I H Chaudry

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Endocrine targets in experimental shock
    Irshad H Chaudry
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham School of Medicine, 35294 0019, USA
    J Trauma 54:S118-25. 2003
  2. pmc Bench-to-bedside review: latest results in hemorrhagic shock
    Martin K Angele
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchionistrasse 15, 81377 Munich, Germany
    Crit Care 12:218. 2008
  3. ncbi request reprint Gender differences in acute response to trauma-hemorrhage
    Mashkoor A Choudhry
    Department of Surgery, University of Alabama, Birmingham, AL 35294 0019, USA
    Shock 24:101-6. 2005
  4. ncbi request reprint Gender and susceptibility to sepsis following trauma
    Mashkoor A Choudhry
    Center for Surgical Research, The University of Alabama at Birmingham, Volker Hall, G094, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Endocr Metab Immune Disord Drug Targets 6:127-35. 2006
  5. ncbi request reprint Impact of sex and age on bone marrow immune responses in a murine model of trauma-hemorrhage
    Christian P Schneider
    Center for Surgical Research, Univ of Alabama at Birmingham, G094Volker Hall, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 102:113-21. 2007
  6. ncbi request reprint Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock
    Z F Ba
    Center for Surgical Research, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    Arch Surg 136:1158-63. 2001
  7. ncbi request reprint Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis
    M D Diodato
    Center for Surgical Research, Brown University School of Medicine, Providence, RI 02903, USA
    Cytokine 14:162-9. 2001
  8. ncbi request reprint Sex steroid-mediated regulation of macrophage/monocyte function in a two-hit model of trauma-hemorrhage and sepsis
    Thomas Dienstknecht
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cytokine 25:110-8. 2004
  9. ncbi request reprint Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury
    M G Schwacha
    Department of Surgery, Brown University School of Medicine, Providence, RI 02903, USA
    Biochim Biophys Acta 1455:45-53. 1999
  10. ncbi request reprint Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage
    S Mayr
    Dept of Surgery, Klinikum Grosshadern, Ludwig Maximilians Univ, Marchioninistr 15, 81377 Munich, Germany
    J Appl Physiol (1985) 101:448-53. 2006

Research Grants

  1. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
  2. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2009
  3. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2002
  4. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2009
  5. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2007
  6. TRAUMA AND INFLAMMATION RESEARCH TRAINING
    Irshad Chaudry; Fiscal Year: 2007
  7. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2006

Detail Information

Publications97

  1. ncbi request reprint Endocrine targets in experimental shock
    Irshad H Chaudry
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham School of Medicine, 35294 0019, USA
    J Trauma 54:S118-25. 2003
    ....
  2. pmc Bench-to-bedside review: latest results in hemorrhagic shock
    Martin K Angele
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchionistrasse 15, 81377 Munich, Germany
    Crit Care 12:218. 2008
    ..Further randomized controlled multicenter clinical trials are needed that utilize standardized criteria for enrolling patients, but existing ethical requirements must be maintained...
  3. ncbi request reprint Gender differences in acute response to trauma-hemorrhage
    Mashkoor A Choudhry
    Department of Surgery, University of Alabama, Birmingham, AL 35294 0019, USA
    Shock 24:101-6. 2005
    ..The information gained from the experimental studies will help in designing innovative therapeutic approaches for the treatment of trauma patients...
  4. ncbi request reprint Gender and susceptibility to sepsis following trauma
    Mashkoor A Choudhry
    Center for Surgical Research, The University of Alabama at Birmingham, Volker Hall, G094, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Endocr Metab Immune Disord Drug Targets 6:127-35. 2006
    ..The findings obtained from these studies will help in designing innovative therapeutic approaches for the treatment of trauma patients...
  5. ncbi request reprint Impact of sex and age on bone marrow immune responses in a murine model of trauma-hemorrhage
    Christian P Schneider
    Center for Surgical Research, Univ of Alabama at Birmingham, G094Volker Hall, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 102:113-21. 2007
    ....
  6. ncbi request reprint Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock
    Z F Ba
    Center for Surgical Research, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    Arch Surg 136:1158-63. 2001
    ....
  7. ncbi request reprint Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis
    M D Diodato
    Center for Surgical Research, Brown University School of Medicine, Providence, RI 02903, USA
    Cytokine 14:162-9. 2001
    ..Female sex hormones, therefore, appear to play an important role not only in maintaining immune function following haemorrhage, but also provide a survival advantage against subsequent septic challenge...
  8. ncbi request reprint Sex steroid-mediated regulation of macrophage/monocyte function in a two-hit model of trauma-hemorrhage and sepsis
    Thomas Dienstknecht
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cytokine 25:110-8. 2004
    ..Thus, events occurring in the tissue-fixed cells are not necessarily reflected in the circulating PBMC population...
  9. ncbi request reprint Role of protein kinase C in cyclic AMP-mediated suppression of T-lymphocyte activation following burn injury
    M G Schwacha
    Department of Surgery, Brown University School of Medicine, Providence, RI 02903, USA
    Biochim Biophys Acta 1455:45-53. 1999
    ..Thus, the suppression of T-lymphocyte activation following burn injury is macrophage-dependent, related to an increased sensitivity to cAMP and due to an uncoupling of cell surface receptors from protein kinase C activation...
  10. ncbi request reprint Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage
    S Mayr
    Dept of Surgery, Klinikum Grosshadern, Ludwig Maximilians Univ, Marchioninistr 15, 81377 Munich, Germany
    J Appl Physiol (1985) 101:448-53. 2006
    ....
  11. ncbi request reprint Divergent immune responses in male and female mice after trauma-hemorrhage: dimorphic alterations in T lymphocyte steroidogenic enzyme activities
    T S Samy
    Center for Surgical Research and Department of Surgery, University of Alabama, Birmingham, Alabama 35294, USA
    Endocrinology 142:3519-29. 2001
    ..This study provides evidence for the involvement of intracrine sex steroid synthesis in gender dimorphic immune responses after trauma-hemorrhage...
  12. ncbi request reprint Influence of gender and age on T-cell responses in a murine model of trauma-hemorrhage: differences between circulating and tissue-fixed cells
    Christian P Schneider
    Center for Surgical Research, Department of Surgery, Univ of Alabama at Birmingham, G 094Volker Hall, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol 100:826-33. 2006
    ..Age is also an important factor in the immune responses after TH. In view of this, both gender and age should be taken into consideration in evaluating the immune status and in treatment of TH shock...
  13. ncbi request reprint Mouse genetic background influences severity of immune responses following trauma-hemorrhage
    Takeshi Matsutani
    Center for Surgical Research, University of Alabama at Birmingham, 35294 0019, USA
    Cytokine 30:168-76. 2005
    ..Thus, genetic background appears to significantly influence the severity of immune responses in males following trauma-hemorrhage...
  14. ncbi request reprint Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury
    M G Schwacha
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Cell Physiol 281:C1180-7. 2001
    ..These findings suggest that Mphis, following thermal injury, display resistance to suppression by IL-10 due in part to downregulation of IL-10R expression...
  15. ncbi request reprint The small intestine plays an important role in upregulating CGRP during sepsis
    M Zhou
    Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
    Am J Physiol Regul Integr Comp Physiol 280:R382-8. 2001
    ....
  16. pmc Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage
    Takashi Kawasaki
    Center for Surgical Research, University of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 296:C124-30. 2009
    ..The depression in IL-15 production by splenic DCs could contribute to the host's enhanced susceptibility to infections following T-H...
  17. ncbi request reprint Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage
    Frank Hildebrand
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Boulevard, Birmingham, AL 35294 0019, USA
    Cytokine 36:107-14. 2006
    ..However, flutamide administration in combination with estrogen does not provide any significant, additional effects over 17beta-estradiol administration alone...
  18. ncbi request reprint Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality
    S Yang
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Crit Care Med 29:1201-6. 2001
    ....
  19. ncbi request reprint Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis
    M W KNOFERL
    Center for Surgical Research, Brown University School of Medicine and Rhode Island Hospital, Providence 02903, USA
    Shock 16:479-83. 2001
    ..Thus, selective inhibition of COX-2 activity may reduce the deleterious consequences of sepsis under such conditions...
  20. ncbi request reprint Dehydroepiandrosterone restores hepatocellular function and prevents liver damage in estrogen-deficient females following trauma and hemorrhage
    J F Kuebler
    Center for Surgical Research, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294-0019, USA
    J Surg Res 97:196-201. 2001
    ..We therefore propose that DHEA should be considered a novel, safe, and useful adjunct in the treatment of trauma-induced hepatocellular dysfunction in ovariectomized and postmenopausal females...
  21. ncbi request reprint Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis
    C S Chung
    Surgical Research, Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, RI 02903, USA
    Surgery 130:339-45. 2001
    ....
  22. ncbi request reprint Estrogen receptor-alpha predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhage
    Takao Suzuki
    Center for Surgical Research and Dept of Surgery, Univ of Alabama, at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 293:C978-84. 2007
    ....
  23. ncbi request reprint Sex-specific p38 MAP kinase activation following trauma-hemorrhage: involvement of testosterone and estradiol
    Martin K Angele
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Endocrinol Metab 285:E189-96. 2003
    ....
  24. ncbi request reprint The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage
    Christian P Schneider
    Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Biochim Biophys Acta 1689:22-32. 2004
    ..Thus, while IL-10 is an important mediator of immunosuppression following traumatic injury, it also is beneficial with regard to its ability to counter-regulate the early inflammatory response under such conditions...
  25. doi request reprint Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process
    Takashi Kawasaki
    Center for Surgical Research, Univ of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 294:C754-64. 2008
    ..Hyporesponsiveness of splenic DCs was also found after stimulation with the TLR2 agonist zymosan. Our results may thus explain the profound immunosuppression that is known to occur under those conditions...
  26. ncbi request reprint Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta?
    Frank Hildebrand
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    J Leukoc Biol 79:1173-80. 2006
    ..These findings collectively suggest that both receptors appear to play a significant role in mediating the immunoprotective effects of E2 in different tissue compartments following trauma-hemorrhage...
  27. ncbi request reprint DHEA: a novel adjunct for the treatment of male trauma patients
    D Jarrar
    Center for Surgical Research and Dept of Surgery, University of Alabama at Birmingham School of Medicine, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294, USA
    Trends Mol Med 7:81-5. 2001
    ....
  28. ncbi request reprint The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production
    M Zhou
    Center for Surgical Research and Department of Surgery, School of Medicine, The University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1537:49-57. 2001
    ....
  29. ncbi request reprint Is prostacyclin responsible for producing the hyperdynamic response during early sepsis?
    P Wang
    Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence 02903, USA
    Crit Care Med 28:1534-9. 2000
    ..The aim of this study was to determine whether inhibition of PGI2 synthesis prevents the occurrence of the hyperdynamic response during early sepsis...
  30. ncbi request reprint Sustained elevation of norepinephrine depresses hepatocellular function
    P Wang
    Department of Surgery, University of Alabama at Birmingham School of Medicine, 1670 University Boulevard, Volker Hall, Room G094P, Birmingham, AL 35294 0019, USA
    Biochim Biophys Acta 1535:36-44. 2000
    ..These findings suggest that sustained elevated levels of NE, observed after sepsis or hemorrhagic shock, may play an important role in producing hepatocellular dysfunction and altered hepatocyte integrity...
  31. ncbi request reprint Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction
    TanJanika Daniel
    Department of Surgery, Center for Surgical Research, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Cell Physiol 208:418-27. 2006
    ..In conclusion, these findings support the concept that NO induces suppression of cell-mediated immune responses by selective action on Th1 T cells, thereby promoting a Th2 response...
  32. pmc Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury
    Wen Hong Kan
    Center for Surgical Research, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    J Appl Physiol (1985) 105:1076-82. 2008
    ..These results indicate that increased expression of iNOS following trauma-hemorrhage plays an important role in the induction of hepatic damage under such conditions...
  33. pmc Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis
    Markus W Knoferl
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, 35294 0019, USA
    Ann Surg 235:105-12. 2002
    ..To determine whether reduction of circulating female sex hormones by ovariectomy causes suppression of macrophage (Mphi) function after trauma-hemorrhage and increases susceptibility to subsequent sepsis...
  34. ncbi request reprint MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury
    Michelle Alexander
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Cell Physiol 201:35-44. 2004
    ..Thus, burn injury increases cross-talk between the MAPKs pathways, suggesting that alterations MAPK activation and signal transduction contribute to the development Mphi hyperactivity post-injury...
  35. ncbi request reprint Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-alpha
    Takao Suzuki
    Center for Surgical Research and Dept of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 292:C2103-11. 2007
    ....
  36. ncbi request reprint Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury
    Xiaoling Li
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, VolkerHall G 094, 1670 Univ Boulevard, Birmingham, AL 35294, USA
    Am J Physiol Regul Integr Comp Physiol 289:R37-44. 2005
    ..These findings suggest that EtOH intoxication before burn injury augments Cort release, which suppresses MLN T cell function by inhibiting p38 and ERK1/2 activation and promotes bacterial accumulation in MLN after EtOH and burn injury...
  37. ncbi request reprint Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage
    M K Angele
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35294, USA
    Cytokine 16:22-30. 2001
    ....
  38. ncbi request reprint L-arginine improves wound healing after trauma-hemorrhage by increasing collagen synthesis
    F Wittmann
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Trauma 59:162-8. 2005
    ..In this respect, administration of the amino acid L-arginine normalized wound immune cell function under those conditions. It remains unknown, however, whether L-arginine improves impaired wound healing after T-H...
  39. ncbi request reprint Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis?
    A Ayala
    Department of Surgery, Michigan State University, East Lansing, USA
    Arch Surg 130:1178-84; discussion 1184-5. 1995
    ..However, it is unknown if levels of ETX comparable to those typically encountered in sepsis induce a similar refractory state in M luminal diameters...
  40. ncbi request reprint The small intestine is an important source of adrenomedullin release during polymicrobial sepsis
    M Zhou
    Center for Surgical Research and Department of Surgery, School of Medicine, University of Alabama at Birmingham, 1670 University Blvd, Birmingham, AL 35294, USA
    Am J Physiol Regul Integr Comp Physiol 281:R654-60. 2001
    ..Thus the gut plays an important role in increasing the levels of circulating AM during the progression of sepsis. Gut-derived AM appears to be a major factor in initiating the hyperdynamic response after the onset of sepsis...
  41. ncbi request reprint A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury
    Xiaoling Li
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Volker Hall G 094, 1670 University Boulevard, Birmingham, AL 35294, USA
    J Leukoc Biol 79:453-62. 2006
    ..Thus, these results suggest that activation of PP1 is likely to play a predominant role in T cell suppression following a combined insult of EtOH intoxication and burn injury...
  42. ncbi request reprint Opiate analgesics contribute to the development of post-injury immunosuppression
    Michelle Alexander
    Department of Surgery, Center for Surgical Research, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Surg Res 129:161-8. 2005
    ..Opiates, the analgesic of choice for the treatment of post-burn pain, can also induce similar immune complications. However, the impact of therapeutic opiates on post-burn immune dysfunction is unknown...
  43. ncbi request reprint Regulation of the postburn wound inflammatory response by gammadelta T-cells
    TanJanika Daniel
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Shock 28:278-83. 2007
    ..In conclusion, these findings suggest that resident gammadelta T-cells are important in the recruitment of inflammatory cells and regulation of the inflammatory response at the wound site after thermal injury...
  44. ncbi request reprint Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage
    Markus W Knoferl
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    J Appl Physiol 95:529-35. 2003
    ....
  45. ncbi request reprint Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice
    Takeshi Matsutani
    Center for Surgical Research, University of Alabama, G 094 Volker Hall, 1670 Univ Blvd, Birmingham, AL 35294 0019, USA
    Am J Physiol Gastrointest Liver Physiol 292:G268-74. 2007
    ..These results collectively suggest that the extent of hepatic damage following Fx-TH is dependent on the age of the subject...
  46. ncbi request reprint Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage?
    Shih Ching Kang
    Center for Surgical Research and Department of Surgery, G094 Volker Hall, 1670 University Blvd, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cytokine 26:223-30. 2004
    ..young mice following Fx-TH remains unknown, the decreased IL-2 production along with other altered T cell and macrophage functions may contribute to an increased susceptibility to sepsis in middle-aged vs. young individuals...
  47. ncbi request reprint The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage
    Bjoern M Thobe
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Cell Physiol 210:667-75. 2007
    ..Thus, Kupffer cell TLR signaling employs different MAPK pathways in eliciting cytokine and chemokine responses following trauma-hemorrhage...
  48. pmc 17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage
    Ya Ching Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Immunol 44:2165-72. 2007
    ....
  49. ncbi request reprint Decreased 5alpha-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage
    Rui Zheng
    Center for Surgical Research and Department of Surgery, University of Alabama School of Medicine, Birmingham, Alabama 35294 0018, USA
    Am J Physiol Cell Physiol 282:C1332-8. 2002
    ....
  50. ncbi request reprint Differences in the expression of LPS-receptors are not responsible for the sex-specific immune response after trauma and hemorrhagic shock
    S J Eisenmenger
    Department of Surgery, Klinikum Grosshadern Ludwig Maximilians University, Marchioninistr 15, D 81377 Munich, Germany
    Cell Immunol 230:17-22. 2004
    ..Thus, the sex specific LPS induced cytokine secretion after (T-H) is not caused by differences in LPS receptor expression on Mphi of male and female mice...
  51. ncbi request reprint The role of adrenomedullin in producing differential hemodynamic responses during sepsis
    D J Koo
    Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, 35294, USA
    J Surg Res 95:207-18. 2001
    ....
  52. ncbi request reprint Thermal injury alters macrophage responses to prostaglandin E2: contribution to the enhancement of inducible nitric oxide synthase activity
    M G Schwacha
    Center for Surgical Research, Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence 02903, USA
    J Leukoc Biol 64:740-6. 1998
    ..Thus, PGE2, which is elevated after thermal injury and can directly suppress T cell function, may also contribute to immune dysfunction through the enhancement of Mphi iNOS activity...
  53. pmc Estrogen: a novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations
    Raghavan Raju
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Mol Med 14:213-21. 2008
    ..The results of the studies exemplify the promise of estrogen as a therapeutic adjunct in treating adverse pathophysiological conditions following trauma-hemorrhage...
  54. ncbi request reprint Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice
    Takashi Kawasaki
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    Am J Physiol Cell Physiol 291:C1049-55. 2006
    ..The enhanced immunosuppressive effects of lidocaine could contribute to the host's enhanced susceptibility to infection following T-H...
  55. ncbi request reprint Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Cell Physiol 214:662-72. 2008
    ....
  56. ncbi request reprint Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 Univ Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    J Appl Physiol 102:163-8. 2007
    ..Both agonists were equally effective on SMPhi and AMPhi. Thus ER subtypes have tissue compartment-specific roles in mediating the effects of 17beta-estradiol on immune cell functions following trauma-hemorrhage...
  57. pmc Inhibition of protein tyrosine phosphatases prevents mesenteric lymph node T-cell suppression following alcohol intoxication and burn injury
    Xiaoling Li
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Alabama 35294, USA
    J Burn Care Res 29:519-30. 2008
    ..These findings suggest that an increase in PTP activity may contribute to T-cell suppression after EtOH intoxication and burn injury...
  58. doi request reprint p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage
    Wen Hong Kan
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Heart Circ Physiol 294:H2627-36. 2008
    ..The salutary effects of E2 on cardiac functions and tissue protection following trauma-hemorrhage are mediated, in part, through activation of p38 MAPK and subsequent eNOS expression and phosphorylation...
  59. ncbi request reprint Immunoprotection in proestrus females following trauma-hemorrhage: the pivotal role of estrogen receptors
    Markus W Knoferl
    Center for Surgical Research, Department of Surgery, University of Alabama at Birmingham, Volker Hall, G094 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Cell Immunol 222:27-34. 2003
    ..These findings indicate that the ability of proestrus females to maintain immune function following trauma-hemorrhage is estrogen-dependent and mediated via estrogen receptors...
  60. pmc Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-{kappa}B signaling
    LuYun Zou
    University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Physiol Heart Circ Physiol 296:H515-23. 2009
    ....
  61. ncbi request reprint Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury
    Michelle Alexander
    Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Cell Immunol 220:63-9. 2002
    ..Thus, unlike patient survival data, burn injury-induced changes in immune function do not necessarily correlate with the size of the injury...
  62. ncbi request reprint Androgen-mediated modulation of macrophage function after trauma-hemorrhage: central role of 5alpha-dihydrotestosterone
    Christian P Schneider
    Department of Research, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    J Appl Physiol 95:104-12. 2003
    ....
  63. ncbi request reprint Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches
    Martin K Angele
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Langenbecks Arch Surg 390:333-41. 2005
    ..Furthermore, the effect of those mediators on cell-mediated immune responses has been studied...
  64. ncbi request reprint The role of lipopolysaccharide in stimulating adrenomedullin production during polymicrobial sepsis
    S Yang
    Center for Surgical Research and Department of Surgery, The University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094P, Birmingham, AL 35294-0019, USA
    Biochim Biophys Acta 1537:167-74. 2001
    ..These results, taken together, suggest that the upregulated AM observed during polymicrobial sepsis is at least in part due to the increase in circulating levels of endotoxin...
  65. ncbi request reprint Adrenal insufficiency during the late stage of polymicrobial sepsis
    D J Koo
    Department of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-0019, USA
    Crit Care Med 29:618-22. 2001
    ..Therefore, the recognition of adrenal insufficiency and interventions to improve adrenal responsiveness may be beneficial in improving the outcome during late sepsis...
  66. ncbi request reprint Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of alpha2-adrenoceptors
    S Yang
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1014-21. 2001
    ..Modulation of hepatic responsiveness to NE by alpha2-adrenergic antagonists should provide a novel approach for maintaining cell and organ functions during sepsis...
  67. ncbi request reprint The role of MIP-1 alpha in the development of systemic inflammatory response and organ injury following trauma hemorrhage
    Chi Hsun Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 181:2806-12. 2008
    ..Thus, interventions that reduce MIP-1alpha levels following T-H should be useful in decreasing the deleterious inflammatory consequence of trauma...
  68. pmc Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation
    Chi Hsun Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama, Birmingham, 35294, USA
    J Immunol 182:4406-14. 2009
    ..Thus, activation of Akt plays a crucial role in mediating the salutary effect of estrogen in restoring trauma-hemorrhage-induced suppression of Kupffer cell phagocytosis...
  69. pmc Salutary effects of 17beta-estradiol on Peyer's patch T cell functions following trauma-hemorrhage
    Takashi Kawasaki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Boulevard, Birmingham, AL 35294, USA
    Cytokine 51:166-72. 2010
    ..E2, PPT or DPN administration normalized these parameters. Since PPT or DPN administration following T-H was effective in normalizing PP T cell functions, the salutary effects of E2 are mediated via ER-alpha and ER-beta...
  70. ncbi request reprint Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation
    Jun Te Hsu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Leukoc Biol 82:1019-26. 2007
    ..These results suggest that the salutary effects of E2 on hepatic injury following trauma-hemorrhage are in part mediated via an ER-related, Akt-dependent up-regulation of HO-1...
  71. ncbi request reprint Metabolic modulators following trauma sepsis: sex hormones
    Ya Ching Hsieh
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Crit Care Med 35:S621-9. 2007
    ..Additionally, sex steroids regulate inflammatory cytokines that cause hypermetabolism/catabolism via acute phase response, leading to increased morbidity and mortality...
  72. pmc Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall, Room G094, Birmingham, AL 35294 0019, USA
    Cytokine 42:32-8. 2008
    ..These findings suggest E2 effects on T cell cytokine production following T-H are mediated at least in part via non-genomic pathway and these non-genomic effects are likely mediated via MAPK pathways...
  73. doi request reprint Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels
    Jun Te Hsu
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Shock 30:372-8. 2008
    ..These results suggest that p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels plays an important role in E2-mediated restoration of cardiac function after trauma-hemorrhage...
  74. pmc Estrogen suppresses cardiac IL-6 after trauma-hemorrhage via a hypoxia-inducible factor 1 alpha-mediated pathway
    Eike A Nickel
    Department of Surgery, Center for Surgical Research, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Shock 31:354-8. 2009
    ..These results indicate that the beneficial effects of estrogen on cardiac function after trauma-hemorrhage seem to be mediated by the inhibition of HIF-1 alpha expression and activity...
  75. pmc ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury
    Xiaoling Li
    Department of Surgery, Burn and Shock Trauma Institute and Alcohol Research Program, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
    J Immunol 183:3955-62. 2009
    ....
  76. ncbi request reprint Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis
    Joachim F Kuebler
    Center for Surgical Research, University of Alabama at Birmingham, Volker Hall G094, 1670 University Blvd, Birmingham, AL 35294 0019, USA
    Arch Surg 137:74-9. 2002
    ..Therefore, we hypothesized that 17beta-estradiol administration following trauma-hemorrhage would also improve cardiac output, splanchnic perfusion, and oxygen utilization, even after the induction of subsequent sepsis...
  77. ncbi request reprint Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms
    Doraid Jarrar
    Center for Surgical Research and Departments of Surgery, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Lung Cell Mol Physiol 283:L799-805. 2002
    ..Because enhanced release of inflammatory mediators by AMPhi may contribute to ARDS after severe trauma, inhibition of intracellular signaling pathways represents a target to attenuate organ injury under those conditions...
  78. ncbi request reprint Effect of estradiol administration on splanchnic perfusion after trauma-hemorrhage and sepsis
    Yukihiro Yokoyama
    Center for Surgical Research and Department of Surgery, University of Alabama, Birmingham 35294 0019, USA
    Curr Opin Crit Care 9:137-42. 2003
    ..This review focuses on the latest mechanistic understanding of the effects of estradiol on the splanchnic circulation and the possibility of estradiol treatment as an adjunct for the treatment of trauma-hemorrhage and sepsis...
  79. ncbi request reprint Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: enhanced local synthesis of 17beta-estradiol
    T S Anantha Samy
    Department of Surgery, University of Alabama School of Medicine, Birmingham, AL 35294, USA
    Am J Physiol Cell Physiol 285:C139-49. 2003
    ....
  80. ncbi request reprint Trauma-haemorrhage-induced alterations in thymic prolactin receptor expression: implications in immune dysfunction
    Eike A Nickel
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Cytokine 18:127-32. 2002
    ..These findings suggest that the gender dimorphism in the immune response to trauma-haemorrhage may in part be related to differences in thymic PRLr expression under such conditions...
  81. ncbi request reprint The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels
    Doraid Jarrar
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham 35294 0019, USA
    Arch Surg 139:896-901. 2004
    ....
  82. ncbi request reprint Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis
    Takao Suzuki
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cytokine 34:76-84. 2006
    ....
  83. ncbi request reprint Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors
    Devin E Eckhoff
    Division of Transplantation and Transplant Center, Department of Surgery Prosthodontics and Biomaterials, University of Alabama School of Dentistry, Birmingham, AL, USA
    Surgery 136:336-45. 2004
    ..Furthermore, inhibition of PIC release has been demonstrated after E2 treatment. In the present study, we evaluated if E2 treatment to BD donors would improve pancreatic islet recovery and functionality...
  84. ncbi request reprint Estrus cycle: influence on cardiac function following trauma-hemorrhage
    Shaolong Yang
    Department of Surgery, University of Alabama at Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 291:H2807-15. 2006
    ..These data collectively suggest that the estrus cycle plays an important role in cardiac function following TH. The salutary effect seen in PE following TH is likely due to a decrease in NF-kappaB-dependent cardiac IL-6 pathway...
  85. ncbi request reprint Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha
    Yuchen Ma
    Department of Pathology, Division of Molecular and Cellular Pathology, Volker Hall, G019, 1670 University Boulevard, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Endocrinology 145:5168-76. 2004
    ..Increased local TNFalpha may play a role in inducing this hepatic insulin resistance after trauma and hemorrhage...
  86. ncbi request reprint Differential fluid regulation during and after soft tissue trauma and hemorrhagic shock in males and proestrus females
    Joachim F Kuebler
    Center for Surgical Research, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Shock 20:144-8. 2003
    ..The increased circulating blood volume could contribute the improved immune and organ functions in proestrus females under those conditions...
  87. ncbi request reprint Hemorrhage induces the rapid development of hepatic insulin resistance
    Yuchen Ma
    Department of Pathology, Division of Molecular and Cellular Pathology, The University of Alabama at Birmingham, 35294, USA
    Am J Physiol Gastrointest Liver Physiol 284:G107-15. 2003
    ..The present study provides convincing evidence of a rapid onset hepatic insulin resistance following a combination of trauma and hemorrhage...
  88. ncbi request reprint Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-alpha production by Kupffer cells
    Y Matsuki
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 35294 0007, USA
    Cell Death Differ 9:626-35. 2002
    ....
  89. ncbi request reprint Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice
    James A Lederer
    Department of Surgery, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Genomics 32:299-310. 2008
    ....
  90. ncbi request reprint Insights into the role of gammadelta T lymphocytes in the immunopathogenic response to thermal injury
    M G Schwacha
    Center for Surgical Research, Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence 02903, USA
    J Leukoc Biol 67:644-50. 2000
    ..Thus, gammadelta T lymphocytes, in part through the modulation of macrophage activity, appear to contribute to the immune dysfunction after thermal injury...
  91. ncbi request reprint Dehydroepiandrosterone modulates toll-like receptor expression on splenic macrophages of mice after severe polymicrobial sepsis
    Akihisa Matsuda
    Surgery for Organ Function and Biological Regulation Department of Surgery I, Nippon Medical School, Graduate School of Medicine, Tokyo, 113 8603, Japan
    Shock 24:364-9. 2005
    ..These results indicate that the anti-inflammatory phase of sepsis induces a marked down-regulation of TLR expression on splenic macrophages; however, administration of DHEA resulted in the restoration of TLR2 and TLR4 mRNA expression...
  92. doi request reprint Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1
    Jun Te Hsu
    Dept of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan corrected
    Am J Physiol Regul Integr Comp Physiol 294:R1825-31. 2008
    ..These results suggest that the p38 MAPK/HO-1 pathway plays a critical role in mediating the salutary effects of E(2) on shock-induced intestinal injury...
  93. ncbi request reprint L-arginine: a unique amino acid for improving depressed wound immune function following hemorrhage
    Martin K Angele
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Eur Surg Res 34:53-60. 2002
    ..To determine whether L-arginine has any salutary effects on wound immune cell function following trauma-hemorrhage...
  94. ncbi request reprint Physiological levels of 5 alpha-dihydrotestosterone depress wound immune function and impair wound healing following trauma-hemorrhage
    Stefan M Nitsch
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Arch Surg 139:157-63. 2004
    ..The aim of the present study was to determine whether depletion of 5 alpha-dihydrotestosterone in males before T-H has any salutary effects on wound immune cell function and wound healing in male mice following T-H...
  95. ncbi request reprint Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity
    Chun Shiang Chung
    Brown University School of Medicine and Rhode Island Hospital, Providence, RI 02903, USA
    J Leukoc Biol 74:344-51. 2003
    ....
  96. ncbi request reprint Gender and sex hormones influence the response to trauma and sepsis: potential therapeutic approaches
    Martin K Angele
    Department of Surgery, Klinikum Grosshadern, Munich, Germany
    Clinics (Sao Paulo) 61:479-88. 2006
    ..Thus, the immunomodulatory properties of sex hormones/receptor antagonists/sex steroid synthesizing enzymes following trauma-hemorrhage suggests novel therapeutic strategies for the treatment of immunodepression in surgical patients...
  97. ncbi request reprint Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage
    Jun Te Hsu
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan
    Am J Physiol Heart Circ Physiol 292:H2982-7. 2007
    ..These results suggest that the salutary effect of E(2) on cardiac function after trauma-hemorrhage is in part mediated via upregulation of p38 MAPK and subsequent phosphorylation of HSP27 and alpha(B)-crystallin...

Research Grants16

  1. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
    ..abstract_text> ..
  2. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2009
    ....
  3. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2002
    ....
  4. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2009
    ..The funding will help to develop gender-specific therapy. Such therapy should prevent organ dysfunction after injury and reduce morbidity and mortality from subsequent sepsis in male and female trauma victims. ..
  5. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2007
    ....
  6. TRAUMA AND INFLAMMATION RESEARCH TRAINING
    Irshad Chaudry; Fiscal Year: 2007
    ..We anticipate that after the completion of the two-year training, trainees will be better prepared with expertise and knowledge to pursue meaningful academic careers in trauma and inflammation disciplines. ..
  7. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad Chaudry; Fiscal Year: 2006
    ....