Jinbo Chen

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Semiparametric maximum likelihood methods for analyzing genetic and environmental effects with case-control mother-child pair data
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biometrics 68:869-77. 2012
  2. pmc Efficient designs of gene-environment interaction studies: implications of Hardy-Weinberg equilibrium and gene-environment independence
    Jinbo Chen
    Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Stat Med 31:2516-30. 2012
  3. pmc Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Infect Agent Cancer 6:6. 2011
  4. doi request reprint Likelihood ratio tests for maternal and fetal genetic effects on obstetric complications
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genet Epidemiol 33:526-38. 2009
  5. doi request reprint Testing Hardy-Weinberg equilibrium using mother-child case-control samples
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genet Epidemiol 33:539-48. 2009
  6. pmc Incremental impact of breast cancer SNP panel on risk classification in a screening population of white and African American women
    Anne Marie McCarthy
    Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Room 1009, Philadelphia, PA 19104, USA
    Breast Cancer Res Treat 138:889-98. 2013
  7. doi request reprint A multi-locus likelihood method for assessing parent-of-origin effects using case-control mother-child pairs
    Dongyu Lin
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Genet Epidemiol 37:152-62. 2013
  8. pmc Two-stage extreme phenotype sequencing design for discovering and testing common and rare genetic variants: efficiency and power
    Guolian Kang
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Hered 73:139-47. 2012
  9. pmc Mammographic parenchymal patterns as an imaging marker of endogenous hormonal exposure: a preliminary study in a high-risk population
    Dania Daye
    Department of Bioengineering, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Acad Radiol 20:635-46. 2013
  10. pmc New genetic variant that might improve warfarin dose prediction in African Americans
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Pittsburgh, PA 19104 6021, USA
    Br J Clin Pharmacol 70:393-9. 2010

Detail Information

Publications40

  1. doi request reprint Semiparametric maximum likelihood methods for analyzing genetic and environmental effects with case-control mother-child pair data
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biometrics 68:869-77. 2012
    ..We demonstrated the performance of our method through extensive simulation studies and the analysis of data from the Jerusalem Perinatal Study...
  2. pmc Efficient designs of gene-environment interaction studies: implications of Hardy-Weinberg equilibrium and gene-environment independence
    Jinbo Chen
    Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Stat Med 31:2516-30. 2012
    ..In addition, supplementing external control data to an existing case-control sample leads to improved power for assessing effects of G or E in the presence of G-E interactions...
  3. pmc Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Infect Agent Cancer 6:6. 2011
    ..The low seroprevalence of S. Typhi in Shanghai is unlikely to explain the high incidence of biliary cancers in this population...
  4. doi request reprint Likelihood ratio tests for maternal and fetal genetic effects on obstetric complications
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genet Epidemiol 33:526-38. 2009
    ..We demonstrate our new methods by applying them to the analysis of data from a pilot study of preeclampsia...
  5. doi request reprint Testing Hardy-Weinberg equilibrium using mother-child case-control samples
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genet Epidemiol 33:539-48. 2009
    ..On the basis of extensive simulation studies to compare the type-I error and power for proposed tests, we recommend the third combined test statistic for routine use in the analysis of case-control studies of mother-child pairs...
  6. pmc Incremental impact of breast cancer SNP panel on risk classification in a screening population of white and African American women
    Anne Marie McCarthy
    Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Room 1009, Philadelphia, PA 19104, USA
    Breast Cancer Res Treat 138:889-98. 2013
    ..Further research is needed to determine the clinical validity and utility of the SNP panel for use in breast cancer risk prediction, particularly among African Americans for whom these risk alleles have generally not been validated...
  7. doi request reprint A multi-locus likelihood method for assessing parent-of-origin effects using case-control mother-child pairs
    Dongyu Lin
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Genet Epidemiol 37:152-62. 2013
    ..We demonstrate our method by examining parent-of-origin effects of the gene PPARGC1A on low birth weight using data from 636 mother-child pairs in the Jerusalem Perinatal Study...
  8. pmc Two-stage extreme phenotype sequencing design for discovering and testing common and rare genetic variants: efficiency and power
    Guolian Kang
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Hered 73:139-47. 2012
    ....
  9. pmc Mammographic parenchymal patterns as an imaging marker of endogenous hormonal exposure: a preliminary study in a high-risk population
    Dania Daye
    Department of Bioengineering, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Acad Radiol 20:635-46. 2013
    ..Here, we investigate the potential of mammographic parenchymal texture as a phenotypic imaging marker of endogenous hormonal exposure...
  10. pmc New genetic variant that might improve warfarin dose prediction in African Americans
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics, Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Pittsburgh, PA 19104 6021, USA
    Br J Clin Pharmacol 70:393-9. 2010
    ..However, these factors seem to explain less of the dose variability in African Americans who have a lower prevalence of the CYP2C9*2 and *3 and VKORC1 1173T alleles...
  11. ncbi request reprint Exploiting Hardy-Weinberg equilibrium for efficient screening of single SNP associations from case-control studies
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Hered 63:196-204. 2007
    ..We conclude that the novel test would be particularly useful for analyzing data from the initial 'screening' stages of contemporary multi-stage association studies...
  12. pmc Reader variability in breast density estimation from full-field digital mammograms: the effect of image postprocessing on relative and absolute measures
    Brad M Keller
    Department of Radiology, University of Pennsylvania Perelman School of Medicine, 3600 Market St Suite 360, Philadelphia, PA 19104, USA
    Acad Radiol 20:560-8. 2013
    ....
  13. pmc Assessing the fit of parametric cure models
    E Paul Wileyto
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biostatistics 14:340-50. 2013
    ..We derive the asymptotic distribution of the residuals and evaluate their performance by simulation in a range of parametric models. We apply our approach to data from a smoking cessation drug trial...
  14. ncbi request reprint Projecting absolute invasive breast cancer risk in white women with a model that includes mammographic density
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Natl Cancer Inst 98:1215-26. 2006
    ..In this study, we developed the corresponding model for absolute risk...
  15. ncbi request reprint Pretreatment vitamin D level and response to neoadjuvant chemotherapy in women with breast cancer on the I-SPY trial (CALGB 150007/150015/ACRIN6657)
    Amy S Clark
    Abramson Cancer Center, Philadelphia, Pennsylvania Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Division of Hematology Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Cancer Med 3:693-701. 2014
    ..However, vitD levels had no impact on tumor response to NACT or short-term prognosis...
  16. pmc Breast cancer risk prediction and mammography biopsy decisions: a model-based study
    Katrina Armstrong
    Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Prev Med 44:15-22. 2013
    ..Controversy continues about screening mammography, in part because of the risk of false-negative and false-positive mammograms. Pre-test breast cancer risk factors may improve the positive and negative predictive value of screening...
  17. pmc Germline genetic variation and treatment response on CCG-1891
    Dana M Sepe
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Pediatr Blood Cancer 58:695-700. 2012
    ..We sought to extend current knowledge by using standard and novel statistical methodology to examine polymorphic variants of genes and relapse risk, toxicity, and drug dose delivery in standard risk ALL...
  18. doi request reprint Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer
    Angela DeMichele
    Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Cancer Res 69:4184-91. 2009
    ..Kaplan-Meier plots show that all patients in this group relapsed by 24 months from diagnosis. This poor-risk haplotype was quite common overall (estimated frequency, 0.20) and twice as frequent among Blacks (estimated frequency, 0.41)...
  19. ncbi request reprint A partially linear tree-based regression model for assessing complex joint gene-gene and gene-environment effects
    Jinbo Chen
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genet Epidemiol 31:238-51. 2007
    ..The proposed model is also useful for exploring gene-environment interactions and has broad implications for applying the tree methodology to genetic epidemiology research...
  20. ncbi request reprint A haplotype-based test of association using data from cohort and nested case-control epidemiologic studies
    Jinbo Chen
    Biostatistics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Hum Hered 58:18-29. 2004
    ..Utilizing simulated data in the context of two genomic regions GPX1 and GPX3, we evaluate the validity of the proposed test for small sample sizes and study its power in the presence and absence of missing genotype data...
  21. pmc Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:525-34. 2008
    ..5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct...
  22. ncbi request reprint Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma
    Roxana Moslehi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 8047, Rockville, MD 20852 USA
    Pharmacogenomics 7:819-29. 2006
    ..Our interest is in the polymorphisms within the NAT1 and NAT2 genes that influence the tobacco-colorectal tumor relationship by impacting on the metabolic activation and detoxification of tobacco smoke-derived carcinogens...
  23. ncbi request reprint Haplotype-based association analysis in cohort and nested case-control studies
    Jinbo Chen
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, Maryland 20852, USA
    Biometrics 62:28-35. 2006
    ..The performance of the proposed estimators is assessed via simulation studies. An application of the proposed method is presented, using data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study...
  24. ncbi request reprint Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 29:568-72. 2008
    ....
  25. ncbi request reprint Genetic polymorphisms in folate metabolism and the risk of stomach cancer
    Fang Fang Zhang
    Division of Cancer Epidemiology and Genetics, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 16:115-21. 2007
    ..Our study did not identify strong genetic determinants in the folate metabolism pathway for stomach cancer risk...
  26. ncbi request reprint Conditional likelihood methods for haplotype-based association analysis using matched case-control data
    Jinbo Chen
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, Maryland 20852, USA
    Biometrics 63:1099-107. 2007
    ..We applied the two methods to analyze a matched case-control study of prostate cancer...
  27. ncbi request reprint Genetic variation and willingness to participate in epidemiologic research: data from three studies
    Parveen Bhatti
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7091, MSC 7238, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 14:2449-53. 2005
    ..To the extent possible, investigators should evaluate their own genetic data for bias in response categories...
  28. ncbi request reprint Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men
    Sophie D Fossa
    Department of Clinical Cancer Research, The Norwegian Radium Hospital, University of Oslo, Norway
    J Natl Cancer Inst 97:1056-66. 2005
    ..We evaluated the risk of contralateral testicular cancer and survival in a large population-based cohort of men diagnosed with testicular cancer before age 55 years...
  29. ncbi request reprint Mannose-binding lectin-2 genetic variation and stomach cancer risk
    Andrea Baccarelli
    EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
    Int J Cancer 119:1970-5. 2006
    ..6-7.6; p = 0.001). Our findings suggest that the codon 52 D MBL2 variant causing a cysteine > arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk...
  30. ncbi request reprint Antibody responses to simian virus 40 T antigen: a case-control study of non-Hodgkin lymphoma
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8010, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:521-4. 2005
    ..We found no association between the presence of T antibody and NHL, arguing against SV40 as a cause of NHL. Infrequent and low-level T antibody responses among humans could represent cross-reactivity to BK virus T antigen...
  31. ncbi request reprint Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China
    Lori C Sakoda
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7234, USA
    Carcinogenesis 27:1251-6. 2006
    ..Further investigation is needed to confirm and extend our findings in studies of biliary tract cancer that more comprehensively examine PTGS2 and other inflammation-related genes...
  32. ncbi request reprint Biliary tract cancer and stones in relation to chronic liver conditions: A population-based study in Shanghai, China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 120:1981-5. 2007
    ..Given that chronic infection with hepatitis B virus (HBV) is the most common cause of liver disease in China, serologic markers of HBV need to be measured in future studies to examine the link between HBV and bile duct cancer...
  33. pmc Family history of gallstones and the risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20852, USA
    Int J Cancer 121:832-8. 2007
    ....
  34. ncbi request reprint Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland
    Fang Fang Zhang
    Department of Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Cancer 121:2060-4. 2007
    ..Furthermore, heavy drinkers of alcohol who were genetically prone to accumulate acetaldehyde may face an increased risk of stomach cancer...
  35. ncbi request reprint MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:2530-6. 2007
    ..The role of MSR1 warrants further investigation in larger studies and other populations...
  36. pmc Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 122:2322-9. 2008
    ..Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis...
  37. doi request reprint Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk
    Victoria L Stevens
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    Int J Cancer 123:2644-50. 2008
    ..55, 95% CI: 0.33, 0.90). Our study suggest that a common haplotype in the TLR10-TLR1-TLR6 gene cluster influences prostate cancer risk and clearly supports the need for further investigation of TLR genes in other populations...
  38. pmc Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics and Office of Preventive Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
    Cancer Res 68:6442-52. 2008
    ....
  39. doi request reprint Polymorphisms in angiogenesis-related genes and prostate cancer
    Eric J Jacobs
    Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 17:972-7. 2008
    ..Potentially functional single nucleotide polymorphisms (SNP) in genes important in prostate angiogenesis (VEGF, HIF1A, and NOS3) have previously been associated with risk or severity of prostate cancer...
  40. pmc Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 29:944-8. 2008
    ..Results from this population-based study suggest that certain genetic variants involved in the regulation of obesity-related insulin sensitivity may increase susceptibility to bile duct cancer and gallstones...

Research Grants5

  1. A partially Linear Tree-based Regression Model for Assessing Complex Joint Gene-g
    Jinbo Chen; Fiscal Year: 2007
    ..The second specific aim is to apply the developed method in analyses of several cancer genetic epidemiology studies to explore joint gene-gene or gene-environment interactions. ..
  2. Statistical Methods in Genetic Epidemiology Research
    Jinbo Chen; Fiscal Year: 2009
    ..The proposed methods are for the estimation and testing of maternal and offspring genotype/haplotype main effects and interactions and interaction effects between genotypes/haplotypes and environment variables. ..
  3. Statistical Methods in Genetic Epidemiology Research
    Jinbo Chen; Fiscal Year: 2010
    ..Fully documented software to implement these methods for public use will be provided using freely available statistical package R. ..