Ajay Chawla

..In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease...

..An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease...

..Thus, our studies are aimed at identifying new therapeutic targets that can improve the action of insulin, and limit or delay the onset of type 2 diabetes mellitus. ..

..Insights from these studies should lead to development of new therapeutics to treat chronic inflammatory and degenerative diseases, and improve modalities for tissue regeneration. ..

..Thus, our studies are aimed at identifying new therapeutic targets that can improve the action of insulin, and limit or delay the onset of type 2 diabetes mellitus. ..

..abstract_text> ..

..Insights from these studies should identify new therapeutic targets for intervening in atherosclerosis in which monocytes and macrophages play a key pathogenic role. ..