Research Topics
Species | Tandra R ChaudhuriSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Imaging Tc-99m-labeled FGF-1 targeting in ratsK R Zinn
Division of Nuclear Medicine, Department of Radiology, University of Alabama, Birmingham, USA
Nucl Med Biol 27:407-14. 2000..Heparin significantly decreased (99m)Tc-FGF-1 liver uptake and increased urinary excretion. These studies illustrate a new method for imaging FGF-1 targeting under various conditions...- Sinusoidal endothelium in mouse liver show rapid and saturable binding of Jo2 anti-Fas antibodyKurt R Zinn
Departments of Medicine and Radiology, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
Mol Imaging Biol 5:326-36. 2003..To evaluate liver binding of Jo2, a Fas agonist antibody known to induce death in mice... - The type 2 human somatostatin receptor as a platform for reporter gene imagingKurt R Zinn
Department of Radiology, University of Alabama at Birmingham, 35294, USA
Eur J Nucl Med Mol Imaging 29:388-99. 2002..This review discusses the rationale and strategy for using the hSSTr2 reporter gene as a platform for imaging applications... - Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in miceKurt R Zinn
Depts of Radiology, University of Alabama at Birmingham, Boshell Bldg, BDB 11, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
Radiology 223:417-25. 2002..To compare two systems for assessing gene transfer to cancer cells and xenograft tumors with noninvasive gamma camera imaging... 
Components of a curriculum for molecular imaging scientistsKurt R Zinn
Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama AL 35294 0019, USA
J Nucl Med 52:650-6. 2011....- Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imagingK R Zinn
Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Nucl Med Biol 28:135-44. 2001..and radioiodinated 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-5-iodouracil (FIAU), respectively. Following gene transfer, expression of hSSTr2 and TK were accurately imaged in vitro... 
Noninvasive bioluminescence imaging in small animalsKurt R Zinn
Laboratory of Multimodal Imaging, University of Alabama, Birmingham, AL 35294 0012, USA
ILAR J 49:103-15. 2008..In summary, bioluminescence imaging has become an important component of biomedical research that will continue in the future...- In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirusAkseli Hemminki
Division of Human Gene Therapy and Gene Therapy Center, Department of Medicine, University of Alabama at Birmingham, 35294 3300, USA
J Natl Cancer Inst 94:741-9. 2002..We used noninvasive imaging to investigate the in vivo antitumor efficacy of gene therapy using this adenovirus in an animal model of ovarian cancer... - In vivo imaging of hepatic growth hormone signalingStuart J Frank
University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
Mol Endocrinol 20:2819-30. 2006..Our imaging system allows detailed in vivo analysis of GH signaling and action and may be a paradigm for studies of additional signaling pathways in liver and other tissues... - Intraperitoneal pretarget radioimmunotherapy with CC49 fusion proteinDonald J Buchsbaum
Department of Radiation Oncology, University of Alabama at Birmingham, Alabama 35294 6832, USA
Clin Cancer Res 11:8180-5. 2005..This study examined a pretarget radioimmunotherapy strategy for treatment of an i.p. tumor model (LS174T)... - Blood-based screening and light based imaging for the early detection and monitoring of ovarian cancer xenograftsTandra R Chaudhuri
Department of Radiology, University of Alabama at Birmingham, JT N333, 619 19th St South, Birmingham, AL 35294 6830, USA
Technol Cancer Res Treat 2:171-80. 2003..This combination will lead to an accurate and widely applicable method for the early detection and monitoring of ovarian cancer, especially in high-risk women.. - Targeted radiotherapy with [(90)Y]-SMT 487 in mice bearing human nonsmall cell lung tumor xenografts induced to express human somatostatin receptor subtype 2 with an adenoviral vectorBuck E Rogers
Department of Radiation Oncology, University of Alabama at Birmingham, 35294, USA
Cancer 94:1298-305. 2002.... - Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancerBenjamin H Beck
Department of Medicine, Division of Hematology and Oncology, University of Alabama at Birmingham, SHEL 571, 1825 University Boulevard, Birmingham, AL 35294, USA
Breast Cancer Res Treat 122:135-44. 2010..Additionally, these studies establish that clinically applicable methods for radiolabeling gammadelta-T cells allows for the tracking of adoptively transferred gammadelta-T cells in tumor-bearing hosts... - Fluorescently labeled cetuximab to evaluate head and neck cancer response to treatmentJohn P Gleysteen
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
Cancer Biol Ther 6:1181-5. 2007..Combining the therapeutic and diagnostic properties of targeted antibodies may improve clinical assessment of disease with limited added toxicity during treatment... - Detection and measurement of in vitro gene transfer by gamma camera imagingK R Zinn
Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294-0012, USA
Gene Ther 8:291-9. 2001..Up to four 96-well plates could be imaged simultaneously, thereby demonstrating the high capacity of the system. This novel in vitro approach provides a new method to test enhanced gene transfer as new vectors are developed... - High-resolution single-photon emission computed tomography and X-ray computed tomography imaging of Tc-99m-labeled anti-DR5 antibody in breast tumor xenograftsHyunki Kim
Department of Radiology, Comprehensive Cancer Center, University of Alabama at Birmingham, 1808 7th Avenue South, Birmingham, AL 35294 0012, USA
Mol Cancer Ther 6:866-75. 2007..Imaging could provide a mechanism to assess DR5 modulation when DR5 therapy is combined with chemotherapy and radiation, and thereby aid in optimizing the dosing schedule... - A non-invasive approach for monitoring breast tumor cells during therapeutic interventionTandra R Chaudhuri
Department of Radiology, Department of Medicine, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
Cancer Biother Radiopharm 17:205-12. 2002..This study was performed to develop a non-invasive imaging method to evaluate non-palpable tumors in a breast xenograft model undergoing therapy... - Assessment of indocyanine green-labeled cetuximab to detect xenografted head and neck cancer cell linesKirk P Withrow
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
Otolaryngol Head Neck Surg 137:729-34. 2007..The aim of this study is to determine the efficacy of indocyanine green (ICG) conjugated to antiepidermal growth factor receptor antibody (cetuximab) to image head and neck cancer... - Use of fluorescent labeled anti-epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenograftsEben L Rosenthal
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
Mol Cancer Ther 6:1230-8. 2007..These results show the feasibility of using fluorescently labeled anti-EGFR antibody to detect human tumors in the surgical setting... - Glomerular targeting of acidic fibroblast growth factor-1 in renal transplanted ratsKurt R Zinn
Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294-0012, USA
Transplantation 73:1447-54. 2002..Unique glomerular targeting of 99mTc-FGF-1 in the transplanted kidney provides additional evidence supporting a role for this growth factor in the pathogenesis of chronic rejection... - Radiotargeted gene therapyDonald J Buchsbaum
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Nucl Med 46:179S-86S. 2005..Clinical studies are needed to determine the most promising of these new therapeutic approaches... - A noninvasive reporter system to image adenoviral-mediated gene transfer to ovarian cancer xenograftsT R Chaudhuri
Department of Radiology, University of Alabama at Birmingham, 35294-0012, USA
Gynecol Oncol 83:432-8. 2001..2 and 0.18 for Ad-hSSTr2-injected mice and controls, respectively. CONCLUSION: This study reports the first noninvasive imaging method for imaging gene transfer to ovarian cancer. A human gene therapy trial is planned... - The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cellsM Kim
Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, 35294, USA
Eur J Cancer 38:1917-26. 2002.... - Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic modelJoseph H Chewning
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
BMC Immunol 10:44. 2009..Luciferase bioluminescence has recently been utilized for non-invasive analysis of in vivo biologic processes in real-time... - Identifying the safety profile of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in anticipation of a phase I clinical trial in patients with recurrent ovarian cancerKellie Matthews
Division of Gynecologic Oncology, University of Alabama at Birmingham, Alabama, USA
Clin Cancer Res 15:4131-7. 2009.... - Light-based imaging of green fluorescent protein-positive ovarian cancer xenografts during therapyT R Chaudhuri
Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Gynecol Oncol 82:581-9. 2001..The purpose of the study was to develop a sensitive, noninvasive imaging method for monitoring ovarian xenografts during therapeutic intervention... - Increased dietary salt accelerates chronic allograft nephropathy in ratsP W Sanders
Department of Medicine, University of Alabama, Birmingham, Alabama 35294 00007, USA
Kidney Int 59:1149-57. 2001.... - An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expressionA Hemminki
The Gene Therapy Center, Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
Mol Ther 4:223-31. 2001..RGDTKSSTR may be a useful agent for treating ovarian cancer in clinical trials... - Non-invasive gamma camera imaging of gene transfer using an adenoviral vector encoding an epitope-tagged receptor as a reporterB E Rogers
Department of Radiation Oncology, University of Alabama at Birmingham, 1825 6th Avenue South, WT1 674, Birmingham, AL 35294, USA
Gene Ther 10:105-14. 2003..5+/-4.1% ID/g) as compared to Ad-hSSTr2-infected tumors (5.1+/-1.5% ID/g). These studies demonstrate the feasibility of using an epitope-tagged reporter receptor for non-invasively imaging gene transfer... - Site-specific delivery of acidic fibroblast growth factor stimulates angiogenic and osteogenic responses in vivoS S Kelpke
Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
J Biomed Mater Res A 71:316-25. 2004..e., osteopontin, osteocalcin). Collectively, these efforts support that site-specific delivery of active FGF-1 in a fibrin/hydroxyapatite composite is competent to induce not only angiogenesis but also osteogenic cellular responses... - Gene transfer strategies for improving radiolabeled peptide imaging and therapyB E Rogers
Department of Radiation Oncology, University of Alabama at Birmingham 35294, USA
Q J Nucl Med 44:208-23. 2000..g. cytosine deaminase, thymidine kinase) encoded within the same vector. This would allow for non-invasive monitoring of gene delivery to tumor sites... - Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeuticsYuanyuan Xu
Division of Clinical Immunology and Rheumatology, Department of Medicine and Laboratory for MultiModality Imaging Assessment, University of Alabama, Birmingham, AL 35294, USA
J Immunol 171:562-8. 2003..Recognizing this fact should facilitate development of safer and more efficacious agonistic Abs... - Syndecan-1 is required for robust growth, vascularization, and metastasis of myeloma tumors in vivoYekaterina B Khotskaya
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Biol Chem 284:26085-95. 2009.... - Breast cancer metastasis to bone: evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in immunodeficient miceS Cowey
Department of Pathology, University of Alabama at Birmingham, 701 South 19th Street, LHRB Room 531, Birmingham, Alabama 35294, USA
Clin Exp Metastasis 24:389-401. 2007..MicroSPECT imaging did not detect metastatic lesions in the legs of these young nude mice... - Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirusK R Zinn
Department of Medicine, University of Alabama at Birmingham, 35294, USA
Gene Ther 11:1482-6. 2004..05) increased transduction of mouse liver cells, as compared to preincubation with C3-/- sera or PBS. These results suggest the classical or alternate complement pathway enhances Ad5-mediated liver transduction... - Sensitivity and specificity of fluorescent immunoguided neoplasm detection in head and neck cancer xenograftsBrian D Kulbersh
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, AL 35294 0012, USA
Arch Otolaryngol Head Neck Surg 133:511-5. 2007.... - Differential effects of Ca(2+) on bisphosphonate-induced growth inhibition in breast cancer and mesothelioma cellsMelinda A Merrell
Department of Medicine, Division of Hematology Oncology, University of Alabama at Birmingham, WTI T558, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
Eur J Pharmacol 559:21-31. 2007..They further suggest that bisphosphonates can accumulate in tumors that are growing at the visceral sites and that differences in tumor accumulation of bisphosphonates may regulate their in vivo sensitivity to these drugs... - Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell functionCunren Liu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
J Immunol 176:1375-85. 2006..We propose that tumor exosomes contribute to the growth of tumors by blocking IL-2-mediated activation of NK cells and their cytotoxic response to tumor cells... - Fluorescent detection of rat parathyroid glands via 5-aminolevulinic acidScott A Asher
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
Laryngoscope 118:1014-8. 2008..We sought to determine whether 5-aminolevulinic acid (5-ALA) could produce parathyroid gland fluorescence to improve their detection in a preclinical model... - Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirusAnna Kanerva
Division of Human Gene Therapy, Department of Medicine, Department of Pathology, and Department of Surgery, Finland
Mol Ther 8:449-58. 2003..Taken together with promising biodistribution and toxicity data, this approach could translate into successful clinical interventions for ovarian cancer patients... - Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11Patsy G Oliver
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35294 6832, USA
Clin Cancer Res 14:2180-9. 2008.... - Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasisDiptiman Chanda
Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
Mol Ther 16:871-8. 2008..Results of this study indicate the potential of rAAV-OPG therapy for reducing morbidity and mortality in breast cancer patients with osteolytic bone damage... - Stereomicroscopic fluorescence imaging of head and neck cancer xenografts targeting CD147J Robert Newman
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
Cancer Biol Ther 7:1063-70. 2008..To demonstrate that systemically administered fluorescently labeled anti-CD147 antibody can detect head and neck squamous cell carcinoma xenografts in vivo... - Breast tumor xenografts: diffusion-weighted MR imaging to assess early therapy with novel apoptosis-inducing anti-DR5 antibodyHyunki Kim
Department of Radiology, University of Alabama at Birmingham, 1530 3rd Ave S, BDB 11, Birmingham, AL 35294, USA
Radiology 248:844-51. 2008..To measure the early therapeutic response to a novel apoptosis-inducing antibody, TRA-8, by using diffusion-weighted magnetic resonance (MR) imaging in a mouse breast cancer model... - Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imagingHyunki Kim
Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
Cancer Res 68:8369-76. 2008..This study supports the clinical use of DWI for pancreatic tumor patients for early assessment of drug efficacy... - Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivityXiangdong Wang
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
Mol Endocrinol 22:1427-37. 2008..These data are the first to demonstrate inducible in vivo GHR proteolysis and suggest this is a mechanism to regulate GH sensitivity and its anabolic effects during sepsis or inflammation... - Fluorescent labeled anti-EGFR antibody for identification of regional and distant metastasis in a preclinical xenograft modelJohn P Gleysteen
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
Head Neck 30:782-9. 2008..Detection of regional and distant metastatic disease has significant implications for patient management. Fluorescent imaging may be a useful technique for metastasis detection and removal... - Gene expression imaging with radiolabeled peptidesDonald J Buchsbaum
Department of Radiation Oncology, University of Alabama at Birmingham 35294 6832, USA
Ann Nucl Med 18:275-83. 2004.... - Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitriteJing Jiao
Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Arch Biochem Biophys 410:187-200. 2003.... - Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone miceXiaodong He
Department of Genetics, University of Alabama at Birmingham, 720 South 20th Street, Birmingham, AL 35294, USA
J Immunol 177:8748-56. 2006.... - Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lungPhil Oh
Sidney Kimmel Cancer Center, 10905 Road to the Cure, San Diego, California 92121, USA
Nat Biotechnol 25:327-37. 2007..In vivo proteomic imaging' as described here integrates organellar proteomics with multiple imaging techniques to identify an accessible target space that includes the transvascular pumping space of the caveola... - Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injuryJohn Roberts
Department of Medicine, Nephrology Research and Training Center, Uniersity of Alabama at Birmingham, Birmingham, AL 35294, USA
Am J Physiol Renal Physiol 293:F1408-12. 2007..Our study shows that using dynamic imaging, renal dysfunction can be detected and quantified reliably as early as 5 h after I/R insult, allowing for evaluation of early treatment interventions... - Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigensLolita Zaliauskiene
Department of Pathology, University of Alabama, Birmingham 35294, USA
J Immunol 169:2337-45. 2002..Our results demonstrate that coupling peptides to Tf enhances peptide presentation, thereby making it possible to take full advantage of peptide-specific therapies in modulating T cell responses... - Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancerLeo Christopher DeRosier
Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 6832, USA
Clin Cancer Res 13:5535s-5543s. 2007..Evaluate the response of human pancreatic cancer cell lines and orthotopic tumors to TRA-8, an agonistic antibody to death receptor 5, in combination with irinotecan (CPT-11)... - TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growthLeo Christopher DeRosier
Departments of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South, Wallace Tumor Institute 674, Birmingham, AL 35294 6832, USA
Mol Cancer Ther 6:3198-207. 2007..To evaluate agonistic TRA-8 monoclonal antibody to human death receptor 5 (DR5) and gemcitabine in vitro and in an orthotopic pancreatic cancer model... - Inhibition of T cell responses by transferrin-coupled competitor peptidesLolita Zaliauskiene
Department of Cell Biology and the UAB Comprehensive Cancer Center, University of Alabama at Birmingham, 35294-0005, USA
Immunol Res 26:77-85. 2002..10 transgenic mouse as our model system... - Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing hostCunren Liu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Alabama 35294 0007, USA
Blood 109:4336-42. 2007..Western blot analyses further suggests that MSCs suppress IL-2-mediated NK cell cytotoxicity by affecting the activity of Stat5... - Neural progenitor cell transplantation and imaging in a large animal modelLei Wang
Scott Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 5525, United States
Neurosci Res 59:327-40. 2007..The characterization of fNPCs and exploration of non-invasive bioluminescent imaging to track transplanted cells in this study will allow evaluation of NPC transplantation therapy using feline models of human neurological diseases...
Research Grants
- IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFERKurt Zinn; Fiscal Year: 2002..The proposed reporter system will determine if gene therapy vectors are targeted to tumor, and when further gene therapy treatment is necessary. ..