Harold A Chapman

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1177-86. 2000
  2. ncbi request reprint Protease crosstalk with integrins: the urokinase receptor paradigm
    H A Chapman
    Pulmonary and Critical Care Division, University of California at San Francisco, 94143 0130, USA
    Thromb Haemost 86:124-9. 2001
  3. pmc Disorders of lung matrix remodeling
    Harold A Chapman
    Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    J Clin Invest 113:148-57. 2004
  4. ncbi request reprint Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    Ying Wei
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    J Biol Chem 282:3929-39. 2007
  5. pmc Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    Kevin K Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, UCSF, San Francisco, CA 94143, USA
    J Clin Invest 119:213-24. 2009
  6. doi request reprint Epithelial responses to lung injury: role of the extracellular matrix
    Harold A Chapman
    Pulmonary and Critical Care Division, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Proc Am Thorac Soc 9:89-95. 2012
  7. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
  8. pmc Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    Young Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 184:309-22. 2009
  9. pmc Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis
    Arnau Ulsamer
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 287:5164-72. 2012
  10. doi request reprint Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins
    Chi Hui Tang
    Pulmonary and Critical Care Division, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 121:3747-56. 2008

Collaborators

Detail Information

Publications34

  1. pmc Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1177-86. 2000
    ..These experiments show that cathepsin F, in a subset of antigen presenting cells (APCs), can efficiently degrade Ii. Different APCs can thus use distinct proteases to mediate MHC class II maturation and peptide loading...
  2. ncbi request reprint Protease crosstalk with integrins: the urokinase receptor paradigm
    H A Chapman
    Pulmonary and Critical Care Division, University of California at San Francisco, 94143 0130, USA
    Thromb Haemost 86:124-9. 2001
    ..Signals derived from integrin/uPAR complexes promote the function of other integrins. Thus the urokinase/plasmin system coordinates with integrins to regulate cell: matrix interactions...
  3. pmc Disorders of lung matrix remodeling
    Harold A Chapman
    Department of Medicine and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    J Clin Invest 113:148-57. 2004
    ..This review examines the common pathogenetic features of these disorders in light of recent observations in both humans and animal models of disease, which reveal important pathways of lung matrix remodeling...
  4. ncbi request reprint Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    Ying Wei
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    J Biol Chem 282:3929-39. 2007
    ..Thus urokinase receptor binding to alpha5beta1 is required for maximal responses to fibronectin and tumor cell invasion, and this operates through an enhanced Src/Rac/ERK signaling pathway...
  5. pmc Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    Kevin K Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, UCSF, San Francisco, CA 94143, USA
    J Clin Invest 119:213-24. 2009
    ..These findings demonstrate epithelial integrin-dependent profibrotic crosstalk between beta-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis...
  6. doi request reprint Epithelial responses to lung injury: role of the extracellular matrix
    Harold A Chapman
    Pulmonary and Critical Care Division, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Proc Am Thorac Soc 9:89-95. 2012
    ..Elucidation of specific inhibitors of EMT should further test the question of whether the process is important to fibrosis in vivo and a viable therapeutic target...
  7. pmc Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    Kevin K Kim
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 103:13180-5. 2006
    ..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis...
  8. pmc Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    Young Kim
    Pulmonary and Critical Care Division, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 184:309-22. 2009
    ..These findings demonstrate that alpha3beta1 coordinates cross talk between beta-catenin and Smad signaling pathways as a function of extracellular contact cues and thereby regulates responses to TGF-beta1 activation...
  9. pmc Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis
    Arnau Ulsamer
    Pulmonary and Critical Care Division, Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 287:5164-72. 2012
    ....
  10. doi request reprint Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins
    Chi Hui Tang
    Pulmonary and Critical Care Division, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 121:3747-56. 2008
    ..Taken together, the results indicate that uPAR-beta1-integrin interactions are essential to signals induced by integrin matrix ligands or uPA that support lung cancer cell invasion in vitro and progression in vivo...
  11. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
    ....
  12. pmc Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding
    Ying Wei
    Department of Medicine and Pulmonary and Critical Care Division, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 168:501-11. 2005
    ..Direct binding and regulation of alpha5beta1 by uPAR implies a modified "bent" integrin conformation can function in an alternative activation state with this and possibly other cis-acting membrane ligands...
  13. pmc Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact
    Feng Zhang
    Pulmonary and Critical Care Division, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0130, USA
    J Cell Biol 163:177-88. 2003
    ..These studies reveal an integrin- and Src-dependent pathway for SLUG expression and mesenchymal transition...
  14. pmc Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis
    Cecilia Marmai
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    Am J Physiol Lung Cell Mol Physiol 301:L71-8. 2011
    ..These data suggest that alveolar type II cells can acquire features of mesenchymal cells in IPF lungs and that TGF-β can mediate this process...
  15. ncbi request reprint Endosomal proteases in antigen presentation
    Harold A Chapman
    Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Curr Opin Immunol 18:78-84. 2006
    ..Repeated implication of cathepsins in processing medically important antigens holds promise for therapeutic manipulation of proteases in diseases in which there is disordered adaptive immunity...
  16. pmc Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease
    Chi Hui Tang
    Department of Medicine, and the Cardiovascular Research Institute, University of California, San Francisco, Box 0111, San Francisco, CA 94143, USA
    Mol Cell Biol 26:2309-16. 2006
    ..cat F is the only cysteine cathepsin whose inactivation alone causes a lysosomal storage defect and progressive neurological features in mice. The late onset suggests that this gene may be a candidate for adult-onset NCL...
  17. doi request reprint Epithelial-mesenchymal interactions in pulmonary fibrosis
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143, USA
    Annu Rev Physiol 73:413-35. 2011
    ..Understanding specific signaling mechanisms driving the mesenchymal response to TGFβ1 may reveal therapeutics to attenuate fibrogenesis yet preserve the important homeostatic functions of TGFβ1...
  18. pmc Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice
    Jon Mallen-St Clair
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0111, USA
    Biol Chem 387:1143-6. 2006
    ..These results show that neither cathepsin L nor S is required for activation of DPPI and suggest that one or more additional proteases is responsible...
  19. pmc Cell Therapy for Lung Diseases. Report from an NIH-NHLBI Workshop, November 13-14, 2012
    Michael A Matthay
    1 Department of Medicine, University of California, San Francisco, San Francisco, California
    Am J Respir Crit Care Med 188:370-5. 2013
    ....
  20. pmc Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
    Barbara Sennino
    Comprehensive Cancer Center, Department of Anatomy, University of California San Francisco UCSF, San Francisco, CA 94143 0452, USA
    Cancer Discov 2:270-87. 2012
    ..These findings document that invasion and metastasis are promoted by selective inhibition of VEGF signaling and can be reduced by the concurrent inhibition of c-Met...
  21. ncbi request reprint Urokinase receptor and integrin interactions
    Matthias C Kugler
    Department of Medicine, Pulmonary and Critical Care Division, and CVRI University of California, San Francisco, 94143, USA
    Curr Pharm Des 9:1565-74. 2003
    ..Together these observations support the idea that uPAR:integrin interactions may be a focal point of intervention in pathobiology where integrin function is crucial, such as tumor metastasis...
  22. pmc Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease
    Mrinalini Kala
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, 93143, USA
    Immunology 116:532-40. 2005
    ..Contrasting findings among organ-specific murine autoimmune models imply that potential uses of Cat S inhibitors to ameliorate autoimmunity must be determined empirically...
  23. ncbi request reprint Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts
    Sha Zhu
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama, Birmingham AL 35294, USA
    Chest 121:34S-35S. 2002
  24. ncbi request reprint Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways
    Supurna Ghosh
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:13021-9. 2006
    ....
  25. ncbi request reprint Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema
    Tao Zheng
    Department of Internal Medicine, Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, New Haven, CT 06520, USA
    J Immunol 174:8106-15. 2005
    ..They also link inflammation, protease/antiprotease alterations, and protease-dependent apoptosis in the pathogenesis of Th1/Tc1 cytokine-induced tissue remodeling and destructive responses...
  26. ncbi request reprint Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis
    Kevin K Kim
    Am J Respir Cell Mol Biol 37:1-2. 2007
  27. ncbi request reprint Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis
    Huan Yang
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Immunol 174:1729-37. 2005
    ..Because Cat S null mice are not severely immunocompromised, Cat S inhibitors could be tested for their therapeutic potential in EAMG...
  28. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  29. ncbi request reprint Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses
    Bing Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77th Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:5779-84. 2006
    ....
  30. ncbi request reprint Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group
    Ronald G Crystal
    Division of Pulmonary and Critical Care Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Crit Care Med 166:236-46. 2002
    ....
  31. ncbi request reprint Random peptide bacteriophage display as a probe for urokinase receptor ligands
    Susan Fong
    Chiron Corporation, Emeryville, CA 94608, USA
    Biol Chem 383:149-58. 2002
    ....
  32. pmc The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
    ....
  33. ncbi request reprint The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006
  34. ncbi request reprint Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice
    Galina K Sukhova
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Mass, USA
    Circ Res 96:368-75. 2005
    ..These findings demonstrate directly the importance of cysteine protease/protease inhibitor balance in dysregulated arterial integrity and remodeling during experimental atherogenesis...