Dionysios V Chartoumpekis


Affiliation: University of Pittsburgh
Country: USA


  1. Ziros P, Habeos I, Chartoumpekis D, Ntalampyra E, Somm E, Renaud C, et al. The NFE2-related transcription factor 2 (Nrf2) coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland. Thyroid. 2018;: pubmed publisher
    ..Nrf2 exerts pleiotropic roles in the thyroid gland to couple cell stress defense mechanisms to iodide metabolism and the thyroid hormone synthesis machinery, both under basal conditions and in response to excess iodide. ..
  2. Chartoumpekis D, Wakabayashi N, Kensler T. Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism. Biochem Soc Trans. 2015;43:639-44 pubmed publisher
    ..Last but not least, the importance of context about Nrf2 and cancer is highlighted as the Nrf2 pathway may be activated in cancers but its pharmacological activators are useful in chemoprevention. ..
  3. Slocum S, Skoko J, Wakabayashi N, Aja S, Yamamoto M, Kensler T, et al. Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet. Arch Biochem Biophys. 2016;591:57-65 pubmed publisher
    ..In conclusion, increased Keap1/Nrf2 signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keap1-hypo mice. ..