Svetlana Chapoval

Summary

Affiliation: University of Maryland School of Medicine
Location: Baltimore, USA
Summary:
research, teaching, supervising, writing, reviewing
Publications:
Chapoval SP, T Neeno, CJ Krco, E Marietta, J Harders, and CS David. 1998. HLA-DQ6 and HLA-DQ8 transgenic mice respond to ragweed allergens and recognize distinct set of epitopes on short and giant ragweed group 5 antigens. J. Immunol. 161: 2032-2037.

Chapoval SP, GH Nabozny, EV Marietta, EL Raymond, CJ Krco, AG Andrews, and CS David. 1999. Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice. J. Clin. Invest.103:1707-1717.

Papouchado BG, SP Chapoval, EV Marietta, CR Weiler, CS David. 2000. HLA-DQ/human CD4-restricted immune response to cockroach allergens in transgenic mice. Tissue Antigens 55:303-311.

Krco CJ, J Harders, S Chapoval, and CS David. 2000. Immune response of HLA-DQ transgenic mice to house dust mite allergen p2: Identification of HLA-DQ restricted minimal epitopes and critical residues. Clin. Immunol. 97:154-161.

Chapoval SP, EV Marietta, MK Smart, CS David. 2001. Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient human leukocyte antigen-DQ transgenic mice. J. Allergy Clin. Immunol. 108:764-771.

Papouchado BG, SP Chapoval, EV Marietta, CR Weiler, CS David. 2001. Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4+ transgenic mice. J. Immunol. 167:4627-4634.

Chapoval SP, EV Marietta, MK Smart, K Iijima, AI Chapoval, AG Andrews, and CS David. 2002. Allergic inflammatory response to short ragweed extract in HLA-DQ transgenic mice lacking CD4 gene. J.Immunol. 168:890-899.

Chapoval SP and CS David. 2003. CD28 costimulation is critical for experimental allergic asthma in HLA-DQ8 transgenic mice. Clin. Immunol. 106:83-94.

Chapoval SP and CS David. 2003. Identification of antigenic epitopes on human allergens: Studies with HLA transgenic mice. Environ. Health Perspect. 111:245-250.

Das P*, S Chapoval*, V Howard, CS David and TE Golde. 2003. Immune response against A1-42 in HLA class II transgenic mice: implications for A1-42 immune-mediated therapies. Neurobiol. Aging. 24:969-976 (*equal contribution).

Lee CG, SJ Cho, MJ Kang, SP Chapoval, PJ Lee, PW Noble, T Yehualaeshet, B Lu, RA Flavell, J Milbrandt, RJ Homer, JA Elias. 2004. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J. Exp. Med. 200:377-389.

Lee CG, H Link, P Baluk, RJ Homer, S Chapoval, V Bhandari, MJ Kang, L Cohn, YK Kim, DM McDonald, and JA Elias. 2004. Vascular endothelial growth factor (VEGF) induces remodeling and enhances Th2-mediated sensitization and inflammation in the lung. Nature Med. 10:1095-1103.

Ma B, CG Lee, S Chapoval, W Liu, A Coyle, J Lora, D Picarella, RJ Homer, JA Elias. 2005.
Role of CCR5 in gamma-interferon-induced and cigarette smoke-induced emphysema. J. Clin. Invest. 115:3460-3472.

Xue A*, SP Chapoval*, ES Finn*, VR Chowdhary, EV Marietta, TA Gaffey, AC Pursifull, CS David. 2005. HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN

Publications

  1. pmc Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice
    S P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 103:1707-17. 1999
  2. ncbi Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice
    B G Papouchado
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 167:4627-34. 2001
  3. pmc Identification of antigenic epitopes on human allergens: studies with HLA transgenic mice
    Svetlana P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Environ Health Perspect 111:245-50. 2003
  4. ncbi CD28 costimulation is critical for experimental allergic asthma in HLA-DQ8 transgenic mice
    Svetlana P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Immunol 106:83-94. 2003
  5. pmc Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar St, 441c TAC, New Haven, CT 06520, USA
    J Exp Med 200:377-89. 2004
  6. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
  7. pmc Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner
    Preeta Dasgupta
    Center for Vascular and Inflammatory Diseases, and Department of Microbiology and Immunology, University of Maryland School of Medicine, 800 W, Baltimore St, Baltimore, MD 21201, USA
    BMC Immunol 12:60. 2011
  8. pmc P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway
    Masashi Yamasaki
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, Department of Internal Medicine, 300 Cedar Street S425A TAC, P O Box 208057, New Haven, CT 06520 8057, USA
    Am J Respir Cell Mol Biol 38:346-53. 2008
  9. pmc Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401 B, New Haven, CT 06520 8057, USA
    Proc Natl Acad Sci U S A 103:11021-6. 2006
  10. ncbi Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13
    Svetlana P Chapoval
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:7030-41. 2007

Collaborators

Detail Information

Publications15

  1. pmc Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice
    S P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 103:1707-17. 1999
    ..These findings demonstrate the crucial role for specific HLA-DQ molecules in SRW-specific CD4(+) T-cell activation and resulting recruitment of eosinophils into the airways...
  2. ncbi Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice
    B G Papouchado
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 167:4627-34. 2001
    ..Our results provide direct evidence that HLA-DQ molecules and CD4 T cells mediate cockroach-induced eosinophilic inflammation in the airways...
  3. pmc Identification of antigenic epitopes on human allergens: studies with HLA transgenic mice
    Svetlana P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Environ Health Perspect 111:245-50. 2003
    ....
  4. ncbi CD28 costimulation is critical for experimental allergic asthma in HLA-DQ8 transgenic mice
    Svetlana P Chapoval
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Immunol 106:83-94. 2003
    ..Proliferation and cytokine profile studies demonstrated that CD28 regulates T-cell activation and effector function. Therefore, CD28 is essential for the extrinsic asthma and can be a target for immunotherapy...
  5. pmc Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar St, 441c TAC, New Haven, CT 06520, USA
    J Exp Med 200:377-89. 2004
    ..They also demonstrate that Egr-1-mediated apoptosis is a prerequisite for TGF-beta(1)-induced fibrosis and remodeling...
  6. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    ..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders...
  7. pmc Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner
    Preeta Dasgupta
    Center for Vascular and Inflammatory Diseases, and Department of Microbiology and Immunology, University of Maryland School of Medicine, 800 W, Baltimore St, Baltimore, MD 21201, USA
    BMC Immunol 12:60. 2011
    ..Since TH2 differentiation and activation plays a pivotal role in this disease, we explored the possibility of developing an asthma model in mice using T cells that were differentiated in vivo...
  8. pmc P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway
    Masashi Yamasaki
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, Department of Internal Medicine, 300 Cedar Street S425A TAC, P O Box 208057, New Haven, CT 06520 8057, USA
    Am J Respir Cell Mol Biol 38:346-53. 2008
    ..Collectively, our studies demonstrate that p21 regulates TGF-beta(1)-induced apoptosis, inflammation, fibrosis, and alveolar remodeling by interacting with TNF-alpha-signaling pathways...
  9. pmc Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401 B, New Haven, CT 06520 8057, USA
    Proc Natl Acad Sci U S A 103:11021-6. 2006
    ..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling...
  10. ncbi Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13
    Svetlana P Chapoval
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:7030-41. 2007
    ..PS1145 inhibits caspase activation and up-regulates inhibitor of apoptosis protein cellular-inhibitor of apoptosis protein 1 (c-IAP-1). Therefore, NF-kappaB is an attractive target for immunotherapy of IL-13-mediated diseases...
  11. pmc Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation
    Svetlana P Chapoval
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441 C TAC, New Haven, CT 06520 8057, USA
    Clin Immunol 132:371-84. 2009
    ..The data presented here demonstrate how lung VEGF expression functionally affects local mDC for the transition from the innate response to a Th2-type inflammatory response...
  12. pmc Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor
    Elizabeth P Smith
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    BMC Immunol 12:30. 2011
    ..However, the expression and regulation of Sema4A, Sema4D, and their receptors in normal and allergic lungs is undefined...
  13. pmc STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease
    Svetlana P Chapoval
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 186:2571-83. 2011
    ..Taken together, our studies demonstrate multiple STAT6-dependent and -independent features of allergic inflammation, which may impact treatments targeting STAT6...
  14. ncbi Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene
    Svetlana P Chapoval
    Department of Immunology, Allergic Diseases Research Laboratory, and Section of Veterinary Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 168:890-9. 2002
    ..IL-5 ELISPOT assay revealed that DN T cells were the cellular origin of IL-5 in allergen-challenged DQ6/CD4(null) mice. Our study shows a role for HLA-DQ-restricted CD4(+) and DN T cells in the allergic response...
  15. ncbi HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN'-induced hypersensitivity
    Ailing Xue
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Immunol 117:302-15. 2005
    ....