Jie Chen

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. pmc Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 284:35425-32. 2009
  2. pmc mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, USA
    Am J Physiol Cell Physiol 297:C1434-44. 2009
  3. doi request reprint PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    J Cell Sci 121:282-9. 2008
  4. pmc Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
    Yuting Sun
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Cell Biol 189:1157-69. 2010
  5. ncbi request reprint Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 283:708-15. 2008
  6. pmc Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components
    Ai Luen Wu
    Department of Cell and Developmental Biology, 601 South Goodwin Avenue, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Endocrinology 149:1407-14. 2008
  7. pmc IGF-II is regulated by microRNA-125b in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 192:69-81. 2011
  8. pmc Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes
    Chongben Zhang
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Am J Physiol Endocrinol Metab 296:E862-8. 2009
  9. pmc Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 195:435-47. 2011
  10. pmc XPLN is an endogenous inhibitor of mTORC2
    Nidhi Khanna
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Proc Natl Acad Sci U S A 110:15979-84. 2013

Research Grants

  1. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2010
  2. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2007
  3. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2004
  4. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2009

Collaborators

Detail Information

Publications27

  1. pmc Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 284:35425-32. 2009
    ....
  2. pmc mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, USA
    Am J Physiol Cell Physiol 297:C1434-44. 2009
    ..Therefore, mTOR regulates muscle regeneration through kinase-independent and kinase-dependent mechanisms at the stages of nascent myofiber formation and myofiber growth, respectively...
  3. doi request reprint PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    J Cell Sci 121:282-9. 2008
    ..Furthermore, exogenous IGF2 fully rescues the differentiation defect resulting from PLD1 knockdown. Hence, PLD1 is critically involved in skeletal myogenesis by regulating the mTOR-IGF2 pathway...
  4. pmc Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
    Yuting Sun
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Cell Biol 189:1157-69. 2010
    ....
  5. ncbi request reprint Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 283:708-15. 2008
    ..Taken together, we propose that mTOR plays a key role in IL-6-induced hepatic insulin resistance by regulating STAT3 activation and subsequent SOCS3 expression...
  6. pmc Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components
    Ai Luen Wu
    Department of Cell and Developmental Biology, 601 South Goodwin Avenue, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Endocrinology 149:1407-14. 2008
    ..Moreover, the addition of exogenous IGF-II fully rescues myocyte differentiation from FoxO inhibition. Taken together, we propose that the mTOR-IGF-II pathway is a major mediator of FoxO's inhibitory function in skeletal myogenesis...
  7. pmc IGF-II is regulated by microRNA-125b in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 192:69-81. 2011
    ....
  8. pmc Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes
    Chongben Zhang
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Am J Physiol Endocrinol Metab 296:E862-8. 2009
    ..Therefore, we propose that nutrient sufficiency, mediated by an mTOR pathway, suppresses TGH-dependent lipolysis stimulated by chronic insulin exposure in adipocytes...
  9. pmc Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 195:435-47. 2011
    ..Finally, we show that the hVps34-PLD1 pathway acts independently of, and in parallel to, the Rag pathway in regulating amino acid activation of mTORC1...
  10. pmc XPLN is an endogenous inhibitor of mTORC2
    Nidhi Khanna
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Proc Natl Acad Sci U S A 110:15979-84. 2013
    ..Our study identifies XPLN as an endogenous inhibitor of mTORC2 and delineates a noncanonical mechanism of XPLN action. ..
  11. pmc Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1)
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 286:35675-82. 2011
    ..These findings underscore the versatility of mTOR signaling in biological regulations and implicate the existence of novel mTOR complexes and/or signaling mechanism in skeletal myogenesis...
  12. pmc mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells
    Jiaxi Zhou
    Department of Cell and Developmental Biology and Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:7840-5. 2009
    ..These results uncover a novel signaling mechanism by which mTOR controls fate decisions in hESCs. Our findings may contribute to effective strategies for tissue repair and regeneration...
  13. doi request reprint Interleukin-6 and insulin resistance
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Vitam Horm 80:613-33. 2009
    ..Herein we review the in vivo and in vitro studies that have examined the role of IL-6 in insulin signaling and glucose metabolism in the insulin target tissues: liver, adipose, and skeletal muscle...
  14. pmc Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 286:29568-74. 2011
    ..In conclusion, we propose a dual mechanism for PA activation of mTORC1: PA displaces FKBP38 from mTOR and allosterically stimulates the catalytic activity of mTORC1...
  15. ncbi request reprint A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
    Rebecca A Bachmann
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA
    J Biol Chem 281:7357-63. 2006
    ..Taken together, our observations suggest the existence of a nuclear shuttling signal in mTOR and provide definitive evidence for the requirement of mTOR nuclear import in its cytoplasmic signaling to S6K1...
  16. pmc Flt3L is a novel regulator of skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    J Cell Sci 126:3370-9. 2013
    ..In summary, our work reveals an unexpected role for an immunoregulatory cytokine in skeletal myogenesis and a new myogenic pathway. ..
  17. pmc Mechanistic target of rapamycin controls homeostasis of adipogenesis
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Lipid Res 54:2166-73. 2013
    ..Our observations reveal an unexpected role of mTOR in suppressing adipogenesis and suggest that mTOR governs the homeostasis of the adipogenic process by modulating multiple signaling pathways. ..
  18. pmc MicroRNAs in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Cell Cycle 10:441-8. 2011
    ..Emerging themes of miRNA regulation in the context of skeletal myogenesis will also be discussed...
  19. ncbi request reprint Mammalian target of rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation
    In Hyun Park
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 280:32009-17. 2005
    ....
  20. ncbi request reprint mTOR signaling: PLD takes center stage
    Yuting Sun
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cell Cycle 7:3118-23. 2008
    ..We also consider the implications from several recent findings and propose mechanistic models of PLD-mTOR signaling to be tested in the near future...
  21. ncbi request reprint Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1
    In Hyun Park
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Exp Cell Res 309:211-9. 2005
    ....
  22. pmc Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 287:43928-35. 2012
    ..Current questions for future studies are also highlighted...
  23. ncbi request reprint regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis
    Jae Eun Kim
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107 Urbana, IL 61801, USA
    Diabetes 53:2748-56. 2004
    ....
  24. pmc RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS ONE 8:e68068. 2013
    ....
  25. pmc Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton
    Yuan He
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801 Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801 Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Mol Biol Cell 24:3369-80. 2013
    ..Together our findings reveal an mTORC2- and mTOR kinase-independent function and mechanism of Rictor in the regulation of neutrophil chemotaxis. ..
  26. pmc Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Mol Biol Cell 24:3754-63. 2013
    ..Our results uncover amino acid-sensing mechanisms controlling the homeostasis of myogenesis and underline the versatility and context dependence of mTOR signaling. ..
  27. pmc IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
    Ebru Erbay
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107, Urbana, IL 61801, USA
    J Cell Biol 163:931-6. 2003
    ..Our findings represent the first identification of a signaling pathway that regulates IGF-II expression in myogenesis and implicate the mTOR-IGF axis as a molecular link between nutritional levels and skeletal muscle development...

Research Grants14

  1. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2010
    ....
  2. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2007
    ....
  3. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2004
    ..abstract_text> ..
  4. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2009
    ....