Harold Chapman

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Random peptide bacteriophage display as a probe for urokinase receptor ligands
    Susan Fong
    Chiron Corporation, Emeryville, CA 94608, USA
    Biol Chem 383:149-58. 2002
  2. pmc Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    Young Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 184:309-22. 2009
  3. doi request reprint Epithelial responses to lung injury: role of the extracellular matrix
    Harold A Chapman
    Pulmonary and Critical Care Division, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Proc Am Thorac Soc 9:89-95. 2012
  4. doi request reprint Epithelial-mesenchymal interactions in pulmonary fibrosis
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Annu Rev Physiol 73:413-35. 2011
  5. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
  6. ncbi request reprint Endosomal proteases in antigen presentation
    Harold A Chapman
    Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Curr Opin Immunol 18:78-84. 2006
  7. pmc Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding
    Ying Wei
    Department of Medicine and Pulmonary and Critical Care Division, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 168:501-11. 2005
  8. pmc Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins
    Sha Zhu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Lung Cell Mol Physiol 297:L97-108. 2009
  9. ncbi request reprint Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries
    Mary A Mathieu
    Department of Pathology, UCSF, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 121:99-105. 2002
  10. ncbi request reprint Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    Ying Wei
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    J Biol Chem 282:3929-39. 2007

Research Grants

  1. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2004
  2. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2003
  3. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2007
  4. Role of Elastolytic Cathepsins in Emphysema
    Harold Chapman; Fiscal Year: 2007
  5. Urokinase Receptor Integrin Interactions in Lung Cancer
    Harold Chapman; Fiscal Year: 2007
  6. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2000
  7. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2009
  8. Urokinase Receptor Integrin Interactions in Lung Cancer
    Harold Chapman; Fiscal Year: 2009
  9. Epithelial Mesenchymal Transition in Pulmonary Fibrosis
    Harold A Chapman; Fiscal Year: 2010
  10. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Random peptide bacteriophage display as a probe for urokinase receptor ligands
    Susan Fong
    Chiron Corporation, Emeryville, CA 94608, USA
    Biol Chem 383:149-58. 2002
    ....
  2. pmc Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    Young Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 184:309-22. 2009
    ..These findings demonstrate that alpha3beta1 coordinates cross talk between beta-catenin and Smad signaling pathways as a function of extracellular contact cues and thereby regulates responses to TGF-beta1 activation...
  3. doi request reprint Epithelial responses to lung injury: role of the extracellular matrix
    Harold A Chapman
    Pulmonary and Critical Care Division, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Proc Am Thorac Soc 9:89-95. 2012
    ..Elucidation of specific inhibitors of EMT should further test the question of whether the process is important to fibrosis in vivo and a viable therapeutic target...
  4. doi request reprint Epithelial-mesenchymal interactions in pulmonary fibrosis
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Annu Rev Physiol 73:413-35. 2011
    ..Understanding specific signaling mechanisms driving the mesenchymal response to TGFβ1 may reveal therapeutics to attenuate fibrogenesis yet preserve the important homeostatic functions of TGFβ1...
  5. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
    ....
  6. ncbi request reprint Endosomal proteases in antigen presentation
    Harold A Chapman
    Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Curr Opin Immunol 18:78-84. 2006
    ..Repeated implication of cathepsins in processing medically important antigens holds promise for therapeutic manipulation of proteases in diseases in which there is disordered adaptive immunity...
  7. pmc Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding
    Ying Wei
    Department of Medicine and Pulmonary and Critical Care Division, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 168:501-11. 2005
    ..Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands...
  8. pmc Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins
    Sha Zhu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Lung Cell Mol Physiol 297:L97-108. 2009
    ..Modulation of fibroblast invasion would be expected to lead to amelioration of fibroproliferative diseases of the lung...
  9. ncbi request reprint Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries
    Mary A Mathieu
    Department of Pathology, UCSF, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 121:99-105. 2002
    ..Predictions of substrate specificity from the library screen were confirmed using single peptide substrates for kinetic assays...
  10. ncbi request reprint Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    Ying Wei
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    J Biol Chem 282:3929-39. 2007
    ..Thus urokinase receptor binding to alpha5beta1 is required for maximal responses to fibronectin and tumor cell invasion, and this operates through an enhanced Src/Rac/ERK signaling pathway...
  11. ncbi request reprint Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts
    Sha Zhu
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama, Birmingham AL 35294, USA
    Chest 121:34S-35S. 2002
  12. pmc Disorders of lung matrix remodeling
    Harold A Chapman
    Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    J Clin Invest 113:148-57. 2004
    ..This review examines the common pathogenetic features of these disorders in light of recent observations in both humans and animal models of disease, which reveal important pathways of lung matrix remodeling...
  13. pmc Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins
    Chi Hui Tang
    Pulmonary and Critical Care Division, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 121:3747-56. 2008
    ..Taken together, the results indicate that uPAR-beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA that support lung cancer cell invasion in vitro and progression in vivo...
  14. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
    ..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis...
  15. pmc Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact
    Feng Zhang
    Pulmonary and Critical Care Division, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0130, USA
    J Cell Biol 163:177-88. 2003
    ..These studies reveal an integrin- and Src-dependent pathway for SLUG expression and mesenchymal transition...
  16. pmc Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    Kevin K Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, UCSF, San Francisco, CA 94143, USA
    J Clin Invest 119:213-24. 2009
    ..These findings demonstrate epithelial integrin-dependent profibrotic crosstalk between beta-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis...
  17. pmc The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
    ....
  18. pmc Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease
    Mrinalini Kala
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 93143, USA
    Immunology 116:532-40. 2005
    ..Contrasting findings among organ-specific murine autoimmune models imply that potential uses of Cat S inhibitors to ameliorate autoimmunity must be determined empirically...
  19. pmc Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis
    Yingjie Liu
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Development 136:843-53. 2009
    ..Together, these results demonstrate how signals from integrins and growth factor receptors can be integrated to regulate the expression of an important family of signaling molecules so as to regulate morphogenetic events...
  20. ncbi request reprint Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice
    Galina K Sukhova
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass, USA
    Circ Res 96:368-75. 2005
    ..These findings demonstrate directly the importance of cysteine protease/protease inhibitor balance in dysregulated arterial integrity and remodeling during experimental atherogenesis...
  21. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  22. ncbi request reprint Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses
    Bing Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77th Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:5779-84. 2006
    ....
  23. ncbi request reprint Urokinase receptor and integrin interactions
    Matthias C Kugler
    Department of Medicine, Pulmonary and Critical Care Division, and CVRI University of California, San Francisco, 94143, USA
    Curr Pharm Des 9:1565-74. 2003
    ..Together these observations support the idea that uPAR:integrin interactions may be a focal point of intervention in pathobiology where integrin function is crucial, such as tumor metastasis...
  24. ncbi request reprint Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis
    Kevin K Kim
    Am J Respir Cell Mol Biol 37:1-2. 2007
  25. ncbi request reprint Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema
    Tao Zheng
    Department of Internal Medicine, Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, New Haven, CT 06520, USA
    J Immunol 174:8106-15. 2005
    ..They also link inflammation, protease/antiprotease alterations, and protease-dependent apoptosis in the pathogenesis of Th1/Tc1 cytokine-induced tissue remodeling and destructive responses...
  26. ncbi request reprint Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways
    Supurna Ghosh
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:13021-9. 2006
    ....
  27. ncbi request reprint Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group
    Ronald G Crystal
    Division of Pulmonary and Critical Care Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Crit Care Med 166:236-46. 2002
    ....
  28. ncbi request reprint The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006
  29. ncbi request reprint Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis
    Huan Yang
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Immunol 174:1729-37. 2005
    ..Because Cat S null mice are not severely immunocompromised, Cat S inhibitors could be tested for their therapeutic potential in EAMG...

Research Grants24

  1. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2004
    ..Results of these experiments could provide a novel approach to regulation of integrin function in the setting of disease. ..
  2. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2003
    ..Results of these experiments could provide a novel approach to regulation of integrin function in the setting of disease. ..
  3. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2007
    ....
  4. Role of Elastolytic Cathepsins in Emphysema
    Harold Chapman; Fiscal Year: 2007
    ..Identification of biomarkers of cathepsin S activity in COPD patients could :erve as a surrogate for disease progression and an in vivo measure of efficacy during drug trials. ..
  5. Urokinase Receptor Integrin Interactions in Lung Cancer
    Harold Chapman; Fiscal Year: 2007
    ....
  6. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2000
    ..Results of these experiments could provide a novel approach to regulation of integrin function in the setting of disease. ..
  7. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2009
    ..abstract_text> ..
  8. Urokinase Receptor Integrin Interactions in Lung Cancer
    Harold Chapman; Fiscal Year: 2009
    ....
  9. Epithelial Mesenchymal Transition in Pulmonary Fibrosis
    Harold A Chapman; Fiscal Year: 2010
    ....
  10. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    ..abstract_text> ..
  11. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2006
    ....
  12. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2000
    ....
  13. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2001
    ..Results of these experiments could provide a novel approach to regulation of integrin function in the setting of disease. ..
  14. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2001
    ....
  15. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2002
    ....
  16. REGULATION OF INTEGRIN FUNCTION
    Harold Chapman; Fiscal Year: 2002
    ..Results of these experiments could provide a novel approach to regulation of integrin function in the setting of disease. ..
  17. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2003
    ....
  18. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2006
    ..abstract_text> ..
  19. Urokinase Receptor Integrin Interactions in Lung Cancer
    Harold A Chapman; Fiscal Year: 2010
    ....