Nirupa Chaudhari

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Functional cell types in taste buds have distinct longevities
    Isabel Perea-Martinez
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e53399. 2013
  2. pmc Oxytocin signaling in mouse taste buds
    Michael S Sinclair
    Program in Neurosciences, Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 5:e11980. 2010
  3. pmc Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice
    Joung Woul Kim
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida, United States of America
    PLoS ONE 3:e2127. 2008
  4. pmc Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    BMC Neurosci 9:110. 2008
  5. pmc The cell biology of taste
    Nirupa Chaudhari
    Department of Physiology and Biophysics, and Program in Neurosciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Biol 190:285-96. 2010
  6. pmc Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells
    CRAIG D ROBERTS
    Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Physiol 587:1657-68. 2009
  7. pmc Knocking out P2X receptors reduces transmitter secretion in taste buds
    Yijen A Huang
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 31:13654-61. 2011
  8. pmc Breadth of tuning and taste coding in mammalian taste buds
    Seth M Tomchik
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 27:10840-8. 2007
  9. ncbi request reprint Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells
    Joung Woul Kim
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine RMSB 4040, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Chem Senses 31:213-9. 2006
  10. pmc Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds
    Gennady Dvoryanchikov
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Comp Neurol 517:1-14. 2009

Research Grants

  1. Voltage-gated calcium channels in taste buds
    Nirupa Chaudhari; Fiscal Year: 2003
  2. Mechanisms of sweet transduction in mammalian taste buds
    Nirupa Chaudhari; Fiscal Year: 2010
  3. SIGNALING IN TASTE CELLS
    Nirupa Chaudhari; Fiscal Year: 2010
  4. Mechanisms of sweet transduction in mammalian taste buds
    Nirupa Chaudhari; Fiscal Year: 2009
  5. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2009
  6. Mechanisms of sweet transduction in mammalian taste buds
    Nirupa Chaudhari; Fiscal Year: 2007
  7. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2007
  8. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2006
  9. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2005

Collaborators

Detail Information

Publications25

  1. pmc Functional cell types in taste buds have distinct longevities
    Isabel Perea-Martinez
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 8:e53399. 2013
    ..A small number of slow-cycling cells may also exist within the perimeter of the taste bud. Based on their incidence, we hypothesize that these may be progenitors for Type III cells...
  2. pmc Oxytocin signaling in mouse taste buds
    Michael S Sinclair
    Program in Neurosciences, Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 5:e11980. 2010
    ..Mutant mice lacking OXT (OXT knockout) overconsume salty and sweet (i.e. sucrose, saccharin) solutions. We asked if OXT might also act on taste buds via its receptor, OXTR...
  3. pmc Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice
    Joung Woul Kim
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida, United States of America
    PLoS ONE 3:e2127. 2008
    ..e. in their native physiological context. Reporter expression in other tissues (such as the heart) where cAMP plays a critical regulatory role, will permit novel biomedical approaches...
  4. pmc Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    BMC Neurosci 9:110. 2008
    ..We utilized RT-PCR, immunocytochemistry and single-cell gene expression profiling to examine the expression of the Galphaq family (q, 11, 14) in mouse taste buds...
  5. pmc The cell biology of taste
    Nirupa Chaudhari
    Department of Physiology and Biophysics, and Program in Neurosciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Biol 190:285-96. 2010
    ..This review discusses the functional classes of taste cells, their cell biology, and current thinking on how taste information is transmitted to the brain...
  6. pmc Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells
    CRAIG D ROBERTS
    Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Physiol 587:1657-68. 2009
    ..Collectively, these data demonstrate cross-talk between cAMP and Ca(2+) signalling in a subclass of taste cells that form synapses with gustatory fibres and may integrate tastant-evoked signals...
  7. pmc Knocking out P2X receptors reduces transmitter secretion in taste buds
    Yijen A Huang
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 31:13654-61. 2011
    ..Importantly, we find that P2X2 is expressed in WT taste buds and appears to function as an autocrine, positive feedback signal to amplify taste-evoked ATP secretion...
  8. pmc Breadth of tuning and taste coding in mammalian taste buds
    Seth M Tomchik
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 27:10840-8. 2007
    ....
  9. ncbi request reprint Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells
    Joung Woul Kim
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine RMSB 4040, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Chem Senses 31:213-9. 2006
    ..These PLCbeta2 promoter-GFP transgenic lines promise to be useful for studying taste transduction, sensory signal processing, and taste bud development...
  10. pmc Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds
    Gennady Dvoryanchikov
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Comp Neurol 517:1-14. 2009
    ..We propose that in taste buds, ROMK in type I/glial-like cells may serve a homeostatic function, excreting excess K(+) through the apical pore, and allowing excitable taste cells to maintain a hyperpolarized resting membrane potential...
  11. pmc Separate populations of receptor cells and presynaptic cells in mouse taste buds
    Richard A DeFazio
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 26:3971-80. 2006
    ..These data demonstrate the existence of at least two molecularly distinct functional classes of taste cells: receptor cells and synapse-forming cells...
  12. pmc Adenosine enhances sweet taste through A2B receptors in the taste bud
    Robin Dando
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 32:322-30. 2012
    ..Our findings suggest that ATP released during taste reception is degraded to adenosine to exert positive modulation particularly on sweet taste...
  13. pmc Umami responses in mouse taste cells indicate more than one receptor
    Yutaka Maruyama
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 26:2227-34. 2006
    ..Furthermore, umami responses were still observed in mutant mice lacking T1R3. A full explanation of umami taste transduction may involve novel combinations of the proposed receptors and/or as-yet-undiscovered taste receptors...
  14. ncbi request reprint Liposome-mediated transfection of mature taste cells
    Ana Marie Landin
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    J Neurobiol 65:12-21. 2005
    ..These studies should permit ex vivo strategies for studying development and cellular function in taste cells...
  15. pmc GABA, its receptors, and GABAergic inhibition in mouse taste buds
    Gennady Dvoryanchikov
    Department of Physiology and Biophysics and Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 31:5782-91. 2011
    ..We conclude that GABA is an inhibitory transmitter released during taste stimulation and possibly also during growth and differentiation of taste buds...
  16. pmc The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds
    Yi Jen Huang
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:6436-41. 2007
    ..They also indicate a route for cell-cell communication and signal processing within the taste bud...
  17. ncbi request reprint Biogenic amine synthesis and uptake in rodent taste buds
    Gennady Dvoryanchikov
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Comp Neurol 505:302-13. 2007
    ..In summary, we postulate that aminergic presynaptic taste cells synthesize only 5-HT, whereas NE (perhaps secreted by sympathetic fibers) may be concentrated and repackaged for secretion...
  18. ncbi request reprint Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds
    Gennady Dvoryanchikov
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136
    J Comp Neurol 517:spc1. 2009
    ..J. Comp. Neurol. 517:1-14, 2009. (c) 2009 Wiley-Liss, Inc...
  19. pmc Taste receptors for umami: the case for multiple receptors
    Nirupa Chaudhari
    Department of Physiology and Biophysics, University of Miami, FL 33136, USA
    Am J Clin Nutr 90:738S-742S. 2009
    ..This receptor diversity may underlie the complex perception of umami, with different mixtures of amino acids, peptides, and nucleotides yielding subtly distinct taste qualities...
  20. ncbi request reprint Tastants evoke cAMP signal in taste buds that is independent of calcium signaling
    Kristina R Trubey
    Dept of Physiology and Biophysics R430 Univ of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    Am J Physiol Cell Physiol 291:C237-44. 2006
    ..Our results suggest that tastant-evoked cAMP signals are not simply a secondary consequence of calcium modulation. Instead, cAMP and released Ca2+ may represent independent second messenger signals downstream of taste receptors...
  21. ncbi request reprint Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds
    Trevor A Richter
    Dept of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Neurophysiol 92:1928-36. 2004
    ..However, our results do not unambiguously identify any one channel as the acid taste transducer...
  22. ncbi request reprint Acid-sensing ion channel-2 is not necessary for sour taste in mice
    Trevor A Richter
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 24:4088-91. 2004
    ..Our results indicate that ASIC2 is not required for acid taste in mice, and that if a universal mammalian acid taste transduction mechanism exists, it likely uses other acid-sensitive receptors or ion channels...
  23. ncbi request reprint Adenylyl cyclase expression and modulation of cAMP in rat taste cells
    Tatjana Abaffy
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Physiol Cell Physiol 284:C1420-8. 2003
    ..Whether AC8 is directly involved in signal transduction of umami taste remains to be established...
  24. pmc Processing umami and other tastes in mammalian taste buds
    Stephen D Roper
    Department of Physiology and Biophysics, and Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Ann N Y Acad Sci 1170:60-5. 2009
    ..The following paragraphs summarize current thinking about how taste signals generally, and umami taste in particular, are processed in taste buds...
  25. ncbi request reprint Multiple pathways for signaling glutamate taste in rodents
    Nirupa Chaudhari
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    Chem Senses 30:i29-30. 2005

Research Grants11

  1. Voltage-gated calcium channels in taste buds
    Nirupa Chaudhari; Fiscal Year: 2003
    ..Through these aims, we hope to gain a novel perspective on voltage-gated calcium channels, which play critical roles in all neuronal systems, but have been minimally studied in taste cells to date. ..
  2. Mechanisms of sweet transduction in mammalian taste buds
    Nirupa Chaudhari; Fiscal Year: 2010
    ....
  3. SIGNALING IN TASTE CELLS
    Nirupa Chaudhari; Fiscal Year: 2010
    ..Because the proteins responsible for regulation are in an accessible location, understanding these mechanisms introduces the possibility of pharmacological manipulation of aversive and appetitive taste sensations. ..
  4. Mechanisms of sweet transduction in mammalian taste buds
    Nirupa Chaudhari; Fiscal Year: 2009
    ....
  5. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2009
    ..Differential library screening will then allow us to begin defining the functional relationship between receptor and output cells. ..
  6. Mechanisms of sweet transduction in mammalian taste buds
    Nirupa Chaudhari; Fiscal Year: 2007
    ....
  7. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2007
    ..Differential library screening will then allow us to begin defining the functional relationship between receptor and output cells. ..
  8. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2006
    ..Differential library screening will then allow us to begin defining the functional relationship between receptor and output cells. ..
  9. Molecular Basis of Taste Cell Signaling
    Nirupa Chaudhari; Fiscal Year: 2005
    ..Differential library screening will then allow us to begin defining the functional relationship between receptor and output cells. ..