IRVIN SY CHEN

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells
    Masakazu Kamata
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    PLoS Pathog 5:e1000342. 2009
  2. pmc Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAs
    Masakazu Kamata
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11834. 2010
  3. pmc Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice
    Gene Errol E Ringpis
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e53492. 2012
  4. pmc Methodology and software to detect viral integration site hot-spots
    Angela P Presson
    Department of Biostatistics, University of California Los Angeles, School of Public Health, USA
    BMC Bioinformatics 12:367. 2011
  5. pmc Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5
    Saki Shimizu
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine and UCLA AIDS Institute, University California, Los Angeles, Los Angeles, California 90095, USA
    Genet Vaccines Ther 7:8. 2009

Research Grants

  1. UCLA CENTER FOR AIDS RESEARCH (CFAR)
    Irvin Chen; Fiscal Year: 2007
  2. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2007
  3. Retargeting of Retroviral Vectors
    Irvin S Y Chen; Fiscal Year: 2010
  4. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2006
  5. Interdisciplinary Training in Virology and Gene Therapy
    Ren Sun; Fiscal Year: 2007
  6. HIV 1 VPR INDUCES G2 CELL CYCLE ARREST AND APOPTOSIS
    Irvin Chen; Fiscal Year: 2002
  7. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2006
  8. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2007
  9. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2003
  10. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2003

Collaborators

  • Masakazu Kamata
  • Geoff P Symonds
  • Ren Sun
  • Saki Shimizu
  • Gene Errol E Ringpis
  • Angela P Presson
  • Dong Sung An
  • Sanggu Kim
  • Bryan P Burke
  • Patrick Y Kim
  • Ruth Cortado
  • Hubert Arokium
  • Joanna Camba-Col√≥n
  • Yiming Xie
  • Fadi N Kandarian
  • Munetoshi Narukawa
  • Emily L Lowe
  • Anna Sahakyan
  • Maria V Carroll
  • Namshin Kim
  • Yan Xiaofei
  • Joshua Boyer
  • F Xiao Feng Qin
  • Kevin N Chen
  • Shen Pang
  • Panyamol Kittipongdaja

Detail Information

Publications5

  1. pmc Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells
    Masakazu Kamata
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    PLoS Pathog 5:e1000342. 2009
    ..Therefore, we conclude that the primary mechanism of HIV-1 restriction in quiescent CD4+ T-cells remains to be elucidated...
  2. pmc Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAs
    Masakazu Kamata
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11834. 2010
    ..These findings demonstrate that a miRNA dependent reporter vector can be a useful tool to monitor living cells during reprogramming of hiPSC and subsequent differentiation to lineage specific cells...
  3. pmc Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice
    Gene Errol E Ringpis
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e53492. 2012
    ..These results demonstrate that transplantation of HSPCs engineered with our combination shRNA vector may be a potential therapy against HIV disease...
  4. pmc Methodology and software to detect viral integration site hot-spots
    Angela P Presson
    Department of Biostatistics, University of California Los Angeles, School of Public Health, USA
    BMC Bioinformatics 12:367. 2011
    ..This is problematic for comparing hot-spot distributions across data sets and patients, where the VIS numbers may vary...
  5. pmc Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5
    Saki Shimizu
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine and UCLA AIDS Institute, University California, Los Angeles, Los Angeles, California 90095, USA
    Genet Vaccines Ther 7:8. 2009
    ..These results have implications for the application of RNAi technology for therapeutic purposes...

Research Grants48

  1. UCLA CENTER FOR AIDS RESEARCH (CFAR)
    Irvin Chen; Fiscal Year: 2007
    ....
  2. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2007
    ..We propose to model siRNA to HIV-1 and CCR5 using lentiviral vectors for stable delivery. ..
  3. Retargeting of Retroviral Vectors
    Irvin S Y Chen; Fiscal Year: 2010
    ..abstract_text> ..
  4. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2006
    ..Aim 2) To characterize the newly described process of Vpr mediated transactivation of unintegrated HIV-1 DNA. Aim 3) To further characterize the role of Vpr in viral pathogenesis. ..
  5. Interdisciplinary Training in Virology and Gene Therapy
    Ren Sun; Fiscal Year: 2007
    ..At UCLA, this rigorous training program with emphasis on vertical integration of basic sciences and therapeutic applications will produce scientists required for long-term development of gene therapy. ..
  6. HIV 1 VPR INDUCES G2 CELL CYCLE ARREST AND APOPTOSIS
    Irvin Chen; Fiscal Year: 2002
    ..The specific aims are: Aim 1. To further characterize cell cycle arrest by HIV-1 Vpr. Aim 2. To further characterize Vpr mediated apoptosis Aim 3. To identify cellular factors involved in Vpr-mediated cell cycle arrest and apoptosis. ..
  7. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2006
    ..We propose to model siRNA to HIV-1 and CCR5 using lentiviral vectors for stable delivery. ..
  8. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2007
    ..Aim 2) To characterize the newly described process of Vpr mediated transactivation of unintegrated HIV-1 DNA. Aim 3) To further characterize the role of Vpr in viral pathogenesis. ..
  9. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2003
    ..We propose to model siRNA to HIV-1 and CCR5 using lentiviral vectors for stable delivery. ..
  10. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2003
    ..Aim 2) To characterize the newly described process of Vpr mediated transactivation of unintegrated HIV-1 DNA. Aim 3) To further characterize the role of Vpr in viral pathogenesis. ..
  11. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2005
    ..We propose to model siRNA to HIV-1 and CCR5 using lentiviral vectors for stable delivery. ..
  12. Retargeting of Retroviral Vectors
    Irvin Chen; Fiscal Year: 2009
    ..abstract_text> ..
  13. HIV 1 VPR INDUCES G2 CELL CYCLE ARREST AND APOPTOSIS
    Irvin Chen; Fiscal Year: 2000
    ..The specific aims are: Aim 1. To further characterize cell cycle arrest by HIV-1 Vpr. Aim 2. To further characterize Vpr mediated apoptosis Aim 3. To identify cellular factors involved in Vpr-mediated cell cycle arrest and apoptosis. ..
  14. HIV 1 VPR INDUCES G2 CELL CYCLE ARREST AND APOPTOSIS
    Irvin Chen; Fiscal Year: 1999
    ..The specific aims are: Aim 1. To further characterize cell cycle arrest by HIV-1 Vpr. Aim 2. To further characterize Vpr mediated apoptosis Aim 3. To identify cellular factors involved in Vpr-mediated cell cycle arrest and apoptosis. ..
  15. STRUCTURE/FUNCTION OF HIV1 VPR ASSOCIATED CELL PROTEINS
    Irvin Chen; Fiscal Year: 1999
    ..Ideally, structures of both the free Vpr and the complex will be determined. However, since Vpr is known to oligomerize, it may only be possible to determine its structure in the complex. ..
  16. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Relevance RNA interference is a means to block the function of genes. We will investigate whether RNA interference can be used as a potential therapy for HIV-1 disease. ..
  17. Molecular Imaging of Cancer In vivo via Targeted Transduction
    Irvin Chen; Fiscal Year: 2009
    ..The proposed studies address fundamental questions regarding the mode of action of the targeting vector and its utility for molecular imaging. ..
  18. Retargeting of Retroviral Vectors
    Irvin Chen; Fiscal Year: 2006
    ..Given our long-standing interest in retroviral biology, recent development of gene therapy vectors and studies in mice and non-human primates, we feel that we are well positioned to address the questions posed in this application. ..
  19. Modeling HIV-1 siRNA Therapy
    Irvin S Y Chen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Relevance RNA interference is a means to block the function of genes. We will investigate whether RNA interference can be used as a potential therapy for HIV-1 disease. ..
  20. Retargeting of Retroviral Vectors
    Irvin Chen; Fiscal Year: 2007
    ..Given our long-standing interest in retroviral biology, recent development of gene therapy vectors and studies in mice and non-human primates, we feel that we are well positioned to address the questions posed in this application. ..
  21. Molecular Imaging of Cancer In vivo via Targeted Transduction
    Irvin Chen; Fiscal Year: 2007
    ..The proposed studies address fundamental questions regarding the mode of action of the targeting vector and its utility for molecular imaging. ..
  22. Targeting Gene Delivery to the CNS Blood-Brain Barrier
    Irvin Chen; Fiscal Year: 2007
    ..Given our long-standing interest in retroviral biology, recently applied to gene therapy vectors, and the novel targeting approach described here, we feel that we are well positioned to address the questions posed in this application. ..
  23. Structure/Function of HIV-1 Vpr Associated Cell Proteins
    Irvin Chen; Fiscal Year: 2001
    ..This understanding will, in turn, provide us with critical information needed to understand the role of Vpr/HHR23A interaction and to develop potential AIDS therapeutic agents based upon the interaction between these proteins. ..
  24. Structure/Function of HIV-1 Vpr Associated Cell Proteins
    Irvin Chen; Fiscal Year: 2003
    ..This understanding will, in turn, provide us with critical information needed to understand the role of Vpr/HHR23A interaction and to develop potential AIDS therapeutic agents based upon the interaction between these proteins. ..
  25. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 2004
    ..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..
  26. Modeling HIV-1 siRNA Therapy
    Irvin Chen; Fiscal Year: 2004
    ..We propose to model siRNA to HIV-1 and CCR5 using lentiviral vectors for stable delivery. ..
  27. Structure/Function of HIV-1 Vpr Associated Cell Proteins
    Irvin Chen; Fiscal Year: 2004
    ..This understanding will, in turn, provide us with critical information needed to understand the role of Vpr/HHR23A interaction and to develop potential AIDS therapeutic agents based upon the interaction between these proteins. ..
  28. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2004
    ..Aim 2) To characterize the newly described process of Vpr mediated transactivation of unintegrated HIV-1 DNA. Aim 3) To further characterize the role of Vpr in viral pathogenesis. ..
  29. STRUCTURE/FUNCTION OF HIV1 VPR ASSOCIATED CELL PROTEINS
    Irvin Chen; Fiscal Year: 2000
    ..Ideally, structures of both the free Vpr and the complex will be determined. However, since Vpr is known to oligomerize, it may only be possible to determine its structure in the complex. ..
  30. Structure/Function of HIV-1 Vpr Associated Cell Proteins
    Irvin Chen; Fiscal Year: 2005
    ..This understanding will, in turn, provide us with critical information needed to understand the role of Vpr/HHR23A interaction and to develop potential AIDS therapeutic agents based upon the interaction between these proteins. ..
  31. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 1999
    ....
  32. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 2001
    ..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..
  33. HIV 1 VPR INDUCES G2 CELL CYCLE ARREST AND APOPTOSIS
    Irvin Chen; Fiscal Year: 2001
    ..The specific aims are: Aim 1. To further characterize cell cycle arrest by HIV-1 Vpr. Aim 2. To further characterize Vpr mediated apoptosis Aim 3. To identify cellular factors involved in Vpr-mediated cell cycle arrest and apoptosis. ..
  34. HIV-1 Vpr Induces G2 Cell Cycle Arrest and Apoptosis
    Irvin Chen; Fiscal Year: 2005
    ..Aim 2) To characterize the newly described process of Vpr mediated transactivation of unintegrated HIV-1 DNA. Aim 3) To further characterize the role of Vpr in viral pathogenesis. ..
  35. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 2002
    ..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..
  36. Structure/Function of HIV-1 Vpr Associated Cell Proteins
    Irvin Chen; Fiscal Year: 2002
    ..This understanding will, in turn, provide us with critical information needed to understand the role of Vpr/HHR23A interaction and to develop potential AIDS therapeutic agents based upon the interaction between these proteins. ..
  37. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 2005
    ..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..
  38. PRIMATE LENTIVIRUS BASED THERAPY VECTORS
    Irvin Chen; Fiscal Year: 2003
    ..3) Based upon the results of Aims 1 and 2, test the effectiveness of the best anti-HIV gene therapeutic vectors to inhibit HIV-1 1/SIV replication in in vivo model systems of SCID-hu mice and rhesus macaque. ..