Tandra R Chaudhuri

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Imaging Tc-99m-labeled FGF-1 targeting in rats
    K R Zinn
    Division of Nuclear Medicine, Department of Radiology, University of Alabama, Birmingham, USA
    Nucl Med Biol 27:407-14. 2000
  2. ncbi request reprint Sinusoidal endothelium in mouse liver show rapid and saturable binding of Jo2 anti-Fas antibody
    Kurt R Zinn
    Departments of Medicine and Radiology, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Mol Imaging Biol 5:326-36. 2003
  3. ncbi request reprint The type 2 human somatostatin receptor as a platform for reporter gene imaging
    Kurt R Zinn
    Department of Radiology, University of Alabama at Birmingham, 35294, USA
    Eur J Nucl Med Mol Imaging 29:388-99. 2002
  4. ncbi request reprint Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice
    Kurt R Zinn
    Depts of Radiology, University of Alabama at Birmingham, Boshell Bldg, BDB 11, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
    Radiology 223:417-25. 2002
  5. doi request reprint Components of a curriculum for molecular imaging scientists
    Kurt R Zinn
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama AL 35294 0019, USA
    J Nucl Med 52:650-6. 2011
  6. ncbi request reprint Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging
    K R Zinn
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nucl Med Biol 28:135-44. 2001
  7. pmc Noninvasive bioluminescence imaging in small animals
    Kurt R Zinn
    Laboratory of Multimodal Imaging, University of Alabama, Birmingham, AL 35294 0012, USA
    ILAR J 49:103-15. 2008
  8. ncbi request reprint In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus
    Akseli Hemminki
    Division of Human Gene Therapy and Gene Therapy Center, Department of Medicine, University of Alabama at Birmingham, 35294 3300, USA
    J Natl Cancer Inst 94:741-9. 2002
  9. ncbi request reprint In vivo imaging of hepatic growth hormone signaling
    Stuart J Frank
    University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 20:2819-30. 2006
  10. ncbi request reprint Intraperitoneal pretarget radioimmunotherapy with CC49 fusion protein
    Donald J Buchsbaum
    Department of Radiation Oncology, University of Alabama at Birmingham, Alabama 35294 6832, USA
    Clin Cancer Res 11:8180-5. 2005

Detail Information

Publications58

  1. ncbi request reprint Imaging Tc-99m-labeled FGF-1 targeting in rats
    K R Zinn
    Division of Nuclear Medicine, Department of Radiology, University of Alabama, Birmingham, USA
    Nucl Med Biol 27:407-14. 2000
    ..Heparin significantly decreased (99m)Tc-FGF-1 liver uptake and increased urinary excretion. These studies illustrate a new method for imaging FGF-1 targeting under various conditions...
  2. ncbi request reprint Sinusoidal endothelium in mouse liver show rapid and saturable binding of Jo2 anti-Fas antibody
    Kurt R Zinn
    Departments of Medicine and Radiology, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Mol Imaging Biol 5:326-36. 2003
    ..To evaluate liver binding of Jo2, a Fas agonist antibody known to induce death in mice...
  3. ncbi request reprint The type 2 human somatostatin receptor as a platform for reporter gene imaging
    Kurt R Zinn
    Department of Radiology, University of Alabama at Birmingham, 35294, USA
    Eur J Nucl Med Mol Imaging 29:388-99. 2002
    ..This review discusses the rationale and strategy for using the hSSTr2 reporter gene as a platform for imaging applications...
  4. ncbi request reprint Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice
    Kurt R Zinn
    Depts of Radiology, University of Alabama at Birmingham, Boshell Bldg, BDB 11, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
    Radiology 223:417-25. 2002
    ..To compare two systems for assessing gene transfer to cancer cells and xenograft tumors with noninvasive gamma camera imaging...
  5. doi request reprint Components of a curriculum for molecular imaging scientists
    Kurt R Zinn
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama AL 35294 0019, USA
    J Nucl Med 52:650-6. 2011
    ....
  6. ncbi request reprint Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging
    K R Zinn
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nucl Med Biol 28:135-44. 2001
    ..and radioiodinated 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-5-iodouracil (FIAU), respectively. Following gene transfer, expression of hSSTr2 and TK were accurately imaged in vitro...
  7. pmc Noninvasive bioluminescence imaging in small animals
    Kurt R Zinn
    Laboratory of Multimodal Imaging, University of Alabama, Birmingham, AL 35294 0012, USA
    ILAR J 49:103-15. 2008
    ..In summary, bioluminescence imaging has become an important component of biomedical research that will continue in the future...
  8. ncbi request reprint In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus
    Akseli Hemminki
    Division of Human Gene Therapy and Gene Therapy Center, Department of Medicine, University of Alabama at Birmingham, 35294 3300, USA
    J Natl Cancer Inst 94:741-9. 2002
    ..We used noninvasive imaging to investigate the in vivo antitumor efficacy of gene therapy using this adenovirus in an animal model of ovarian cancer...
  9. ncbi request reprint In vivo imaging of hepatic growth hormone signaling
    Stuart J Frank
    University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 861, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 20:2819-30. 2006
    ..Our imaging system allows detailed in vivo analysis of GH signaling and action and may be a paradigm for studies of additional signaling pathways in liver and other tissues...
  10. ncbi request reprint Intraperitoneal pretarget radioimmunotherapy with CC49 fusion protein
    Donald J Buchsbaum
    Department of Radiation Oncology, University of Alabama at Birmingham, Alabama 35294 6832, USA
    Clin Cancer Res 11:8180-5. 2005
    ..This study examined a pretarget radioimmunotherapy strategy for treatment of an i.p. tumor model (LS174T)...
  11. ncbi request reprint Blood-based screening and light based imaging for the early detection and monitoring of ovarian cancer xenografts
    Tandra R Chaudhuri
    Department of Radiology, University of Alabama at Birmingham, JT N333, 619 19th St South, Birmingham, AL 35294 6830, USA
    Technol Cancer Res Treat 2:171-80. 2003
    ..This combination will lead to an accurate and widely applicable method for the early detection and monitoring of ovarian cancer, especially in high-risk women..
  12. ncbi request reprint Targeted radiotherapy with [(90)Y]-SMT 487 in mice bearing human nonsmall cell lung tumor xenografts induced to express human somatostatin receptor subtype 2 with an adenoviral vector
    Buck E Rogers
    Department of Radiation Oncology, University of Alabama at Birmingham, 35294, USA
    Cancer 94:1298-305. 2002
    ....
  13. pmc Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer
    Benjamin H Beck
    Department of Medicine, Division of Hematology and Oncology, University of Alabama at Birmingham, SHEL 571, 1825 University Boulevard, Birmingham, AL 35294, USA
    Breast Cancer Res Treat 122:135-44. 2010
    ..Additionally, these studies establish that clinically applicable methods for radiolabeling gammadelta-T cells allows for the tracking of adoptively transferred gammadelta-T cells in tumor-bearing hosts...
  14. ncbi request reprint Fluorescently labeled cetuximab to evaluate head and neck cancer response to treatment
    John P Gleysteen
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Biol Ther 6:1181-5. 2007
    ..Combining the therapeutic and diagnostic properties of targeted antibodies may improve clinical assessment of disease with limited added toxicity during treatment...
  15. ncbi request reprint Detection and measurement of in vitro gene transfer by gamma camera imaging
    K R Zinn
    Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294-0012, USA
    Gene Ther 8:291-9. 2001
    ..Up to four 96-well plates could be imaged simultaneously, thereby demonstrating the high capacity of the system. This novel in vitro approach provides a new method to test enhanced gene transfer as new vectors are developed...
  16. ncbi request reprint High-resolution single-photon emission computed tomography and X-ray computed tomography imaging of Tc-99m-labeled anti-DR5 antibody in breast tumor xenografts
    Hyunki Kim
    Department of Radiology, Comprehensive Cancer Center, University of Alabama at Birmingham, 1808 7th Avenue South, Birmingham, AL 35294 0012, USA
    Mol Cancer Ther 6:866-75. 2007
    ..Imaging could provide a mechanism to assess DR5 modulation when DR5 therapy is combined with chemotherapy and radiation, and thereby aid in optimizing the dosing schedule...
  17. ncbi request reprint Assessment of indocyanine green-labeled cetuximab to detect xenografted head and neck cancer cell lines
    Kirk P Withrow
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Otolaryngol Head Neck Surg 137:729-34. 2007
    ..The aim of this study is to determine the efficacy of indocyanine green (ICG) conjugated to antiepidermal growth factor receptor antibody (cetuximab) to image head and neck cancer...
  18. ncbi request reprint A non-invasive approach for monitoring breast tumor cells during therapeutic intervention
    Tandra R Chaudhuri
    Department of Radiology, Department of Medicine, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biother Radiopharm 17:205-12. 2002
    ..This study was performed to develop a non-invasive imaging method to evaluate non-palpable tumors in a breast xenograft model undergoing therapy...
  19. ncbi request reprint Use of fluorescent labeled anti-epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenografts
    Eben L Rosenthal
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Mol Cancer Ther 6:1230-8. 2007
    ..These results show the feasibility of using fluorescently labeled anti-EGFR antibody to detect human tumors in the surgical setting...
  20. ncbi request reprint Glomerular targeting of acidic fibroblast growth factor-1 in renal transplanted rats
    Kurt R Zinn
    Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Transplantation 73:1447-54. 2002
    ..Consequently, there is an increasing need to monitor FGF-1 pharmacokinetics and distribution for both therapeutic and diagnostic opportunities. We now describe in vivo imaging and targeting of FGF-1 in renal transplanted rats...
  21. ncbi request reprint Radiotargeted gene therapy
    Donald J Buchsbaum
    Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Nucl Med 46:179S-86S. 2005
    ..Clinical studies are needed to determine the most promising of these new therapeutic approaches...
  22. ncbi request reprint A noninvasive reporter system to image adenoviral-mediated gene transfer to ovarian cancer xenografts
    T R Chaudhuri
    Department of Radiology, University of Alabama at Birmingham, 35294-0012, USA
    Gynecol Oncol 83:432-8. 2001
    ..2 and 0.18 for Ad-hSSTr2-injected mice and controls, respectively. CONCLUSION: This study reports the first noninvasive imaging method for imaging gene transfer to ovarian cancer. A human gene therapy trial is planned...
  23. ncbi request reprint The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells
    M Kim
    Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, 35294, USA
    Eur J Cancer 38:1917-26. 2002
    ....
  24. pmc Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic model
    Joseph H Chewning
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    BMC Immunol 10:44. 2009
    ..Luciferase bioluminescence has recently been utilized for non-invasive analysis of in vivo biologic processes in real-time...
  25. doi request reprint Identifying the safety profile of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in anticipation of a phase I clinical trial in patients with recurrent ovarian cancer
    Kellie Matthews
    Division of Gynecologic Oncology, University of Alabama at Birmingham, Alabama, USA
    Clin Cancer Res 15:4131-7. 2009
    ....
  26. ncbi request reprint Light-based imaging of green fluorescent protein-positive ovarian cancer xenografts during therapy
    T R Chaudhuri
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Gynecol Oncol 82:581-9. 2001
    ..The purpose of the study was to develop a sensitive, noninvasive imaging method for monitoring ovarian xenografts during therapeutic intervention...
  27. ncbi request reprint Increased dietary salt accelerates chronic allograft nephropathy in rats
    P W Sanders
    Department of Medicine, University of Alabama, Birmingham, Alabama 35294 00007, USA
    Kidney Int 59:1149-57. 2001
    ....
  28. ncbi request reprint An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression
    A Hemminki
    The Gene Therapy Center, Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    Mol Ther 4:223-31. 2001
    ..RGDTKSSTR may be a useful agent for treating ovarian cancer in clinical trials...
  29. ncbi request reprint Non-invasive gamma camera imaging of gene transfer using an adenoviral vector encoding an epitope-tagged receptor as a reporter
    B E Rogers
    Department of Radiation Oncology, University of Alabama at Birmingham, 1825 6th Avenue South, WT1 674, Birmingham, AL 35294, USA
    Gene Ther 10:105-14. 2003
    ..5+/-4.1% ID/g) as compared to Ad-hSSTr2-infected tumors (5.1+/-1.5% ID/g). These studies demonstrate the feasibility of using an epitope-tagged reporter receptor for non-invasively imaging gene transfer...
  30. ncbi request reprint Site-specific delivery of acidic fibroblast growth factor stimulates angiogenic and osteogenic responses in vivo
    S S Kelpke
    Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Biomed Mater Res A 71:316-25. 2004
    ..e., osteopontin, osteocalcin). Collectively, these efforts support that site-specific delivery of active FGF-1 in a fibrin/hydroxyapatite composite is competent to induce not only angiogenesis but also osteogenic cellular responses...
  31. ncbi request reprint Gene transfer strategies for improving radiolabeled peptide imaging and therapy
    B E Rogers
    Department of Radiation Oncology, University of Alabama at Birmingham 35294, USA
    Q J Nucl Med 44:208-23. 2000
    ..g. cytosine deaminase, thymidine kinase) encoded within the same vector. This would allow for non-invasive monitoring of gene delivery to tumor sites...
  32. ncbi request reprint Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics
    Yuanyuan Xu
    Division of Clinical Immunology and Rheumatology, Department of Medicine and Laboratory for MultiModality Imaging Assessment, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 171:562-8. 2003
    ..Recognizing this fact should facilitate development of safer and more efficacious agonistic Abs...
  33. pmc Syndecan-1 is required for robust growth, vascularization, and metastasis of myeloma tumors in vivo
    Yekaterina B Khotskaya
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 284:26085-95. 2009
    ....
  34. ncbi request reprint Breast cancer metastasis to bone: evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in immunodeficient mice
    S Cowey
    Department of Pathology, University of Alabama at Birmingham, 701 South 19th Street, LHRB Room 531, Birmingham, Alabama 35294, USA
    Clin Exp Metastasis 24:389-401. 2007
    ..MicroSPECT imaging did not detect metastatic lesions in the legs of these young nude mice...
  35. ncbi request reprint Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus
    K R Zinn
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Gene Ther 11:1482-6. 2004
    ..05) increased transduction of mouse liver cells, as compared to preincubation with C3-/- sera or PBS. These results suggest the classical or alternate complement pathway enhances Ad5-mediated liver transduction...
  36. ncbi request reprint Sensitivity and specificity of fluorescent immunoguided neoplasm detection in head and neck cancer xenografts
    Brian D Kulbersh
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, AL 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 133:511-5. 2007
    ....
  37. ncbi request reprint Differential effects of Ca(2+) on bisphosphonate-induced growth inhibition in breast cancer and mesothelioma cells
    Melinda A Merrell
    Department of Medicine, Division of Hematology Oncology, University of Alabama at Birmingham, WTI T558, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Eur J Pharmacol 559:21-31. 2007
    ..They further suggest that bisphosphonates can accumulate in tumors that are growing at the visceral sites and that differences in tumor accumulation of bisphosphonates may regulate their in vivo sensitivity to these drugs...
  38. ncbi request reprint Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    Cunren Liu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    J Immunol 176:1375-85. 2006
    ..We propose that tumor exosomes contribute to the growth of tumors by blocking IL-2-mediated activation of NK cells and their cytotoxic response to tumor cells...
  39. doi request reprint Fluorescent detection of rat parathyroid glands via 5-aminolevulinic acid
    Scott A Asher
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 118:1014-8. 2008
    ..We sought to determine whether 5-aminolevulinic acid (5-ALA) could produce parathyroid gland fluorescence to improve their detection in a preclinical model...
  40. ncbi request reprint Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus
    Anna Kanerva
    Division of Human Gene Therapy, Department of Medicine, Department of Pathology, and Department of Surgery, Finland
    Mol Ther 8:449-58. 2003
    ..Taken together with promising biodistribution and toxicity data, this approach could translate into successful clinical interventions for ovarian cancer patients...
  41. pmc Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11
    Patsy G Oliver
    Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35294 6832, USA
    Clin Cancer Res 14:2180-9. 2008
    ....
  42. doi request reprint Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasis
    Diptiman Chanda
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Mol Ther 16:871-8. 2008
    ..Results of this study indicate the potential of rAAV-OPG therapy for reducing morbidity and mortality in breast cancer patients with osteolytic bone damage...
  43. pmc Stereomicroscopic fluorescence imaging of head and neck cancer xenografts targeting CD147
    J Robert Newman
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Cancer Biol Ther 7:1063-70. 2008
    ..To demonstrate that systemically administered fluorescently labeled anti-CD147 antibody can detect head and neck squamous cell carcinoma xenografts in vivo...
  44. pmc Breast tumor xenografts: diffusion-weighted MR imaging to assess early therapy with novel apoptosis-inducing anti-DR5 antibody
    Hyunki Kim
    Department of Radiology, University of Alabama at Birmingham, 1530 3rd Ave S, BDB 11, Birmingham, AL 35294, USA
    Radiology 248:844-51. 2008
    ..To measure the early therapeutic response to a novel apoptosis-inducing antibody, TRA-8, by using diffusion-weighted magnetic resonance (MR) imaging in a mouse breast cancer model...
  45. pmc Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imaging
    Hyunki Kim
    Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Cancer Res 68:8369-76. 2008
    ..This study supports the clinical use of DWI for pancreatic tumor patients for early assessment of drug efficacy...
  46. pmc Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity
    Xiangdong Wang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 22:1427-37. 2008
    ..These data are the first to demonstrate inducible in vivo GHR proteolysis and suggest this is a mechanism to regulate GH sensitivity and its anabolic effects during sepsis or inflammation...
  47. doi request reprint Fluorescent labeled anti-EGFR antibody for identification of regional and distant metastasis in a preclinical xenograft model
    John P Gleysteen
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Head Neck 30:782-9. 2008
    ..Detection of regional and distant metastatic disease has significant implications for patient management. Fluorescent imaging may be a useful technique for metastasis detection and removal...
  48. ncbi request reprint Gene expression imaging with radiolabeled peptides
    Donald J Buchsbaum
    Department of Radiation Oncology, University of Alabama at Birmingham 35294 6832, USA
    Ann Nucl Med 18:275-83. 2004
    ....
  49. ncbi request reprint Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite
    Jing Jiao
    Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Arch Biochem Biophys 410:187-200. 2003
    ....
  50. ncbi request reprint Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice
    Xiaodong He
    Department of Genetics, University of Alabama at Birmingham, 720 South 20th Street, Birmingham, AL 35294, USA
    J Immunol 177:8748-56. 2006
    ....
  51. pmc Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung
    Phil Oh
    Sidney Kimmel Cancer Center, 10905 Road to the Cure, San Diego, California 92121, USA
    Nat Biotechnol 25:327-37. 2007
    ..In vivo proteomic imaging' as described here integrates organellar proteomics with multiple imaging techniques to identify an accessible target space that includes the transvascular pumping space of the caveola...
  52. pmc Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury
    John Roberts
    Department of Medicine, Nephrology Research and Training Center, Uniersity of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Renal Physiol 293:F1408-12. 2007
    ..Our study shows that using dynamic imaging, renal dysfunction can be detected and quantified reliably as early as 5 h after I/R insult, allowing for evaluation of early treatment interventions...
  53. ncbi request reprint Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigens
    Lolita Zaliauskiene
    Department of Pathology, University of Alabama, Birmingham 35294, USA
    J Immunol 169:2337-45. 2002
    ..Our results demonstrate that coupling peptides to Tf enhances peptide presentation, thereby making it possible to take full advantage of peptide-specific therapies in modulating T cell responses...
  54. pmc Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer
    Leo Christopher DeRosier
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 6832, USA
    Clin Cancer Res 13:5535s-5543s. 2007
    ..Evaluate the response of human pancreatic cancer cell lines and orthotopic tumors to TRA-8, an agonistic antibody to death receptor 5, in combination with irinotecan (CPT-11)...
  55. ncbi request reprint TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth
    Leo Christopher DeRosier
    Departments of Surgery, University of Alabama at Birmingham, 1530 3rd Avenue South, Wallace Tumor Institute 674, Birmingham, AL 35294 6832, USA
    Mol Cancer Ther 6:3198-207. 2007
    ..To evaluate agonistic TRA-8 monoclonal antibody to human death receptor 5 (DR5) and gemcitabine in vitro and in an orthotopic pancreatic cancer model...
  56. ncbi request reprint Inhibition of T cell responses by transferrin-coupled competitor peptides
    Lolita Zaliauskiene
    Department of Cell Biology and the UAB Comprehensive Cancer Center, University of Alabama at Birmingham, 35294 0005, USA
    Immunol Res 26:77-85. 2002
    ..10 transgenic mouse as our model system...
  57. pmc Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host
    Cunren Liu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Alabama 35294 0007, USA
    Blood 109:4336-42. 2007
    ..Western blot analyses further suggests that MSCs suppress IL-2-mediated NK cell cytotoxicity by affecting the activity of Stat5...
  58. ncbi request reprint Neural progenitor cell transplantation and imaging in a large animal model
    Lei Wang
    Scott Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 5525, United States
    Neurosci Res 59:327-40. 2007
    ..The characterization of fNPCs and exploration of non-invasive bioluminescent imaging to track transplanted cells in this study will allow evaluation of NPC transplantation therapy using feline models of human neurological diseases...

Research Grants4

  1. IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
    Kurt Zinn; Fiscal Year: 1999
    ..The proposed reporter system will determine if gene therapy vectors are targeted to tumor, and when further gene therapy treatment is necessary. ..
  2. IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
    Kurt Zinn; Fiscal Year: 2000
    ..The proposed reporter system will determine if gene therapy vectors are targeted to tumor, and when further gene therapy treatment is necessary. ..
  3. IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
    Kurt Zinn; Fiscal Year: 2001
    ..The proposed reporter system will determine if gene therapy vectors are targeted to tumor, and when further gene therapy treatment is necessary. ..
  4. IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
    Kurt Zinn; Fiscal Year: 2002
    ..The proposed reporter system will determine if gene therapy vectors are targeted to tumor, and when further gene therapy treatment is necessary. ..