Israel Charo

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK
    Simone R Green
    Department of Medicine, University of California, San Diego, La Jolla, 92093, USA
    J Immunol 176:7412-20. 2006
  2. pmc Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
    Laura L Koth
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Respir Res 5:12. 2004
  3. doi request reprint Anti-inflammatory therapeutics for the treatment of atherosclerosis
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street 149, San Francisco, California 94158, USA
    Nat Rev Drug Discov 10:365-76. 2011
  4. ncbi request reprint Macrophage polarization and insulin resistance: PPARgamma in control
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, and Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Metab 6:96-8. 2007
  5. ncbi request reprint The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  6. ncbi request reprint Chemokines in the pathogenesis of vascular disease
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141 9100, USA
    Circ Res 95:858-66. 2004
  7. ncbi request reprint Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    Microcirculation 10:259-64. 2003
  8. pmc Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
    Chia Lin Tsou
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94158, USA
    J Clin Invest 117:902-9. 2007
  9. pmc Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis
    Philippe Lesnik
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 111:333-40. 2003
  10. ncbi request reprint CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia
    Gale Tang
    Pacific Vascular Research Laboratory, Department of Surgery, Division of Vascular Surgery, University of California, San Francisco 94143 0222, USA
    J Vasc Surg 40:786-95. 2004

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi request reprint The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK
    Simone R Green
    Department of Medicine, University of California, San Diego, La Jolla, 92093, USA
    J Immunol 176:7412-20. 2006
    ..Together, our data suggest that a chemokine signal is required for firm CX3CR1-dependent adhesion and demonstrate that CCR2 is an important regulator of CX3CL1-dependent leukocyte adhesion...
  2. pmc Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
    Laura L Koth
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Respir Res 5:12. 2004
    ..Furthermore, MCP-1-deficient mice have not previously been studied in models of experimental allergic asthma...
  3. doi request reprint Anti-inflammatory therapeutics for the treatment of atherosclerosis
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street 149, San Francisco, California 94158, USA
    Nat Rev Drug Discov 10:365-76. 2011
    ....
  4. ncbi request reprint Macrophage polarization and insulin resistance: PPARgamma in control
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, and Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Metab 6:96-8. 2007
    ..2007) extend this paradigm to the vessel wall by showing that both M1 and M2 macrophages are present in atherosclerotic lesions and that activation of PPARgamma polarizes circulating blood monocytes to become M2 macrophages...
  5. ncbi request reprint The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  6. ncbi request reprint Chemokines in the pathogenesis of vascular disease
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141 9100, USA
    Circ Res 95:858-66. 2004
    ....
  7. ncbi request reprint Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    Microcirculation 10:259-64. 2003
    ..This review will summarize evidence supporting a key role for CCR2 in the pathogenesis of atherosclerosis, infections with intracellular pathogens, and regulation of the type I adaptive immune response...
  8. pmc Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
    Chia Lin Tsou
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94158, USA
    J Clin Invest 117:902-9. 2007
    ..These findings provide evidence that CCR2 and MCP-3/MCP-1 are critical for monocyte mobilization and suggest new roles for monocyte chemoattractants in leukocyte homeostasis...
  9. pmc Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis
    Philippe Lesnik
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 111:333-40. 2003
    ..CX(3)CR1(-/-) mice have a significant reduction in macrophage recruitment to the vessel wall and decreased atherosclerotic lesion formation. Taken together, these data provide strong evidence that FK plays a key role in atherogenesis...
  10. ncbi request reprint CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia
    Gale Tang
    Pacific Vascular Research Laboratory, Department of Surgery, Division of Vascular Surgery, University of California, San Francisco 94143 0222, USA
    J Vasc Surg 40:786-95. 2004
    ....
  11. pmc Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection
    Ting Jia
    Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 180:6846-53. 2008
    ..Our data demonstrate that MCP-3 and MCP-1 provide parallel contributions to CCR2-mediated inflammatory monocyte recruitment and that both chemokines are required for optimal innate immune defense against L. monocytogenes infection...
  12. pmc Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis
    Noah Saederup
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
    Circulation 117:1642-8. 2008
    ..The aim of this study was to determine whether these 2 chemokines act independently or redundantly in promoting atherogenesis...
  13. ncbi request reprint MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells
    Alison D Schecter
    The Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Leukoc Biol 75:1079-85. 2004
    ..This alternative receptor may be important in mediating some of the effects of MCP-1 in atherosclerotic arteries and in other inflammatory processes...
  14. ncbi request reprint CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis
    Wendy Peters
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141, USA
    J Immunol 172:7647-53. 2004
    ..Further investigation revealed a critical role for CCR2 in the recruitment of F4/80(dim) macrophages and CD11c(dim/intermediate) DCs to the infected lung...
  15. pmc CCR2 modulates inflammatory and metabolic effects of high-fat feeding
    Stuart P Weisberg
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 116:115-24. 2006
    ....
  16. ncbi request reprint CCR2 deficiency decreases intimal hyperplasia after arterial injury
    Merce Roque
    Zena and Michael A Wiener Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Arterioscler Thromb Vasc Biol 22:554-9. 2002
    ..CCR2 may thus be an important target for inhibiting the response to acute arterial injury...
  17. ncbi request reprint Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions
    Ara M Aslanian
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, USA
    Arterioscler Thromb Vasc Biol 25:628-32. 2005
    ..However, the contribution of NKT cells to mature lesion formation and the effector mechanisms through which they act are unknown...
  18. ncbi request reprint Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis
    Ara M Aslanian
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, Calif 94158, USA
    Circulation 114:583-90. 2006
    ..These properties, as well as the expression of CXCL16 in human and mouse atheroma, suggest that CXCL16 plays a role in atherosclerosis...
  19. pmc CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice
    Yue Si
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    J Clin Invest 120:1192-203. 2010
    ..These findings reveal what we believe to be a novel role for CCR2 in the homing of HSCs/HPCs to sites of inflammation and suggest new functions for chemokines in promoting tissue repair and regeneration...
  20. pmc Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1
    Oliver T Keppler
    Gladstone Institute of Virology and Immunology, School of Medicine, University of California at San Francisco, San Francisco, CA 94141, USA
    J Exp Med 195:719-36. 2002
    ..Transgenic rats also displayed a low-level plasma viremia early in infection. Thus, transgenic rats expressing the appropriate human receptor complex are promising candidates for a small animal model of HIV-1 infection...
  21. ncbi request reprint Monocyte recruitment in venous thrombus resolution
    Tahir Ali
    Academic Department of Surgery, Cardiovascular Division, GKT, King s College, St Thomas s Hospital, London, United Kingdom
    J Vasc Surg 43:601-8. 2006
    ..To investigate the importance of monocyte recruitment in thrombus resolution and the role of cysteine-cysteine (CC) chemokines and the CC chemokine receptor, CCR2, in this process...
  22. pmc CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice
    Nathan B Sautter
    Head and Neck Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Assoc Res Otolaryngol 7:361-72. 2006
    ..Possible mechanisms of neuroprotection by CCR2 are discussed...
  23. doi request reprint Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model
    Jeffrey D Alexis
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
    J Vasc Res 45:538-46. 2008
    ..Using knockout mice, we have now examined the role of MCP-1 and CCR2 in the development of the intimal proliferation of transplant arteriopathy...
  24. ncbi request reprint In CCR2-/- mice monocyte recruitment and egress of LDL cholesterol in vivo is impaired
    Olga Stein
    Department of Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Biochem Biophys Res Commun 300:477-81. 2003
    ..The present study provides definite evidence that recruitment of macrophages is required for LDL cholesterol clearance, which plays a prominent role in regression of an atheroma...
  25. ncbi request reprint Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo
    Niels R Veillard
    Division of Cardiology, Foundation for Medical Research, University Hospital Geneva, Geneva, Switzerland
    Circulation 112:870-8. 2005
    ..We investigated whether the deletion of both of these 2 important receptors expressed on the principal inflammatory cells present in atheroma would further affect atherogenesis in vivo...
  26. ncbi request reprint The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization
    Chikako Tsutsumi
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Leukoc Biol 74:25-32. 2003
    ..Collectively, we conclude that ocular-infiltrating macrophages play an important role in CNV generation...
  27. ncbi request reprint Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice
    DeRen Huang
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 22:10633-42. 2002
    ..These studies characterize a novel model of reversible inflammatory encephalopathy that is dependent on both genetic and environmental factors...
  28. ncbi request reprint Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells
    Angela Panoskaltsis-Mortari
    University of Minnesota, Department of Pediatrics, Division of Hematology Oncology, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Am J Physiol Lung Cell Mol Physiol 286:L284-92. 2004
    ..Therefore, IPS can occur independently of host expression of CCL2 or CCR2, and compensatory mechanisms exist for regulating APC recruitment into the lung during the early post-BMT period...
  29. ncbi request reprint Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling
    Minako Ishibashi
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circ Res 94:1203-10. 2004
    ..The present study suggests that CCR2 expression in monocytes has a critical role in vascular inflammation and remodeling in Ang II-induced hypertension, and possibly in other forms of hypertension...
  30. ncbi request reprint Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice
    Minako Ishibashi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 24:e174-8. 2004
    ..The present data suggest that vascular inflammation mediated by CCR2 in leukocytes is a reasonable target of therapy for treatment of atherosclerosis...
  31. ncbi request reprint Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion
    Manhong Ma
    Department of Physiology and Cell Biology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA
    J Neurosci Res 68:691-702. 2002
    ..Together, these results indicate that chemokines acting through CCR2 contribute to the early recruitment of monocytes to the lesion epicenter following SCI...
  32. pmc Impaired lung dendritic cell activation in CCR2 knockout mice
    Bo Chin Chiu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, USA
    Am J Pathol 165:1199-209. 2004
    ..In conclusion, CCR2 knockout confers an intrinsic DC activation defect and CCR2 ligands likely promote the local activation/maturation of inflammatory DCs...
  33. ncbi request reprint Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys
    Kensuke Egashira
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 90:1167-72. 2002
    ..Therefore, the MCP-1/CCR2 pathway can be a therapeutic target for human restenosis after coronary intervention...
  34. pmc Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes
    Chunfeng Qu
    Dept of Gene and Cell Medicine, Mt Sinai School of Medicine, Box 1496, 1425 Madison Ave, New York, NY 10029, USA
    J Exp Med 200:1231-41. 2004
    ..When these monocyte-derived DCs exit skin to emigrate to LNs, they use not only CCR7 but also CCR8, which was not previously recognized to participate in migration to LNs...
  35. ncbi request reprint IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling
    Zhou Zhu
    Section of Pulmonary and Critical Care Medicine, Departments of Internal Medicine and Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:2953-62. 2002
    ..These studies demonstrate that IL-13 is a potent stimulator of MCPs and other CC chemokines and document the importance of MCP-CCR2 signaling in the pathogenesis of the IL-13-induced pulmonary phenotype...
  36. ncbi request reprint Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons
    Davide Ragozzino
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita La Sapienza, Centro di Eccellenza BEMM, 00185 Roma, Italy
    J Neurosci 26:10488-98. 2006
    ..Together, these findings indicate that CX3CL1 negatively modulates AMPA receptor function at active glutamatergic synapses through cell-signaling pathways by influencing the balance between kinase and phosphatase activity...
  37. ncbi request reprint CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis
    Mehrnaz Gharaee-Kermani
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Cytokine 24:266-76. 2003
    ..These findings suggest that CCR2 signaling plays a key role in bleomycin-induced pulmonary fibrosis by regulating fibrogenic cytokine expression and fibroblast responsiveness to TGF-beta...
  38. ncbi request reprint Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice
    DeRen Huang
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 19:761-72. 2005
    ..These results indicate that huGFAP-CCL2hi tg+ mice provide a useful model to study how chronic CNS expression of CCL2 alters microglial function and CNS physiology...

Research Grants26

  1. 2005 Atherosclerosis Gordon Conference
    Israel Charo; Fiscal Year: 2005
    ..abstract_text> ..
  2. CCR2 in Atherosclerosis and Leukocyte Trafficking
    Israel Charo; Fiscal Year: 2006
    ..This data will speak directly to the therapeutic prospects for CCR2 antagonists. ..
  3. FRACTALKINE: ROLES IN CELL ADHESION AND ATHEROSCLEROSIS
    Israel Charo; Fiscal Year: 2007
    ..Completion of these aims will significantly advance our understanding of the mechanisms by which fractalkine contributes to lesion formation in atherosclerosis. ..
  4. CCR2 in Atherosclerosis and Monocyte Trafficking
    Israel Charo; Fiscal Year: 2007
    ..Completion of these studies will deepen our understanding of the role of chemokines in monocyte homeostasis and the importance of macrophage activation in atherosclerotic plaque instability. ..
  5. FRACTALKINE: ROLES IN CELL ADHESION AND ATHEROSCLEROSIS
    Israel Charo; Fiscal Year: 2003
    ..abstract_text> ..
  6. CCR2 AND CCR5--ATHEROSCLEROSIS AND CONTROL OF EXPRESSION
    Israel Charo; Fiscal Year: 2002
    ..the experiments proposed in this grant will utilize novel and complementary approaches to provide the first detailed information on the role of chemokines and chemokine receptors in vascular disease. ..
  7. CCR2 in Atherosclerosis and Monocyte Trafficking
    Israel F Charo; Fiscal Year: 2010
    ..Completion of these studies will deepen our understanding of the role of chemokines in monocyte homeostasis and the importance of macrophage activation in atherosclerotic plaque instability. ..