Genomes and Genes
Ching Ju Chen
Affiliation: University of North Carolina
- A mutant form of the Neisseria gonorrhoeae pilus secretin protein PilQ allows increased entry of heme and antimicrobial compoundsChing Ju Chen
Department of Medicine Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7031, USA
J Bacteriol 186:730-9. 2004..These results show that PilQ forms a channel that allows entry of heme and certain antimicrobial compounds and that a gain-of function point mutation in pilQ results in TonB-independent, PilT-dependent increase of entry...
- Point mutations in HpuB enable gonococcal HpuA deletion mutants to grow on hemoglobinChing Ju Chen
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Bacteriol 184:420-6. 2002..Thus, HpuB point mutants internalized heme in the absence of HpuA despite reduced binding of Hb. HpuA facilitated Hb binding and was important in allowing use of heme from Hb for growth...
- Comparison of immune responses to gonococcal PorB delivered as outer membrane vesicles, recombinant protein, or Venezuelan equine encephalitis virus replicon particlesWeiyan Zhu
University of North Carolina at Chapel Hill, Department of Medicine, Division of Infectious Disease Research, 8341 Medical Biomolecular Research Bldg, 103 Mason Farm Road, CB 7031, Chapel Hill, NC 27599, USA
Infect Immun 73:7558-68. 2005..This information coupled with an understanding of protective antigonococcal immune responses will enable the design of the optimal vaccine for N. gonorrhoeae...