Hexin Chen

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. pmc CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling
    P K Lo
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Oncogene 31:2614-26. 2012
  2. doi request reprint Proteomic characterization of Her2/neu-overexpressing breast cancer cells
    Hexin Chen
    Department of Biology, University of South Carolina, Columbia, South Carolina, USA
    Proteomics 10:3800-10. 2010
  3. doi request reprint Expansion of breast cancer stem cells with fibrous scaffolds
    Sheng Feng
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    Integr Biol (Camb) 5:768-77. 2013
  4. doi request reprint Breast tumour initiating cell fate is regulated by microenvironmental cues from an extracellular matrix
    Sharmistha Saha
    Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, SC 29208, USA
    Integr Biol (Camb) 4:897-904. 2012
  5. pmc Nonlinear growth kinetics of breast cancer stem cells: implications for cancer stem cell targeted therapy
    Xinfeng Liu
    Department of Mathematics, University of South Carolina, Columbia, SC 29208
    Sci Rep 3:2473. 2013
  6. doi request reprint Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice
    Deepak Kanojia
    Department of Biological Science, Centre for Colon Cancer, University of South Carolina, Columbia, SC 29205, USA
    Proteomics 12:3407-15. 2012
  7. doi request reprint Discrimination of colon cancer stem cells using noncanonical amino acid
    Xinrui Duan
    Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, SC 29208, USA
    Chem Commun (Camb) 48:9035-7. 2012
  8. pmc Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas
    Pang Kuo Lo
    Department of Biological Sciences, Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Exp Mol Pathol 94:262-9. 2013
  9. pmc Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway
    Xinna Zhang
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Cancer Res 70:7176-86. 2010
  10. pmc Electrospun fibrous scaffolds promote breast cancer cell alignment and epithelial-mesenchymal transition
    Sharmistha Saha
    Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, South Carolina 29208, USA
    Langmuir 28:2028-34. 2012

Collaborators

Detail Information

Publications11

  1. pmc CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling
    P K Lo
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Oncogene 31:2614-26. 2012
    ....
  2. doi request reprint Proteomic characterization of Her2/neu-overexpressing breast cancer cells
    Hexin Chen
    Department of Biology, University of South Carolina, Columbia, South Carolina, USA
    Proteomics 10:3800-10. 2010
    ..Finally, an in silico analysis of published cancer microarray data sets revealed a 23-gene signature, which can be used to predict the probability of metastasis-free survival in breast cancer patients...
  3. doi request reprint Expansion of breast cancer stem cells with fibrous scaffolds
    Sheng Feng
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA
    Integr Biol (Camb) 5:768-77. 2013
    ..These data suggest that the increase of CSC proportion in a 3D culture system may account for the enhanced malignancy. Therefore, our PCL fibrous scaffolds can potentially be used for CSCs enrichment and anti-cancer drug screening...
  4. doi request reprint Breast tumour initiating cell fate is regulated by microenvironmental cues from an extracellular matrix
    Sharmistha Saha
    Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, SC 29208, USA
    Integr Biol (Camb) 4:897-904. 2012
    ....
  5. pmc Nonlinear growth kinetics of breast cancer stem cells: implications for cancer stem cell targeted therapy
    Xinfeng Liu
    Department of Mathematics, University of South Carolina, Columbia, SC 29208
    Sci Rep 3:2473. 2013
    ..The model predictions can help us explain a few long-standing questions in the field of cancer stem cell research, and can be potentially used to predict the efficicacy of anti-cancer therapy. ..
  6. doi request reprint Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice
    Deepak Kanojia
    Department of Biological Science, Centre for Colon Cancer, University of South Carolina, Columbia, SC 29205, USA
    Proteomics 12:3407-15. 2012
    ....
  7. doi request reprint Discrimination of colon cancer stem cells using noncanonical amino acid
    Xinrui Duan
    Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, SC 29208, USA
    Chem Commun (Camb) 48:9035-7. 2012
    ..Metabolic labelling of newly synthesized proteins with non-canonical amino acids allows us to discriminate CSCs in mixed populations due to the quiescent nature of these cells...
  8. pmc Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas
    Pang Kuo Lo
    Department of Biological Sciences, Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Exp Mol Pathol 94:262-9. 2013
    ....
  9. pmc Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway
    Xinna Zhang
    Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    Cancer Res 70:7176-86. 2010
    ..Together, our results suggest an important role of miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis...
  10. pmc Electrospun fibrous scaffolds promote breast cancer cell alignment and epithelial-mesenchymal transition
    Sharmistha Saha
    Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, South Carolina 29208, USA
    Langmuir 28:2028-34. 2012
    ..The results of this study indicate that the topographical cue may play a significant role in tumor progression...
  11. ncbi request reprint Redox potential ultrasensitive nanoparticle for the targeted delivery of camptothecin to HER2-positive cancer cells
    Bahadur K C Remant
    Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter Street, Columbia, South Carolina 29208, United States
    Mol Pharm 11:1897-905. 2014
    ..Furthermore, confocal microscopy revealed that HCN could specifically enter HER2-positive cancer cells. As a consequence, HCN could effectively kill HER2-positive cancer cells while not affecting HER2-negative cells...