Chao Yin Chen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice
    Chao Yin Chen
    Dept of Pharmacology, Univ of California, Davis, GBSF 3510C, 1 Shields Ave, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 295:H632-9. 2008
  2. pmc Retrograde release of endocannabinoids inhibits presynaptic GABA release to second-order baroreceptive neurons in NTS
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, CA 95616, USA
    Auton Neurosci 158:44-50. 2010
  3. pmc Postexercise hypotension: central mechanisms
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, CA 95616, USA
    Exerc Sport Sci Rev 38:122-7. 2010
  4. ncbi request reprint Postexercise hypotension in conscious SHR is attenuated by blockade of substance P receptors in NTS
    Chao Yin Chen
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of California Davis, TB 172, One Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 283:H1856-62. 2002
  5. pmc Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, Davis, California 95616, USA
    J Neurosci 29:2754-61. 2009
  6. ncbi request reprint Neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates
    Chao Yin Chen
    Department of Internal Medicine, School of Medicine, University of California at Davis, 95616, USA
    J Appl Physiol 94:819-27. 2003
  7. ncbi request reprint Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P
    Jesse P Joad
    Department of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Am J Respir Crit Care Med 169:499-504. 2004
  8. pmc Synaptic transmission in nucleus tractus solitarius is depressed by Group II and III but not Group I presynaptic metabotropic glutamate receptors in rats
    Chao Yin Chen
    Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA
    J Physiol 538:773-86. 2002
  9. ncbi request reprint Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes
    Ann C Bonham
    Department of Medical Pharmacology, University of California, Davis, CA, USA
    J Appl Physiol (1985) 101:322-7. 2006
  10. doi request reprint Extended secondhand tobacco smoke exposure induces plasticity in nucleus tractus solitarius second-order lung afferent neurons in young guinea pigs
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, Davis, CA 95616, USA
    Eur J Neurosci 28:771-81. 2008

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice
    Chao Yin Chen
    Dept of Pharmacology, Univ of California, Davis, GBSF 3510C, 1 Shields Ave, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 295:H632-9. 2008
    ..The data provide insights into possible mechanisms underlying documented increases in cardiovascular morbidity and mortality in humans exposed to SHS...
  2. pmc Retrograde release of endocannabinoids inhibits presynaptic GABA release to second-order baroreceptive neurons in NTS
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, CA 95616, USA
    Auton Neurosci 158:44-50. 2010
    ..The data suggest that endocannabinoid signaling in the NTS regulates short-term synaptic plasticity and provide a mechanism for endocannabinoid modulation of central baroreflex control...
  3. pmc Postexercise hypotension: central mechanisms
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, CA 95616, USA
    Exerc Sport Sci Rev 38:122-7. 2010
    ..This review focuses on the exercise-induced changes in brainstem nuclei involved in blood pressure regulation...
  4. ncbi request reprint Postexercise hypotension in conscious SHR is attenuated by blockade of substance P receptors in NTS
    Chao Yin Chen
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of California Davis, TB 172, One Shields Avenue, Davis, CA 95616, USA
    Am J Physiol Heart Circ Physiol 283:H1856-62. 2002
    ..Vehicle microinjection had no effect. The antagonist also had no effect on heart rate responses during both exercise and the PEH period. The data suggest that a substance P (NK-1) receptor mechanism in the NTS contributes to PEH...
  5. pmc Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats
    Chao Yin Chen
    Department of Pharmacology, University of California, Davis, Davis, California 95616, USA
    J Neurosci 29:2754-61. 2009
    ..The data suggest that exercise-induced NK1-R internalization results in a reduced intrinsic inhibitory input to the neurons in the baroreflex pathway...
  6. ncbi request reprint Neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates
    Chao Yin Chen
    Department of Internal Medicine, School of Medicine, University of California at Davis, 95616, USA
    J Appl Physiol 94:819-27. 2003
    ..The finding that NTS neurons undergo plasticity with repeated ozone exposures may help to explain the adaptation of the respiratory motor responses...
  7. ncbi request reprint Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P
    Jesse P Joad
    Department of Pediatrics, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Am J Respir Crit Care Med 169:499-504. 2004
    ..We conclude that in young guinea pigs extended exposure to ETS increases citric acid-induced cough and bronchoconstriction in part by an NK-1 receptor mechanism in the nucleus tractus solitarius...
  8. pmc Synaptic transmission in nucleus tractus solitarius is depressed by Group II and III but not Group I presynaptic metabotropic glutamate receptors in rats
    Chao Yin Chen
    Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA
    J Physiol 538:773-86. 2002
    ....
  9. ncbi request reprint Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes
    Ann C Bonham
    Department of Medical Pharmacology, University of California, Davis, CA, USA
    J Appl Physiol (1985) 101:322-7. 2006
    ..This review focuses on existing evidence for plasticity in the NTS, potential targets for plasticity in the NTS, and the impact of this plasticity on lung and airway reflexes...
  10. doi request reprint Extended secondhand tobacco smoke exposure induces plasticity in nucleus tractus solitarius second-order lung afferent neurons in young guinea pigs
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, Davis, CA 95616, USA
    Eur J Neurosci 28:771-81. 2008
    ..The mechanism may help to explain some of the exaggerated respiratory responses of children exposed to SHS...
  11. pmc Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats
    Chao Yin Chen
    Department of Medical Pharmacology and Toxicology, Tupper Hall Room 1311, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Physiol 562:535-51. 2005
    ....
  12. ncbi request reprint GABA(A) receptor activation at medullary sympathetic neurons contributes to postexercise hypotension
    Radhika Kajekar
    Department of Internal Medicine, University of California at Davis, Davis, California 95616, USA
    Am J Physiol Heart Circ Physiol 282:H1615-24. 2002
    ..05). Baroreflex control of RVLM neuronal activity operated with a reduced gain (P < 0.05). Thus increased GABA signaling at RVLM neurons may contribute to PEH...
  13. pmc Protection of signal processing at low temperature in baroreceptive neurons in the nucleus tractus solitarius of Syrian hamsters, a hibernating species
    Shin ichi Sekizawa
    Department of Pharmacology, University of California, Davis, California
    Am J Physiol Regul Integr Comp Physiol 305:R1153-62. 2013
    ..The latter (shorter duration of non-NMDAR currents) would likely limit NMDAR coincidence gating and may help protect hamster NTS neurons, enabling them to contribute to signal processing at low body temperatures...
  14. pmc Temporal relationships of blood pressure, heart rate, baroreflex function, and body temperature change over a hibernation bout in Syrian hamsters
    Barbara A Horwitz
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, California
    Am J Physiol Regul Integr Comp Physiol 305:R759-68. 2013
    ..arousal...
  15. doi request reprint Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species
    Shin ichi Sekizawa
    Department of Pharmacology, University of California Davis, GBSF 3617, 451 Health Sciences Drive, Davis, CA 95616, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:267-82. 2012
    ..Changes were significant (P < 0.05), supporting our hypothesis by showing that, as temperature falls, rapid-onset neurons contribute more to signal processing but less to energy conservation than do delayed-onset neurons...
  16. ncbi request reprint Glutamatergic neural transmission in the nucleus tractus solitarius: N-methyl-D-aspartate receptors
    Ann C Bonham
    Department of Internal Medicine, University of California, Davis, California 95616, USA
    Clin Exp Pharmacol Physiol 29:497-502. 2002
    ....
  17. ncbi request reprint Plasticity of brainstem mechanisms of cough
    Ann C Bonham
    Department of Pharmacology, University of California, Davis School of Medicine, 4150 V Street, 1104 PSSB, Sacramento, CA 95817, USA
    Respir Physiol Neurobiol 152:312-9. 2006
    ..This review integrates evidence implicating the NTS in exaggerated cough with proof of the concept that NTS neurons undergo plasticity to contribute to an exaggeration of cough...
  18. ncbi request reprint Air pollutants and cough
    Jesse P Joad
    Department of Pediatrics, University of California, Davis, 2516 Stockton Blvd, Sacramento, CA 95817, USA
    Pulm Pharmacol Ther 20:347-54. 2007
    ..Ozone and allergen increased the intrinsic excitability of second-order neurones in the NTS. The animal studies suggest that the cough and wheeze experienced by humans exposed to pollutants may involve plasticity in the nervous system...
  19. doi request reprint Oxidative injury in the lungs of neonatal rats following short-term exposure to ultrafine iron and soot particles
    Cai Yun Zhong
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    J Toxicol Environ Health A 73:837-47. 2010
    ..Data indicate that combined Fe and soot particle exposure induces oxidative injury, cytotoxicity and pro-inflammatory responses in the lungs of neonatal rats...
  20. pmc Central neuroplasticity and decreased heart rate variability after particulate matter exposure in mice
    Hai Pham
    Department of Pharmacology, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Environ Health Perspect 117:1448-53. 2009
    ..Impaired cardiac autonomic function, which manifests as reduced heart rate variability (HRV), may be one of the underlying causes. However, the cellular mechanism(s) by which PM(2.5) exposure induces decreased HRV is not known...
  21. doi request reprint Issues and challenges of non-tenure-track research faculty: the UC Davis School of Medicine experience
    Lydia Pleotis Howell
    University of California, Davis, School of Medicine, Sacramento, CA, USA
    Acad Med 85:1041-7. 2010
    ..Challenges in addressing these issues include limited availability of tenure-track positions, financial resources, adequate communication regarding change, and compliance with existing faculty search policies...

Research Grants5

  1. Particulate Matter Exposure: Cardiovascular Mechanisms
    Chao Yin Chen; Fiscal Year: 2007
    ....