pmc Adoptive regulatory T-cell therapy protects against cerebral ischemia
    Peiying Li
    Anesthesiology Department of Huashan Hospital, State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Ann Neurol 74:458-71. 2013
    ..We therefore evaluated the effect of Treg transfer in rodent models of ischemic stroke and further investigated the mechanism underlying Treg-afforded neuroprotection...
  49. pmc Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection
    Peiying Li
    Anesthesiology Department of Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Antioxid Redox Signal 14:1905-18. 2011
    ..Further understanding of mechanisms for oxidative DNA damage and its repair processes may lead to new avenues for stroke management...
  50. pmc Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury
    Yejie Shi
    Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Nat Commun 7:10523. 2016
    ..Thus, we identify a previously unexplored role for early BBB disruption in stroke outcomes, whereby BBB rupture may be a cause rather than a consequence of parenchymal cell injury. ..
  51. ncbi request reprint Sevoflurane preconditioning confers neuroprotection via anti-inflammatory effects
    Hailian Wang
    State Key Laboratory of Medical Neurobiology, Department of Anesthesiology of Huashan Hospital, Fudan University, Shanghai, China
    Front Biosci (Elite Ed) 3:604-15. 2011
    ..Thus, the data suggest that APC with sevoflurane confers neuroprotection against focal ischemic brain injury, at least in part, by the anti-inflammatory effects of sevoflurane...
  52. ncbi request reprint BimEL up-regulation potentiates AIF translocation and cell death in response to MPTP
    Anthony K F Liou
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    FASEB J 19:1350-2. 2005
    ....
  53. ncbi request reprint Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death
    Armando P Signore
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 96:428-43. 2006
    ..These studies suggest that erythropoietin can be an effective neuroprotective agent for dopaminergic neurons, and may be useful in reversing behavioral deficits associated with Parkinson's disease...
  54. pmc Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells
    Charleen T Chu
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 94:1685-95. 2005
    ..Studies of primary mouse midbrain cultures further supported a role for AIF in caspase-independent cell death in MPP+-treated dopaminergic neurons...
  55. ncbi request reprint Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 23:1137-50. 2003
    ....
  56. pmc A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activities
    Jun Chen
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Carcinogenesis 32:1198-206. 2011
    ....
  57. ncbi request reprint Focal cerebral ischemia activates neurovascular restorative dynamics in mouse brain
    Min Chu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China
    Front Biosci (Elite Ed) 4:1926-36. 2012
    ..However, axon damage and the loss of white matter integrity after ischemic stroke were almost irreversible, as revealed by sustained decreases of myelin basic protein (MBP) and neurofilament-200 expression...
  58. pmc Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia
    Xiangrong Liu
    From the Department of Neurology, University of Pittsburgh School of Medicine, PA X L, S Z, H Z, W C, J C, X H Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, P R China X L, X J State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences, Fudan University, Shanghai, China J L, M C, Y G, J C, X H Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA R K L and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, PA J C, X H
    Stroke 47:498-504. 2016
    ..Thus, we examined the effect of IL-4 on long-term recovery and microglia/macrophage polarization in 2 well-established stroke models...
  59. pmc Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury
    Jiayin Wang
    1 Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China 2 Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sci Rep 5:9621. 2015
    ..In sum, s-NSC transplantation confers robust neuroprotection against cerebral ischemia, probably by alleviating white matter injury and modulating microglial/macrophage function. ..
  60. pmc Drug-induced hypothermia in stroke models: does it always protect?
    Meijuan Zhang
    Department of Neurology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15213, USA
    CNS Neurol Disord Drug Targets 12:371-80. 2013
    ..This article provides guidance for future clinical trials and animal studies on pharmacological cooling in the setting of acute stroke...
  61. ncbi request reprint Delivery of neurotherapeutics across the blood brain barrier in stroke
    Xiaoming Hu
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China
    Curr Pharm Des 18:3704-20. 2012
    ..Continuing modifications and improvements of CPPs are expected to enhance both their feasibility in clinical stroke management and their specificity towards particular cell types...
  62. pmc n-3 PUFA supplementation benefits microglial responses to myelin pathology
    Songela Chen
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Sci Rep 4:7458. 2014
    ..These results suggest that n-3 PUFAs may be clinically useful as immunomodulatory agents for demyelinating diseases through a novel mechanism involving microglial phenotype switching. ..
  63. doi request reprint Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2
    Jun Chen
    Departments of Pharmacology, and Urology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Res 68:3844-53. 2008
    ..In summary, our data indicate that PKD3 contributes to growth and survival of prostate cancer cells and may represent a novel therapeutic target for prostate cancer...
  64. pmc Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke
    Jiayin Wang
    Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
    Neurobiol Dis 68:91-103. 2014
    ..Taken together, our findings strongly suggest that n-3 PUFA supplementation is a potential angiogenic treatment capable of augmenting brain repair and improving long-term functional recovery after cerebral ischemia. ..
  65. ncbi request reprint Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family
    Jun Chen
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem J 411:333-42. 2008
    ..In summary, individual C1 domains of PKD isoforms differ in ligand-binding activity and selectivity, implying isoform-selective regulation of PKD by phorbol esters and DAG...
  66. pmc Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury
    Zheng Jing
    1 Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA 2 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Cereb Blood Flow Metab 34:1613-21. 2014
    ..These data suggest a novel neuroprotective role for secreted NAMPT in the protection of white matter after ischemic injury. ..
  67. ncbi request reprint Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway
    Wenjin Li
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 26:181-98. 2006
    ..These results suggest that the activation of the BER pathway may contribute to IP-induced neuroprotection by enhancing the repair of endogenous oxidative DNA damage after ischemic injury...
  68. ncbi request reprint Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway
    Yanqin Gao
    Department of Neurology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Cereb Blood Flow Metab 25:694-712. 2005
    ....
  69. pmc Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai Medical College, Shanghai 200032, China Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, USA
    Prog Neurobiol 114:58-83. 2014
    ..In this review, we focus on the experimental evidence of preconditioning in the brain and systematically survey the models used to develop paradigms for neuroprotection, and then discuss the clinical potential of brain preconditioning. ..
  70. pmc Microglial and macrophage polarization—new prospects for brain repair
    Xiaoming Hu
    Centre of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Nat Rev Neurol 11:56-64. 2015
    ..Breakthroughs in the identification of regulatory molecules that control these phenotypic shifts could ultimately accelerate research towards curing brain disorders. ..
  71. ncbi request reprint 6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression
    Qinghua Liang
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci Res 77:747-61. 2004
    ....
  72. pmc Bid-cardiolipin interaction at mitochondrial contact site contributes to mitochondrial cristae reorganization and cytochrome C release
    Tae Hyoung Kim
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Biol Cell 15:3061-72. 2004
    ..These findings thus suggest that interactions of Bid with mitochondrial cardiolipin at the contact site can contribute significantly to its functions...
  73. pmc Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility
    Courtney R LaValle
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    BMC Chem Biol 10:5. 2010
    ..In an effort to further enhance its selectivity and potency for potential in vivo application, small molecule analogs of CID755673 were generated by modifying both the core structure and side-chains...
  74. pmc Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles
    Xiaoming Hu
    Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15240, USA Electronic address
    Prog Neurobiol 119:60-84. 2014
    ..Specific regulation of theses microglial receptors may be a promising therapeutic strategy against CNS injuries. ..
  75. pmc HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis
    Guohua Wang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213
    Proc Natl Acad Sci U S A 112:2853-8. 2015
    ..Thus, inhibition of HDACs in microglia is a potential future therapy in TBI and other neurological conditions with white matter destruction. ..
  76. pmc Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia
    Peiying Li
    From the Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA P L, L M, J C, X H Anesthesiology Department of Huashan Hospital, State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China P L, L M, J C, X H Department of Neurology and Key Laboratory of Cerebral Microcirculation, University of Shandong, Taian, Shandong, China G Z, B L S Affiliated Hospital of Taishan Medical College, Taian, Shandong, China G Z, B L S Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA R K L and Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA J C, X H
    Stroke 44:3509-15. 2013
    ..However, the effect of Tregs on systemic inflammatory responses and immune status has not been fully characterized...
  77. ncbi request reprint Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection
    Xunming Ji
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Front Biosci 12:1737-47. 2007
    ..These results suggest that the attenuation of oxidative DNA damage and DNA damage-triggered pro-death signaling events may be an important mechanism underlying the neuroprotective effect of mild hypothermia against ischemic brain injury...
  78. ncbi request reprint Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia
    Xiao Ming Yin
    Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    J Biol Chem 277:42074-81. 2002
    ..Thus, the role of Bid in the induction of ischemic neuronal death may render this molecule an attractive target for future therapeutic intervention...
  79. ncbi request reprint Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion
    Jing Lan
    Department of Neurology and Pittsburgh Institute of Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 23:1324-39. 2003
    ..These results strongly suggest that inducible DNA BER constitutes an important endogenous mechanism that protects brain against ischemia-induced oxidative neuronal injury...
  80. ncbi request reprint PCR expression mutagenesis: a high-throughput mutation assay applied to the glucocorticoid receptor ligand-binding domain
    Jun Chen
    Steroid Hormones Section, NIDDK LMCB, National Institutes of Health, Bethesda, MD, USA
    Biochem Biophys Res Commun 321:893-9. 2004
    ..In combination with automation, PEM provides a more rapid and efficient tool for probing the role of each amino acid in the biological functions of a given protein...
  81. ncbi request reprint Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus
    Kenji Kawaguchi
    Department of Neurology, University of Pittsburgh, PA 15260, USA
    Brain Res 1050:130-7. 2005
    ..These results suggest that COX-2 activity can contribute to epileptic neuronal injury and that selective COX-2 inhibitors are neuroprotective...
  82. pmc Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury
    Ling Zhang
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Tissue Eng Part A 19:1909-18. 2013
    ..The present study demonstrated that UBM is not only biocompatible within the brain tissue, but also can exert protective effects upon injured brain. ..
  83. pmc Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    Meijuan Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai, China
    Prog Neurobiol 100:30-47. 2013
    ..Following this background, we expand our discussion to the neuroprotective effects of phase II enzymes and the potential application of Nrf2 inducers to the treatment of neurological diseases...
  84. ncbi request reprint Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells
    Wei Pei
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    FASEB J 17:520-2. 2003
    ..Taken together, these results suggest that there are two routes by which cortical neurons degenerate during ischemic injury or in neurodegenerative diseases...
  85. pmc Mitochondrial targets for stroke: focusing basic science research toward development of clinically translatable therapeutics
    Peter S Vosler
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 40:3149-55. 2009
    ..Despite many promising prospects, attempts at translating neuroprotective agents that show success in animal models of stroke have resulted in very limited clinical success...
  86. pmc Protective effects and mechanisms of sirtuins in the nervous system
    Feng Zhang
    State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China
    Prog Neurobiol 95:373-95. 2011
    ....
  87. pmc Heat shock proteins: cellular and molecular mechanisms in the central nervous system
    R Anne Stetler
    Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261, United States
    Prog Neurobiol 92:184-211. 2010
    ....
  88. ncbi request reprint Enhancement of metabolic oxidative stress-induced cytotoxicity by the thioredoxin inhibitor 1-methylpropyl 2-imidazolyl disulfide is mediated through the ASK1-SEK1-JNK1 pathway
    Yong J Lee
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Mol Pharmacol 62:1409-17. 2002
    ..Therefore, IV-2 enhances glucose deprivation-induced cytotoxicity by promoting glucose deprivation-induced activation of the ASK1-SEK1-JNK1 pathway...
  89. pmc The dynamics of the mitochondrial organelle as a potential therapeutic target
    R Anne Stetler
    State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University Shanghai Medical College, Shanghai, China
    J Cereb Blood Flow Metab 33:22-32. 2013
    ..An overview of the system as it is currently understood is presented, and current assessment strategies and their limitations are discussed...
  90. ncbi request reprint To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways
    Anthony K F Liou
    Department of Neurology, University of Pittsburgh School of Medicine, S526 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Prog Neurobiol 69:103-42. 2003
    ..Hopefully, this added research effort will provide a more detailed knowledge from which better therapeutic strategies can be developed to treat these acute brain injuries...
  91. ncbi request reprint Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes
    Jun Chen
    Department of Pharmacology, University of Pittsburgh, E1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Mol Pharmacol 67:152-62. 2005
    ..Taken together, our results indicate that PKD, specifically PKD3, directly contributes to insulin-independent basal glucose uptake in L6 skeletal muscle cells...
  92. ncbi request reprint Differential expression of splice variants of chemokine CCL27 mRNA in lens, cornea, and retina of the normal mouse eye
    Dolena R Ledee
    National Eye Institute, NIH, Bethesda, MD, USA
    Mol Vis 10:663-7. 2004
    ..Constitutive expression of RNA sequences complementary to the chemokine CCL27 mRNA has been found in the normal mouse eye. This study examines the nature and location of these endogenous RNAs in ocular tissues...
  93. ncbi request reprint Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex
    Jun Chen
    Steroid Hormones Section, NIDDK LMCB, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
    Biochemistry 43:245-55. 2004
    ..Finally, as the domain organization of GMEB-2 and -1 is extremely similar, we conclude that the quantitative differences in activities derive from variations in amino acid sequence rather than more global features of protein structure...
  94. ncbi request reprint Cloning of a novel Apaf-1-interacting protein: a potent suppressor of apoptosis and ischemic neuronal cell death
    Guodong Cao
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 24:6189-201. 2004
    ....
  95. ncbi request reprint Individual C1 domains of PKD3 in phorbol ester-induced plasma membrane translocation of PKD3 in intact cells
    Gülsüm Anderson
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cell Signal 17:1397-411. 2005
    ..PKC, by directly activating PKD3, regulates its plasma membrane localization in intact cells...
  96. ncbi request reprint Correlations between edema and the immediate and prolonged painful consequences of inflammation: therapeutic implications?
    William R Lariviere
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Sheng Li Xue Bao 57:278-88. 2005
    ..This analysis represents a method for determining which inflammatory processes are the most promising therapeutic targets against the multiple painful consequences of inflammation...
  97. ncbi request reprint In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis
    Guodong Cao
    Department of Neurology and Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:5423-31. 2002
    ....
  98. pmc Monocyte chemotactic protein 1 promotes lung cancer-induced bone resorptive lesions in vivo
    Zhong Cai
    Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA 15240, USA
    Neoplasia 11:228-36. 2009
    ..The MCP-1 knockdown significantly diminished A549 cell growth. We conclude that MCP-1 promotes lung cancer-induced osteoclast activity and thus bone resorptive lesions in vivo...
  99. ncbi request reprint Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
    Shuchen Li
    Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Biol Chem 277:26912-20. 2002
    ..Together, these events ensure a successful progression of the death program initiated by the death receptor activation in the hepatocyte...
  100. ncbi request reprint Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria
    Dexi Chen
    Department of Neurology, Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 81:1273-84. 2002
    ..These results strongly suggest that the decline in BER activity may be an important mechanism contributing to the age-dependent accumulation of oxidative DNA lesions in brain mitochondria...
  101. ncbi request reprint Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite
    Xiaopeng Zhang
    Department of Anesthesiology and Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    J Neurochem 82:181-91. 2002
    ....

Research Grants4

  1. Programmed Cell Death Induced by Cerebral Ischemia
    Jun Chen; Fiscal Year: 2006
    ..abstract_text> ..
  2. Apoptosis Execution Pathways in Dopaminergic Cell Death
    Jun Chen; Fiscal Year: 2007
    ..3. Test the hypotheses that Bax is a direct mediator for AIF release, and Bax contributes to dopaminergic cell death by activating both AIF-dependent and caspase-dependent pathways. ..
  3. Neuroprotective effect of HSP27 in Cerebral Ischemia
    Jun Chen; Fiscal Year: 2010
    ..The in vitro models will complement the in vivo studies by allowing for precise mechanistic studies to be performed. ..