Herbert Chen

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Changes in swallowing-related quality of life after parathyroidectomy for hyperparathyroidism: a prospective cohort study
    Scott N Pinchot
    F A C S, K3 705 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Oncologist 17:1271-6. 2012
  2. ncbi ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: a case report and review of the literature
    Scott N Pinchot
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    World J Surg Oncol 7:39. 2009
  3. ncbi Do medical school surgical rotations influence subspecialty choice?
    H Chen
    Department of Surgery, The University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Surg Res 97:172-8. 2001
  4. ncbi MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype
    Jui Yu Chen
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Surg Res 158:15-9. 2010
  5. ncbi Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1
    Herbert Chen
    Department of Surgery, University of Wisconsin Medical School, The University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, USA
    Thyroid 15:511-21. 2005
  6. ncbi The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer
    Herbert Chen
    Department of Surgery, University of Wisconsin, Madison, WI 53792 7375, USA
    Pancreas 39:775-83. 2010
  7. ncbi A comprehensive evaluation of perioperative adjuncts during minimally invasive parathyroidectomy: which is most reliable?
    Herbert Chen
    Section of Endocrine Surgery, Department of Surgery, The University of Wisconsin Medical School, Madison, WI 53792, USA
    Ann Surg 242:375-80; discussion 380-3. 2005
  8. ncbi Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands
    Herbert Chen
    University of Wisconsin Medical School Department of Surgery, H4 750 CSC 600 Highland Avenue, Madison, WI, USA
    Ann Surg 238:332-7; discussion 337-8. 2003
  9. ncbi Operative failures after parathyroidectomy for hyperparathyroidism: the influence of surgical volume
    Herbert Chen
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    Ann Surg 252:691-5. 2010
  10. ncbi The effectiveness of radioguided parathyroidectomy in patients with negative technetium tc 99m-sestamibi scans
    Herbert Chen
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin Medical School, H4 750 Clinical Science Center, Madison, WI 53792, USA
    Arch Surg 144:643-8. 2009

Research Grants

  1. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2010
  2. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2010
  3. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2007
  4. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2007
  5. Novel Signaling Targets in GI Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2005
  6. Signaling Pathways in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2004
  7. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2010

Detail Information

Publications113 found, 100 shown here

  1. ncbi Changes in swallowing-related quality of life after parathyroidectomy for hyperparathyroidism: a prospective cohort study
    Scott N Pinchot
    F A C S, K3 705 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Oncologist 17:1271-6. 2012
    ..To prospectively evaluate the impact of parathyroidectomy on swallowing-related quality of life using the Swallowing Quality Of Life (SWAL-QOL) validated outcomes assessment tool...
  2. ncbi ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: a case report and review of the literature
    Scott N Pinchot
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    World J Surg Oncol 7:39. 2009
    ..Pituitary carcinomas are rare neuroendocrine tumors affecting the adenohypophysis. The hallmark of these lesions is the demonstration of distant metastatic spread. To date, few well-documented cases have been reported in the literature...
  3. ncbi Do medical school surgical rotations influence subspecialty choice?
    H Chen
    Department of Surgery, The University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Surg Res 97:172-8. 2001
    ..Often, this decision is heavily based on their experience on various surgical clerkships. MATERIALS and..
  4. ncbi MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype
    Jui Yu Chen
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Surg Res 158:15-9. 2010
    ..In this study, we investigate the ability of MG-132, a proteasome inhibitor, to inhibit carcinoid growth, the neuroendocrine phenotype, and its association with GSK-3beta...
  5. ncbi Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1
    Herbert Chen
    Department of Surgery, University of Wisconsin Medical School, The University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, USA
    Thyroid 15:511-21. 2005
    ..Specifically, we discuss the role of the raf-1 and achaete-scute homologue-1 pathways in the MTC tumor growth and differentiation...
  6. ncbi The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer
    Herbert Chen
    Department of Surgery, University of Wisconsin, Madison, WI 53792 7375, USA
    Pancreas 39:775-83. 2010
    ..Genetic testing for RET mutations has allowed identification of familial cases and prophylactic thyroidectomy for cure. The only curative treatment is complete surgical resection...
  7. ncbi A comprehensive evaluation of perioperative adjuncts during minimally invasive parathyroidectomy: which is most reliable?
    Herbert Chen
    Section of Endocrine Surgery, Department of Surgery, The University of Wisconsin Medical School, Madison, WI 53792, USA
    Ann Surg 242:375-80; discussion 380-3. 2005
    ....
  8. ncbi Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands
    Herbert Chen
    University of Wisconsin Medical School Department of Surgery, H4 750 CSC 600 Highland Avenue, Madison, WI, USA
    Ann Surg 238:332-7; discussion 337-8. 2003
    ..To determine the utility of radioguided parathyroidectomy for patients with hyperparathyroidism, we studied the properties of 180 resected, hyperfunctioning parathyroid glands...
  9. ncbi Operative failures after parathyroidectomy for hyperparathyroidism: the influence of surgical volume
    Herbert Chen
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    Ann Surg 252:691-5. 2010
    ..To determine whether surgical volume influences the cause of operative failures after parathyroidectomy for hyperparathyroidism...
  10. ncbi The effectiveness of radioguided parathyroidectomy in patients with negative technetium tc 99m-sestamibi scans
    Herbert Chen
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin Medical School, H4 750 Clinical Science Center, Madison, WI 53792, USA
    Arch Surg 144:643-8. 2009
    ..Thus, we were interested in determining the role of radio-guided techniques in patients with primary hyperparathyroidism and negative or nonlocalizing sestamibi scans...
  11. ncbi Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors
    Scott N Pinchot
    University of Wisconsin, Department of Surgery, Section of Endocrine Surgery, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Curr Opin Investig Drugs 9:576-82. 2008
    ..In this review, several pathways thought to be involved in GI NET carcinogenesis are discussed, and novel approaches that are currently in development to target these pathways are highlighted...
  12. ncbi Do future general surgery residents have adequate exposure to endocrine surgery during medical school?
    Herbert Chen
    Department of Surgery, Blalock 679, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    World J Surg 26:17-21. 2002
    ..This paucity of exposure may have significant educational and career ramifications...
  13. ncbi Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy
    Herbert Chen
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin Medical School, Madison 53792, USA
    Surgery 138:583-7; discussion 587-90. 2005
    ..However, several investigators report that these assays are not cost effective and do not improve outcomes significantly...
  14. ncbi Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway
    Scott N Pinchot
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Am J Surg 197:313-9. 2009
    ..Raf-1 pathway activation has been shown to suppress hormone production in carcinoid cells. We investigated a novel treatment for carcinoid cell growth based on pharmacologic Raf-1 activation using the compound tautomycin (TTY)...
  15. ncbi Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors
    Joel T Adler
    Department of Surgery, University of Wisconsin, Clinical Science Center, Madison, 53792, USA
    Ann Surg Oncol 16:481-6. 2009
    ..This combination effectively reduces growth. Thus, lower-dose combination therapy may be a viable therapeutic approach for carcinoid tumors...
  16. ncbi Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells
    David Yu Greenblatt
    F A C S, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Oncologist 12:942-51. 2007
    ..On the basis of this study, a clinical trial of VPA for patients with advanced carcinoid cancer will be conducted. Disclosure of potential conflicts of interest is found at the end of this article...
  17. ncbi Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma
    Li Ning
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin School of Medicine and Public Health, and the University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI, USA
    Ann Surg Oncol 15:2600-5. 2008
    ..Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy that frequently metastasizes and has few treatments. This study was aimed at assessing the antitumor effects of suberoyl bishydroxamic acid (SBHA) in an in vivo model of MTC...
  18. ncbi Valproic acid induces Notch1 signaling in small cell lung cancer cells
    Christopher S Platta
    Endocrine Surgery Research Laboratories, Department of Surgery and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Surg Res 148:31-7. 2008
    ..Activation of the Notch1 signaling pathway also impairs SCLC cell viability. In this study, we investigated the ability of the HDAC inhibitor valproic acid (VPA) to activate Notch1 signaling and inhibit proliferation in SCLC cells...
  19. ncbi Preoperative ultrasonography findings predict the need for repeated surgery in papillary thyroid cancer
    Jennifer L Poehls
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Endocr Pract 18:403-9. 2012
    ..To determine the impact of neck ultrasonography in predicting papillary thyroid cancer persistence or recurrence...
  20. ncbi Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors
    Susan C Pitt
    Endocrine Surgery Research Laboratory, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Ann Surg Oncol 16:2936-42. 2009
    ..Therefore, we hypothesized that inhibition of the PI3K/Akt pathway would suppress carcinoid tumor cell growth and neuroendocrine (NE) marker production...
  21. ncbi Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells
    David Yu Greenblatt
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
    Ann Surg 247:1036-40. 2008
    ..To examine the effects of valproic acid (VPA) on Notch1 expression and cancer cell proliferation in medullary thyroid cancer (MTC) cells...
  22. ncbi Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth
    Mackenzie R Cook
    Endocrine Surgery Research Laboratory, University of Wisconsin, and the University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA
    Mol Cancer Ther 9:429-37. 2010
    ..In summary, LFN and TFN inhibit carcinoid cell proliferation in vitro and in vivo and alter the expression of NET markers. This compound thus represents an attractive target for further clinical investigation...
  23. ncbi Focal adhesion kinase, a downstream mediator of Raf-1 signaling, suppresses cellular adhesion, migration, and neuroendocrine markers in BON carcinoid cells
    Li Ning
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin School of Medicine and Public Health and University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA
    Mol Cancer Res 8:775-82. 2010
    ..Our results showed for the first time that FAK is an essential downstream effector of the Raf-1/MEK1/2/ERK1/2 signaling cascade and negatively regulated the neuroendocrine and metastatic phenotype in BON cells...
  24. ncbi Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells
    Rebecca S Sippel
    Dept of Surgery, Univ of Wisconsin Medical School, University of Wisconsin Comprehensive Cancer Center, Madison 53792, USA
    Am J Physiol Gastrointest Liver Physiol 285:G245-54. 2003
    ..These results show that raf-1 induction suppresses neuroendocrine marker and hormone production in human gastrointestinal carcinoid cells via a pathway dependent on MEK activation...
  25. ncbi Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells
    Muthusamy Kunnimalaiyaan
    University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Mol Cancer Ther 6:1151-8. 2007
    ..Also, our results show that inactivation of GSK-3beta alone is sufficient to inhibit the growth of TT cells both in vitro and in vivo...
  26. ncbi Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells
    David Yu Greenblatt
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Gastrointest Surg 11:1515-20; discussion 1520. 2007
    ..We conclude that SBHA shows promise as a potential anticancer agent for the treatment of patients with advanced carcinoid tumor disease...
  27. ncbi Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells
    Li Ning
    Department of Surgery, University of Wisconsin, Wisconsin, USA
    Oncologist 13:98-104. 2008
    ..Therefore, Notch-1 activation with SBHA is an attractive new strategy for the treatment of patients with MTC...
  28. ncbi Tertiary hyperparathyroidism: is less than a subtotal resection ever appropriate? A study of long-term outcomes
    Susan C Pitt
    Department of Surgery, Section of Endocrine Surgery, University of Wisconsin, Madison, WI 53792 3284, USA
    Surgery 146:1130-7. 2009
    ..Our aim was to examine the outcomes of patients with tertiary hyperparathyroidism (3-HPT) who had limited resection of 1 or 2 parathyroids...
  29. ncbi Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells
    Susan C Pitt
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Am Coll Surg 209:82-8. 2009
    ..But the importance of PI3K-Akt signaling has not been explored in pulmonary carcinoids. In this study, our objective was to establish the role of the PI3K-Akt signal transduction pathway in pulmonary carcinoid cells...
  30. ncbi Older age and larger tumor size predict malignancy in hürthle cell neoplasms of the thyroid
    Yi Wei Zhang
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI, 53792, USA
    Ann Surg Oncol 15:2842-6. 2008
    ..However, differentiating HCC from HCA either before or during surgery is a challenge. The purpose of this study was to identify factors that predict malignancy in patients with HCN...
  31. ncbi Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors
    Xueming Xiao
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI 53792 7375, USA
    Mol Cancer Ther 8:350-6. 2009
    ....
  32. ncbi Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta
    Joel T Adler
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Mol Cancer Ther 8:914-20. 2009
    ..Importantly, we describe a novel action of these compounds: inhibition of glycogen synthase kinase-3beta...
  33. ncbi The role of gender in primary hyperparathyroidism: same disease, different presentation
    Haggi Mazeh
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Ann Surg Oncol 19:2958-62. 2012
    ..Hyperparathyroidism is much more common in women and therefore may represent different diseases in men and women. In order to understand the role of gender in hyperparathyroidism, we reviewed our experience...
  34. ncbi Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride
    Joel T Adler
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Surg Res 159:640-4. 2010
    ..These compounds have been shown to limit growth and suppress hormonal secretion; thus, targeting different signaling pathways may be an effective treatment...
  35. ncbi Can biochemical abnormalities predict symptomatology in patients with primary hyperparathyroidism?
    Anna E Bargren
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    J Am Coll Surg 213:410-4. 2011
    ..We sought to determine if the severity of preoperative biochemical abnormalities (calcium, parathyroid hormone, vitamin D levels) correlated with symptomatology in patients undergoing surgical treatment for primary hyperparathyroidism...
  36. ncbi Does routine use of ultrasound result in additional thyroid procedures in patients with primary hyperparathyroidism?
    Joel T Adler
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Am Coll Surg 211:536-9. 2010
    ..How the identification of incidental thyroid lesions affects patient management is unclear...
  37. ncbi Thallium-pertechnetate subtraction scanning in the preoperative localization of an ectopic undescended parathyroid gland
    James Frydman
    Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Clin Nucl Med 29:542-4. 2004
    ..This case report illustrates the importance of TPSS as a second-line modality in preoperative adenoma localization, thereby using minimally invasive techniques to successfully treat this patient's primary hyperparathyroidism...
  38. ncbi ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines
    Dustin Deming
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Surg Res 161:28-32. 2010
    ..GSK-3beta has previously been shown to mediate cell survival in pancreatic cancer cells. Here we determine the effects of ZM336372 on GSK-3beta phosphorylation, apoptosis, and growth in pancreatic adenocarcinoma cell lines...
  39. ncbi ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line
    Dustin Deming
    Department of Medicine, University of Wisconsin, K4 528, Madison, WI 53792, USA
    J Gastrointest Surg 12:852-7. 2008
    ..ZM336372 causes growth inhibition, suppression of hormone secretion, and up-regulation of cell cycle inhibitors in a human hepatocellular carcinoma cell line, similar to that previously seen in NETs...
  40. ncbi Follicular thyroid cancer cell growth inhibition by proteosome inhibitor MG132
    Samantha J Stoll
    Endocrine Surgery Research Laboratory, Department of Surgery, University of Wisconsin, Madison, WI 53792 3284, USA
    J Surg Res 156:39-44. 2009
    ..Therefore, we sought to determine the effects of proteosome inhibition, an emerging class of chemotherapeutic agents, on metastatic FTC cells...
  41. ncbi ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells
    Jamie J Van Gompel
    Department of Surgery, University of Wisconsin Medical School, Madison, 53792, USA
    Mol Cancer Ther 4:910-7. 2005
    ..In summary, ZM336372 targets both proliferation and palliative issues associated with carcinoid tumor cells, and therefore, warrants further investigation as a possible therapeutic strategy for patients with carcinoid tumors...
  42. ncbi Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo
    Xiao Min Yu
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    Cancer 119:774-81. 2013
    ..It is suspected that the Notch signaling pathway, which is not active in ATC, may have a tumor suppressor function in this neoplasm. However, it remains unknown whether activation of Notch can yield therapeutic efficacies in ATC...
  43. ncbi Sestamibi imaging for primary hyperparathyroidism: the impact of surgeon interpretation and radiologist volume
    Saqib Zia
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Ann Surg Oncol 19:3827-31. 2012
    ..We hypothesized that the accuracy of sestamibi scanning for primary hyperparathyroidism is dependent upon surgeon interpretation and radiologist volume...
  44. ncbi Using body mass index to predict optimal thyroid dosing after thyroidectomy
    Kristin A Ojomo
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Am Coll Surg 216:454-60. 2013
    ..This method can lead to considerable delays in achieving euthyroidism and often fails to accurately dose over- and underweight patients. Our aim was to develop an accurate dosing method that uses patient body mass index (BMI) data...
  45. ncbi Neurocognitive dysfunction: a predictor of parathyroid hyperplasia
    Daniel Repplinger
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Surgery 146:1138-43. 2009
    ..To determine whether a symptomatic presentation was associated with parathyroid hyperplasia, we retrospectively examined pre-operative symptom profiles of patients who underwent parathyroidectomy...
  46. ncbi Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways
    Muthusamy Kunnimalaiyaan
    Endocrine Surgery Research Laboratories, Section of Endocrine Surgery, Department of Surgery, Madison, Wisconsin, USA
    Surgery 142:959-64; discussion 959-64. 2007
    ..In the present study, we further characterize the molecular details of the growth inhibition by the signaling-based compound ZM336372 in neuroendocrine neoplasms (NENs)...
  47. ncbi Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells
    Joel T Adler
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, H4 722 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    World J Surg 33:2452-7. 2009
    ..We hypothesized that inhibition of the PI3K-Akt pathway would be a viable strategy to inhibit growth and hormonal secretion in pheochromocytoma cells...
  48. ncbi Preserving function and quality of life after thyroid and parathyroid surgery
    Joel T Adler
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet Oncol 9:1069-75. 2008
    ..In this Review, we summarise current approaches to surgical treatment of thyroid and parathyroid disease, focusing on how these approaches both preserve function and improve quality of life after surgery...
  49. ncbi The role of human achaete-scute homolog-1 in medullary thyroid cancer cells
    Rebecca S Sippel
    Department of Surgery, The University of Wisconsin Medical School and the University of Wisconsin Comprehensive Cancer Center, 600 Highland Avenue, Madison, WI 53792, USA
    Surgery 134:866-71; discussion 871-3. 2003
    ..Thyroid C-cells do not develop in hASH1 knockout mice, which suggests that hASH1 is essential for normal C-cell development...
  50. ncbi Does frozen section alter surgical management of multinodular thyroid disease?
    Sarah Olson
    Department of Surgery, Section of Endocrine Surgery, University of Wisconsin, Madison, Wisconsin 58792, USA
    J Surg Res 136:179-81. 2006
    ..Frozen section (FS) evaluation during thyroid surgery is often used to guide intraoperative management. We sought to determine the utility of FS in patients undergoing thyroidectomy for multinodular thyroid disease...
  51. ncbi The need for intraoperative parathyroid hormone monitoring during radioguided parathyroidectomy by video-assisted thoracoscopy (VATS)
    Jeffrey L Wild
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    Clin Nucl Med 31:9-12. 2006
    ..This case also emphasizes that although VATS was planned, in treating patients with 1HPT, one must also be prepared to perform a neck exploration...
  52. ncbi Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells
    Muthusamy Kunnimalaiyaan
    Dept of Surgery, University of Wisconsin Medical School, Madison, WI 53792, USA
    Am J Physiol Gastrointest Liver Physiol 289:G636-42. 2005
    ..Therefore, manipulation of the Notch1 signaling pathway may be useful for expanding the targets for therapeutic and palliative treatment of patients with carcinoid tumors...
  53. ncbi Radioguided parathyroidectomy in patients with secondary and tertiary hyperparathyroidism
    Peter F Nichol
    Department of Surgery, The University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Surgery 134:713-7; discussion 717-9. 2003
    ..Thus RGP appears to be a useful adjunct in the treatment of secondary and tertiary hyperparathyroidism...
  54. ncbi The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing
    Fumito Ito
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Ann Surg 245:959-63. 2007
    ..To determine the utility of routine perioperative bilateral internal jugular venous sampling of parathyroid hormone (BIJ PTH) for localization during parathyroid surgery...
  55. ncbi Training our future endocrine surgeons: a look at the endocrine surgery operative experience of U.S. surgical residents
    Barbara Zarebczan
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison 53792 7375, USA
    Surgery 148:1075-80; discussion 1080-1. 2010
    ..We sought to determine whether this has translated into an increase in operative volume for general surgery and otolaryngology residents...
  56. ncbi In patients with thyroid cancer of follicular cell origin, a family history of nonmedullary thyroid cancer in one first-degree relative is associated with more aggressive disease
    Haggi Mazeh
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    Thyroid 22:3-8. 2012
    ..The aim of this study was to determine whether patients with a family history of NMTC, but who do not meet the definition of FNMTC, have more aggressive disease...
  57. ncbi Pheochromocytoma: current approaches and future directions
    Joel T Adler
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Oncologist 13:779-93. 2008
    ..In this review, we discuss the presentation, diagnosis, management, and future directions in the management of this disease...
  58. ncbi Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
    Muthusamy Kunnimalaiyaan
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Biol Chem 281:39819-30. 2006
    ..Mechanistically, we show that MTC cell growth inhibition by NOTCH1 is mediated by cell cycle arrest associated with up-regulation of p21...
  59. ncbi Thyroid resection improves perception of swallowing function in patients with thyroid disease
    David Yu Greenblatt
    Department of Surgery, University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA
    World J Surg 33:255-60. 2009
    ..We used the swallowing quality of life (SWAL-QOL) validated outcomes assessment tool to measure changes in swallowing-related QOL in patients undergoing thyroid surgery...
  60. ncbi Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells
    Joel T Adler
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, Wis, USA
    Surgery 144:956-61; discussion 961-2. 2008
    ..We hypothesized that HDAC inhibition would be an effective strategy to activate the Notch-1 pathway and inhibit growth and hormonal secretion in pheochromocytoma cells...
  61. ncbi Carcinoid tumors
    Scott N Pinchot
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    Oncologist 13:1255-69. 2008
    ..The prognosis for patients with these tumors is generally favorable; however, it can be quite variable and is related to the location of the primary tumor, extent of metastatic disease at initial presentation, and time of diagnosis...
  62. ncbi ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells
    Ashley Kappes
    Endocrine Surgery Research Laboratories, Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Surg Res 133:42-5. 2006
    ..In pheochromocytoma cells, ZM336372 blocks cellular proliferation and suppresses NE vasoactive peptide production. Thus, ZM336372 may be used for both therapeutic and palliative treatment for patients with pheochromocytomas...
  63. ncbi Clinical efficacy of fine-needle aspiration biopsy of thyroid nodules in males
    Adam J Schiro
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Surg Res 159:645-50. 2010
    ..We hypothesize that FNA biopsy is an accurate preoperative tool for detecting thyroid cancer in men, and that false negative rates are significantly lower than recently reported...
  64. ncbi Utility of intraoperative PTH for primary hyperparathyroidism due to multigland disease
    Ashley K Cayo
    Department of Surgery, University of Wisconsin, Madison, WI, USA
    Ann Surg Oncol 16:3450-4. 2009
    ..The aim of this study was to determine the utility of ioPTH monitoring for MGD...
  65. ncbi Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling
    Eric K Nakakura
    Department of Surgery, University of California, San Francisco, California 94115, USA
    J Clin Endocrinol Metab 90:4350-6. 2005
    ....
  66. ncbi Initial lymph node dissection increases cure rates in patients with medullary thyroid cancer
    David Yu Greenblatt
    Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Asian J Surg 30:108-12. 2007
    ..We reviewed our experience to determine if the initial operation influences clinical outcomes...
  67. ncbi Radioguided Parathyroid surgery
    Herbert Chen
    Department of Surgery, The University of Wisconsin, Madison, Wisconsin, USA
    Adv Surg 38:377-92. 2004
  68. ncbi Influence of surgical volume on operative failures for hyperparathyroidism
    Barbara Zarebczan
    Department of Surgery, University of Wisconsin, 600 Highland Avenue, H4 722, Madison, WI 53792, USA
    Adv Surg 45:237-48. 2011
    ..In the hands of experienced surgeons, both initial cure rates and those for reoperations are much higher, illustrating that the surgical volume does affect failure in parathyroid surgery...
  69. ncbi The necessity and reliability of intraoperative parathyroid hormone (PTH) testing in patients with mild hyperparathyroidism and PTH levels in the normal range
    Amal Alhefdhi
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, H4 722 CSC 600 Highland Avenue, Madison, WI 53792, USA
    World J Surg 35:2006-9. 2011
    ..We sought to determine if IoPTH testing is necessary in these patients and if the 50% rule delineating surgical cure is reliable...
  70. ncbi Ex vivo radioactive counts and decay rates of tissues resected during radioguided parathyroidectomy
    Jordan Olson
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison Wisconsin 53792, USA
    J Surg Res 136:187-91. 2006
    ..These tissues have similar decay rates, allowing these predictions to be made anytime up to 30 min after gland resection...
  71. ncbi A pilot phase II study of valproic acid for treatment of low-grade neuroendocrine carcinoma
    Tabraiz A Mohammed
    D O, M S, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Oncologist 16:835-43. 2011
    ..Thus, this study aimed to evaluate the role of VPA in treating NETs and to determine whether VPA induced the Notch signaling pathway signaling in vivo...
  72. ncbi A preclinical and clinical study of lithium in low-grade neuroendocrine tumors
    Sam J Lubner
    University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA
    Oncologist 16:452-7. 2011
    ..Use of lithium chloride in murine models suppressed carcinoid cell growth, reduced GSK-3β levels, and reduced expression of chromogranin A. This study assessed the efficacy of lithium chloride in patients with NETs...
  73. ncbi Lithium ions: a novel treatment for pheochromocytomas and paragangliomas
    Ashley Kappes
    Department of Surgery, Endocrine Surgery Research Laboratories, Section of Endocrine Surgery, University of Wisconsin, Madison, WI 53792, USA
    Surgery 141:161-5; discussion 165. 2007
    ..Thus, we hypothesized that inhibition of this signaling pathway with lithium chloride (LiCl), a well-known GSK3beta inhibitor, could be a potential therapeutic strategy to control tumor growth and hormone production...
  74. ncbi Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
    Muthusamy Kunnimalaiyaan
    Department of Surgery, Section of Endocrine Surgery, Endocrine Surgery Research Laboratories, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Surgery 140:1009-14; discussion 1014-5. 2006
    ..Inhibition of this important signal transduction pathway may lead to a possible therapeutic strategy to treat patients with MTC...
  75. ncbi The negative sestamibi scan: is a minimally invasive parathyroidectomy still possible?
    Alysandra Lal
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Ann Surg Oncol 14:2363-6. 2007
    ..The objectives of this study were to determine whether patients with primary HPT and negative sestamibi scans can benefit from additional imaging studies and are still potential candidates for MIP...
  76. ncbi What is the biology and optimal treatment for papillary microcarcinoma of the thyroid?
    Yusra Cheema
    Department of Surgery, Section of Endocrine Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Surg Res 134:160-2. 2006
    ..Therefore, to characterize the biology and optimal treatment for papillary microcarcinomas, we reviewed our experience...
  77. ncbi Radioguided parathyroidectomy in patients with familial hyperparathyroidism
    Alysandra Lal
    Department of Surgery, Section of Endocrine Surgery, University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Ann Surg Oncol 14:739-43. 2007
    ..No studies have focused on the role of RGP in patients with familial HPT...
  78. ncbi Is tumor size the best predictor of outcome for papillary thyroid cancer?
    Yusra Cheema
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, H4 750 CSC, Madison, WI 53792, USA
    Ann Surg Oncol 13:1524-8. 2006
    ..Therefore, we reviewed our experience in order to determine which factors best predict outcome for papillary thyroid cancer. In addition, we sought to establish a tumor size threshold beyond which papillary cancers require treatment...
  79. ncbi Activation of the ras/raf-1 signal transduction pathway in carcinoid tumor cells results in morphologic transdifferentiation
    Rebecca S Sippel
    Department of Surgery, The University of Wisconsin Medical School, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Surgery 132:1035-9; discussion 1039. 2002
    ..The mechanism by which it alters neuroendocrine tumor cells is unclear. We hypothesize that activation of the ras/raf signal transduction pathway may alter gastrointestinal carcinoid cells by inducing morphologic transdifferentiation...
  80. ncbi How should medical student surgical rotations be structured to optimize education?
    Sharon M Weber
    University of Wisconsin, Department of Surgery, Madison, Wisconsin, USA
    J Surg Res 126:145-8. 2005
    ..We evaluated improvements in knowledge for students exposed to the two following types of surgical education: (1) traditional service-based rotations and (2) focused mini-rotations in a surgical subspecialty...
  81. ncbi Radioguided techniques for parathyroid surgery
    Brenda Satchie
    Department of Surgery, University of Wisconsin Medical School, Madison 53792, USA
    Asian J Surg 28:77-81. 2005
  82. ncbi Diagnostic utility of fine-needle aspiration cytology in pediatric differentiated thyroid cancer
    Anna E Bargren
    Section of Endocrine Surgery, Department of Surgery, H4 722 Clinical Science Center, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    World J Surg 34:1254-60. 2010
    ..This study was designed to determine the ability of fine-needle aspiration cytology (FNA) to diagnose accurately and facilitate management of thyroid neoplasms in pediatric patients...
  83. ncbi Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancer
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Thyroid 19:1373-80. 2009
    ..Within these parameters, however, there are a number of controversies regarding the extent of surgery...
  84. ncbi Insulin-like growth factor 1 signaling in human gastrointestinal carcinoid tumor cells
    Jamie Joseph Van Gompel
    Department of Surgery, University of Wisconsin Comprehensive Cancer Center, 600 Highland Avenue, Madison, WI 53792, USA
    Surgery 136:1297-302. 2004
    ..Therefore, raf-1/MEK1 activation may be a viable method to block IGF-1-mediated cellular effects and serve as a therapeutic target in gastrointestinal carcinoid tumors...
  85. ncbi Radioguided thoracoscopic mediastinal parathyroidectomy with intraoperative parathyroid hormone testing
    Tracey L Weigel
    Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA
    Ann Thorac Surg 80:1262-5. 2005
    ..The goal of this study was to evaluate the feasibility of radioguided thoracoscopic mediastinal parathyroidectomy and intraoperative immunoreactive parathyroid hormone (iPTH) level testing to guide completeness of resection...
  86. ncbi Current management of medullary thyroid cancer
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin, Wisconsin 53792 7375, USA
    Oncologist 13:539-47. 2008
    ..The extent and timing of surgical excision are discussed. Systemic therapeutic options are limited for medullary thyroid cancer, but several therapeutic targets show promise for the development of new therapies in the future...
  87. ncbi The role of intraoperative frozen section if suspicious for papillary thyroid cancer
    Megan R Haymart
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Thyroid 18:419-23. 2008
    ..However, if there are characteristics of an aspirate suspicious for PTC but not meeting criteria for diagnosis of PTC, the management is less clear...
  88. ncbi Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion
    David Yu Greenblatt
    Endocrine Surgery Research Laboratories, Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA
    Am J Surg 193:331-5; discussion 335. 2007
    ..Activation of the Raf-1 signaling pathway in carcinoid cells results in morphologic changes. These Raf-1-induced structural changes may affect cellular adhesion, thereby altering metastatic potential...
  89. ncbi In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer
    Abram Vaccaro
    Endocrine Surgery Research Laboratories, Department of Surgery and University of Wisconsin Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin, USA
    Anticancer Drugs 17:849-53. 2006
    ..These results suggest that strategies to activate the raf-1/MEK/ERK1/2 signaling pathway may be a viable approach to treat patients with metastatic medullary thyroid cancer...
  90. ncbi Radioguided parathyroidectomy for recurrent parathyroid cancer
    Kimberly Placzkowski
    Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Clin Nucl Med 32:358-60. 2007
    ..The use of radioguidance and intraoperative PTH monitoring were the keys to a successful resection, and our patient remains disease free with 17 months of follow-up...
  91. ncbi Contralateral papillary thyroid cancer: does size matter?
    Susan C Pitt
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Am J Surg 197:342-7. 2009
    ..The optimal extent of thyroidectomy for papillary thyroid cancer (PTC) <1 cm is controversial. Our aim was to identify the rate and factors predictive of contralateral PTC in these patients...
  92. ncbi The role of intraoperative parathyroid hormone testing in patients with tertiary hyperparathyroidism after renal transplantation
    Silke V Haustein
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin Medical School, Madison, WI 53792, USA
    Surgery 138:1066-71; discussion 1071. 2005
    ..Therefore, similar to its role in patients with primary HPT, intraoperative PTH testing appears to play an equally important role in the management of patients with tertiary HPT undergoing parathyroidectomy...
  93. ncbi Multi-targeted approach in the treatment of thyroid cancer
    B Zarebczan
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, WI, USA
    Minerva Chir 65:59-69. 2010
    ..We will also address many of the studied genetic pathways and new therapeutic drug targets for treating individual thyroid malignancies...
  94. ncbi Palliative thyroidectomy for malignant lymphoma of the thyroid
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Ann Surg Oncol 9:907-11. 2002
    ..In this group of patients, thyroidectomy can be associated with good long-term palliation and low morbidity...
  95. ncbi Effective surgical residents strongly influence medical students to pursue surgical careers
    Sandeepa Musunuru
    Department of Surgery, University of Wisconsin, Madison, WI 53792, USA
    J Am Coll Surg 204:164-7. 2007
    ..There is a paucity of data about the influence of surgical residents on the career choices of medical students. We hypothesized that medical students exposed to effective surgical residents would be more likely to pursue careers in surgery...
  96. ncbi Risks and consequences of incidental parathyroidectomy during thyroid resection
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    ANZ J Surg 77:33-6. 2007
    ..Inadvertent removal of the parathyroid glands during elective thyroid surgery occurs more frequently in certain high-risk patients and can lead to symptomatic hypocalcaemia...
  97. ncbi Radioguided parathyroidectomy for recurrent hyperparathyroidism caused by forearm graft hyperplasia
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Bone Miner Res 18:939-42. 2003
    ..The intraoperative radioprobe allowed quick identification and removal of the abnormal parathyroid tissue in a case that was made particularly challenging by the absence of marking sutures...
  98. ncbi The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells
    Christopher S Platta
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
    J Surg Res 142:219-26. 2007
    ..Histone deacetylase inhibitors (HDACIs) represent a new class of anticancer agents. Trichostatin A (TSA), an HDACI, has been shown to inhibit growth in several cancers. We hypothesized that TSA may inhibit proliferation of SCLC cells...
  99. ncbi Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors
    Muthusamy Kunnimalaiyaan
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    Oncologist 12:535-42. 2007
    ..Therefore, identification of compound(s) that activate the Notch-1 pathway in NETs could be a potential strategy to treat patients with NETs...
  100. ncbi Radioguided parathyroidectomy via VATS combined with intraoperative parathyroid hormone testing: the surgical approach of choice for patients with mediastinal parathyroid adenomas?
    Jacquelyn K O'Herrin
    Department of Surgery, University of Wisconsin Medical School, Madison 53792, USA
    J Bone Miner Res 17:1368-71. 2002
    ....
  101. ncbi Surgery for primary hyperparathyroidism: what is the best approach?
    Herbert Chen
    Ann Surg 236:552-3. 2002

Research Grants15

  1. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2010
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  2. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2010
    ..In this proposal, we will explore the potential to utilize GSK3B inhibitors to improve surgical outcomes for patients with metastatic MTC. ..
  3. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2007
    ..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. ..
  4. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2007
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  5. Novel Signaling Targets in GI Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2005
    ..The possibility that raf-l-mediated hormone suppression could be induced by a soluble factor would provide a plausible, therapeutic delivery method. ..
  6. Signaling Pathways in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2004
    ..abstract_text> ..
  7. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2010
    ..In this proposal, we will explore the potential to utilize GSK3B inhibitors to improve surgical outcomes for patients with metastatic MTC. ..