Benjamin Ping-Chi Chen

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles
    Yu Fen Lin
    Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 9:e93579. 2014
  2. pmc DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
    Yu Fen Lin
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390, USA and Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Tottori University, Japan
    Nucleic Acids Res 42:4463-73. 2014
  3. pmc Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
    Shichuan Zhang
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 193:295-305. 2011
  4. doi request reprint New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress
    Benjamin P C Chen
    Department of Radiation Oncology Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9187, USA
    Cancer Lett 327:103-10. 2012
  5. pmc Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage
    Birgitte B Olsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    BMC Mol Biol 13:7. 2012
  6. ncbi request reprint Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
    Benjamin P C Chen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    J Biol Chem 280:14709-15. 2005
  7. ncbi request reprint MDC1 regulates DNA-PK autophosphorylation in response to DNA damage
    Zhenkun Lou
    Department of Oncology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 279:46359-62. 2004
  8. pmc A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment
    Hao Luo
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 24:8356-65. 2004
  9. pmc Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    Doug W Chan
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genes Dev 16:2333-8. 2002

Research Grants

Collaborators

  • Aroumougame Asaithamby
  • Barry P Sleckman
  • Andre Nussenzweig
  • Junya Kobayashi
  • Sandeep Burma
  • Yu Fen Lin
  • David J Chen
  • Hung Ying Shih
  • Birgitte B Olsen
  • Shichuan Zhang
  • Doug W Chan
  • Akihiro Kurimasa
  • Hao Luo
  • Zhenkun Lou
  • Jun Qin
  • John R Brogan
  • Hatsumi Nagasawa
  • Takamitsu A Kato
  • Joel S Bedford
  • John B Little
  • Paul F Wilson
  • Xian Jin Xie
  • Zengfu Shang
  • Shinji Matsunaga
  • Tina H Svenstrup
  • Shih Ya Wang
  • Barbara Guerra
  • Mengxia Li
  • Elsa Callen
  • Hirohiko Yajima
  • Samuel Bunting
  • Hua Tang Chen
  • Nancy Wong
  • Eric Gapud
  • Cheng Cheng Zhang
  • Michael Story
  • Junke Zheng
  • Kyung Jone Lee
  • HoangDinh Huynh
  • Zhou Songyang
  • Katherine Minter-Dykhouse
  • Mei Leng
  • Yi Wang
  • Maria Rodriguez
  • David Chen
  • Junjie Chen
  • Tao Yang
  • Jung Jung Mu
  • Michael D Story
  • Sheela Prithivirajsingh

Detail Information

Publications10

  1. pmc Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles
    Yu Fen Lin
    Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 9:e93579. 2014
    ....
  2. pmc DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
    Yu Fen Lin
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390, USA and Division of Molecular Pharmacology, Department of Pathophysiological and Therapeutic Science, Tottori University, Japan
    Nucleic Acids Res 42:4463-73. 2014
    ..Taken together, these results suggest that DNA-PKcs, in addition to its direct role in DNA damage repair, facilitates ATR-Chk1 signaling pathway in response to replication stress. ..
  3. pmc Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
    Shichuan Zhang
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 193:295-305. 2011
    ..We conclude that phosphorylation of DNA-PKcs is essential for the normal activation of multiple DNA repair pathways, which in turn is critical for the maintenance of diverse populations of tissue stem cells in mice...
  4. doi request reprint New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress
    Benjamin P C Chen
    Department of Radiation Oncology Division of Molecular Radiation Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9187, USA
    Cancer Lett 327:103-10. 2012
    ..The growing understanding of the involvement of ATM, DNA-PKcs, and ATR in the oxidative stress response will offer new possibilities for the treatment of ROS-related diseases...
  5. pmc Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage
    Birgitte B Olsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    BMC Mol Biol 13:7. 2012
    ....
  6. ncbi request reprint Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
    Benjamin P C Chen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    J Biol Chem 280:14709-15. 2005
    ..These results indicate that although IR-induced DNA-PKcs phosphorylation is attenuated in the S phase, DNA-PKcs is preferentially activated by the physiologically relevant DNA replication-associated DSBs at the sites of DNA synthesis...
  7. ncbi request reprint MDC1 regulates DNA-PK autophosphorylation in response to DNA damage
    Zhenkun Lou
    Department of Oncology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 279:46359-62. 2004
    ..Therefore, MDC1 acts not only as a mediator of DNA damage checkpoint but also as a mediator of DNA damage repair...
  8. pmc A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment
    Hao Luo
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 24:8356-65. 2004
    ..Collectively, these data provide insights into the SSBR molecular machinery in the cell and point to the involvement of aprataxin in SSBR, thus linking SSBR to the neurological disease AOA...
  9. pmc Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    Doug W Chan
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genes Dev 16:2333-8. 2002
    ..Mutation of Thr2609 to Ala leads to radiation sensitivity and impaired DSB rejoining. These findings establish that Ku-dependent phosphorylation of DNA-PKcs at Thr2609 is required for the repair of DSBs by NHEJ...

Research Grants1

  1. Translational Control of Radiation-Induced Apoptosis
    Benjamin Chen; Fiscal Year: 2005
    ..With regard to the approaches, ..