Research Topics
Species | H P ChaseSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Post-prandial glucose excursions following four methods of bolus insulin administration in subjects with type 1 diabetesH P Chase
Department of Paediatrics, Barbara Davis Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Diabet Med 19:317-21. 2002..To determine if one method of short-acting insulin bolus administration is superior to other methods in managing a meal high in carbohydrates, calories and fat...
Timing of meal insulin boluses to achieve optimal postprandial glycemic control in patients with type 1 diabetesErin Cobry
Barbara Davis Center for Childhood Diabetes, Aurora, Colorado 80045, USA
Diabetes Technol Ther 12:173-7. 2010..This study determined the optimal timing of insulin bolus administration in relation to meal consumption in adolescents and adults with type 1 diabetes...
Reduced hypoglycemic episodes and improved glycemic control in children with type 1 diabetes using insulin glargine and neutral protamine Hagedorn insulinH Peter Chase
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado, USA
J Pediatr 143:737-40. 2003..The numbers of nonsevere and severe hypoglycemic events, hemoglobin A1c values, body weight, and daily insulin dose were recorded at each clinic visit...
Elevated C-reactive protein levels in the development of type 1 diabetesH Peter Chase
Department of Pediatrics, The Barbara Davis Center for Childhood Diabetes, Denver, Colorado, USA
Diabetes 53:2569-73. 2004..The elevated CRP levels may provide an additional marker for risk of progression to type 1 diabetes...
The use of insulin pumps with meal bolus alarms in children with type 1 diabetes to improve glycemic controlH Peter Chase
Department of Pediatrics, University of Colorado Health Sciences Center, Barbara Davis Center for Childhood Diabetes, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
Diabetes Care 29:1012-5. 2006..The aim of this study was to determine whether the use of meal bolus alarms would result in fewer missed meal boluses per week in youth with type 1 diabetes using continuous subcutaneous insulin infusion (CSII) therapy...
Insulin glargine versus intermediate-acting insulin as the basal component of multiple daily injection regimens for adolescents with type 1 diabetes mellitusH Peter Chase
Barbara Davis Center, University of Colorado, Aurora, CO 80045 6511, USA
J Pediatr 153:547-53. 2008....
Modem transmission of glucose values reduces the costs and need for clinic visitsH Peter Chase
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, USA
Diabetes Care 26:1475-9. 2003..To determine whether modem technology allows for effective management of type 1 diabetes when used in lieu of a clinic visit...
Redefining the clinical remission period in children with type 1 diabetesH Peter Chase
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Pediatr Diabetes 5:16-9. 2004..To redefine the clinical remission period for different aged children receiving the current standard of diabetes care...
Continuous subcutaneous glucose monitoring in children with type 1 diabetesH P Chase
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, Denver, Colorado 80262, USA
Pediatrics 107:222-6. 2001....
The impact of the diabetes control and complications trial and humalog insulin on glycohemoglobin levels and severe hypoglycemia in type 1 diabetesH P Chase
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, USA
Diabetes Care 24:430-4. 2001....
Long-term efficacy of humalog in subjects with Type 1 diabetes mellitusS K Garg
Barbara Davis Center for Childhood Diabetes, Department of Paediatrics, University of Colorado Health Sciences Center, Denver, USA
Diabet Med 16:384-7. 1999..To evaluate the long-term effectiveness of Humalog insulin in lowering post meal glucose excursions...
Use of the GlucoWatch biographer in children with type 1 diabetesH Peter Chase
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
Pediatrics 111:790-4. 2003..The use of the biographer with an alarm to detect nocturnal hypoglycemia has the potential to increase the safety of diabetes management in children...
Improved glycemic control after long-term insulin pump use in pediatric patients with type 1 diabetesLaura Scrimgeour
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Diabetes Technol Ther 9:421-8. 2007..There are currently few data available on the long-term use of continuous subcutaneous insulin infusion (CSII) (insulin pump) therapy in children...
Continuous subcutaneous insulin infusion therapy for children and adolescents: an option for routine diabetes careA K Maniatis
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Pediatrics 107:351-6. 2001..CONCLUSIONS: CSII therapy is an appropriate option for some children in routine pediatric diabetes care. It can effectively decrease the HbA(1c) and reduce hypoglycemic episodes, without producing an abnormal increase in BMI...
Use of a subcutaneous injection port to improve glycemic control in children with type 1 diabetesPatricia Burdick
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO, USA
Pediatr Diabetes 10:116-9. 2009..To determine if use of an injection port, the Insuflon, would help to improve glycemic control in youth with type 1 diabetes (TID) who were in suboptimal glycemic control (hemoglobin A1c, HbA1c >8.0%)...
Missed insulin boluses for snacks in youth with type 1 diabetesBrandon W Vanderwel
University of Colorado, Aurora, Colorado, USA
Diabetes Care 33:507-8. 2010..3 vs. 1.1 mg/dl per minute; P < 0.001). CONCLUSIONS This study shows that afternoon snacks without insulin boluses are common and result in significantly higher glucose excursions than snacks with insulin administration...
Diabetic subjects diagnosed through the Diabetes Prevention Trial-Type 1 (DPT-1) are often asymptomatic with normal A1C at diabetes onsetTaylor M Triolo
University of Colorado Denver, Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA
Diabetes Care 32:769-73. 2009..Metabolic tests and the presence of symptoms were described at diabetes onset during the Diabetes Prevention Trial-Type 1 (DPT-1)...
A pilot trial of pramlintide home usage in adolescents with type 1 diabetesChristopher M Kishiyama
Department of Pediatrics, University of Colorado, Aurora, Colorado 80045, USA
Pediatrics 124:1344-7. 2009..The objective of this study was to evaluate the safety and efficacy of home pramlintide use in adolescents with type 1 diabetes...
Continuous glucose monitoring in youth with type 1 diabetesR Paul Wadwa
Barbara Davis Center for Childhood Diabetes, Aurora, Colorado 80045, USA
Diabetes Technol Ther 11:S83-91. 2009..In the future, CGM use in youth may couple with insulin pump technology to create a "closed-loop" system in which the CGM device will direct insulin administration without user input...
Factors affecting improved glycaemic control in youth using insulin pumpsJ Wilkinson
University of Colorado, Aurora, CO, USA
Diabet Med 27:1174-7. 2010..The purpose of this study was to evaluate factors associated with insulin pump therapy resulting in lower HbA(1c) levels in young people with Type 1 diabetes mellitus...
Correlation of fingerstick blood glucose measurements with GlucoWatch biographer glucose results in young subjects with type 1 diabetesS K Garg
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
Diabetes Care 22:1708-14. 1999..Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home setting...
Mixing rapid-acting insulin analogues with insulin glargine in children with type 1 diabetes mellitusRosanna Fiallo-Scharer
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Pediatr 148:481-4. 2006..To determine whether mixing insulin glargine (IG) with a rapid-acting insulin (RAI) analogue in the same syringe had any deleterious effects on glycemic control in children with type 1 diabetes mellitus...
Prevention strategies for type 1 diabetesChristopher M Kishiyama
The Barbara Davis Center for Childhood Diabetes, Denver, CO, USA
Rev Endocr Metab Disord 7:215-24. 2006..This review article describes the past, current and upcoming strategies for diabetes prevention for patients at risk for developing autoimmunity, after antibody production, and patients with new onset diabetes...
Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testingJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Pediatr 150:31-36.e6. 2007....
The role of continuous glucose sensors in diabetes careSatish K Garg
Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Campus Box B-140, Denver, CO 80262, USA
Endocrinol Metab Clin North Am 33:163-73, x-xi. 2004
Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetesJill M Norris
Department of Preventive Medicine and Biostatistics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
JAMA 298:1420-8. 2007..Cod liver oil supplements in infancy have been associated with a decreased risk of type 1 diabetes mellitus in a retrospective study...
Use of CoZmonitor in youth with type 1 diabetesErin Cobry
Department of Pediatrics, Barbara Davis Center, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
Pediatr Diabetes 9:148-51. 2008..The purpose of this study was to evaluate the effectiveness of directly integrating self-monitoring blood glucose (BG) information with insulin pump therapy on overall glycemic control...
The use of insulin pumps in youth with type 1 diabetesDavid M Maahs
University of Colorado Barbara Davis Center for Childhood Diabetes, 1775 Aurora Court, Aurora, CO 80045, USA
Diabetes Technol Ther 12:S59-65. 2010..Finally, diabetes management in the 21st century, in which pump therapy is combined with continuous glucose monitoring, and its potential for a closed-loop pancreas are presented...
Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapyJonathan Burdick
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
Pediatrics 113:e221-4. 2004..414) and mean blood glucose levels (r =.70). CONCLUSION: Missed mealtime insulin boluses seem to be the major cause of suboptimal glycemic control in youths with diabetes receiving continuous subcutaneous insulin infusion therapy...
Glycemic parameters with multiple daily injections using insulin glargine versus insulin pumpSatish K Garg
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes Technol Ther 6:9-15. 2004..However, costs and episodes of diabetic ketoacidosis are significantly higher for insulin pump users...
Improved glycemic control without an increase in severe hypoglycemic episodes in intensively treated patients with type 1 diabetes receiving morning, evening, or split dose insulin glargineSatish K Garg
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Diabetes Res Clin Pract 66:49-56. 2004..Sixty-three subjects were taking glargine in the morning, 125 were taking glargine in the evening, and 104 were splitting the glargine dose between the morning and evening...
Continuous glucose monitoring in type 1 diabetesStuart A Weinzimer
Yale University School of Medicine, Department of Pediatrics, PO Box 208064, 333 Cedar Street, New Haven, CT 06520, USA
Curr Diab Rep 4:95-100. 2004..The current "state of the art" of this technology, including accuracy, performance in clinical trials, limitations, and recommendations for use, is discussed for the two currently approved continuous glucose monitoring devices...
Inflammatory markers and diabetic retinopathy in type 1 diabetesKenneth E Izuora
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B-140, Denver, CO, USA
Diabetes Care 28:714-5. 2005
Continuous glucose monitoring in youth with type 1 diabetes: 12-month follow-up of the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trialH Peter Chase
Barbara Davis Center, Denver, Colorado, USA
Diabetes Technol Ther 12:507-15. 2010..The use of continuous glucose monitoring (CGM) in the pediatric population is not well characterized. We have evaluated the use of CGM over a 12-month interval in youth with type 1 diabetes (TID) and have provided a description of CGM use...
Predictors of acute complications in children with type 1 diabetesArleta Rewers
Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado, School of Medicine, The Children s Hospital, Denver, CO 80218, USA
JAMA 287:2511-8. 2002..Diabetic ketoacidosis and severe hypoglycemia are acute complications of type 1 diabetes that are related, respectively, to insufficient or excessive insulin treatment. However, little is known about additional modifiable risk factors...
Pramlintide lowered glucose excursions and was well-tolerated in adolescents with type 1 diabetes: results from a randomized, single-blind, placebo-controlled, crossover studyH Peter Chase
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
J Pediatr 155:369-73. 2009..To evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of pramlintide in treating adolescents with type 1 diabetes...
In utero dietary exposures and risk of islet autoimmunity in childrenCarolyn M Fronczak
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
Diabetes Care 26:3237-42. 2003..CONCLUSIONS: Our findings suggest that maternal intake of vitamin D through food during pregnancy may have a protective effect on the appearance of IA in offspring...
Don't take away my pump! Switching to injections may cause problemsH Peter Chase
University of Colorado Health Sciences Center, Denver, Colorado, USA
Diabetes Forecast 58:55-6. 2005
Preventing post-exercise nocturnal hypoglycemia in children with type 1 diabetesCraig E Taplin
University of Colorado, Barbara Davis Center for Childhood Diabetes, Aurora, CO 80045, USA
J Pediatr 157:784-8.e1. 2010..To determine the effects of reducing overnight basal insulin or a bedtime dose of terbutaline on nocturnal blood glucose (BG) nadir and hypoglycemia after exercise in children with type 1 diabetes mellitus...
First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetesH P Chase
Barbara Davis Center, University of Colorado Health Sciences Center, Denver, USA
J Pediatr 138:244-9. 2001..CONCLUSION: FPIR in the IV-GTT correlates strongly with risk factors for development of type 1 diabetes...
Clinical trials for the prevention of type 1 diabetesH Peter Chase
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
Adv Exp Med Biol 552:291-305. 2004
Bedside monitoring of blood beta-hydroxybutyrate levels in the management of diabetic ketoacidosis in childrenArleta Rewers
Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80218, USA
Diabetes Technol Ther 8:671-6. 2006..The purpose of this study was to evaluate if bedside monitoring of blood beta-OHB levels can simplify management of DKA through elimination of superfluous laboratory monitoring...
Detection of ketosis and monitoring of diabetic ketoacidosisH Peter Chase
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, USA
Manag Care 13:5-6; discussion 19-21. 2004
Cost-effectiveness of use of the GlucoWatch Biographer in children and adolescents with type 1 diabetes: a preliminary analysis based on a randomized controlled trialRichard C Eastman
Cygnus, Inc, 400 Penobscot Drive, Redwood City, California 94063, USA
Pediatr Diabetes 4:82-6. 2003..To conduct a preliminary analysis of the cost-effectiveness of the use of the GlucoWatch Biographer in the management of type 1 diabetes in children and adolescents...
Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitusEva Tsalikian
DirectNet Coordinating Center, Jaeb Center for Health Research, Tampa, Florida 33647, USA
J Pediatr 147:528-34. 2005..To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes mellitus (T1DM)...
JDRF randomized clinical trial to assess the efficacy of real-time continuous glucose monitoring in the management of type 1 diabetes: research design and methodsWilliam V Tamborlane
Diabetes Technol Ther 10:310-21. 2008..RESULTS: Recruitment for the study was completed on December 15, 2007. CONCLUSION: Results of this clinical trial should help establish whether or not current RT-CGM devices are beneficial to patients with T1D...
The accuracy of the Guardian RT continuous glucose monitor in children with type 1 diabetesMichael Tansey
Diabetes Technol Ther 10:266-72. 2008..The Guardian RT has an accuracy similar to that of other available continuous glucose monitors and can give important and useful clinical information...
Continuous glucose monitoring and intensive treatment of type 1 diabetesWilliam V Tamborlane
N Engl J Med 359:1464-76. 2008..Further work is needed to identify barriers to effectiveness of continuous monitoring in children and adolescents. (ClinicalTrials.gov number, NCT00406133.)..
Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise studyStuart A Weinzimer
DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
Diabetes Technol Ther 7:675-80; discussion 681-3. 2005..The objective of this study was to assess how the accuracy of the FreeStyle Flash (Abbott Diabetes Care, Alameda, CA) meter compares with that of the One Touch Ultra (Lifescan, Milpitas, CA) home glucose meter (HGM)...
Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1Jay M Sosenko
Division of Endocrinology, University of Miami, PO Box 016960 D110, Miami, FL 33101, USA
Diabetes Care 29:643-9. 2006..The goal of this study was to utilize data from the Diabetes Prevention Trial-Type 1 (DPT-1) to obtain a picture of the metabolic progression to type 1 diabetes over a period of approximately 2.5 years before its diagnosis...
A randomized multicenter trial comparing the GlucoWatch Biographer with standard glucose monitoring in children with type 1 diabetesH Peter Chase
DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
Diabetes Care 28:1101-6. 2005..This study assesses whether use of the GlucoWatch G2 Biographer (GW2B) in addition to standard glucose monitoring lowers HbA(1c) and reduces hypoglycemia compared with standard glucose monitoring alone...
Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1Jay S Skyler
University of Miami, PO Box 016960 D 110, Miami, FL 33101 6960, USA
Diabetes Care 28:1068-76. 2005..This randomized, double-masked, placebo-controlled clinical trial tested whether oral insulin administration could delay or prevent type 1 diabetes in nondiabetic relatives at risk for diabetes...
Nocturnal hypoglycemia--an unrelenting problemH Peter Chase
J Clin Endocrinol Metab 91:2038-9. 2006
Treatment of adolescents with type 1 diabetes mellitusSatish Garg
J Pediatr Endocrinol Metab 17:805-6. 2004
Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1Jay M Sosenko
Division of Endocrinology, University of Miami, P O Box 016960 D110, Miami, FL 33101, USA
Diabetes Care 30:38-42. 2007....
Glycemic control in prepubertal yearsH Peter Chase
Diabetes Care 26:1304-5. 2003
Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy studyNelly Mauras
DirecNet Coordinating Center, Tampa, Florida, USA
J Pediatr 144:770-5. 2004..CONCLUSIONS: Neither the CGMS nor the GW2B is accurate enough to establish population standards of the glycemic profile of healthy children and cannot be recommended in the workup of hypoglycemia in nondiabetic youth...
Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator)Bruce Buckingham
Pediatr Diabetes 9:142-7. 2008..CONCLUSIONS: These results show the feasibility of implementing the DATA when real-time continuous glucose monitoring is initiated and support its use in future clinical trials of real-time continuous glucose monitoring...
How should we interpret "real life" conditionsRichard C Eastman
Pediatr Diabetes 4:59. 2003
Research Grants
- Glucose Sensors in Children with Type I DiabetesH Chase; Fiscal Year: 2006..Quality of Life and Fear of Hypoglycemia Questionnaires will be used to evaluate psychological factors in both the factors in both the feasibility and the two-year trials. ..
