Ajay Chawla

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    Khoa D Nguyen
    Immunology Program, Stanford University, Palo Alto, California 94305, USA
    Nature 480:104-8. 2011
  2. pmc Macrophage-mediated inflammation in metabolic disease
    Ajay Chawla
    Cardiovascular Research Institute, University of California San Francisco, California 94158 9001, USA
    Nat Rev Immunol 11:738-49. 2011
  3. pmc Eosinophils secrete IL-4 to facilitate liver regeneration
    Y P Sharon Goh
    Department of Genetics and Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 110:9914-9. 2013
  4. pmc Connecting type 1 and type 2 diabetes through innate immunity
    Justin I Odegaard
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cold Spring Harb Perspect Med 2:a007724. 2012
  5. pmc Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes
    Khoa D Nguyen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158 9001, USA
    Science 341:1483-8. 2013
  6. pmc The immune system as a sensor of the metabolic state
    Justin I Odegaard
    Cardiovascular Research Institute, University of California San Francisco, CA 94158 9001, USA
    Immunity 38:644-54. 2013
  7. pmc Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    Divya Vats
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine and Graduate Program in Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Metab 4:13-24. 2006
  8. pmc Type 2 innate lymphoid cells control eosinophil homeostasis
    Jesse C Nussbaum
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 502:245-8. 2013
  9. ncbi request reprint Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    Yifu Qiu
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 9001, USA
    Cell 157:1292-308. 2014
  10. pmc Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    Justin I Odegaard
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 9001, USA
    Science 339:172-7. 2013

Collaborators

Detail Information

Publications14

  1. pmc Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    Khoa D Nguyen
    Immunology Program, Stanford University, Palo Alto, California 94305, USA
    Nature 480:104-8. 2011
    ..Thus, we have discovered a role for alternatively activated macrophages in the orchestration of an important mammalian stress response, the response to cold...
  2. pmc Macrophage-mediated inflammation in metabolic disease
    Ajay Chawla
    Cardiovascular Research Institute, University of California San Francisco, California 94158 9001, USA
    Nat Rev Immunol 11:738-49. 2011
    ..In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease...
  3. pmc Eosinophils secrete IL-4 to facilitate liver regeneration
    Y P Sharon Goh
    Department of Genetics and Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 110:9914-9. 2013
    ..Instead, IL-4 exerts its proliferative actions via IL-4Rα in hepatocytes. Our findings thus provide a unique mechanism by which eosinophil-derived IL-4 stimulates hepatocyte proliferation in regenerating liver...
  4. pmc Connecting type 1 and type 2 diabetes through innate immunity
    Justin I Odegaard
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cold Spring Harb Perspect Med 2:a007724. 2012
    ..We conclude with a discussion of the therapeutic implications of this integrated understanding of diabetic pathology...
  5. pmc Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes
    Khoa D Nguyen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158 9001, USA
    Science 341:1483-8. 2013
    ..These findings have unveiled a critical role for BMAL1 in controlling the diurnal rhythms in Ly6C(hi) monocyte numbers. ..
  6. pmc The immune system as a sensor of the metabolic state
    Justin I Odegaard
    Cardiovascular Research Institute, University of California San Francisco, CA 94158 9001, USA
    Immunity 38:644-54. 2013
    ..Such an integrated perspective both advances our understanding of basic physiology and highlights potential opportunities for therapeutic intervention in metabolic dysfunction...
  7. pmc Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    Divya Vats
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine and Graduate Program in Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Metab 4:13-24. 2006
    ....
  8. pmc Type 2 innate lymphoid cells control eosinophil homeostasis
    Jesse C Nussbaum
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 502:245-8. 2013
    ....
  9. ncbi request reprint Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    Yifu Qiu
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 9001, USA
    Cell 157:1292-308. 2014
    ..Together, our findings have uncovered the efferent circuit controlling biogenesis of beige fat and provide support for its targeting to treat obesity. ..
  10. pmc Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    Justin I Odegaard
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 9001, USA
    Science 339:172-7. 2013
    ..An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease...
  11. pmc Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration
    Jose E Heredia
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 9001, USA
    Cell 153:376-88. 2013
    ..Surprisingly, type 2 cytokine signaling is also required in FAPs, but not in myeloid cells, for rapid clearance of necrotic debris, a process that is necessary for timely and complete regeneration of tissues...
  12. pmc Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity
    Shannon E Dunn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    J Exp Med 207:1599-608. 2010
    ..Collectively, these findings suggest that PPAR-delta serves as an important molecular brake for the control of autoimmune inflammation...
  13. pmc Adipose tissue macrophages: Amicus adipem?
    Justin I Odegaard
    Cardiovascular Research Institute, University of California, San Francisco, 94158 9001, USA
    Cell Metab 18:767-8. 2013
    ..Xu et al. (2013) now describe the unexpected ability of adipose tissue macrophages to buffer lipids released from obese adipocytes in a manner independent of inflammatory macrophage activation. ..

Research Grants12

  1. Transcriptional Control of Macrophage in Atherogenesis
    Ajay Chawla; Fiscal Year: 2004
    ..abstract_text> ..
  2. Transcriptional Control of Macrophage in Atherogenesis
    Ajay Chawla; Fiscal Year: 2006
    ..abstract_text> ..
  3. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2010
    ..Insights from these studies should lead to development of new therapeutics to treat chronic inflammatory and degenerative diseases, and improve modalities for tissue regeneration. ..
  4. Role of Cytokine Signaling Pathways and Macrophages in Type 2 Diabetes Mellitus
    Ajay Chawla; Fiscal Year: 2007
    ..Thus, our studies are aimed at identifying new therapeutic targets that can improve the action of insulin, and limit or delay the onset of type 2 diabetes mellitus. ..
  5. Role of Cytokine Signaling Pathways and Macrophages in Type 2 Diabetes Mellitus
    Ajay Chawla; Fiscal Year: 2010
    ..Thus, our studies are aimed at identifying new therapeutic targets that can improve the action of insulin, and limit or delay the onset of type 2 diabetes mellitus. ..
  6. Role of Cytokine Signaling Pathways and Macrophages in Type 2 Diabetes Mellitus
    Ajay Chawla; Fiscal Year: 2009
    ..Thus, our studies are aimed at identifying new therapeutic targets that can improve the action of insulin, and limit or delay the onset of type 2 diabetes mellitus. ..
  7. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2009
    ..Insights from these studies should lead to development of new therapeutics to treat chronic inflammatory and degenerative diseases, and improve modalities for tissue regeneration. ..
  8. Transcriptional Control of Macrophage in Atherogenesis
    Ajay Chawla; Fiscal Year: 2007
    ..abstract_text> ..
  9. Transcriptional Control of Macrophage in Atherogenesis
    Ajay Chawla; Fiscal Year: 2005
    ..abstract_text> ..
  10. Transcriptional Control of Macrophage in Atherogenesis
    Ajay Chawla; Fiscal Year: 2010
    ..Insights from these studies should identify new therapeutic targets for intervening in atherosclerosis in which monocytes and macrophages play a key pathogenic role. ..