A C Charles

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels
    Charles E Stout
    Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    J Biol Chem 277:10482-8. 2002
  2. ncbi request reprint Teaching resources. Glial intercellular waves
    Andrew Charles
    Department of Neurology, David Geffen School of Medicine, UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Sci STKE 2005:tr19. 2005
  3. doi request reprint Migraine: a brain state
    Andrew Charles
    Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Neurol 26:235-9. 2013
  4. pmc Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
    Hector E Lopez-Valdes
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Cancer Cell Int 10:35. 2010
  5. doi request reprint Advances in the basic and clinical science of migraine
    Andrew Charles
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, 635 Charles Young Drive, Los Angeles, CA 90095, USA
    Ann Neurol 65:491-8. 2009
  6. pmc Memantine for prevention of migraine: a retrospective study of 60 cases
    Andrew Charles
    Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine at UCLA, 635 Charles Young Drive, Suite 575, Los Angeles, CA 90095, USA
    J Headache Pain 8:248-50. 2007
  7. ncbi request reprint Reaching out beyond the synapse: glial intercellular waves coordinate metabolism
    Andrew Charles
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Sci STKE 2005:pe6. 2005
  8. ncbi request reprint From inhibition to excitation: functional effects of interaction between opioid receptors
    Andrew C Charles
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Life Sci 76:479-85. 2004
  9. ncbi request reprint Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory
    Andrew C Charles
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Pharmacol 63:89-95. 2003
  10. ncbi request reprint Intercellular calcium waves in glia
    A Charles
    Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
    Glia 24:39-49. 1998

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels
    Charles E Stout
    Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    J Biol Chem 277:10482-8. 2002
    ..Release of ATP through connexin hemichannels represents a novel signaling pathway for intercellular communication in astrocytes and other non-excitable cells...
  2. ncbi request reprint Teaching resources. Glial intercellular waves
    Andrew Charles
    Department of Neurology, David Geffen School of Medicine, UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Sci STKE 2005:tr19. 2005
    ..Thus, long-range intercellular calcium signaling in astrocytes may enable them to spatially coordinate their function in supporting neuronal metabolism...
  3. doi request reprint Migraine: a brain state
    Andrew Charles
    Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Neurol 26:235-9. 2013
    ..This review outlines evidence that supports a broader view of migraine as a pathological brain state...
  4. pmc Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
    Hector E Lopez-Valdes
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Cancer Cell Int 10:35. 2010
    ..Interaction between bradykinin and purinergic signaling may therefore be involved in the regulation of glial tumor cells...
  5. doi request reprint Advances in the basic and clinical science of migraine
    Andrew Charles
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, 635 Charles Young Drive, Los Angeles, CA 90095, USA
    Ann Neurol 65:491-8. 2009
    ..Rapid evolution of concepts regarding its prevalence, pathophysiology, and clinical management is leading to growing recognition of migraine as a fundamentally important disorder of the nervous system...
  6. pmc Memantine for prevention of migraine: a retrospective study of 60 cases
    Andrew Charles
    Headache Research and Treatment Program, Department of Neurology, David Geffen School of Medicine at UCLA, 635 Charles Young Drive, Suite 575, Los Angeles, CA 90095, USA
    J Headache Pain 8:248-50. 2007
    ..Side effects were uncommon and generally mild. This limited retrospective case review suggests that memantine may be an effective preventive therapy for patients with frequent migraine. A prospective trial is warranted...
  7. ncbi request reprint Reaching out beyond the synapse: glial intercellular waves coordinate metabolism
    Andrew Charles
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Sci STKE 2005:pe6. 2005
    ..Thus, one function of long-range intercellular calcium signaling in astrocytes may be to spatially coordinate their function in supporting neuronal metabolism...
  8. ncbi request reprint From inhibition to excitation: functional effects of interaction between opioid receptors
    Andrew C Charles
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Life Sci 76:479-85. 2004
    ..This phenomenon could represent an adaptive mechanism involved in tolerance, dependence and subsequent withdrawal...
  9. ncbi request reprint Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory
    Andrew C Charles
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Pharmacol 63:89-95. 2003
    ..These results indicate that interaction between micro- and delta-opioid receptors causes a change in the functional response to micro ligands, possibly by the formation of a micro/delta heterodimer with distinct functional properties...
  10. ncbi request reprint Intercellular calcium waves in glia
    A Charles
    Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
    Glia 24:39-49. 1998
    ..This original data is discussed in the context of a review of the literature and current concepts regarding the potential mechanisms, physiological and pathological roles of this dynamic pattern of glial intercellular signaling...
  11. ncbi request reprint cAMP modulates the excitability of immortalized H=hypothalamic (GT1) neurons via a cyclic nucleotide gated channel
    A Charles
    Department of Neurology, University of California Los Angeles, School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Mol Endocrinol 15:997-1009. 2001
    ..These results indicate that CNG channels play a primary role in mediating the effects of cAMP on excitability in GT1 cells, and thereby may be important in the modulation of GnRH release...
  12. ncbi request reprint L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells
    A C Charles
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 274:7508-15. 1999
    ..Differential regulation of these channels can produce frequency or amplitude modulation of calcium signaling that stimulates specific pituitary cell functions...
  13. ncbi request reprint Modulation of Ca(2+) signaling by K(+) channels in a hypothalamic neuronal cell line (GT1-1)
    J L Costantin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA
    J Neurophysiol 85:295-304. 2001
    ..K(+) current modulation of electrical activity and Ca(2+) signaling may be important in the generation of the patterns of cellular activity responsible for the pulsatile release of GnRH...
  14. ncbi request reprint Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells
    Albert Lai
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Cell Sci 119:532-41. 2006
    ....
  15. ncbi request reprint EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells
    Joshua A Bryant
    Department of Neurology David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California90095, USA
    Cancer Biol Ther 3:1243-9. 2004
    ..Distinct intra- and intercellular Ca2+ signaling pathways may be mechanisms by which EGF modulates the growth and migration of tumor cells...
  16. ncbi request reprint Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model
    J Sneyd
    Department of Biomathematics, School of Medicine, University of California, Los Angeles 90024, USA
    Am J Physiol 268:C1537-45. 1995
    ..These predictions constitute a rigorous test of the hypothesis that the intercellular Ca2+ waves are mediated by IP3 diffusion...
  17. doi request reprint Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice
    E A Bates
    Department of Neurology, University of California, San Francisco, CA 94158, USA
    Cephalalgia 30:170-8. 2010
    ..We found that the threshold of CSD was unaffected by NTG, suggesting that NTG stimulates migraine mechanisms that are independent of the regulation of cortical excitability...
  18. ncbi request reprint Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium
    Luis Beltran-Parrazal
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Am J Physiol Cell Physiol 291:C1193-7. 2006
    ....
  19. ncbi request reprint Reduced threshold for cortical spreading depression in female mice
    Kevin C Brennan
    Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Ann Neurol 61:603-6. 2007
    ..These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle...
  20. ncbi request reprint Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture
    Cristina A Ghiani
    Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
    J Neurochem 97:35-43. 2006
    ..Nicotine effects on immature cortical neurons perhaps do not require gene regulation but may be still acting on signalling pathways...
  21. ncbi request reprint Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
    Hiroshi Yoshida
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA
    Mol Endocrinol 17:1982-90. 2003
    ..Genetically targeted expression of PDE4D1 represents a powerful approach to study the role of cAMP levels in specific populations of neurons in transgenic animals...
  22. ncbi request reprint Distinct vascular conduction with cortical spreading depression
    Kevin C Brennan
    Department of Neurology, David Geffen School of Medicine at UCLA, Neurocience Research Building, Room 575, 635 Charles E Young Drive South, Los Angeles, CA 90095, USA
    J Neurophysiol 97:4143-51. 2007
    ..Distinct vascular conduction could be important for the pathogenesis of conditions that involve CSD, including migraine, stroke, and traumatic brain injury...

Research Grants5

  1. MECHANISMS AND FUNCTIONS OF ASTROCYTE CALCIUM SIGNALING
    Andrew Charles; Fiscal Year: 2004
    ....