Wan Pin Chang

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, 825 N E 13th St, Oklahoma City, OK 73104, USA
    FASEB J 21:3184-96. 2007
  2. ncbi request reprint Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2
    Xiangyuan He
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    FEBS Lett 524:183-7. 2002
  3. ncbi request reprint In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    J Neurochem 89:1409-16. 2004
  4. ncbi request reprint Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein
    Xiang Ping Huang
    Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 279:37886-94. 2004
  5. ncbi request reprint GGA proteins mediate the recycling pathway of memapsin 2 (BACE)
    Xiangyuan He
    Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:11696-703. 2005
  6. pmc Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    FASEB J 25:775-84. 2011
  7. ncbi request reprint The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Dev Comp Immunol 29:265-73. 2005

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, 825 N E 13th St, Oklahoma City, OK 73104, USA
    FASEB J 21:3184-96. 2007
    ..These results suggest that memapsin 2 immunization in Tg2576 was effective in reducing Abeta production and improving cognitive function and that the current approach warrants further investigation as a therapy for AD...
  2. ncbi request reprint Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2
    Xiangyuan He
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    FEBS Lett 524:183-7. 2002
    ..These observations suggest that the endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2...
  3. ncbi request reprint In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    J Neurochem 89:1409-16. 2004
    ..These observations verified that memapsin 2 is a therapeutic target for Abeta reduction and also establish that transgenic mice are suitable in vivo models for the study of memapsin 2 inhibition...
  4. ncbi request reprint Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein
    Xiang Ping Huang
    Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 279:37886-94. 2004
    ..In addition, full-length memapsin 2 and APP, immunoprecipitated together from cell lysates, suggested that the interaction of these two proteins is part of the native cellular processes...
  5. ncbi request reprint GGA proteins mediate the recycling pathway of memapsin 2 (BACE)
    Xiangyuan He
    Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:11696-703. 2005
    ..These observations suggest that GGA proteins function with the phosphorylated ACDL in the memapsin 2-recycling pathway from endosomes to trans-Golgi on the way back to the cell surface...
  6. pmc Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    FASEB J 25:775-84. 2011
    ..These observations substantiate the idea that Aβ accumulation plays a major role in the cognitive decline of Tg2576 mice and support the concept of Aβ reduction therapy as a treatment of AD...
  7. ncbi request reprint The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken
    Wan Pin Chang
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Dev Comp Immunol 29:265-73. 2005
    ..From these studies, we conclude that plasma thymulin concentrations directly correlate with plasma T(3) concentrations which are negatively affected by a Se deficiency...