Roger L Chang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Deterministic graph-theoretic algorithm for detecting modules in biological interaction networks
    Roger L Chang
    University of California San Diego, La Jolla, San Diego, CA 92093 0412, USA
    Int J Bioinform Res Appl 6:101-19. 2010
  2. pmc Antibacterial mechanisms identified through structural systems pharmacology
    Roger L Chang
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    BMC Syst Biol 7:102. 2013
  3. pmc Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction
    Edward J O'Brien
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Mol Syst Biol 9:693. 2013
  4. pmc Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli
    Roger L Chang
    Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA 92093 0412, USA
    Science 340:1220-3. 2013
  5. pmc Network context and selection in the evolution to enzyme specificity
    Hojung Nam
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Science 337:1101-4. 2012
  6. pmc Drug off-target effects predicted using structural analysis in the context of a metabolic network model
    Roger L Chang
    Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 6:e1000938. 2010
  7. pmc Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism
    Roger L Chang
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Mol Syst Biol 7:518. 2011

Detail Information

Publications7

  1. ncbi request reprint Deterministic graph-theoretic algorithm for detecting modules in biological interaction networks
    Roger L Chang
    University of California San Diego, La Jolla, San Diego, CA 92093 0412, USA
    Int J Bioinform Res Appl 6:101-19. 2010
    ..dMoNet simultaneously processes structurally equivalent edges while preserving intuitive foundations of the MoNet algorithm and generates modules with full network coverage...
  2. pmc Antibacterial mechanisms identified through structural systems pharmacology
    Roger L Chang
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    BMC Syst Biol 7:102. 2013
    ..coli, structurally accounting for protein complexes. Carefully selected case studies are demonstrated to display the potential for this structural systems pharmacology framework in discovery and development of antibacterial compounds...
  3. pmc Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction
    Edward J O'Brien
    Department of Bioengineering, University of California San Diego, La Jolla, CA, USA
    Mol Syst Biol 9:693. 2013
    ..Our results unify many existing principles developed to describe bacterial growth...
  4. pmc Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli
    Roger L Chang
    Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA 92093 0412, USA
    Science 340:1220-3. 2013
    ..Inclusion of structural information expanded the content and predictive capability of genome-scale metabolic networks that enable structural systems biology of metabolism...
  5. pmc Network context and selection in the evolution to enzyme specificity
    Hojung Nam
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Science 337:1101-4. 2012
    ..Furthermore, these properties are conserved in Archaea and Eukarya. Thus, the metabolic network context and environmental conditions influence enzyme evolution toward high specificity...
  6. pmc Drug off-target effects predicted using structural analysis in the context of a metabolic network model
    Roger L Chang
    Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 6:e1000938. 2010
    ..The methodology introduced herein has important implications for drug development and personalized medicine...
  7. pmc Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism
    Roger L Chang
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Mol Syst Biol 7:518. 2011
    ..The network offers insight into algal metabolism and potential for genetic engineering and efficient light source design, a pioneering resource for studying light-driven metabolism and quantitative systems biology...