Guangchun Chen

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Antiviral immunity in amphibians
    Guangchun Chen
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Viruses 3:2065-86. 2011
  2. pmc Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs
    Francisco De Jesús Andino
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 432:435-43. 2012
  3. pmc Immune evasion strategies of ranaviruses and innate immune responses to these emerging pathogens
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Viruses 4:1075-92. 2012
  4. pmc Waterborne infectivity of the Ranavirus frog virus 3 in Xenopus laevis
    Jacques Robert
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 417:410-7. 2011
  5. pmc Improved knockout methodology reveals that frog virus 3 mutants lacking either the 18K immediate-early gene or the truncated vIF-2alpha gene are defective for replication and growth in vivo
    Guangchun Chen
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Virol 85:11131-8. 2011

Collaborators

Detail Information

Publications5

  1. pmc Antiviral immunity in amphibians
    Guangchun Chen
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Viruses 3:2065-86. 2011
    ....
  2. pmc Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs
    Francisco De Jesús Andino
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 432:435-43. 2012
    ..Furthermore, greater proportions of larval than adult PLs were infected by FV3. Our study suggests that tadpole susceptibility to FV3 infection is partially due to poor virus-elicited innate immune responses...
  3. pmc Immune evasion strategies of ranaviruses and innate immune responses to these emerging pathogens
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Viruses 4:1075-92. 2012
    ..This review focuses on the recent advances in the understanding of the RV immune evasion strategies with emphasis on the roles of the innate immune system in ranaviral infections...
  4. pmc Waterborne infectivity of the Ranavirus frog virus 3 in Xenopus laevis
    Jacques Robert
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 417:410-7. 2011
    ..These data highlight the efficiency of FV3 infectivity by the water route and the ability of FV3 to adapt to its hosts...
  5. pmc Improved knockout methodology reveals that frog virus 3 mutants lacking either the 18K immediate-early gene or the truncated vIF-2alpha gene are defective for replication and growth in vivo
    Guangchun Chen
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Virol 85:11131-8. 2011
    ..In addition, our study describes a powerful methodology that lays the foundation for the discovery of potentially new ranaviral genes involved in virulence and immune escape...