Nora M Chapman

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc The microbiology of human hygiene and its impact on type 1 diabetes
    Nora M Chapman
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Islets 4:253-61. 2012
  2. ncbi request reprint Persistent coxsackievirus infection: enterovirus persistence in chronic myocarditis and dilated cardiomyopathy
    N M Chapman
    University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Curr Top Microbiol Immunol 323:275-92. 2008
  3. pmc 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart
    Nora M Chapman
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Virology 375:480-91. 2008
  4. pmc Coxsackievirus expression of the murine secretory protein interleukin-4 induces increased synthesis of immunoglobulin G1 in mice
    N M Chapman
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Virol 74:7952-62. 2000
  5. pmc A group B coxsackievirus/poliovirus 5' nontranslated region chimera can act as an attenuated vaccine strain in mice
    N M Chapman
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6495, USA
    J Virol 74:4047-56. 2000
  6. ncbi request reprint Endogenous low-level expression of the coxsackievirus and adenovirus receptor enables coxsackievirus B3 infection of RD cells
    Steven D Carson
    University of Nebraska Medical Center, Omaha, NE, USA
    J Gen Virol 88:3031-8. 2007
  7. ncbi request reprint The stem loop II within the 5' nontranslated region of clinical coxsackievirus B3 genomes determines cardiovirulence phenotype in a murine model
    James J Dunn
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Infect Dis 187:1552-61. 2003
  8. pmc Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency
    Toru Kanno
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 80:5637-43. 2006
  9. doi request reprint Enteroviruses and type 1 diabetes
    Steven Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Diabetes Metab Res Rev 27:820-3. 2011
  10. pmc 5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA
    K S Kim
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 79:7024-41. 2005

Research Grants

  1. 5' End Genomic Deletions and Enterovirus Persistence
    Nora M Chapman; Fiscal Year: 2010
  2. Enterovirus persistence in myocarditis
    Nora Chapman; Fiscal Year: 2003

Detail Information

Publications22

  1. pmc The microbiology of human hygiene and its impact on type 1 diabetes
    Nora M Chapman
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Islets 4:253-61. 2012
    ....
  2. ncbi request reprint Persistent coxsackievirus infection: enterovirus persistence in chronic myocarditis and dilated cardiomyopathy
    N M Chapman
    University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Curr Top Microbiol Immunol 323:275-92. 2008
    ....
  3. pmc 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart
    Nora M Chapman
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Virology 375:480-91. 2008
    ..This is the first report of these naturally-occurring defective enteroviral genomes in human myocarditis...
  4. pmc Coxsackievirus expression of the murine secretory protein interleukin-4 induces increased synthesis of immunoglobulin G1 in mice
    N M Chapman
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Virol 74:7952-62. 2000
    ..Comparison of the murine antibody responses to CVB3-PL2-mIL4/46 and the parental CVB3/0 strain demonstrated an increased level of CVB3-binding serum immunoglobulin G1 in mice inoculated with CVB3-PL2-mIL4/46...
  5. pmc A group B coxsackievirus/poliovirus 5' nontranslated region chimera can act as an attenuated vaccine strain in mice
    N M Chapman
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6495, USA
    J Virol 74:4047-56. 2000
    ....
  6. ncbi request reprint Endogenous low-level expression of the coxsackievirus and adenovirus receptor enables coxsackievirus B3 infection of RD cells
    Steven D Carson
    University of Nebraska Medical Center, Omaha, NE, USA
    J Gen Virol 88:3031-8. 2007
    ..Cells within cultures of cell types that have been considered non-permissive may express receptor transiently, leading to persistent replication of virus within the cultured population...
  7. ncbi request reprint The stem loop II within the 5' nontranslated region of clinical coxsackievirus B3 genomes determines cardiovirulence phenotype in a murine model
    James J Dunn
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Infect Dis 187:1552-61. 2003
    ..The identity of this higher-order RNA structure may be essential for productive infection of cardiac cells...
  8. pmc Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency
    Toru Kanno
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 80:5637-43. 2006
    ..While any CVB strain may be able to induce T1D in prediabetic NOD mice, T1D onset is linked both to the viral replication rate and infectious dose...
  9. doi request reprint Enteroviruses and type 1 diabetes
    Steven Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Diabetes Metab Res Rev 27:820-3. 2011
    ....
  10. pmc 5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA
    K S Kim
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 79:7024-41. 2005
    ..These studies describe a naturally occurring genomic alteration to an enteroviral genome associated with long-term viral persistence...
  11. pmc Variations of coxsackievirus B3 capsid primary structure, ligands, and stability are selected for in a coxsackievirus and adenovirus receptor-limited environment
    Steven D Carson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 85:3306-14. 2011
    ....
  12. pmc Replication of coxsackievirus B3 in primary cell cultures generates novel viral genome deletions
    K S Kim
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 82:2033-7. 2008
    ..The cellular environment of contact-inhibited primary cell cultures or the myocardium in vivo is sufficient for the selection of 5' TDs over undeleted genomes...
  13. ncbi request reprint Evolution of virulence in picornaviruses
    S Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Curr Top Microbiol Immunol 299:193-209. 2006
    ..Ultimately, the ability of a picornavirus to induce disease depends upon viral genetics and how they are modulated by the host environment...
  14. ncbi request reprint Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease
    S Tracy
    Dept of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 6495, USA
    Trends Microbiol 4:175-9. 1996
    ..The relative importance of these sites to expression of the phenotype remains unclear...
  15. ncbi request reprint Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate
    C K Lee
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198, USA
    J Gen Virol 86:197-210. 2005
    ..This is the first report characterizing a cloned CVB3 genome from an avirulent strain...
  16. pmc Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence
    S Tracy
    Enterovirus Research Laboratory, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Virol 76:12097-111. 2002
    ..To the contrary, CVB infections provide significant protection from T1D onset in NOD mice. Possible mechanisms by which this virus-induced protection may occur are discussed...
  17. ncbi request reprint Coxsackievirus and adenovirus receptor (CAR) binds immunoglobulins
    S D Carson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, Nebraska 68198 6495, USA
    Biochemistry 40:14324-9. 2001
    ..These results demonstrate that the CAR binds IgG and IgM present in serum, and reveal a direct interaction between the coxsackievirus and adenovirus receptor and the immune system...
  18. ncbi request reprint Monoclonal antibody against mouse CAR following genetic immunization
    Steven D Carson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6495, USA
    Hybrid Hybridomics 23:19-22. 2004
    ..Since CAR has been shown to form dimers, expression of human CAR in cells that express mouse CAR may have stimulated the host immune system to recognize endogenous CAR in heterodimers...
  19. ncbi request reprint The group B coxsackieviruses and myocarditis
    K S Kim
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, USA
    Rev Med Virol 11:355-68. 2001
    ....
  20. ncbi request reprint Myocarditis and heart failure associated with hepatitis C virus infection
    Akira Matsumori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Card Fail 12:293-8. 2006
    ..HCV infection has recently been noted in patients with cardiomyopathies and myocarditis. However, prevalence of HCV infection in myocarditis and heart failure remains to be clarified...
  21. ncbi request reprint Caspase-3 activation and ERK phosphorylation during CVB3 infection of cells: influence of the coxsackievirus and adenovirus receptor and engineered variants
    Kelly A Cunningham
    The Picornaviral Research Unit, Discipline of Immunology and Microbiology, Faculty of Medicine and Health Sciences, The University of Newcastle, Newcastle, New South Wales 2300, Australia
    Virus Res 92:179-86. 2003
    ..These results show that ERK phosphorylation precedes caspase-3 activation, both occur late in the infection, and both are influenced by the presence of CAR...
  22. ncbi request reprint National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy
    Leslie T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:199-204. 2006
    ..The major recommendations from the members of the workshop are organized according to the following themes: cardiotropic viruses, innate and acquired immune responses, environmental factors, novel diagnostics, and novel therapeutics...

Research Grants2

  1. 5' End Genomic Deletions and Enterovirus Persistence
    Nora M Chapman; Fiscal Year: 2010
    ..Understanding how selection of these variant viruses occurs and how these viruses replicate will provide the basis for developing treatments and detection of these viruses in heart, neurological and pancreatic disease. ..
  2. Enterovirus persistence in myocarditis
    Nora Chapman; Fiscal Year: 2003
    ....