Jie Chen

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. pmc Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
    Yuting Sun
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Cell Biol 189:1157-69. 2010
  2. pmc Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 195:435-47. 2011
  3. pmc RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS ONE 8:e68068. 2013
  4. pmc IGF-II is regulated by microRNA-125b in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 192:69-81. 2011
  5. pmc Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 284:35425-32. 2009
  6. doi request reprint PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    J Cell Sci 121:282-9. 2008
  7. pmc IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
    Ebru Erbay
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107, Urbana, IL 61801, USA
    J Cell Biol 163:931-6. 2003
  8. pmc mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, USA
    Am J Physiol Cell Physiol 297:C1434-44. 2009
  9. ncbi request reprint Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 283:708-15. 2008
  10. pmc Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Mol Biol Cell 24:3754-63. 2013

Research Grants

Collaborators

Detail Information

Publications33

  1. pmc Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
    Yuting Sun
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Cell Biol 189:1157-69. 2010
    ....
  2. pmc Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 195:435-47. 2011
    ..Finally, we show that the hVps34-PLD1 pathway acts independently of, and in parallel to, the Rag pathway in regulating amino acid activation of mTORC1...
  3. pmc RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS ONE 8:e68068. 2013
    ....
  4. pmc IGF-II is regulated by microRNA-125b in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Cell Biol 192:69-81. 2011
    ....
  5. pmc Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 284:35425-32. 2009
    ....
  6. doi request reprint PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    J Cell Sci 121:282-9. 2008
    ..Furthermore, exogenous IGF2 fully rescues the differentiation defect resulting from PLD1 knockdown. Hence, PLD1 is critically involved in skeletal myogenesis by regulating the mTOR-IGF2 pathway...
  7. pmc IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
    Ebru Erbay
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107, Urbana, IL 61801, USA
    J Cell Biol 163:931-6. 2003
    ..Our findings represent the first identification of a signaling pathway that regulates IGF-II expression in myogenesis and implicate the mTOR-IGF axis as a molecular link between nutritional levels and skeletal muscle development...
  8. pmc mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, USA
    Am J Physiol Cell Physiol 297:C1434-44. 2009
    ..Therefore, mTOR regulates muscle regeneration through kinase-independent and kinase-dependent mechanisms at the stages of nascent myofiber formation and myofiber growth, respectively...
  9. ncbi request reprint Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 283:708-15. 2008
    ..Taken together, we propose that mTOR plays a key role in IL-6-induced hepatic insulin resistance by regulating STAT3 activation and subsequent SOCS3 expression...
  10. pmc Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Mol Biol Cell 24:3754-63. 2013
    ..Our results uncover amino acid-sensing mechanisms controlling the homeostasis of myogenesis and underline the versatility and context dependence of mTOR signaling. ..
  11. pmc Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components
    Ai Luen Wu
    Department of Cell and Developmental Biology, 601 South Goodwin Avenue, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Endocrinology 149:1407-14. 2008
    ..Moreover, the addition of exogenous IGF-II fully rescues myocyte differentiation from FoxO inhibition. Taken together, we propose that the mTOR-IGF-II pathway is a major mediator of FoxO's inhibitory function in skeletal myogenesis...
  12. pmc Flt3L is a novel regulator of skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    J Cell Sci 126:3370-9. 2013
    ..In summary, our work reveals an unexpected role for an immunoregulatory cytokine in skeletal myogenesis and a new myogenic pathway. ..
  13. pmc Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 286:29568-74. 2011
    ..In conclusion, we propose a dual mechanism for PA activation of mTORC1: PA displaces FKBP38 from mTOR and allosterically stimulates the catalytic activity of mTORC1...
  14. pmc XPLN is an endogenous inhibitor of mTORC2
    Nidhi Khanna
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Proc Natl Acad Sci U S A 110:15979-84. 2013
    ..Our study identifies XPLN as an endogenous inhibitor of mTORC2 and delineates a noncanonical mechanism of XPLN action. ..
  15. pmc Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes
    Chongben Zhang
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Am J Physiol Endocrinol Metab 296:E862-8. 2009
    ..Therefore, we propose that nutrient sufficiency, mediated by an mTOR pathway, suppresses TGH-dependent lipolysis stimulated by chronic insulin exposure in adipocytes...
  16. pmc Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton
    Yuan He
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801 Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801 Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Mol Biol Cell 24:3369-80. 2013
    ..Together our findings reveal an mTORC2- and mTOR kinase-independent function and mechanism of Rictor in the regulation of neutrophil chemotaxis. ..
  17. pmc Mechanistic target of rapamycin controls homeostasis of adipogenesis
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Lipid Res 54:2166-73. 2013
    ..Our observations reveal an unexpected role of mTOR in suppressing adipogenesis and suggest that mTOR governs the homeostasis of the adipogenic process by modulating multiple signaling pathways. ..
  18. ncbi request reprint A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
    Rebecca A Bachmann
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA
    J Biol Chem 281:7357-63. 2006
    ..Taken together, our observations suggest the existence of a nuclear shuttling signal in mTOR and provide definitive evidence for the requirement of mTOR nuclear import in its cytoplasmic signaling to S6K1...
  19. ncbi request reprint PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1
    Yimin Fang
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    Curr Biol 13:2037-44. 2003
    ..In this study, we set out to test the hypotheses that phospholipase D 1 (PLD1) is an upstream regulator of mTOR and that the previously reported S6K1 activation by Cdc42 is mediated by PLD1...
  20. ncbi request reprint Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1
    In Hyun Park
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Exp Cell Res 309:211-9. 2005
    ....
  21. ncbi request reprint mTOR signaling: PLD takes center stage
    Yuting Sun
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cell Cycle 7:3118-23. 2008
    ..We also consider the implications from several recent findings and propose mechanistic models of PLD-mTOR signaling to be tested in the near future...
  22. pmc mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells
    Jiaxi Zhou
    Department of Cell and Developmental Biology and Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:7840-5. 2009
    ..These results uncover a novel signaling mechanism by which mTOR controls fate decisions in hESCs. Our findings may contribute to effective strategies for tissue repair and regeneration...
  23. pmc Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1)
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 286:35675-82. 2011
    ..These findings underscore the versatility of mTOR signaling in biological regulations and implicate the existence of novel mTOR complexes and/or signaling mechanism in skeletal myogenesis...
  24. ncbi request reprint regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis
    Jae Eun Kim
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107 Urbana, IL 61801, USA
    Diabetes 53:2748-56. 2004
    ....
  25. ncbi request reprint Mammalian target of rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation
    In Hyun Park
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 280:32009-17. 2005
    ....
  26. ncbi request reprint Interleukin-6 and insulin resistance
    Jeong Ho Kim
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Vitam Horm 80:613-33. 2009
    ..Herein we review the in vivo and in vitro studies that have examined the role of IL-6 in insulin signaling and glucose metabolism in the insulin target tissues: liver, adipose, and skeletal muscle...
  27. pmc MicroRNAs in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Cell Cycle 10:441-8. 2011
    ..Emerging themes of miRNA regulation in the context of skeletal myogenesis will also be discussed...
  28. pmc Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis
    Yejing Ge
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 287:43928-35. 2012
    ..Current questions for future studies are also highlighted...
  29. pmc MicroRNA-146b Promotes Myogenic Differentiation and Modulates Multiple Gene Targets in Muscle Cells
    Nidhi Khanna
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS ONE 9:e100657. 2014
    ..In conclusion, miR-146b is a positive regulator of myogenic differentiation, possibly acting through multiple targets. ..
  30. ncbi request reprint A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
    Jie Chen
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, B107, Urbana, IL 61801, USA
    Biochem Pharmacol 64:1071-7. 2002
    ....
  31. doi request reprint A Bayesian measurement error approach to QT interval correction and prolongation
    Jie Chen
    Abbott Laboratories, Abbott Park, Illinois, USA
    J Biopharm Stat 20:523-42. 2010
    ..The proposed approach is illustrated using a real data set. Simulation studies show that our proposed Bayesian measurement error approach outperforms the current most commonly used frequentist methods...
  32. pmc Probing cellular protein complexes using single-molecule pull-down
    Ankur Jain
    Center for Biophysics and Computational Biology and Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nature 473:484-8. 2011
    ..SiMPull should provide a rapid, sensitive and robust platform for analysing protein assemblies in biological pathways...
  33. ncbi request reprint Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin
    In Hyun Park
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 277:31423-9. 2002
    ..Taken together, our observations suggest a novel regulatory mechanism in which an optimal cytoplasmic-nuclear distribution or shuttling rate for mTOR is required for maximal activation of the nuclear S6K2...

Research Grants14

  1. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2010
    ....
  2. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 1999
    ..abstract_text> ..
  3. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2009
    ....
  4. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2006
    ....
  5. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2004
    ..abstract_text> ..
  6. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2009
    ....
  7. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2004
    ....
  8. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2003
    ..abstract_text> ..
  9. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2003
    ....
  10. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2000
    ..abstract_text> ..
  11. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2002
    ..abstract_text> ..
  12. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2007
    ....
  13. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2001
    ..abstract_text> ..
  14. mTOR Signaling in Skeletal Myogenesis
    Jie Chen; Fiscal Year: 2005
    ....