F F Chehab

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Leptin as a regulator of adipose mass and reproduction
    F F Chehab
    Department of Laboratory Medicine, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0134, USA
    Trends Pharmacol Sci 21:309-14. 2000
  2. ncbi request reprint Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes
    J Qiu
    Department of Laboratory Medicine, University of California, San Francisco, California 94143 0134, USA
    Endocrinology 142:3421-5. 2001
  3. ncbi request reprint Hyperleptinemia precipitates diet-induced obesity in transgenic mice overexpressing leptin
    S Ogus
    Department of Laboratory Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0134, USA
    Endocrinology 144:2865-9. 2003
  4. ncbi request reprint Effect of the genetic background on the reproduction of leptin-deficient obese mice
    A Ewart-Toland
    Department of Laboratory Medicine, University of California, San Francisco 94143 0134, USA
    Endocrinology 140:732-8. 1999
  5. ncbi request reprint Leptin treatment rescues the sterility of genetically obese ob/ob males
    K Mounzih
    Department of Laboratory Medicine, University of California, San Francisco 94143 0134, USA
    Endocrinology 138:1190-3. 1997
  6. ncbi request reprint Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age
    J Qiu
    Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
    Endocrinology 142:348-58. 2001
  7. ncbi request reprint Early onset of reproductive function in normal female mice treated with leptin
    F F Chehab
    Department of Laboratory Medicine, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0134, USA
    Science 275:88-90. 1997

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Leptin as a regulator of adipose mass and reproduction
    F F Chehab
    Department of Laboratory Medicine, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0134, USA
    Trends Pharmacol Sci 21:309-14. 2000
    ..This article provides an update of past and present theories that link nutrition and reproduction in light of new research...
  2. ncbi request reprint Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes
    J Qiu
    Department of Laboratory Medicine, University of California, San Francisco, California 94143 0134, USA
    Endocrinology 142:3421-5. 2001
    ..These studies show that the abnormalities caused by leptin deficiency can be genetically dissected and separated from each other, suggesting discrete pathways controlled by leptin modifier genes...
  3. ncbi request reprint Hyperleptinemia precipitates diet-induced obesity in transgenic mice overexpressing leptin
    S Ogus
    Department of Laboratory Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0134, USA
    Endocrinology 144:2865-9. 2003
    ....
  4. ncbi request reprint Effect of the genetic background on the reproduction of leptin-deficient obese mice
    A Ewart-Toland
    Department of Laboratory Medicine, University of California, San Francisco 94143 0134, USA
    Endocrinology 140:732-8. 1999
    ..We conclude that the inheritance of modifier genes at the identified loci acts to promote fertility of otherwise sterile leptin-deficient obese male mice...
  5. ncbi request reprint Leptin treatment rescues the sterility of genetically obese ob/ob males
    K Mounzih
    Department of Laboratory Medicine, University of California, San Francisco 94143 0134, USA
    Endocrinology 138:1190-3. 1997
    ..Furthermore, reproductive indices such as testicular weight and histology are normalized in leptin-treated animals. Therefore, as in ob/ob females, leptin plays a significant role in the male mouse reproductive pathways...
  6. ncbi request reprint Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age
    J Qiu
    Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
    Endocrinology 142:348-58. 2001
    ..The mechanisms that lead to the accumulation of fat at an older age remain largely unknown, and this hyperleptinemic mouse model will allow the uncovering of at least some of these mechanisms...
  7. ncbi request reprint Early onset of reproductive function in normal female mice treated with leptin
    F F Chehab
    Department of Laboratory Medicine, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0134, USA
    Science 275:88-90. 1997
    ..These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract...