Grace Y Chen
Affiliation: University of Michigan
Chen G, Shaw M, Kim Y, Nunez G. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol. 2009;4:365-98 pubmed publisher
Chen G, Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10:826-37 pubmed publisher
..The sterile inflammation that ensues either resolves the initial insult or leads to disease. Here, we review the triggers and receptor pathways that result in sterile inflammation and its impact on human health. ..
Li Y, Zhang T, Chen G. Flavonoids and Colorectal Cancer Prevention. Antioxidants (Basel). 2018;7: pubmed publisher
Zhan Y, Seregin S, Chen J, Chen G. Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-? Production. J Immunol. 2016;196:5121-9 pubmed publisher
..Collectively, these results suggest a previously unappreciated role for the innate immune receptor Nod1 in suppressing colitis-associated tumorigenesis through a T cell-mediated mechanism. ..
Chen G. Regulation of the gut microbiome by inflammasomes. Free Radic Biol Med. 2017;105:35-40 pubmed publisher
..A better understanding of the function of inflammasomes in microbiome regulation may lead to the development of effective strategies for the prevention and treatment of diseases driven by dysbiosis. ..
Chen G, Liu M, Wang F, Bertin J, Nunez G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol. 2011;186:7187-94 pubmed publisher
..This study highlights the importance of NLR function in maintaining intestinal homeostasis to prevent the development of aberrant inflammation and tumor development within the colon. ..
Chen G, Nunez G. Inflammasomes in intestinal inflammation and cancer. Gastroenterology. 2011;141:1986-99 pubmed publisher
Seregin S, Golovchenko N, Schaf B, Chen J, Pudlo N, Mitchell J, et al
. NLRP6 Protects Il10-/- Mice from Colitis by Limiting Colonization of Akkermansia muciniphila. Cell Rep. 2017;19:733-745 pubmed publisher
..Our results demonstrate that A. muciniphila can act as a pathobiont to promote colitis in a genetically susceptible host and that NLRP6 is a key regulator of its abundance. ..