J Don Chen

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Nuclear localization of coactivator RAC3 is mediated by a bipartite NLS and importin alpha3
    Percy Luk Yeung
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Biochem Biophys Res Commun 348:13-24. 2006
  2. ncbi Daxx contains two nuclear localization signals and interacts with importin alpha3
    Percy Luk Yeung
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Cell Biochem 103:456-70. 2008
  3. pmc Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
    H Li
    Departments of Pharmacology and Molecular Toxicology and Cell Biology, Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cell Biol 20:1784-96. 2000
  4. ncbi NuRD complex component Mi-2beta binds to and represses RORgamma-mediated transcriptional activation
    David R Johnson
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Biochem Biophys Res Commun 318:714-8. 2004
  5. ncbi Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT
    Guoqing Liao
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:5052-61. 2003
  6. ncbi Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid
    Jilin Liu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Pharmacol 63:983-92. 2003
  7. pmc Interactions that determine the assembly of a retinoid X receptor/corepressor complex
    Jagadish C Ghosh
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 99:5842-7. 2002
  8. ncbi Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators
    Aihua Zhang
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 279:33799-805. 2004
  9. ncbi SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1
    M Alexandra Monroy
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63122, USA
    Mol Endocrinol 17:2519-28. 2003
  10. pmc Daxx silencing sensitizes cells to multiple apoptotic pathways
    Liuh Yow Chen
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 23:7108-21. 2003

Collaborators

Detail Information

Publications16

  1. ncbi Nuclear localization of coactivator RAC3 is mediated by a bipartite NLS and importin alpha3
    Percy Luk Yeung
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ, USA
    Biochem Biophys Res Commun 348:13-24. 2006
    ..Together, these results reveal a previous unknown mechanism for nuclear translocation of p160 coactivators and a critical function of the conserved bHLH within the coactivator...
  2. ncbi Daxx contains two nuclear localization signals and interacts with importin alpha3
    Percy Luk Yeung
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Cell Biochem 103:456-70. 2008
    ..Together, these data unveil a molecular mechanism that controls nuclear localization of Daxx and support a nuclear role of Daxx in transcriptional regulation...
  3. pmc Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
    H Li
    Departments of Pharmacology and Molecular Toxicology and Cell Biology, Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cell Biol 20:1784-96. 2000
    ..Consistently, Daxx is found at condensed chromatin in cells that lack PML. These data suggest that Daxx is a novel nuclear protein bearing transcriptional repressor activity that may be regulated by interaction with PML...
  4. ncbi NuRD complex component Mi-2beta binds to and represses RORgamma-mediated transcriptional activation
    David R Johnson
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Biochem Biophys Res Commun 318:714-8. 2004
    ..These results may provide evidence as to how RORgamma-mediated transactivation is regulated by other nuclear proteins...
  5. ncbi Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT
    Guoqing Liao
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:5052-61. 2003
    ..Our data establish a significant role of SMRT in modulating AR transcriptional activity...
  6. ncbi Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid
    Jilin Liu
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Pharmacol 63:983-92. 2003
    ..These studies also implicate other potential therapeutic actions of AJA through PPARgamma activation in multiple signaling pathways...
  7. pmc Interactions that determine the assembly of a retinoid X receptor/corepressor complex
    Jagadish C Ghosh
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 99:5842-7. 2002
    ..On the basis of these results, we propose a structural model to help understand the molecular mechanism of corepressor recruitment by RXR...
  8. ncbi Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators
    Aihua Zhang
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Biol Chem 279:33799-805. 2004
    ..Taken together, we have identified a novel family of ankyrin repeats containing cofactors that may recruit histone deacetylases to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation...
  9. ncbi SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1
    M Alexandra Monroy
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63122, USA
    Mol Endocrinol 17:2519-28. 2003
    ..We propose that SRCAP, by virtue of its ability to interact with CBP, functions as a coactivator to regulate transcription initiated by several signaling pathways...
  10. pmc Daxx silencing sensitizes cells to multiple apoptotic pathways
    Liuh Yow Chen
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 23:7108-21. 2003
    ..These data strongly suggest that Daxx may inhibit Fas and stress-mediated apoptosis by suppressing proapoptotic gene expression outside of PML domains...
  11. pmc Characterization of transcriptional regulatory domains of ankyrin repeat cofactor-1
    Aihua Zhang
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    Biochem Biophys Res Commun 358:1034-40. 2007
    ..Together, these results indicate that the transcriptional potential of ANCO-1 may be modulated by a combination of repression and activation signals...
  12. ncbi Subcellular localization of ankyrin repeats cofactor-1 regulates its corepressor activity
    Aihua Zhang
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 5635, USA
    J Cell Biochem 101:1301-15. 2007
    ..These results suggest that ANCO-1 subnuclear localization is regulated by both nuclear import and export signals, and that proper subcellular localization of ANCO-1 is essential for its corepressor function...
  13. ncbi Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators
    Wen Lin
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    J Biochem Mol Biol 39:304-10. 2006
    ....
  14. pmc Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486
    Zheng Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:7940-4. 2002
    ....
  15. ncbi Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
    Kimberly B Kegel
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:7466-76. 2002
    ..Proteolysis of mutant huntingtin may alter nuclear functions by disrupting protein complexes and inappropriately repressing transcription in HD...
  16. ncbi Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function
    Chia Wei Li
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Biochem J 413:349-57. 2008
    ..These data suggest that ADA3 is a newly identified target of the ANCO proteins, which may modulate co-activator function in a transcription-factor-specific manner...