Myriam M Chaumeil

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street Box 2532, San Francisco, CA 94158, USA
    Neuroimage 59:193-201. 2012
  2. pmc Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma
    Humsa S Venkatesh
    University of California, San Francisco, San Francisco, CA 94158, USA
    Neuro Oncol 14:315-25. 2012
  3. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
  4. pmc Metabolic reprogramming in mutant IDH1 glioma cells
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 10:e0118781. 2015
  5. pmc Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Neuro Oncol 14:1050-61. 2012
  6. pmc IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
    Cancer Res 75:2999-3009. 2015
  7. pmc Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells
    Ilwoo Park
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California
    Cancer Res 74:7115-24. 2014
  8. pmc Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy
    Christopher S Ward
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:1296-305. 2010
  9. pmc Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e108289. 2014
  10. pmc Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
    Arman Jahangiri
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94158, USA
    Clin Cancer Res 19:1773-83. 2013

Collaborators

Detail Information

Publications10

  1. pmc Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street Box 2532, San Francisco, CA 94158, USA
    Neuroimage 59:193-201. 2012
    ..It highlights the potential of HP lactate-to-pyruvate ratio as an early biomarker of response, thereby supporting further investigation of this non-invasive imaging approach for eventual clinical application...
  2. pmc Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma
    Humsa S Venkatesh
    University of California, San Francisco, San Francisco, CA 94158, USA
    Neuro Oncol 14:315-25. 2012
    ..This study highlights the potential of PC and hyperpolarized lactate as noninvasive MR biomarkers of response to targeted inhibitors in GBM...
  3. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
    ..In contrast, in cells that express mutant IDH1, hyperpolarized [1-(13)C] 2-hydroxyglutarate is also observed, both in cell lysates and in vivo in orthotopic tumours. ..
  4. pmc Metabolic reprogramming in mutant IDH1 glioma cells
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 10:e0118781. 2015
    ..The goal of this work was to determine whether the IDH1 mutation leads to additional magnetic resonance spectroscopy (MRS)-detectable changes in the cellular metabolome...
  5. pmc Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Neuro Oncol 14:1050-61. 2012
    ..In summary, our results indicate that hMSCs and fNSCs exhibit similar properties regarding tumor tropism and intratumoral dissemination, highlighting the potential of these 2 SC sources as adequate candidates for SC-based therapies...
  6. pmc IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
    Cancer Res 75:2999-3009. 2015
    ..Taken together, our results established that the IDH1 mutation induces an MRS-detectable reprogramming of pyruvate metabolism, which is essential for cell proliferation and clonogenicity, with immediate therapeutic implications...
  7. pmc Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells
    Ilwoo Park
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California
    Cancer Res 74:7115-24. 2014
    ..Overall, our findings showed how TMZ-induced DNA damage is linked through PKM2 to changes in pyruvate metabolism, and how these changes can be exploited by MRI methods as an early sensor of TMZ therapeutic response...
  8. pmc Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy
    Christopher S Ward
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:1296-305. 2010
    ....
  9. pmc Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase
    Jose L Izquierdo-García
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e108289. 2014
    ..The goal of this study was to determine whether PC serves as a source of TCA anaplerosis in IDH1 mutant cells wherein glutamine is used for 2-hydroxyglutarate production...
  10. pmc Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
    Arman Jahangiri
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94158, USA
    Clin Cancer Res 19:1773-83. 2013
    ..To identify mediators of glioblastoma antiangiogenic therapy resistance and target these mediators in xenografts...