B Charlesworth

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Lack of degeneration of loci on the neo-Y chromosome of Drosophila americana americana
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genetics 145:989-1002. 1997
  2. ncbi Recombination load associated with selection for increased recombination
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genet Res 67:27-41. 1996
  3. pmc Genetics of a pheromonal difference affecting sexual isolation between Drosophila mauritiana and D. sechellia
    J A Coyne
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genetics 145:1015-30. 1997
  4. pmc A selective sweep associated with a recent gene transposition in Drosophila miranda
    S Yi
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637 1573, USA
    Genetics 156:1753-63. 2000
  5. ncbi The effect of recombination on background selection
    M Nordborg
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genet Res 67:159-74. 1996
  6. ncbi The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genet Res 70:155-74. 1997
  7. ncbi Mutation-selection balance and the evolutionary advantage of sex and recombination
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637
    Genet Res 55:199-221. 1990
  8. pmc The pattern of neutral molecular variation under the background selection model
    D Charlesworth
    Department of Ecology and Evolution, University of Chicago, Illinois 60637 1573, USA
    Genetics 141:1619-32. 1995
  9. ncbi Contrasting patterns of molecular evolution of the genes on the new and old sex chromosomes of Drosophila miranda
    S Yi
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Mol Biol Evol 17:703-17. 2000
  10. ncbi The effects of spontaneous mutation on quantitative traits. II. Dominance of mutations with effects on life-history traits
    D Houle
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genet Res 70:27-34. 1997

Detail Information

Publications21

  1. pmc Lack of degeneration of loci on the neo-Y chromosome of Drosophila americana americana
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genetics 145:989-1002. 1997
    ..This is consistent with the recent origin of the neo-Y and neo-X chromosomes, and the slow rates at which the forces that cause Y chromosome degeneration are likely to work...
  2. ncbi Recombination load associated with selection for increased recombination
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genet Res 67:27-41. 1996
    ..Further experiments are needed to determine whether the selection against recombination due to the immediate load is outweighed by the increased additive variance in fitness produced by recombination...
  3. pmc Genetics of a pheromonal difference affecting sexual isolation between Drosophila mauritiana and D. sechellia
    J A Coyne
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genetics 145:1015-30. 1997
    ....
  4. pmc A selective sweep associated with a recent gene transposition in Drosophila miranda
    S Yi
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637 1573, USA
    Genetics 156:1753-63. 2000
    ..This explanation is supported by the pattern of within-species sequence variation at exu1 and the nearby exu2 locus. The implications of this phenomenon for genome evolution are discussed...
  5. ncbi The effect of recombination on background selection
    M Nordborg
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genet Res 67:159-74. 1996
    ..Large overall effects are less likely in species with higher levels of genetic recombination, such as mammals, although local reductions in regions of reduced recombination might be detectable...
  6. ncbi The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genet Res 70:155-74. 1997
    ..We discuss how these theoretical results can be related to data on genetic diversity within and between local populations of a species...
  7. ncbi Mutation-selection balance and the evolutionary advantage of sex and recombination
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637
    Genet Res 55:199-221. 1990
    ..Recombination is selectively disadvantageous when there is diminishing returns epistasis. These results are compared with the results of previous theoretical studies of this problem, and with experimental data...
  8. pmc The pattern of neutral molecular variation under the background selection model
    D Charlesworth
    Department of Ecology and Evolution, University of Chicago, Illinois 60637 1573, USA
    Genetics 141:1619-32. 1995
    ..It remains to be decided whether background selection is sufficient to explain the observed extent of reduction in diversity in regions of restricted recombination...
  9. ncbi Contrasting patterns of molecular evolution of the genes on the new and old sex chromosomes of Drosophila miranda
    S Yi
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Mol Biol Evol 17:703-17. 2000
    ..This is not expected under a model where the faster evolution of the X chromosome is postulated to be the main force driving the degeneration of the Y chromosome...
  10. ncbi The effects of spontaneous mutation on quantitative traits. II. Dominance of mutations with effects on life-history traits
    D Houle
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genet Res 70:27-34. 1997
    ..These results are consistent with those of many other studies that suggest that both unselected mutations and those found segregating in natural populations are partially recessive...
  11. pmc Evidence for selection at the fused locus of Drosophila virilis
    J Vieira
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 155:1701-9. 2000
    ..Our results suggest that the fused alanine haplotypes have recently increased in frequency in the D. virilis population...
  12. pmc X chromosome DNA variation in Drosophila virilis
    J Vieira
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK
    Proc Biol Sci 266:1905-12. 1999
    ..There is no reduction in variation at two loci close to the centromeric heterochromatin, in contrast to Drosophila melanogaster...
  13. ncbi How was the Sdic gene fixed?
    B Charlesworth
    Nature 400:519-20. 1999
  14. ncbi Genealogies and weak purifying selection
    M Przeworski
    University of Chicago, Illinois 60637, USA
    Mol Biol Evol 16:246-52. 1999
    ..We caution, however, that the effect of weak selection on the genealogy is specific to the model; a (more realistic) model of multiple linked sites could lead to a more distorted genealogy than is observed for a single site...
  15. ncbi Measures of divergence between populations and the effect of forces that reduce variability
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago
    Mol Biol Evol 15:538-43. 1998
    ....
  16. ncbi The changing sizes of genes
    B Charlesworth
    Nature 384:315-6. 1996
  17. ncbi The evolution of lethals in the t-haplotype system of the mouse
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, Illinois 60637
    Proc Biol Sci 258:101-7. 1994
    ..The theoretical predictions are compared with data on natural populations...
  18. ncbi Genome analysis: More Drosophila Y chromosome genes
    B Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
    Curr Biol 11:R182-4. 2001
    ..The D. melanogaster genome sequence has now allowed characterization of two more male fertility genes, shedding light on the function and evolution of Y chromosomes...
  19. pmc Evidence for selection at the fused1 locus of Drosophila americana
    J Vieira
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 158:279-90. 2001
    ..These patterns of variation are best explained as a result of selection acting on amino acid substitutions, with geographic variation in selection pressures...
  20. ncbi Steps in the evolution of heteromorphic sex chromosomes
    D Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, UK
    Heredity (Edinb) 95:118-28. 2005
    ..We discuss how selection during the period when a chromosome is adapting to its role as a Y chromosome might drive such a process...
  21. ncbi Low mitochondrial variability in birds may indicate Hill-Robertson effects on the W chromosome
    S Berlin
    Department of Genetics and Genomics, Roslin Institute Edinburgh, Midlothian, UK
    Heredity (Edinb) 99:389-96. 2007
    ....