Jeon Hor Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Correlation of endogenous hormonal levels, fibroglandular tissue volume and percent density measured using 3D MRI during one menstrual cycle
    J H Chen
    Center for Functional Onco Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, USA
    Ann Oncol 24:2329-35. 2013
  2. pmc Background parenchymal enhancement in the contralateral normal breast of patients undergoing neoadjuvant chemotherapy measured by DCE-MRI
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, CA, USA Department of Radiology, E Da Hospital and I Shou University, Kaohsiung 82445, Taiwan Electronic address
    Magn Reson Imaging 31:1465-71. 2013
  3. pmc Numerical analysis of airflow alteration in central airways following tracheobronchial stent placement
    Chien Yi Ho
    Division of Chest Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, 40402, Taiwan
    Exp Hematol Oncol 1:23. 2012
  4. pmc Response of bilateral breasts to the endogenous hormonal fluctuation in a menstrual cycle evaluated using 3D MRI
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, California, United States
    Magn Reson Imaging 31:538-44. 2013
  5. pmc Consistency of breast density measured from the same women in four different MR scanners
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging of Department of Radiological Science, University of California Irvine, California 92697 5020, USA
    Med Phys 39:4886-95. 2012
  6. pmc Estrogen receptor and breast MR imaging features: a correlation study
    Jeon Hor Chen
    Center for Functional Onco Imaging, School of Medicine, University of California, Irvine, California 92697, USA
    J Magn Reson Imaging 27:825-33. 2008
  7. pmc Decrease in breast density in the contralateral normal breast of patients receiving neoadjuvant chemotherapy: MR imaging evaluation
    Jeon Hor Chen
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine Hall 164, Irvine, CA 92697, USA
    Radiology 255:44-52. 2010
  8. ncbi request reprint MRI evaluation of pathologically complete response and residual tumors in breast cancer after neoadjuvant chemotherapy
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine, California 92697, USA
    Cancer 112:17-26. 2008
  9. pmc Breast cancer: evaluation of response to neoadjuvant chemotherapy with 3.0-T MR imaging
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging and Department of Radiological Sciences, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
    Radiology 261:735-43. 2011
  10. pmc Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS
    J H Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    NMR Biomed 24:316-24. 2011

Collaborators

Detail Information

Publications90

  1. pmc Correlation of endogenous hormonal levels, fibroglandular tissue volume and percent density measured using 3D MRI during one menstrual cycle
    J H Chen
    Center for Functional Onco Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, USA
    Ann Oncol 24:2329-35. 2013
    ..We measured breast density (BD) on MRI and correlated with endogenous hormonal levels...
  2. pmc Background parenchymal enhancement in the contralateral normal breast of patients undergoing neoadjuvant chemotherapy measured by DCE-MRI
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, CA, USA Department of Radiology, E Da Hospital and I Shou University, Kaohsiung 82445, Taiwan Electronic address
    Magn Reson Imaging 31:1465-71. 2013
    ..BPE was significantly decreased in F/U-2 MRI after NAC in women <55 years old. The reduction in BPE was most likely due to the ovarian ablation induced by chemotherapeutic agents...
  3. pmc Numerical analysis of airflow alteration in central airways following tracheobronchial stent placement
    Chien Yi Ho
    Division of Chest Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, 40402, Taiwan
    Exp Hematol Oncol 1:23. 2012
    ..The results showed that the pressure drop after tracheal stent implantation became significantly smaller. For bronchial stent implantation cases, the airway resistance improved insignificantly...
  4. pmc Response of bilateral breasts to the endogenous hormonal fluctuation in a menstrual cycle evaluated using 3D MRI
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, California, United States
    Magn Reson Imaging 31:538-44. 2013
    ....
  5. pmc Consistency of breast density measured from the same women in four different MR scanners
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging of Department of Radiological Science, University of California Irvine, California 92697 5020, USA
    Med Phys 39:4886-95. 2012
    ..To compare the breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from breast MRI of the same women using four different MR scanners...
  6. pmc Estrogen receptor and breast MR imaging features: a correlation study
    Jeon Hor Chen
    Center for Functional Onco Imaging, School of Medicine, University of California, Irvine, California 92697, USA
    J Magn Reson Imaging 27:825-33. 2008
    ..To compare the MRI features between estrogen receptor (ER) positive and negative breast cancers...
  7. pmc Decrease in breast density in the contralateral normal breast of patients receiving neoadjuvant chemotherapy: MR imaging evaluation
    Jeon Hor Chen
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine Hall 164, Irvine, CA 92697, USA
    Radiology 255:44-52. 2010
    ..To investigate the change of breast density with quantitative magnetic resonance (MR) imaging in the contralateral normal breast of patients receiving neoadjuvant chemotherapy...
  8. ncbi request reprint MRI evaluation of pathologically complete response and residual tumors in breast cancer after neoadjuvant chemotherapy
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine, California 92697, USA
    Cancer 112:17-26. 2008
    ....
  9. pmc Breast cancer: evaluation of response to neoadjuvant chemotherapy with 3.0-T MR imaging
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging and Department of Radiological Sciences, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
    Radiology 261:735-43. 2011
    ..0-T magnetic resonance (MR) imaging...
  10. pmc Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS
    J H Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    NMR Biomed 24:316-24. 2011
    ..The higher choline level in younger women may be caused by their more aggressive tumor type. The results presented here may aid in the better interpretation of (1)H MRS for the diagnosis of breast lesions...
  11. pmc Magnetic resonance imaging features of fibrocystic change of the breast
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697 5020, USA
    Magn Reson Imaging 26:1207-14. 2008
    ..Studies specifically reporting MRI of fibrocystic change (FCC) of the breast are very few and its MRI features are not clearly known. The purpose of this study was to analyze the MRI features of FCC of the breast...
  12. pmc Fibrocystic change of the breast presenting as a focal lesion mimicking breast cancer in MR imaging
    Jeon Hor Chen
    Center for Functional Onco Imaging, University of California Irvine, No 164, Irvine Hall, Irvine, CA 92697, USA
    J Magn Reson Imaging 28:1499-505. 2008
    ....
  13. pmc Predicting pathologic response to neoadjuvant chemotherapy in breast cancer by using MR imaging and quantitative 1H MR spectroscopy
    Hyeon Man Baek
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine Hall 164, Irvine, CA 92697 5020, USA
    Radiology 251:653-62. 2009
    ....
  14. pmc Quantitative analysis of breast parenchymal patterns using 3D fibroglandular tissues segmented based on MRI
    Ke Nie
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
    Med Phys 37:217-26. 2010
    ..In this study the morphology of fibroglandular tissue distribution was analyzed using three-dimensional breast MRI, which is not subject to the tissue overlapping problem...
  15. pmc Effect of taxane-based neoadjuvant chemotherapy on fibroglandular tissue volume and percent breast density in the contralateral normal breast evaluated by 3T MR
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California Irvine, CA, USA Department of Radiology, E Da Hospital and I Shou University, Kaohsiung, Taiwan
    NMR Biomed 26:1705-13. 2013
    ..The effect of breast density reduction was age related and duration related...
  16. pmc Impact of factors affecting the residual tumor size diagnosed by MRI following neoadjuvant chemotherapy in comparison to pathology
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, California Department of Radiology, E Da Hospital and I Shou University, Kaohsiung, Taiwan
    J Surg Oncol 109:158-67. 2014
    ..To investigate accuracy of magnetic resonance imaging (MRI) for measuring residual tumor size in breast cancer patients receiving neoadjuvant chemotherapy (NAC)...
  17. pmc Diagnostic performance of magnetic resonance imaging for assessing tumor response in patients with HER2-negative breast cancer receiving neoadjuvant chemotherapy is associated with molecular biomarker profile
    Aida Kuzucan
    John Tu and Thomas Yuen Center for Functional Onco Imaging of Department of Radiological Sciences, University of California, Irvine, California, USA
    Clin Breast Cancer 12:110-8. 2012
    ....
  18. pmc Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences
    Daniel H E Chang
    Department of Radiological Sciences, University of California, Irvine, CA 92697, USA
    Med Phys 38:5961-8. 2011
    ..To investigate the difference of MR percent breast density measured from fat-suppressed versus nonfat-suppressed imaging sequences...
  19. pmc Residual breast cancer diagnosed by MRI in patients receiving neoadjuvant chemotherapy with and without bevacizumab
    Shadfar Bahri
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, USA
    Ann Surg Oncol 16:1619-28. 2009
    ..To investigate the impact of antiangiogenic therapy with bevacizumab on pathological response and the diagnostic performance of magnetic resonance imaging (MRI) in breast cancer patients...
  20. ncbi request reprint Comparison of choline and pharmacokinetic parameters in breast cancer measured by MR spectroscopic imaging and dynamic contrast enhanced MRI
    Min Ying Su
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697 5020, USA
    Technol Cancer Res Treat 5:401-10. 2006
    ..Since Choline is associated with cell replication and angiogenesis is required to support tumor growth, this might explain the correlation between these two sets of measures among different lesions...
  21. pmc Spatial shrinkage/expansion patterns between breast density measured in two MRI scans evaluated by non-rigid registration
    Muqing Lin
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, CA, USA
    Phys Med Biol 56:5865-75. 2011
    ..The presented registration method can be further developed into a clinical tool for evaluating therapy-induced changes and for early diagnosis of breast cancer in screening MRI...
  22. pmc Selection of diagnostic features on breast MRI to differentiate between malignant and benign lesions using computer-aided diagnosis: differences in lesions presenting as mass and non-mass-like enhancement
    Dustin Newell
    Tu and Yuen Centre for Functional Onco Imaging CFOI, University of California, Irvine, CA 92697 5020, USA
    Eur Radiol 20:771-81. 2010
    ....
  23. pmc Impact of MRI-evaluated neoadjuvant chemotherapy response on change of surgical recommendation in breast cancer
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697 5020, USA
    Ann Surg 249:448-54. 2009
    ..To investigate how MRI imaging of neoadjuvant chemotherapy (NAC) tumor response affects the recommendation for optimal breast cancer surgery, both before and after NAC...
  24. pmc Detection of choline signal in human breast lesions with chemical-shift imaging
    Hyeon Man Baek
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697 5020, USA
    J Magn Reson Imaging 27:1114-21. 2008
    ..To investigate the application of MR spectroscopy using chemical-shift imaging (CSI) for characterizing human breast lesions at 1.5T, and to evaluate the diagnostic performance using ROC (receiver operating characteristics) analysis...
  25. ncbi request reprint MRI measurements of tumor size and pharmacokinetic parameters as early predictors of response in breast cancer patients undergoing neoadjuvant anthracycline chemotherapy
    Hon J Yu
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697 5020, USA
    J Magn Reson Imaging 26:615-23. 2007
    ....
  26. pmc Development of a quantitative method for analysis of breast density based on three-dimensional breast MRI
    Ke Nie
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
    Med Phys 35:5253-62. 2008
    ..It may also provide a reliable method for evaluating the change of breast density for risk management of women, or for evaluating the benefits/risks when considering hormonal replacement therapy or chemoprevention...
  27. pmc A new bias field correction method combining N3 and FCM for improved segmentation of breast density on MRI
    Muqing Lin
    Department of Radiological Sciences, Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
    Med Phys 38:5-14. 2011
    ..A new bias field correction method by combining the nonparametric nonuniformity normalization (N3) algorithm and fuzzy-C-means (FCM)-based inhomogeneity correction algorithm is developed in this work...
  28. pmc Algorithm-based method for detection of blood vessels in breast MRI for development of computer-aided diagnosis
    Muqing Lin
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697 5020, USA
    J Magn Reson Imaging 30:817-24. 2009
    ....
  29. ncbi request reprint Pathological complete response in triple negative poorly differentiated invasive ductal breast carcinoma detected during pregnancy
    Garima Agrawal
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA, USA
    J Clin Oncol 25:2618-20. 2007
  30. pmc Impact of skin removal on quantitative measurement of breast density using MRI
    Ke Nie
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
    Med Phys 37:227-33. 2010
    ..This study investigated the impact of skin to the quantitative measurement of breast density using MRI...
  31. pmc Quantitative correlation between (1)H MRS and dynamic contrast-enhanced MRI of human breast cancer
    Hyeon Man Baek
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697 5020, USA
    Magn Reson Imaging 26:523-31. 2008
    ..The results suggest a correlation between Cho metabolism and angiogenesis activity, which might be explained by the association of Cho with cell replication and angiogenesis required to support tumor growth...
  32. pmc Age- and race-dependence of the fibroglandular breast density analyzed on 3D MRI
    Ke Nie
    Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    Med Phys 37:2770-6. 2010
    ..The purpose of this study was to evaluate the age- and race-dependence of the breast fibroglandular tissue density based on three-dimensional breast MRI...
  33. pmc Reduction of breast density following tamoxifen treatment evaluated by 3-D MRI: preliminary study
    Jeon Hor Chen
    Tu and Yuen Center for Functional Onco Imaging and Department of Radiological Science, University of California Irvine, Irvine, CA 92697, USA
    Magn Reson Imaging 29:91-8. 2011
    ..Three-dimensional MRI may be useful for the measurement of the small changes of ΔFV and Δ%BD after tamoxifen. These changes can potentially be used to correlate with the future reduction of cancer risk...
  34. pmc Quantitative analysis of lesion morphology and texture features for diagnostic prediction in breast MRI
    Ke Nie
    Tu and Yuen Center for Functional Onco Imaging, University of California, CFOI, 164 Irvine Hall, Irvine, CA 92697, USA
    Acad Radiol 15:1513-25. 2008
    ....
  35. pmc Selective thrombosis of tumor blood vessels in mammary adenocarcinoma implants in rats
    M K Samoszuk
    Pathology Department, University of California, Irvine, USA
    Am J Pathol 159:245-51. 2001
    ..On the basis of these results, we conclude that protamine accumulates within adenocarcinoma implants and induces selective thrombosis of blood vessels within the tumor, probably by neutralizing the endogenous heparin within tumors...
  36. pmc Quantitative fluorescence tomography with functional and structural a priori information
    Yuting Lin
    Center for Functional Onco Imaging, University of California, Irvine, Irvine, California 92697, USA
    Appl Opt 48:1328-36. 2009
    ..On the other hand, the true fluorophore concentration could be recovered when both functional and structural a priori information is utilized to guide and constrain the FT reconstruction algorithm...
  37. pmc Template-based automatic breast segmentation on MRI by excluding the chest region
    Muqing Lin
    Tu and Yuen Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, California 92697 5020 and National Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, School of Medicine, Shenzhen University, 518060 China
    Med Phys 40:122301. 2013
    ..Methods for quantification of breast density on MRI using semiautomatic approaches are commonly used. In this study, the authors report on a fully automatic chest template-based method...
  38. pmc Significance of breast lesion descriptors in the ACR BI-RADS MRI lexicon
    Garima Agrawal
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, California 92697, USA
    Cancer 115:1363-80. 2009
    ..This may, in turn, help physicians and patients to jointly select an appropriate management protocol for each patient's clinical situation...
  39. ncbi request reprint Resolution improvement in positron emission tomography using anatomical Magnetic Resonance Imaging
    Yong Chu
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    Technol Cancer Res Treat 5:311-7. 2006
    ..We conclude that a Sharpness-Constrained Wiener filter having parameters optimized from a MMI criterion may be useful for restoring spatial resolution in PET based on a priori information from correlated MRI...
  40. pmc Dual-contrast dynamic MRI-DOT for small animal imaging
    David Thayer
    Tu and Yuen Center for Functional Onco Imaging, University of California Irvine, CA 92692, USA
    Technol Cancer Res Treat 9:61-70. 2010
    ....
  41. ncbi request reprint A longitudinal study of radiation-induced changes in tumor vasculature by contrast-enhanced magnetic resonance imaging
    Hon Yu
    Health Sciences Research Imaging Center, College of Medicine, Department of Physics and Astronomy, University of California, Irvine 92697 5020, USA
    Radiat Res 158:152-8. 2002
    ..The value of K(2) measured with Gd-DTPA did not show any significant changes after either the low or the high radiation dose...
  42. ncbi request reprint A simple simultaneous geometric and intensity correction method for echo-planar imaging by EPI-based phase modulation
    Jr Yuan Chiou
    Department of Electrical and Computer Engineering, John Tu and Thomas Yuen Center for Functional Onco Imaging, College of Medicine, University of California, Irvine, CA 92697 5020, USA
    IEEE Trans Med Imaging 22:200-5. 2003
    ..The results suggest the proposed technique is superior in correcting severely distorted images...
  43. ncbi request reprint In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration
    David J Cuccia
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
    Appl Opt 42:2940-50. 2003
    ..In contrast, MB behaves as a small-molecular-weight contrast agent that leaks rapidly from the vasculature into the extravascular, extracellular space, and is sensitive to blood flow and the arterial input function...
  44. pmc Clinical application of magnetic resonance imaging in management of breast cancer patients receiving neoadjuvant chemotherapy
    Jeon Hor Chen
    Center for Functional Onco Imaging, Department of Radiological Sciences, University of California, Irvine, CA 92697 5020, USA
    Biomed Res Int 2013:348167. 2013
    ..MRI has been proven a valuable tool and will continue to provide important information facilitating individualized image-guided treatment and personalized management for breast cancer patients undergoing NAC. ..
  45. pmc A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging
    Y Lin
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    Phys Med Biol 56:4731-47. 2011
    ..2 mm-diameter cylindrical objects embedded in a 38 mm-diameter cylindrical phantom when MRI structural a priori information is utilized...
  46. ncbi request reprint Measurement of ion diffusion using magnetic resonance electrical impedance tomography
    Mark J Hamamura
    Tu and Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
    Phys Med Biol 51:2753-62. 2006
    ..The results indicate that MREIT was able to monitor the changing conductivity and concentration distributions resulting from the diffusion of ions within the agarose gel phantom...
  47. doi request reprint Development of a new RF coil and gamma-ray radiation shielding assembly for improved MR image quality in SPECT/MRI
    Seunghoon Ha
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA, USA
    Phys Med Biol 55:2495-504. 2010
    ....
  48. doi request reprint Development of an MR-compatible SPECT system (MRSPECT) for simultaneous data acquisition
    Mark J Hamamura
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA, USA
    Phys Med Biol 55:1563-75. 2010
    ....
  49. ncbi request reprint Initial Investigation of preclinical integrated SPECT and MR imaging
    Mark J Hamamura
    Tu and Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall Irvine, CA 92697 5020 USA
    Technol Cancer Res Treat 9:21-8. 2010
    ..Finally, simultaneous dual-imaging of a nude mouse was performed to demonstrated the utility of co-registration for accurate localization of a radioactive source...
  50. pmc Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging
    Mehmet Burcin Unlu
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 13:060501. 2008
    ..The absorption enhancements in the ROIs were calculated. An enhancement of the ICG was observed in the viable region. On the contrary, there was a lower enhancement in the nonviable region...
  51. ncbi request reprint Quantification of choline-containing compounds in malignant breast tumors by 1H MR spectroscopy using water as an internal reference at 1.5 T
    Hyun Man Baik
    John Tu and Thomas Center for Functional Onco Imaging, University of Califorinia, Irvine Hall 164, Irvine, CA 92697 5020, USA
    MAGMA 19:96-104. 2006
    ..Therefore, we conclude that the internal method using the fully relaxed water as a reference could be used for quantifying Cho metabolite accurately in breast cancer patients using a clinical 1.5 T scanner...
  52. ncbi request reprint Design and implementation of a multifrequency near-infrared diffuse optical tomography system
    Gultekin Gulsen
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 11:014020. 2006
    ..It is shown that the multifrequency reconstruction approach provides superior image quality compared to the single frequency counterpart...
  53. ncbi request reprint Coregistration of dynamic contrast enhanced MRI and broadband diffuse optical spectroscopy for characterizing breast cancer
    David Hsiang
    Chao Comprehensive Cancer Center, Division of Oncological Surgery, University of California, Irvine Medical Center, 101 The City Drive, Orange, CA 92868, USA
    Technol Cancer Res Treat 4:549-58. 2005
    ..These results provide qualitative confirmation of the common signal origin and complementary information content that can be achieved by combining optical and MR imaging for breast cancer detection and clinical management...
  54. ncbi request reprint Pharmacokinetic parameters analyzed from mr contrast enhancement kinetics of multiple malignant and benign breast lesions detected in the same patients
    Min Y Su
    John Tu and Thomas Yuen Center for Functional Onco Imaging, Irvine Hall 164, University of California, Irvine, CA 92697 5020, USA
    Technol Cancer Res Treat 4:255-63. 2005
    ....
  55. ncbi request reprint Resolution and contrast in magnetic resonance electrical impedance tomography (MREIT) and its application to cancer imaging
    L Tugan Muftuler
    Tu and Yuen Center for Functional Onco Imaging, 164 Irvine Hall, University of California, Irvine, CA, USA
    Technol Cancer Res Treat 3:599-609. 2004
    ..The method was also applied to a live rat bearing a R3230 AC tumor. Tumor location was identified by contrast enhanced imaging...
  56. pmc Increased blood clotting, microvascular density, and inflammation in eotaxin-secreting tumors implanted into mice
    Michael Samoszuk
    Pathology Department, University of California, Irvine, Building 10, Route 40, 101 The City Drive, Orange, CA 92868, USA
    Am J Pathol 165:449-56. 2004
    ..Thus, eotaxin and eosinophils may play a more complex role in modulating the growth of tumors than the simple, anti-tumor cytotoxic effect that has been previously proposed...
  57. ncbi request reprint Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer
    Min Ying Su
    Center for Functional Onco Imaging and Chao Family Comprehensive Cancer Center, University of California Irvine, USA
    J Magn Reson Imaging 18:467-77. 2003
    ....
  58. ncbi request reprint Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin
    Michael Samoszuk
    Department of Pathology, University of California Irvine, UCI Medical Center Building 10, Route 40, 101 The City Drive, Orange, CA 92868 3298, USA
    Thromb Haemost 90:351-60. 2003
    ..Our results also suggest that thrombosis and hemostasis within melanoma may play a complex role in modulating the growth of the tumor...
  59. ncbi request reprint Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumors
    Gultekin Gulsen
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine, California 92697, USA
    Technol Cancer Res Treat 1:497-505. 2002
    ....
  60. ncbi request reprint Measurement of volumetric and vascular changes with dynamic contrast enhanced MRI for cancer therapy monitoring
    Min Ying Su
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine Hall 164, Irvine, CA 92697, USA
    Technol Cancer Res Treat 1:479-88. 2002
    ..The vascular properties measured by macromolecular contrast medium may have the potential to serve as early therapeutic efficacy indicators...
  61. ncbi request reprint Assessment of protamine-induced thrombosis of tumor vessels for cancer therapy using dynamic contrast-enhanced MRI
    Min Ying Su
    Health Sciences Research Imaging Center, University of California Irvine, Irvine, CA 92697 5020, USA
    NMR Biomed 15:106-13. 2002
    ..Dynamic contrast-enhanced MRI can serve as a suitable means to investigate the mechanism of this novel approach to induce selective thrombosis for anti-vascular cancer therapy...
  62. ncbi request reprint Measuring microvascular density in tumors by digital dissection
    Michael Samoszuk
    Hematology Oncology Center, Quest Diagnostics, Inc, San Juan Capistrano, California, USA
    Anal Quant Cytol Histol 24:15-22. 2002
    ..To develop and validate a digital dissection techniquefor measuring the cross-sectional area of blood vessels in histologic sections of tumors routinely stained with hematoxylin and eosin...
  63. ncbi request reprint Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals
    Gultekin Gulsen
    Tu and Yuen Center for Functional Onco Imaging, 164 Irvine Hall, University of California, Irvine, California 92697, USA
    Technol Cancer Res Treat 5:351-63. 2006
    ..ENU induced tumor model is used to test the performance of the system in vivo...
  64. ncbi request reprint In vivo MRI electrical impedance tomography (MREIT) of tumors
    L Tugan Muftuler
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
    Technol Cancer Res Treat 5:381-7. 2006
    ..Although heterogeneity of conductivity was observed in the tumor, the mean was still higher than the background...
  65. pmc In vivo MRI volumetric measurement of prostate regression and growth in mice
    Kent L Nastiuk
    Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA
    BMC Urol 7:12. 2007
    ..Temporal monitoring of mouse prostate regression requires multiple animals and examination of histological sections...
  66. ncbi request reprint Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice
    Rebecca A Nishi
    CRF Spinal Cord Injury Core Research Facility, University of California, Irvine, California 92697 4540, USA
    J Neurotrauma 24:674-89. 2007
    ..These results give researchers more options in how to analyze spinal cord injuries in animal models...
  67. ncbi request reprint An optimization method for designing SENSE imaging RF coil arrays
    Gang Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    J Magn Reson 186:273-81. 2007
    ..Imaging results showed reasonable agreement with the simulations, thus the method can be applied to RF coil array designs for SENSE imaging when optimum imaging performance is desired...
  68. ncbi request reprint An inverse method to design RF coil arrays optimized for SENSE imaging
    L Tugan Muftuler
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, Irvine, CA 92697 5020, USA
    Phys Med Biol 51:6457-69. 2006
    ..A simple two-coil array was designed and built to test the method and phantom images were collected. The results show that the new coil design method yielded better uniformity and SNR in SENSE images compared to those of standard coils...
  69. ncbi request reprint Diffuse optical tomographic reconstruction using multifrequency data
    Mehmet Burcin Unlu
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 11:054008. 2006
    ..2. The use of two-frequency data is sufficient to improve the quantitative accuracy compared with the single frequency reconstruction with appropriate selection of these frequencies...
  70. ncbi request reprint Contrast and spatial resolution in MREIT using low amplitude current
    Ozlem Birgul
    Tu and Yuen Center for Functional Onco Imaging, University of California Irvine, USA
    Phys Med Biol 51:5035-49. 2006
    ..7 mm is achieved for the 3 mm insulator case. For the contrast analysis, the conductivity of a 15 mm object is varied between 44% and 500% with respect to the background and results are compared to the ideal reconstruction...
  71. pmc MR-based keyhole SPECT for small animal imaging
    Keum Sil Lee
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, Irvine, CA, USA
    Phys Med Biol 56:685-702. 2011
    ..The K-SPECT reconstruction technique significantly improved the spatial resolution and quantification while reducing artifacts from the contributions outside the LFOV as well as reducing the dimension of the reconstruction matrix...
  72. doi request reprint Simultaneous in vivo dynamic contrast-enhanced magnetic resonance and scintigraphic imaging
    Mark J Hamamura
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA, USA
    Phys Med Biol 56:N63-9. 2011
    ..Our results demonstrate the feasibility of measuring multiple biological processes at the same time using both MR contrast agents and radiotracers...
  73. ncbi request reprint Effect of vasodilator hydralazine on tumor microvascular random flow and blood volume as measured by intravoxel incoherent motion (IVIM) weighted MRI in conjunction with Gd-DTPA-Albumin enhanced MRI
    Z Wang
    Center for Functional Onco-Imaging, College of Medicine, University of California, Irvine, CA 92697-5020, USA
    Magn Reson Imaging 19:1063-72. 2001
    ..The mean microvascular random flow velocity magnitude increased from 0.52 +/- 0.15 (s.d.) mm/sec to 0.73 +/- 0.23 (s.d.) mm/sec (p < 0.05) in the presence of the above blood volume fraction change...
  74. pmc Computational simulation of breast compression based on segmented breast and fibroglandular tissues on magnetic resonance images
    Tzu Ching Shih
    Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, 40402, Taiwan, Republic of China
    Phys Med Biol 55:4153-68. 2010
    ....
  75. ncbi request reprint Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging
    M Y Su
    Health Sciences Research Imaging Center, University of California, Irvine 92697, USA
    Neurobiol Aging 19:479-85. 1998
    ..These findings indicate that BBB dysfunction detected by magnetic resonance imaging may be useful for predicting and potentially diagnosing early pathological conditions...
  76. ncbi request reprint Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model
    Sean Merritt
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
    Appl Opt 42:2951-9. 2003
    ..15 M/microM). Tissue hemoglobin oxygen saturation (StO2) also showed a large variation between tissue types: viable tissue had an optically measured StO2 value of 61 +/- 5%, whereas StO2 determined for necrotic tissue was 43 +/- 6%...
  77. ncbi request reprint Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study
    Y Lin
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92617, USA
    Phys Med Biol 52:5569-85. 2007
    ....
  78. ncbi request reprint FMRI study relevant to the Mozart effect: brain areas involved in spatial-temporal reasoning
    M Bodner
    Department of Physics, University of California, Irvine, 92697, USA
    Neurol Res 23:683-90. 2001
    ..It would be of great interest to explicitly test this expectation. We propose an fMRI study comparing (subject by subject) brain areas activated in music listening conditions and in spatial-temporal tasks...
  79. pmc Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers
    Céline M Dubé
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, USA
    J Neurosci 30:7484-94. 2010
    ....
  80. doi request reprint A PIN diode controlled dual-tuned MRI RF coil and phased array for multi nuclear imaging
    Seunghoon Ha
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA, USA
    Phys Med Biol 55:2589-600. 2010
    ..We demonstrated that the performance is significantly improved at both frequencies with the PIN diode switched dual-frequency operation compared to an identical coil with a trap circuit...
  81. ncbi request reprint Automatic tuned MRI RF coil for multinuclear imaging of small animals at 3T
    L Tugan Muftuler
    John Tu and Thomas Yuen Center for Functional Onco Imaging, College of Medicine, University of California, Irvine 92697, USA
    J Magn Reson 155:39-44. 2002
    ..Good matching and tuning were obtained at both resonance frequencies. The tuning and matching of the coil were changed from one resonance frequency to the other within 60 s...
  82. ncbi request reprint A double end-cap birdcage RF coil for small animal whole body imaging
    Gultekin Gulsen
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, California, USA
    J Magn Reson 156:309-12. 2002
    ..Furthermore, if one wishes to obtain the same homogeneity within a given volume, a double end-cap would have less than half of the length of the single end-cap coil leading to a superior S/N performance...
  83. pmc Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death
    Celine Dube
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697 4475, USA
    Ann Neurol 56:709-14. 2004
    ..Although these changes do not signify cell death, they may denote pathological cellular processes that promote epileptogenesis. ...
  84. pmc Cognitive dysfunction after experimental febrile seizures
    Céline M Dubé
    Department of Pediatrics, ZOT 4475, University of California, Irvine 92697 4475, USA
    Exp Neurol 215:167-77. 2009
    ....
  85. ncbi request reprint Magnetic resonance imaging in predicting pathological response of triple negative breast cancer following neoadjuvant chemotherapy
    Jeon Hor Chen
    J Clin Oncol 25:5667-9. 2007
  86. pmc Choline as a biomarker for cell proliferation: do the results from proton MR spectroscopy show difference between HER2/neu positive and negative breast cancers?
    Hyeon Man Baek
    Int J Cancer 123:1219-21. 2008
  87. ncbi request reprint Pathological axillary lymph node status in HER-2 receptor positive and negative breast cancers
    Jeon Hor Chen
    Ann Surg Oncol 15:941-2. 2008
  88. pmc The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis
    Patric Lundberg
    Division of Virology, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    J Virol 82:7078-88. 2008
    ..We conclude that fatal HSE in 129 mice results from widespread damage in the brain stem caused by destructive inflammatory responses initiated early in infection by massive infiltration of innate cells...